Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middleaged women with and without manifest coronary heart disease

2005 ◽  
Vol 93 (02) ◽  
pp. 351-358 ◽  
Author(s):  
Margita Eriksson-Berg ◽  
Hiroyuki Deguchi ◽  
Emma Hawe ◽  
Daniela Scanavini ◽  
Kristina Orth-Gomér ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Large Scale ◽  
Plasma Concentrations ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Major Influence ◽  
Serum Triglycerides ◽  
Coagulation Factor Vii ◽  
Functional Polymorphisms

SummaryPlasma concentrations of coagulation factorVII (FVII) are determined by environmental and genetic factors. The influence of functional polymorphisms in the FVII gene (-670A>C, –402G>A, –401G>T and R353Q) and of established cardiovascular risk factors on plasma concentrations of FVII were investigated in a representative sample of middle-aged women with (n=238) and without (n=220) coronary heart disease (CHD). Specific and sensitive assays were used to measure FVII antigen (VIIag) and activated factorVII (VIIa).The effect of genotypes was markedly stronger on VIIa than on VIIag, with the percentage variation in FVII levels accounted for by genotypes being greater in controls than in patients. Of the four polymorphisms examined, only the R353Q contributed to the variation inVIIa (24.1% in patients and 30.3% in controls). The –401G>T and –670A>C promoter polymorphisms together accounted for 12.2% of the variation in VIIag amongst patients whereas the –401G>T polymorphism alone contributed 19.7% of the variation in VIIag in controls. Serum triglycerides exerted a major influence onVIIag in both patients (13.0%) and controls (7.2%).Three main haplotypes emerged from the four polymorphisms which accounted for 98% of all haplotypes. Large-scale prospective studies of CHD including FVII haplotypes and sensitive and specific FVII measurements are needed in women.

Coagulation Factor VII in Middle-aged Women with and without Coronary Heart Disease

2001 ◽  
Vol 85 (05) ◽  
pp. 787-792 ◽  
Author(s):  
Angela Silveira ◽  
Kristina Orth-Gomér ◽  
Anders Hamsten ◽  
Karin Schenck-Gustafsson ◽  
Margita Eriksson-Berg
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Plasma Concentrations ◽  
Coagulation Factor ◽  
Epidemiological Studies ◽  
Factor Vii ◽  
Community Based ◽  
Coagulation Factor Vii ◽  
Activated Factor Vii ◽  
Control Study

SummaryEpidemiological studies of coagulation factor VII as a risk factor for coronary heart disease (CHD), mainly conducted in men, have shown discrepant results. We examined the associations of coagulation factor VII antigen (VIIag) and activated factor VII (VIIa) with manifest CHD in a community-based case-control study of women aged ≤65 years. Mean plasma concentrations of VIIag and VIIa in patients and controls were 443 ± 108 and 418 ± 89 ng/L (p <0.01) and 5.26 ± 2.21 and 4.90 ± 1.65 ng/L (NS), respectively. The odds ratio (OR) for CHD for the highest versus the lowest quartile of VIIag was 1.75 (95% CI, 1.05 to 2.92). The adjusted OR was 0.76 (95% CI, 0.28-1.98) after controlling for other cardiovascular risk factors. The corresponding ORs for VIIa were non-significant. In conclusion, the plasma concentration of VIIa was not significantly increased in a large group of women with precocious CHD, and VIIag levels, although elevated, were not independently associated with manifest disease.

Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease

2004 ◽  
Vol 113 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Anja S. Lindman ◽  
Jan I. Pedersen ◽  
Harald Arnesen ◽  
Elsa M. Hjerkinn ◽  
Marit B. Veierød ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Risk ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Coagulation Factor Vii

Two Common Functional Polymorphisms in the Promoter Region of the Coagulation Factor VII Gene Determining Plasma Factor VII Activity and Mass Concentration

Blood ◽  
1999 ◽  
Vol 93 (10) ◽  
pp. 3432-3441 ◽  
Author(s):  
Ferdinand M. van ’t Hooft ◽  
Angela Silveira ◽  
Per Tornvall ◽  
Anastasia Iliadou ◽  
Ewa Ehrenborg ◽  
...  
Keyword(s):  
Promoter Region ◽  
Nuclear Protein ◽  
Plasma Concentrations ◽  
Coagulation Factor ◽  
Protein S ◽  
Factor Vii ◽  
Binding Properties ◽  
Coagulation Factor Vii ◽  
Functional Polymorphisms ◽  
Plasma Factor

Recent studies have provided evidence for associations between common polymorphic markers in the coagulation factor VII (FVII) gene and plasma FVII levels. Here we describe two common, nonrelated, functional polymorphisms in the promoter region of the FVII gene, a G to T substitution at position −401 and a novel G to A substitution at position −402. Both polymorphisms strongly influence the binding properties of nuclear protein(s). The rare −401T allele is associated with a reduced basal rate of transcription of the FVII gene in human hepatoblastoma cells and with reduced plasma concentrations of total FVII (VIIag) and fully activated FVII molecules (VIIa). In contrast, the rare −402A allele confers increased transcriptional activity and is associated with increased plasma FVII levels. Together, the two polymorphisms explained 18% and 28% of the variation in VIIag and VIIa, respectively, in a group of 183 healthy, middle-aged men. It is concluded that these polymorphisms are important for the regulation of the plasma levels of FVII and that they are likely to be useful genetic markers to resolve the issue of whether a causal relationship exists between FVII levels and risk of coronary heart disease.

Coagulation Factor VII and the Risk of Coronary Heart Disease in Healthy Men

1997 ◽  
Vol 17 (8) ◽  
pp. 1539-1544 ◽  
Author(s):  
Ralf Junker ◽  
Jürgen Heinrich ◽  
Helmut Schulte ◽  
Jürgen van de Loo ◽  
Gerd Assmann
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Healthy Men ◽  
Coagulation Factor Vii

Coagulation factor VII and inflammatory markers in patients with coronary heart disease

2007 ◽  
Vol 18 (5) ◽  
pp. 473-477 ◽  
Author(s):  
Mattias Ekstr??m ◽  
Angela Silveira ◽  
Marie Bennermo ◽  
Per Eriksson ◽  
Per Tornvall
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Markers ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Coagulation Factor Vii

scholarly journals PREDICTING THE RISK OF ATRIAL FIBRILLATION AND CORONARY HEART DISEASE DEVELOPMENT WITH MUTATION OF HEMOSTASIS SYSTEM GENES

2018 ◽  
Vol 25 (5) ◽  
pp. 147-151
Author(s):  
D. I. Panchenko ◽  
A. S. Adamchik
Keyword(s):  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coagulation Factor ◽  
Mthfr Gene ◽  
Factor Vii ◽  
Clotting Factor ◽  
Control Group ◽  
Disease Development ◽  
Hemostasis System

Aim. This study was conducted to assess the risk of atrial fibrillation and coronary heart disease development with mutation of hemostasis system genes.Materials and methods. Genes polymorphisms of factor GII210A II (FII), G169A factor V (FV), Arg 353G1p factor VII (FVII), C677T MTHFR, 22Met (66a-g) MTRR, 675 5G / 4G PAI type 1 and 455G-A fibrinogen β (FGB) were examined in the patients of the main group and control group. The genotyping was carried out by PCR method using competing TagMan probes complementary to the polymorphic region of DNA.Results. As a result of the research, there was identified a reliable prognostic risk of the development of coronary heart disease (CHD) and atrial fibrillation paroxysms (AFP) in patients with mutations of the VII blood coagulation factor genes, mutations in the MTHFR gene, mutations in the MTRR gene.Conclusion. The obtained results indicate the risk of CHD and AFP development in patients with mutations of the VII gene of the clotting factor, mutation in the MTHFR gene and mutation in the MTRR gene. It may be the basis for early diagnosis, monitoring and treatment of this category of patients. 

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