Circulating bactericidal/permeability-increasing protein (BPI) is associated with serum lipids and endothelial function

2010 ◽  
Vol 103 (04) ◽  
pp. 780-787 ◽  
Author(s):  
Eduardo Esteve ◽  
Antoni Castro ◽  
Jose Maria Moreno ◽  
Joan Vendrell ◽  
Wifredo Ricart ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Glucose Tolerance ◽  
Endothelial Function ◽  
Total Cholesterol ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Linear Regression Analysis ◽  
Normal Glucose Tolerance ◽  
Major Constituent ◽  
Normal Glucose

SummaryBactericidal/permeability-increasing protein (BPI), a major constituent of neutrophils that possesses anti-inflammatory properties, shows a structure similar to some proteins implicated in lipid metabolism. We evaluated circulating BPI as a biomarker of endothelial function and lipid metabolism. Circulating BPI concentrations (ELISA) and serum lipids were measured in 202 Caucasian non-smoking men. In a subgroup of 91 consecutive subjects brachial vascular reactivity (high resolution external ultrasound) was assessed. Plasma BPI concentrations were positively associated with total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) (r= 0.203, 0.204 and 0.18; all p<0.05, respectively). In a multiple linear regression analysis, BPI levels were independent contributors to the variance of HDL-C, total cholesterol and LDL-cholesterol after adjusting for age, body mass index and glucose tolerance status. Plasma BPI concentration correlated positively with endothelium-dependent vasodilatation (r=0.277; p<0.05) and HDL-C (r=0.36; p<0.05) in subjects with normal glucose tolerance. In conclusion, circulating BPI could constitute a biomarker of lipid metabolism in subjects with normal glucose tolerance and could help to identify those subjects with preserved endothelial function.

scholarly journals The effects of postprandial glucose and insulin levels on postprandial endothelial function in subjects with normal glucose tolerance

2012 ◽  
Vol 11 (1) ◽  
pp. 98 ◽  
Author(s):  
Kazunari Suzuki ◽  
Kentaro Watanabe ◽  
Shoko Futami-Suda ◽  
Hiroyuki Yano ◽  
Masayuki Motoyama ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Endothelial Function ◽  
Postprandial Glucose ◽  
Normal Glucose Tolerance ◽  
Insulin Levels ◽  
Normal Glucose

scholarly journals Glucose Tolerance,MTHFRC677T andNOS3G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Tandi E. Matsha ◽  
Carmen Pheiffer ◽  
Tinashe Mutize ◽  
Rajiv T. Erasmus ◽  
Andre P. Kengne
Keyword(s):  
Dna Methylation ◽  
Glucose Tolerance ◽  
Linear Regression Analysis ◽  
Mthfr C677t ◽  
Normal Glucose Tolerance ◽  
Global Dna Methylation ◽  
Mixed Ancestry ◽  
Direct Dna Sequencing ◽  
Diabetes Status ◽  
Normal Glucose

The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa. Global DNA methylation was measured, andMTHFRrs1801133 andNOS3rs1799983 polymorphisms were genotyped using high throughput real-time polymerase chain reaction and direct DNA sequencing. Of the 564 participants, 158 (28%) individuals had T2DM of which 97 (17.2%) were screen-detected cases. Another 119 (21.1%) had prediabetes, that is, impaired fasting glucose, impaired glucose tolerance, or the combination of both, and the remainder 287 (50.9%) had normal glucose tolerance. Global DNA methylation was significantly higher in prediabetes and screen-detected diabetes than in normal glucose tolerance (bothp≤0.033) and in screen-detected diabetes compared to known diabetes on treatment (p=0.019). There was no difference in global DNA methylation between known diabetes on treatment and normal glucose tolerance (p>0.999). In multivariable linear regression analysis, onlyNOS3was associated with increasing global DNA methylation (β=0.943; 95% CI: 0.286 to 1.560). The association of global DNA methylation with screen-detected diabetes but not treated diabetes suggests that glucose control agents to some extent may be reversing DNA methylation. The association betweenNOS3rs1799983 polymorphisms and DNA methylation suggests gene-epigenetic mechanisms through which vascular diabetes complications develop despite adequate metabolic control.

scholarly journals Effect of diets enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes

2002 ◽  
Vol 76 (5) ◽  
pp. 1000-1006 ◽  
Author(s):  
Jennifer C Lovejoy ◽  
Marlene M Most ◽  
Michael Lefevre ◽  
Frank L Greenway ◽  
Jennifer C Rood
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Insulin Action ◽  
Serum Lipids ◽  
Normal Glucose Tolerance ◽  
Normal Glucose

scholarly journals Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis

2017 ◽  
Vol 40 (2) ◽  
pp. 59 ◽  
Author(s):  
Adèle Coriati ◽  
Elizabeth Arslanian ◽  
Guillaume F Bouvet ◽  
Annik Prat ◽  
Nabil G Seidah ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lipid Metabolism ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Healthy Population ◽  
Healthy Individuals ◽  
Proprotein Convertase ◽  
Insulin Homeostasis ◽  
Normal Glucose

Purpose: Cystic Fibrosis (CF) is the most common genetic disorder and, with improved survival, glucose abnormalities have emerged as a major comorbidity. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a regulator of plasma LDL-cholesterol homeostasis, is associated with lipid and glucose metabolism in healthy individuals. Here we report on the link between PCSK9 and markers of metabolism in CF. Methods: Cross-sectional analysis was performed on CF patients (≥ 18 years, N=94) from the Montreal Cohort, without known diabetes, and on healthy individuals (N=19). The levels of PCSK9 and lipid markers were quantified and all subjects underwent a 2 h oral glucose tolerance test. Results: No significant differences in PCSK9 levels were found between healthy individuals and patients with CF, or between the groups with different degrees of glucose tolerance. No association was found between PCSK9 and markers of lipid metabolism; however, a positive correlation was found between PCSK9 and total insulin secretion and a negative one with insulin sensitivity in CF patients who had normal glucose tolerance. Conclusion: Circulating levels of PCSK9 in the CF population are comparable to those in the healthy population. There are no associations between PCSK9 levels and either glucose or lipid homeostasis parameters. Nevertheless, a statistically significant link was observed between PCSK9 and markers of insulin homeostasis, solely in CF patients who presented normal glucose tolerance. Further exploration of the relationship between PCSK9 and insulin homeostasis in CF patients with normal glucose tolerance is warranted.

scholarly journals Plasma DPP4 Activities Are Associated With Osteoporosis in Postmenopausal Women With Normal Glucose Tolerance

2015 ◽  
Vol 100 (10) ◽  
pp. 3862-3870 ◽  
Author(s):  
Tianpeng Zheng ◽  
Liuxue Yang ◽  
Yihong Liu ◽  
Hongbo Liu ◽  
Jian Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Total Cholesterol ◽  
Postmenopausal Women ◽  
Type I Collagen ◽  
Normal Glucose Tolerance ◽  
Type I ◽  
Normal Glucose ◽  
Hs Crp

Context: Inflammation, insulin resistance, dyslipidemia, and glucagon-like peptide-1 (GLP-1) are risk factors for osteoporosis. Dipeptidyl peptidase-4 (DPP4) is a newly identified adipokine related to these risk factors. Objective: To investigate the association between plasma DPP4 activities and osteoporosis. Design, Setting, and Patients: This was a cross-sectional study conducted in Guilin, China. A total of 744 postmenopausal women with normal glucose tolerance were studied. Main Outcome Measures: Plasma DPP4 activity, inflammatory markers, blood lipids, homeostatic model assessment of insulin resistance (HOMA-IR), active GLP-1, bone turnover markers, and bone mineral density (BMD) were measured in all participants. Results: Participants in the highest quartile of DPP4 activity had higher triglyceride, total cholesterol, HOMA-IR, IL-6, high-sensitivity C-reactive protein (hs-CRP), C-terminal telopeptide of type I collagen, and osteocalcin and lower BMD (lumbar spine and femoral neck) and active GLP-1 compared with participants in the lowest quartile (P &lt; .05). DPP4 activities were associated positively with triglyceride, total cholesterol, HOMA-IR, IL-6, hs-CRP, C-terminal telopeptide of type I collagen, and osteocalcin and negatively with active GLP-1 and BMD (P &lt; .05). In the highest DPP4 quartile, osteoporosis risk was significantly higher (odds ratio, 3.01; 95% confidence interval, 1.66–5.43) than in the lowest quartile after adjustment for potential confounders. The risk for osteoporosis increased more with higher levels of DPP4 activity, HOMA-IR, IL-6, and hs-CRP (P &lt; .05), but not with higher levels of triglyceride and total cholesterol or lower levels of active GLP-1. Conclusions: This study shows that increased DPP4 activities are independently associated with osteoporosis. The mechanisms may be partly explained by the effect of DPP4 on inflammation and insulin resistance.

Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C

2000 ◽  
Vol 279 (3) ◽  
pp. H1172-H1178 ◽  
Author(s):  
Nobutaka Hirai ◽  
Hiroaki Kawano ◽  
Osamu Hirashima ◽  
Takeshi Motoyama ◽  
Yasushi Moriyama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Endothelial Dysfunction ◽  
Vitamin C ◽  
Glucose Tolerance ◽  
Endothelial Function ◽  
Thiobarbituric Acid ◽  
Normal Glucose Tolerance ◽  
Normal Glucose

Cigarette smoking impairs endothelial function and is one of the major risk factors for atherosclerosis and coronary heart disease. Insulin resistance is associated with major risk factors for atherosclerosis. We examined the effects of vitamin C on insulin sensitivity and endothelial function by measuring steady-state plasma glucose (SSPG) and flow-mediated dilation (FMD) of the brachial artery. We studied 16 current smokers with normal glucose tolerance, 15 nonsmokers with impaired glucose tolerance (IGT), and 17 nonsmokers with normal glucose tolerance as controls. Both SSPG and FMD were blunted in smokers and nonsmokers with IGT compared with controls. In smokers, vitamin C decreased SSPG ( P < 0.01 by ANOVA) with decreasing plasma thiobarbituric acid-reactive substances (TBARS) ( P < 0.05 by ANOVA) and improved FMD ( P < 0.05 by ANOVA). Furthermore, vitamin C improved both SSPG ( P < 0.005 by ANOVA) and FMD ( P < 0.05 by ANOVA) in nonsmokers with IGT. SSPG, FMD, or TBARS in controls did not change after vitamin C infusion. There was a significant correlation between SSPG and FMD both in smokers and nonsmokers with IGT, whereas no correlation was observed in controls. In conclusion, both insulin sensitivity and endothelial function were impaired in smokers and nonsmokers with IGT and were improved by vitamin C. Thus increased reactive oxygen species play an important role in the pathogenesis of insulin resistance as well as endothelial dysfunction in smokers and nonsmokers with IGT.

STUDIES IN CONGENITAL GENERALIZED LIPODYSTROPHY (SEIP-BERARDINELLI SYNDROME)

1973 ◽  
Vol 72 (3) ◽  
pp. 475-494 ◽  
Author(s):  
Svein Oseid
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Juvenile Form ◽  
Congenital Generalized Lipodystrophy ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Glucose Tolerance Tests ◽  
The One ◽  
Adipose Organ

ABSTRACT Six cases of congenital generalized lipodystrophy have been studied at different ages from infancy to adolescence with regard to glucose tolerance, insulin secretion, and insulin sensitivity. During the first few years of life there is normal glucose tolerance. The fasting immuno-reactive insulin (IRI) levels are either slightly elevated or normal. The IRI response to glucose is exaggerated and prolonged, at least from the third year of life. Some degree of insulin resistance is already present in infancy. From the age of 8–10 years glucose tolerance decreases rapidly. The fasting IRI levels are usually grossly elevated, while fasting plasma glucose levels are only moderately elevated or normal. The IRI responses to oral and iv administered glucose, and to tolbutamide are exaggerated; the insulinogenic indices are high. Cortisone primed glucose tolerance tests become abnormal. Insulin resistance is marked, and increases with age. After cessation of growth at approximately 12 years of age, frank diabetes with fasting hyperglycaemia and diabetic glucose tolerance curves developed in the one patient followed beyond this age. Her fasting IRI was increased, but there was a poor IRI response to glucose stimulation, suggesting a partial exhaustion of the β-cells. Her initial IRI response to tolbutamide was still good, but not as brisk as in the younger patients. This type of diabetes is quite different from the juvenile form, and also from the diabetes of older age. It may be causally related to the lack of an adequate adipose organ necessary for the disposal of excesses of glucose, or possibly related to another anti-insulin mechanism.

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