scholarly journals Interleukin-1β Regulation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Involves the p42/44 and p38 MAPK Signaling Pathways in Cardiac Myocytes

Hypertension ◽  
1999 ◽  
Vol 33 (1) ◽  
pp. 276-282 ◽  
Author(s):  
Margot C. LaPointe ◽  
Esma Isenović
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Signaling Pathways ◽  
Cardiac Myocytes ◽  
P38 Mapk ◽  
Inducible Nitric Oxide Synthase ◽  
Mapk Signaling ◽  
Oxide Synthase ◽  
Mapk Signaling Pathways ◽  
Inducible Nitric Oxide

Effect of Triterpene Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf and MAPK Signal Transduction Pathway on Inducible Nitric Oxide Synthase Expression in Alveolar Macrophage of Chronic Bronchitis Rats

2009 ◽  
Vol 37 (06) ◽  
pp. 1099-1111 ◽  
Author(s):  
Y. Huang ◽  
J. Li ◽  
X. M. Meng ◽  
G. L. Jiang ◽  
H. Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
Nitric Oxide Synthase ◽  
Alveolar Macrophage ◽  
P38 Mapk ◽  
Inducible Nitric Oxide Synthase ◽  
Inos Expression ◽  
Eriobotrya Japonica ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The goal of this study was to investigate the possible therapy mechanism of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf (TAL) in alveolar macrophage (AM) of chronic bronchitis (CB) rats. CB model was established by injection of bacillus calmette guein (BCG) plus lipopolisacharide (LPS) in rats. TAL significantly inhibited the increased NO concentration, iNOS expression and phosphorylation of p38 MAPK in alveolar macrophages (AMs) of CB rats. Using in vivo test, we found that SB203580, a p38 MAPK inhibitor, (10 μM) significantly inhibited inducible nitric oxide synthase (iNOS) mRNA expression in AM. This data indicate that TAL highly decreases excessive iNOS expression and NO induction, and p38 MAPK signal transduction participates in iNOS expression and NO induction in AM of CB rats. The effect of TAL on iNOS expression in AM may be related to its inhibition of p38 MAPK signal transduction.

scholarly journals Mechanical Strain Suppresses Inducible Nitric-oxide Synthase in Cardiac Myocytes

1998 ◽  
Vol 273 (19) ◽  
pp. 11862-11866 ◽  
Author(s):  
Keiji Yamamoto ◽  
Quynh N. Dang ◽  
Ralph A. Kelly ◽  
Richard T. Lee
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cardiac Myocytes ◽  
Inducible Nitric Oxide Synthase ◽  
Mechanical Strain ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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