scholarly journals The relationship of the renin-angiotensin system in type I diabetes to microvascular disease.

Hypertension ◽  
1985 ◽  
Vol 7 (6_pt_2) ◽  
Author(s):  
P L Drury ◽  
H J Bodansky
Keyword(s):  
Type I Diabetes ◽  
Microvascular Disease ◽  
Renin Angiotensin System ◽  
Type I ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Relationship Of ◽  
The Relationship

scholarly journals Relationship of renin-angiotensin system and ET-1 system activation in long-lasting response to postural changes

1996 ◽  
Vol 270 (4) ◽  
pp. H1200-H1206 ◽  
Author(s):  
P. A. Modesti ◽  
I. Cecioni ◽  
A. Naldoni ◽  
A. Migliorini ◽  
G. G. Neri Serneri
Keyword(s):  
Urinary Excretion ◽  
Free Water ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Urinary Volume ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Postural Changes ◽  
Relationship Of ◽  
The Relationship

The present study was performed in seven healthy subjects (aged 22-35 years) to investigate 1) whether plasma and urinary endothelin-1 (ET-1) are involved in the response to postural changes and 2) the relationship between ET-1 formation and the renin-angiotensin system (RAS). Six hours of standing caused a prompt but very short-lasting increase in plasma ET-1 concentration (59% after 5 min, 12% after 1 h) and a notable and sustained enhancement of urinary ET-1 excretion (from 0.59 +/- 0.10 to 1.43 +/- 0.28 pg/min, or 142%; P < 0.001). Plasma renin activity increased by 169% after 1 h of standing. A parallel contraction of urinary volume (-62%), sodium excretion (-55%), and free water reabsorption (-24%) occurred. The return to the supine position after 6 h of orthostasis caused a reduction to baseline values of the ET-1 urinary excretion and urinary volume within 2 h. Inhibition of angiotensin-converting enzyme blunted, but did not eliminate, the orthostasis-induced increase in ET-1 urinary excretion (100%, P < 0.002) and changes in the renal functions. The present results indicate that renal ET-1 is involved in the hemodynamic long-lasting responses to postural changes and that its increase is partially controlled by RAS and suggest that ET-1 might play a role in the regulation of renal function in humans.

Association between Regional Cerebral Blood Flow during Hypoglycemia and Genetic and Phenotypic Traits of the Renin–Angiotensin System

2009 ◽  
Vol 29 (11) ◽  
pp. 1790-1795
Author(s):  
Lise Grimmeshave Bie-Olsen ◽  
Ulrik Pedersen-Bjergaard ◽  
Troels Wesenberg Kjær ◽  
Markus Nowak Lonsdale ◽  
Ian Law ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Renin Angiotensin System ◽  
Severe Hypoglycemia ◽  
Parahippocampal Gyrus ◽  
Phenotypic Traits ◽  
Type I ◽  
Angiotensin System ◽  
Healthy Men ◽  
Renin Angiotensin ◽  
Cerebral Activity

The risk of severe hypoglycemia in patients with type I diabetes and high basal activity in the renin–angiotensin system (RAS) is significantly higher than in patients with low basal RAS activity. In healthy men, we tested the hypothesis that differences in spontaneous RAS activity are associated with differences in cerebral activity responses during mild hypoglycemia. A total of 10 healthy men with high and 10 with low spontaneous RAS activity were selected. An H215O-PET (H215O-positron emission tomography) study was conducted with a series of six scans, i.e., two during normoglycemia, two during hypoglycemia, and two after hypoglycemia. The mean plasma glucose concentration was similar in both the groups (i.e., 2.1 mmol/L (s.d.: 0.4) in the low RAS group and 2.2 mmol/L (s.d.: 0.4) in the high RAS group ( P=0.47)). The high RAS group has lower cerebral activity in the frontal area and a higher cerebral activity in the entorhinal area that expanded to include the parahippocampal gyrus after hypoglycemia. Our findings suggest that the high RAS group to a lesser extent than the low RAS group activates areas involving executive function that may explain the correlation between high basal RAS activity and risk of severe hypoglycemia in type I diabetes.

scholarly journals The Relationship between the Intrarenal Dopamine System and Intrarenal Renin-angiotensin System Depending on the Renal Function

2018 ◽  
Vol 57 (22) ◽  
pp. 3241-3247 ◽  
Author(s):  
Takashi Matsuyama ◽  
Naro Ohashi ◽  
Sayaka Ishigaki ◽  
Shinsuke Isobe ◽  
Naoko Tsuji ◽  
...  
Keyword(s):  
Renal Function ◽  
Renin Angiotensin System ◽  
Dopamine System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Relationship

scholarly journals The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System

2006 ◽  
Vol 2006 ◽  
pp. 1-6 ◽  
Author(s):  
Suyeon Kim ◽  
Morvarid Soltani-Bejnood ◽  
Annie Quignard-Boulange ◽  
Florence Massiera ◽  
Michele Teboul ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Renin Angiotensin System ◽  
Total Body Weight ◽  
Receptor Protein ◽  
Type I ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Protein Levels ◽  
Total Body ◽  
Plasma Leptin

Background. The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism.Methods and results. A panel of mouse models including mice lacking angiotensinogen,Agt(Agt-KO), mice expressingAgtsolely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressingAgtin adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased inAgt-KO mice, while plasma adiponectin levels were increased. aP2-Agtmice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agtmice.Conclusion. These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.

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