Abstract 448: Association of CHADS2 and CHA2DS2-VASc Score with Coronary Atherosclerosis Burden in Nonvalvular Atrial Fibrillation

Background: This study is to examine association of CHADS2 and CHA2DS2-VASc score with coronary artery disease (CAD) in nonvalvular atrial fibrillation (AF) Method: A total of 676 consecutive nonvalvular AF patients without known history of CAD underwent coronary artery calcium score (CACS) evaluation by multi-detector cardiac computed tomography. Clinical characteristics and CACS were compared between different CHADS2 and CHA2DS2-VASc score groups. Results: The cohort comprised of 68% (461 of 676) male with a mean ± SD age of 63 ± 10 years. Median 10-year risk of CAD by Framingham score was 11% (range 2%-53%). Median CHADS2 score was 1 (range 0-6) and median CHA2DS2-VASc score was 2 (range 0-8). Mean ± SD CACS was 215 ± 504. Compared to CHADS2 score ≤ 1, those with CHADS2 score > 1 had higher mean ± SD CACS (359 ± 738 VS 158 ± 359; p<0.001). CHADS2 score > 1 is associated with CACS > 0 (OR 1.751; 95%CI 1.168, 2.624; p 0.007) and CACS > 400 (OR 2.528; 95%CI 1.641, 3.896; p < 0.001). Similarly, compared to CHA2DS2-VASc score ≤ 1, those with CHA2DS2-VASc score > 1 had higher mean ± SD CACS (270 ± 586 VS 150 ± 376; p<0.001). CHA2DS2-VASc score > 1 is associated with CACS > 0 (OR 1.713; 95%CI 1.217, 2.409; p 0.002) and CACS > 400 (OR 2.683; 95%CI 1.678, 4.289; p < 0.001). Receiver operating characteristics of CHADS2 and CHA2DS2-VASc score models for CACS > 400 is shown in the figure. Conclusion: In nonvalvular AF patients, higher CHADS2 and CHA2DS2-VASc score are comparably associated with presence and severity of CAD.

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Abstract 449: Increased Risk of Coronary Artery Disease in Patients with Persistent Type of Nonvalvular Atrial Fibrillation

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.34.suppl_1.449 ◽

2014 ◽

Vol 34 (suppl_1) ◽

Author(s):

Kongkiat Chaikriangkrai ◽

Sama Alchalabi ◽

Sayf Khaleel bala ◽

Su Min Chang

Keyword(s):

Atrial Fibrillation ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiac Computed Tomography ◽

Framingham Score ◽

Nonvalvular Atrial Fibrillation ◽

Increased Risk ◽

Significant Difference ◽

History Of ◽

Artery Disease

Background: This study is to examine relationship between coronary artery disease (CAD) and types of atrial fibrillation (AF) Methods: A total of 403 nonvalvular atrial fibrillation patients without known history of CAD underwent coronary artery calcium score (CACS) evaluation by multi-detector cardiac computed tomography. Clinical characteristics and CACS were compared between patients with persistent type of AF and paroxysmal type of AF. Results: The cohort comprised of 65% (279 of 430) male with a mean (SD) age of 63(10) years. Prevalence of persistent AF was 60% (259 of 430). Mean (SD) 10-year risk of CAD by Framingham score was 14(7)%. Median CACS was 22 (range 0-5402) with 75% CACS>0 (321 of 430). Compared to paroxysmal type, those with persistent type had higher prevalence of CAC>0 as shown in Figure1 and more history of hypertension (p<0.001) but less history of smoking (p0.004), statins use (p0.018) and warfarin use (p<0.001). There was no statistically significant difference in mean age (p0.783) and CAD risk by Framingham score (p0.477) between two groups. In multivariate analysis, persistent type is an independent predictor for CACS>0 (OR 1.938; 95%CI 1.197, 3.138; p0.007). Conclusion: In patients with AF, persistent type of AF is independently associated with CACS>0. Our findings suggest potential benefit from evaluation of CAD in this population.

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Coronary artery calcium score and the long-term risk of atrial fibrillation in patients undergoing non-contrast cardiac computed tomography for suspected coronary artery disease: a Danish registry-based cohort study

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jex201 ◽

2017 ◽

Vol 19 (8) ◽

pp. 926-932 ◽

Cited By ~ 7

Author(s):

Nicklas Vinter ◽

Amanda M S Christesen ◽

Leif S Mortensen ◽

Grazina Urbonaviciene ◽

Jes Lindholt ◽

...

Keyword(s):

Computed Tomography ◽

Atrial Fibrillation ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Artery Calcium Score ◽

Cardiac Computed Tomography ◽

Calcium Score ◽

Suspected Coronary Artery Disease ◽

Artery Disease

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P4577Coronary artery calcium score and the long-term risk of atrial fibrillation in patients undergoing non-contrast cardiac computed tomography for suspected coronary artery disease

European Heart Journal ◽

10.1093/eurheartj/ehx504.p4577 ◽

2017 ◽

Vol 38 (suppl_1) ◽

Author(s):

N. Vinter ◽

A.M.S. Christesen ◽

L.S. Mortensen ◽

G. Urbonaviciene ◽

J.S. Lindholt ◽

...

Keyword(s):

Computed Tomography ◽

Atrial Fibrillation ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiac Computed Tomography ◽

Calcium Score ◽

Suspected Coronary Artery Disease ◽

Artery Disease

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Relationship between Cardiovascular Calcium and Atrial Fibrillation

Journal of Clinical Medicine ◽

10.3390/jcm11020371 ◽

2022 ◽

Vol 11 (2) ◽

pp. 371

Author(s):

Sung Ho Lee ◽

Mi Yeon Lee ◽

Seung Yong Shin ◽

Wang-Soo Lee ◽

Sang-Wook Kim ◽

...

Keyword(s):

Atrial Fibrillation ◽

Coronary Artery ◽

Multivariable Analysis ◽

Calcium Score ◽

Cross Sectional Study ◽

Health Examination ◽

Cross Sectional ◽

Increased Risk ◽

History Of ◽

Artery Disease

Coronary artery calcium score (CACS) is associated with increased risk of atrial fibrillation (AF). However, the relationship between the burden of CACS and extra-coronary calcium and the AF is unclear. This cross-sectional study retrospectively analyzed the data of 143,529 participants (74.9% men; mean age, 41.7 ± 8.6 years) who underwent health examination including non-contrast cardiac CT and electrocardiography, from 2010 to 2018 to evaluate the association between cardiac calcium and AF. AF was diagnosed in 679 participants. The prevalence of AF was significantly increased as the CACS increased (p < 0.01). Multivariable analysis adjusted for age, sex, body mass index, hypertension, diabetes, hyperlipidemia, smoking, alcohol, and history of coronary artery disease showed a significant association between a high CACS ≥1000 and AF (OR 2.26, 95% CI 1.07–4.77, p = 0.032). In a subgroup analysis of participants with a CACS ≥100, aortic valve and thoracic aorta calcium were significantly associated with AF (OR 3.49, 95% CI 1.57–7.77, p = 0.002 and OR 2.19, 95% CI 1.14–4.21, p = 0.01, respectively). High CACS was associated with AF, and extra-coronary atherosclerosis was associated with AF in participants with a moderate to very high CACS.

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Faculty Opinions recommendation of Evaluation of the predictive value of coronary artery calcium score for obstructive coronary artery disease in asymptomatic Korean patients with type 2 diabetes mellitus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725087687.793510525 ◽

2015 ◽

Author(s):

Nathan Wong

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Type 2 Diabetes Mellitus ◽

Coronary Artery ◽

Coronary Artery Calcium Score ◽

Obstructive Coronary Artery Disease ◽

Calcium Score ◽

Artery Disease

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Bicuspid Aortic Valve Is Associated with Less Coronary Calcium and Coronary Artery Disease Burden

Journal of Clinical Medicine ◽

10.3390/jcm10143070 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3070

Author(s):

Gudrun Feuchtner ◽

Sven Bleckwenn ◽

Leon Stoessl ◽

Fabian Plank ◽

Christoph Beyer ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Aortic Valve ◽

Bicuspid Aortic Valve ◽

Coronary Artery Calcium ◽

Coronary Artery Calcium Score ◽

Calcium Score ◽

Coronary Calcium ◽

Retrospective Case ◽

Artery Disease

(1) Background. Bicuspid aortic valve (BAV) is associated with genetic defects (NOTCH 1, GATA 5) and aortopathy. Differences in the flow patterns and a genetic predisposition could also affect coronary arteries. The objective was to assess the coronary artery calcium score (CACS) and coronary artery disease (CAD) burden by coronary computed tomography angiography (CTA) in patients with BAV stenosis, as compared to stenotic tricuspid aortic valves (TAV). (2) Methods. A retrospective case–control study. A total of 47 patients with BAV stenosis (68.9 years ± 12.9, 38.3% females) who underwent CTA were matched with 47 TAV stenosis patients for age, gender, smoking, arterial hypertension, dyslipidemia, diabetes, body-mass-index and chronic kidney disease. (3) Results. The coronary artery calcium score (CACS) was lower in BAV (237.4 vs. 1013.3AU; p < 0.001) than in TAV, and stenosis severity was less (CAD-RADTM: p < 0.001). More patients with BAV had CACS zero (27.7% vs. 0%; p < 0.001). The majority (68.1%) of patients with BAV had no or non-obstructive CAD but only 25.5% of TAV (p < 0.001). Obstructive CAD (>50% stenosis) by CTA was more frequently observed in patients with TAV (68.1%; p < 0.001). (4) Conclusions and Relevance. Patients with BAV stenosis have markedly less coronary calcium and less severe coronary stenosis. CTA succeeds to rule out obstructive CAD in the majority of BAV, with adherent implications for TAVR planning.

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