Abstract 581: Identification on Anti-Atherosclerotic Mechanism of SGLT-2 Inhibitor in Diabetic Rabbit Model

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Seulgee Lee ◽  
Jung-Sun Kim ◽  
Jaewon Oh ◽  
Sung-Kyung Bong ◽  
jung-jae lee
Keyword(s):  
Rabbit Model ◽  
Diabetic Rabbit

404 EVALUATION OF A DIABETIC RABBIT MODEL FOR IN-STENT RESTENOSIS

2011 ◽  
Vol 12 (1) ◽  
pp. 86
Author(s):  
P.W. Radke ◽  
A. Joost ◽  
A. Kaiser ◽  
M. Basler ◽  
M. Mandapathil ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Stent Restenosis ◽  
Diabetic Rabbit ◽  
In Stent Restenosis

scholarly journals Antidiabetogenic impact of bitter melon (Momordica charantia) and garlic (Allium sativum) on alloxan induced diabetic rabbit model

2016 ◽  
Vol 2 (3) ◽  
pp. 402-408
Author(s):  
Ambiara ◽  
Fahima Binthe Aziz ◽  
Md Mahmudul Hasan ◽  
Md Shajedur Rahman ◽  
Misrat Masuma Parvez ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Combined Treatment ◽  
Rabbit Model ◽  
Treated Group ◽  
Control Group ◽  
Bitter Melon ◽  
Diabetic Rabbit ◽  
Group A ◽  
Group B

The present study was undertaken to investigate the antidiabetic effect of the Bitter melon and Garlic on Alloxan induced diabetes in experimental rabbits. At 2 to 3 months of age, rabbits were assigned into five groups (A, B, C, D and E) and each group was remained 4 rabbits. Group A was kept for control, Group B was treated with Alloxanintramuscullarly at a dose of 75mg /kg body weight, Group C was treated with bitter melon 250gm/kg body weight orally, Group D was treated with garlic 750mg/kg body weight orally, Group E treated with combined at previous dose. After acclimatization, diabetes was induced in four groups of rabbits (B, C, D and E) by administering Alloxan injection in a dose of 75mg/kg body weight (b.wt.) intramuscularlly. There was significant decreased in blood glucose level in all treated group C, D, E compared to the B group and lowest glucose was recorded in E group when treated with combined medicinal herbs and body weight was increased in all treated group C, D, E compared to the B group and highest was recorded in Dgroup while treated with those.% of PCV level and Hb gm/dl concentration was the highest in group E which was treated with both garlic and bitter melon compare to the A group. ESR was highest in group B treated with Alloxan and lowest in group E. The present study reveals that combined treatment increases body weight and decreases glucose level without affecting health of rabbits.Asian J. Med. Biol. Res. September 2016, 2(3): 402-408

377 EFFECTS OF TACROLIMUS-ELUTING STENTS IN A DIABETIC RABBIT MODEL OF IN-STENT RESTENOSIS

2011 ◽  
Vol 12 (1) ◽  
pp. 81
Author(s):  
P.W. Radke ◽  
A. Joost ◽  
A. Kaiser ◽  
M. Mandapathil ◽  
M. Basler ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Stent Restenosis ◽  
Diabetic Rabbit ◽  
In Stent Restenosis

scholarly journals Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model

2014 ◽  
Vol 224 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Xiaojun Zhou ◽  
Jianjun Dong ◽  
Li Zhang ◽  
Ju Liu ◽  
Xiaofeng Dong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Percutaneous Transluminal Angioplasty ◽  
Independent Risk Factor ◽  
Rabbit Model ◽  
Intima Media Thickness ◽  
Transluminal Angioplasty ◽  
Diabetic Rabbit ◽  
Patients With Diabetes ◽  
Percutaneous Transluminal

It is well known that hyperglycemia is a trigger of atherosclerosis in patients with diabetes mellitus. However, the role of hyperglycemia in restenosis remains unclear. In this study, we investigated the effects of hyperglycemia on restenosis. Stenosis was evaluated in two sets of diabetic rabbit models: i) diabetic restenosis versus nondiabetic restenosis and ii) diabetic atherosclerosis versus nondiabetic atherosclerosis. Our results indicated that there was no difference in rates of stenosis between the diabetic and the nondiabetic groups in restenosis rabbit models. However, the incidence of stenosis was significantly higher in the diabetic atherosclerosis group compared with the nondiabetic atherosclerosis group. Similarly, the intima–media thickness and cell proliferation rate were significantly increased in the diabetic atherosclerosis group compared with the nondiabetic atherosclerosis group, but there was no difference between the diabetic restenosis and the nondiabetic restenosis groups. Our results indicate that hyperglycemia is an independent risk factor for atherosclerosis, but it has no evident effect on restenosis. These findings indicate that the processes of atherosclerosis and restenosis may involve different pathological mechanisms.

scholarly journals Evaluating the Effect ofSarconesiopsis magellanica(Diptera: Calliphoridae) Larvae-Derived Haemolymph and Fat Body Extracts on Chronic Wounds in Diabetic Rabbits

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jennifher Góngora ◽  
Andrea Díaz-Roa ◽  
Alejandro Ramírez-Hernández ◽  
Jesús A. Cortés-Vecino ◽  
María A. Gaona ◽  
...  
Keyword(s):  
Rating Scales ◽  
Chronic Wounds ◽  
Histological Analysis ◽  
Fat Body ◽  
Rabbit Model ◽  
Tissue Proliferation ◽  
Diabetic Rabbit ◽  
Fat Bodies ◽  
Diabetic Rabbits ◽  
Glucose Analogue

We evaluated extracts taken fromS. magellanicathird instar larvae fat body and haemolymph using a diabetic rabbit model and compared this to the effect obtained with the same substances taken fromLucilia sericatalarvae. Alloxan (a toxic glucose analogue) was used to induce experimental diabetes in twelve rabbits. Dorsal wounds were made in each animal and they were infected withStaphylococcus aureusandPseudomonas aeruginosa. They were then treated with haemolymph and lyophilized extracts taken from the selected blowflies’ larvae fat bodies. Each wound was then evaluated by using rating scales and histological analysis. More favourable scores were recorded on the PUSH and WBS scales for the wounds treated with fat body derived from the larvae of both species compared to that obtained with haemolymph; however, wounds treated with the substances taken fromS. magellanicahad better evolution. Histological analysis revealed that treatment led to tissue proliferation and more effective neovascularisation in less time with both species’ fat body extracts compared to treatment with just haemolymph. The results suggest the effectiveness of the substances evaluated and validate them in the animal model being used here as topical agents in treating chronic wounds.

scholarly journals The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiaojun Zhou ◽  
Yaru Mou ◽  
Xue Shen ◽  
Tianshu Yang ◽  
Ju Liu ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Diabetic Rabbit

scholarly journals Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model

2017 ◽  
Vol 248 ◽  
pp. 53-59 ◽  
Author(s):  
Behnoush Khorsand ◽  
Nate Nicholson ◽  
Anh-Vu Do ◽  
John E. Femino ◽  
James A. Martin ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Long Bone ◽  
Diabetic Rabbit ◽  
Regeneration Of Bone
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