scholarly journals Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model

2017 ◽  
Vol 248 ◽  
pp. 53-59 ◽  
Author(s):  
Behnoush Khorsand ◽  
Nate Nicholson ◽  
Anh-Vu Do ◽  
John E. Femino ◽  
James A. Martin ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Long Bone ◽  
Diabetic Rabbit ◽  
Regeneration Of Bone

404 EVALUATION OF A DIABETIC RABBIT MODEL FOR IN-STENT RESTENOSIS

2011 ◽  
Vol 12 (1) ◽  
pp. 86
Author(s):  
P.W. Radke ◽  
A. Joost ◽  
A. Kaiser ◽  
M. Basler ◽  
M. Mandapathil ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Stent Restenosis ◽  
Diabetic Rabbit ◽  
In Stent Restenosis

scholarly journals Irregular bone defect repair via tissue-engineered periosteum approach in rabbit model.

2019 ◽  
Author(s):  
Lin Zhao ◽  
Jia-Jia Yu ◽  
Cangyu Zhang ◽  
Xiuhui Wang
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Rabbit Model ◽  
Long Bone ◽  
3D Scaffold ◽  
Promising Alternative ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Group 3 ◽  
Group 2

Abstract Background As an alternative of bone grafts for defect repair, tissue engineering is much promising for clinical application. In previous studies, we have succeeded in repair of long bone defect with homemade tissue-engineered periosteum (TEP), of which is fabraicated by incorporating osteogenically induced mesenchymal stem cells (MSCs) of rabbits with a scaffold of small intestinal submucosa (SIS).Methods In this study, we are aimed to discuss the feasibility of allogenic irregular bone defect repair with the TEP. Thirty-six rabbits whose scapulas were subtotally resected to establish large irregular bone defects model in allogenic rabbits. The defects were treat respectively with TEP (Group 1, n=12), allogenic deproteinized bone (DPB) (Group 2, n=12) and hybrid of TEP and DPB (Group 3, n=12). At 4, 8, and 12 weeks after surgery, the rabbits were sacrificed, and the implants were harvested. X-ray radiographic and histological examinations were performed.ResultsThe findings suggested that the radiographic score in TEP-DPB hybrided implantation (Group 3) was higher than TEP or DPB grafting only (p<0.05).But that was inconsistent with histological findings, which Group1 appeared to possess significantly higher bone formation than Group 2 (p<0.05) and Group3 has higher new bone volume than that of Group 2 (p<0.05).Conclusion We conclude that TEP is a promising alternative in repair of large irregular bone defect.DPB served as a 3D scaffold in combining TEP could provide mechanical support and shaping guide, but hinder new bone formation via TEP approach due to retard degradation.

Abstract 581: Identification on Anti-Atherosclerotic Mechanism of SGLT-2 Inhibitor in Diabetic Rabbit Model

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Seulgee Lee ◽  
Jung-Sun Kim ◽  
Jaewon Oh ◽  
Sung-Kyung Bong ◽  
jung-jae lee
Keyword(s):  
Rabbit Model ◽  
Diabetic Rabbit

scholarly journals Antidiabetogenic impact of bitter melon (Momordica charantia) and garlic (Allium sativum) on alloxan induced diabetic rabbit model

2016 ◽  
Vol 2 (3) ◽  
pp. 402-408
Author(s):  
Ambiara ◽  
Fahima Binthe Aziz ◽  
Md Mahmudul Hasan ◽  
Md Shajedur Rahman ◽  
Misrat Masuma Parvez ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Combined Treatment ◽  
Rabbit Model ◽  
Treated Group ◽  
Control Group ◽  
Bitter Melon ◽  
Diabetic Rabbit ◽  
Group A ◽  
Group B

The present study was undertaken to investigate the antidiabetic effect of the Bitter melon and Garlic on Alloxan induced diabetes in experimental rabbits. At 2 to 3 months of age, rabbits were assigned into five groups (A, B, C, D and E) and each group was remained 4 rabbits. Group A was kept for control, Group B was treated with Alloxanintramuscullarly at a dose of 75mg /kg body weight, Group C was treated with bitter melon 250gm/kg body weight orally, Group D was treated with garlic 750mg/kg body weight orally, Group E treated with combined at previous dose. After acclimatization, diabetes was induced in four groups of rabbits (B, C, D and E) by administering Alloxan injection in a dose of 75mg/kg body weight (b.wt.) intramuscularlly. There was significant decreased in blood glucose level in all treated group C, D, E compared to the B group and lowest glucose was recorded in E group when treated with combined medicinal herbs and body weight was increased in all treated group C, D, E compared to the B group and highest was recorded in Dgroup while treated with those.% of PCV level and Hb gm/dl concentration was the highest in group E which was treated with both garlic and bitter melon compare to the A group. ESR was highest in group B treated with Alloxan and lowest in group E. The present study reveals that combined treatment increases body weight and decreases glucose level without affecting health of rabbits.Asian J. Med. Biol. Res. September 2016, 2(3): 402-408

377 EFFECTS OF TACROLIMUS-ELUTING STENTS IN A DIABETIC RABBIT MODEL OF IN-STENT RESTENOSIS

2011 ◽  
Vol 12 (1) ◽  
pp. 81
Author(s):  
P.W. Radke ◽  
A. Joost ◽  
A. Kaiser ◽  
M. Mandapathil ◽  
M. Basler ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Stent Restenosis ◽  
Diabetic Rabbit ◽  
In Stent Restenosis

scholarly journals VI. The rôle of the various elements in the development and regeneration of bone

1908 ◽  
Vol 199 (251-261) ◽  
pp. 253-279 ◽  
Keyword(s):  
Chief Factor ◽  
Long Bone ◽  
Direct Experiment ◽  
Regeneration Of Bone

The present inquiry has been undertaken with the view of obtaining data, chiefly by direct experiment, as to the rôle which the various elements play in the development and reproduction of bone. The periosteum has long been regarded as the chief factor in the reproduction of bone. W hat is its potentiality in this respect ? Preservation of Periosteum and Removal of Bone .—Result. If a portion of the shaft of a growing long bone, including its entire circumference, were removed, leaving its periosteum intact, would restoration of osseous continuity ensue?

scholarly journals Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model

2014 ◽  
Vol 224 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Xiaojun Zhou ◽  
Jianjun Dong ◽  
Li Zhang ◽  
Ju Liu ◽  
Xiaofeng Dong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Percutaneous Transluminal Angioplasty ◽  
Independent Risk Factor ◽  
Rabbit Model ◽  
Intima Media Thickness ◽  
Transluminal Angioplasty ◽  
Diabetic Rabbit ◽  
Patients With Diabetes ◽  
Percutaneous Transluminal

It is well known that hyperglycemia is a trigger of atherosclerosis in patients with diabetes mellitus. However, the role of hyperglycemia in restenosis remains unclear. In this study, we investigated the effects of hyperglycemia on restenosis. Stenosis was evaluated in two sets of diabetic rabbit models: i) diabetic restenosis versus nondiabetic restenosis and ii) diabetic atherosclerosis versus nondiabetic atherosclerosis. Our results indicated that there was no difference in rates of stenosis between the diabetic and the nondiabetic groups in restenosis rabbit models. However, the incidence of stenosis was significantly higher in the diabetic atherosclerosis group compared with the nondiabetic atherosclerosis group. Similarly, the intima–media thickness and cell proliferation rate were significantly increased in the diabetic atherosclerosis group compared with the nondiabetic atherosclerosis group, but there was no difference between the diabetic restenosis and the nondiabetic restenosis groups. Our results indicate that hyperglycemia is an independent risk factor for atherosclerosis, but it has no evident effect on restenosis. These findings indicate that the processes of atherosclerosis and restenosis may involve different pathological mechanisms.

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