scholarly journals In vivo evaluation of a conjugated poly(lactide-ethylene glycol) nanoparticle depot formulation for prolonged insulin delivery in the diabetic rabbit model

2013 ◽  
pp. 505 ◽  
Author(s):  
Viness Pillay ◽  
Tomar ◽  
Tyagi ◽  
Kumar ◽  
Manoj Kumar ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Rabbit Model ◽  
Insulin Delivery ◽  
Depot Formulation ◽  
In Vivo Evaluation ◽  
Diabetic Rabbit

scholarly journals Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 444
Author(s):  
Alaa Mahran ◽  
Sayed Ismail ◽  
Ayat A. Allam
Keyword(s):  
Triamcinolone Acetonide ◽  
Delivery System ◽  
Histopathological Examination ◽  
Rabbit Model ◽  
Subconjunctival Injection ◽  
In Vivo Evaluation ◽  
Ternary Phase Diagrams ◽  
Ophthalmic Delivery

Treatment of uveitis (i.e., inflammation of the uvea) is challenging due to lack of convenient ophthalmic dosage forms. This work is aimed to determine the efficiency of triamcinolone acetonide (TA)-loaded microemulsion as an ophthalmic delivery system for the treatment of uveitis. Water titration method was used to construct different pseudo-ternary phase diagrams. Twelve microemulsion formulations were prepared using oleic acid, Cremophor EL, and propylene glycol. Among all tested formulations, Formulation F3, composed of oil: surfactant-co-surfactant (1:1): water (15:35:50% w/w, respectively), was found to be stable and showed acceptable pH, viscosity, conductivity, droplet size (211 ± 1.4 nm), and zeta potential (−25 ± 1.7 mV) and almost complete in vitro drug release within 24 h. The in vivo performance of the optimized formulation was evaluated in experimentally uveitis-induced rabbit model and compared with a commercial TA suspension (i.e., Kenacort®-A) either topically or by subconjunctival injection. Ocular inflammation was evaluated by clinical examination, white blood cell count, protein content measurement, and histopathological examination. The developed TA-loaded microemulsion showed superior therapeutic efficiency in the treatment of uveitis with high patient compliance compared to commercial suspension. Hence, it could be considered as a potential ocular treatment option in controlling of uveitis.

In Vivo Evaluation of a Nasal Insulin Delivery System Based on Thiolated Chitosan

2006 ◽  
Vol 95 (11) ◽  
pp. 2463-2472 ◽  
Author(s):  
Alexander H. Krauland ◽  
Verena M. Leitner ◽  
Vjera Grabovac ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan ◽  
Insulin Delivery System

In vivo evaluation of a new hydrophobic acrylic intraocular lens in the rabbit model

2018 ◽  
Vol 44 (12) ◽  
pp. 1497-1502 ◽  
Author(s):  
Liliana Werner ◽  
Nathan Ellis ◽  
Joshua Bo Heczko ◽  
Marcia Ong ◽  
Rakhi Jain ◽  
...  
Keyword(s):  
Intraocular Lens ◽  
Rabbit Model ◽  
In Vivo Evaluation ◽  
Hydrophobic Acrylic

Preparation, in vitro and in vivo evaluation of PLGA/Chitosan based nano-complex as a novel insulin delivery formulation

2019 ◽  
Vol 572 ◽  
pp. 118710 ◽  
Author(s):  
Fatemeh Mohammadpour ◽  
Farzin Hadizadeh ◽  
Mohsen Tafaghodi ◽  
Kayvan Sadri ◽  
Amir Hooshang Mohammadpour ◽  
...  
Keyword(s):  
Insulin Delivery ◽  
In Vivo Evaluation

In Vivo Evaluation of The Novel Nanocomposite Porous 3D Scaffold in a Rabbit Model

2018 ◽  
Vol 11 (19) ◽  
pp. 1-15
Author(s):  
Saffanah Khuder Mahmood ◽  
Intan Shameha Binti Abdul Razak ◽  
Sahar Mohammed Ibrahim ◽  
Loqman Mohamed Yusof ◽  
Adamu Abdul Abubakar ◽  
...  
Keyword(s):  
Rabbit Model ◽  
The Novel ◽  
3D Scaffold ◽  
In Vivo Evaluation

scholarly journals An Amperometric Glucose Sensor Integrated into an Insulin Delivery Cannula: In Vitro and In Vivo Evaluation

2017 ◽  
Vol 19 (4) ◽  
pp. 226-236 ◽  
Author(s):  
W. Kenneth Ward ◽  
Gabriel Heinrich ◽  
Matthew Breen ◽  
Sheila Benware ◽  
Nicole Vollum ◽  
...  
Keyword(s):  
Glucose Sensor ◽  
Insulin Delivery ◽  
In Vivo Evaluation ◽  
Amperometric Glucose Sensor

scholarly journals In Vivo Evaluation of the Mechanical Strength of a Slide Lengthening Technique With a Locking Mechanism Using a Rabbit Model

Cureus ◽  
2020 ◽  
Author(s):  
Dai Iwase ◽  
Kentaro Uchida ◽  
Yukie Metoki ◽  
Hiroyuki Sekiguchi ◽  
Jun Aikawa ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Rabbit Model ◽  
In Vivo Evaluation ◽  
Locking Mechanism

Bone regeneration strategy by different sized multichanneled biphasic calcium phosphate granules: In vivo evaluation in rabbit model

2018 ◽  
Vol 32 (10) ◽  
pp. 1406-1420 ◽  
Author(s):  
Mirana Taz ◽  
Sang Ho Bae ◽  
Hae Il Jung ◽  
Hyun-Deuk Cho ◽  
Byong-Taek Lee
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Rabbit Model ◽  
Morphological Characteristics ◽  
Confocal Imaging ◽  
Bone Tissue Regeneration ◽  
Micro Computed Tomography ◽  
In Vivo Evaluation

A variety of synthetic materials are currently in use as bone substitutes, among them a new calcium phosphate-based multichannel, cylindrical, granular bone substitute that is showing satisfactory biocompatibility and osteoconductivity in clinical applications. These cylindrical granules differ in their mechanical and morphological characteristics such as size, diameter, surface area, pore size, and porosity. The aim of this study is to investigate whether the sizes of these synthetic granules and the resultant inter-granular spaces formed by their filling critical-sized bone defects affect new bone formation characteristics and to determine the best formulations from these individual types by combining the granules in different proportions to optimize the bone tissue regeneration. We evaluated two types of multichanneled cylindrical granules, 1 mm and 3 mm in diameter, combined the granules in two different proportions (wt%), and compared their different mechanical, morphological, and in vitro and in vivo biocompatibility characteristics. We assessed in vitro biocompatibility and cytotoxicity using MC3T3-E1 osteoblast-like cells using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and confocal imaging. In vivo investigation in a rabbit model indicated that all four samples formed significantly better bone than the control after four weeks and eight weeks of implantation. Micro-computed tomography analysis showed more bone formation by the 1 mm cylindrical granules with 160 ± 10 µm channeled pore and 50% porosity than the other three samples ( p<.05), which we confirmed by histological analysis.

scholarly journals In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent

Bioimpacts ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Cécilia Delattre ◽  
Diego Velazquez ◽  
Caroline Roques ◽  
Graciela Pavon-Djavid ◽  
Véronique Ollivier ◽  
...  
Keyword(s):  
Bacterial Adhesion ◽  
Neointimal Hyperplasia ◽  
Rabbit Model ◽  
Metallic Stent ◽  
In Vivo Evaluation ◽  
Endothelial Colony Forming Cells ◽  
Cell Coverage ◽  
Stent Coating

Introduction: The major complications of stent implantation are restenosis and late stent thrombosis. PBMA polymers are used for stent coating because of their mechanical properties. We previously synthesized and characterized Dextrangraft-polybutylmethacrylate copolymer (Dex-PBMA) as a potential stent coating. In this study, we evaluated the haemocompatibility and biocompatibility properties of Dex-PBMA in vitro and in vivo. Methods: Here, we investigated: (1) the effectiveness of polymer coating under physiological conditions and its ability to release Tacrolimus®, (2) the capacity of Dex-PBMA to inhibit Staphylococcus aureus adhesion, (3) the thrombin generation and the human platelet adhesion in static and dynamic conditions, (4) the biocompatibility properties in vitro on human endothelial colony forming cells ( ECFC) and on mesenchymal stem cells (MSC) and in vivo in rat models, and (5) we implanted Dex-PBMA and Dex-PBMATAC coated stents in neointimal hyperplasia restenosis rabbit model. Results: Dex-PBMA coating efficiently prevented bacterial adhesion and release Tacrolimus®. Dex-PBMA exhibit haemocompatibility properties under flow and ECFC and MSC compatibility. In vivo, no pathological foreign body reaction was observed neither after intramuscular nor intravascular aortic implantation. After Dex-PBMA and Dex-PBMATAC coated stents 30 days implantation in a restenosis rabbit model, an endothelial cell coverage was observed and the lumen patency was preserved. Conclusion: Based on our findings, Dex-PBMA exhibited vascular compatibility and can potentially be used as a coating for metallic coronary stents.

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