Abstract 17325: Obesity, Blood Pressure, and Diurnal Variation in Natriuretic Peptides: A Clinical Trial

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Vibhu Parcha ◽  
Nirav Patel ◽  
Orlando M GUTIERREZ ◽  
Peng Li ◽  
Kiran Musunuru ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Diurnal Variation ◽  
Heart Tissue ◽  
Human Trial ◽  
Healthy Obese ◽  
Relationship Of ◽  
Np Gene ◽  
The Relationship ◽  
Lower Expression

Background: Obese individuals have disturbed blood pressure (BP) rhythmicity and relative natriuretic peptide (NP) deficiency. The relationship of diurnal variation in NP levels and 24h BP rhythm is not known. Furthermore, mechanisms behind difference in circulating NPs in healthy obese and lean individuals has not been explored. We conducted a prospective clinical trial to evaluate 1) the diurnal rhythmicity of NPs and its relationship with 24-hour BP rhythm between healthy lean and obese individuals, and 2) elucidate mechanism behind NP deficiency in obese. Methods: Healthy, normotensive, lean (BMI:18.5-25 kg/m 2 ) and obese (BMI:30-45 kg/m 2 ) individuals aged 18-40 years, underwent 24-hour standardized inpatient protocol involving ambulatory BP monitoring (ABPM), controlled light intensity, and 10 blood draws, following 5-days of standardized diet. NP gene expression was evaluated in a cohort of 37 healthy donor heart tissues obtained from the MAGNet repository. Results: Among 52 participants screened, a total of 40 participants (18 lean; 22 obese) were enrolled. Diurnal variation in MRproANP levels was seen in both lean and obese individuals (p for rhythmicity=0.001). The mesor of the NP rhythm was 15% (8.5-21.6%) lower in obese. The diurnal variation in MRproANP was in antiphase with diurnal variation of systolic BP (p<0.001) ( Figure ). Obese participants had lower 24h renin levels (p=0.06) and higher nocturnal sodium excretion (p=0.08). Among obese, there was lower expression of NP production genes ( NPPA, NPPB) (p<0.05) , and higher expression of clearance gene ( NPR3 ) (p<0.001) in heart tissue. Conclusions: In a mechanistic human trial, we elucidate key neurohormonal differences in rhythm and evidence of poor salt handling in obese. Decreased production and increased clearance may contribute to the NP deficiency in obese. Targeting the diurnal NP-BP rhythm axis may reduce the cardiovascular risk burden, specifically in obese individuals.

The relationship of age-adjusted Charlson comorbidity ındex and diurnal variation of blood pressure

2018 ◽  
Vol 41 (2) ◽  
pp. 113-117
Author(s):  
Belma Kalaycı ◽  
Yunus Turgay Erten ◽  
Tunahan Akgün ◽  
Turgut Karabag ◽  
Furuzan Kokturk
Keyword(s):  
Blood Pressure ◽  
Diurnal Variation ◽  
Charlson Comorbidity Index ◽  
Comorbidity Index ◽  
Relationship Of ◽  
The Relationship

scholarly journals 600 THE RELATIONSHIP OF CHILDHOOD AND ADULT BLOOD PRESSURE–30 YEARS LATER

1985 ◽  
Vol 19 (4) ◽  
pp. 210A-210A
Author(s):  
Ruth Whittemore ◽  
G J Beck ◽  
Lisa McKay
Keyword(s):  
Blood Pressure ◽  
Relationship Of ◽  
The Relationship

scholarly journals HUBUNGAN INDEKSMASSA TUBUH DAN LINGKAR PINGGANG DENGAN TEKANAN DARAH LAKI-LAKI DEWASA

2018 ◽  
Vol 9 (2) ◽  
pp. 193-199
Author(s):  
Tamariani Manullang
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Study Design ◽  
Computer Software ◽  
Adult Males ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

Prevalence of hypertension in adult males was highest in PuskesmasBasuki Rahmat (16.2%) as many as 648 cases of hypertension patients which hasincreased compared to 2012 by 12% in cases of hypertension totaled 482 patients((Dinkes Kota, 2013). This study aims to determine the relationship of body massindex (BMI) and waist circumference (WC) with systolic blood pressure (BP) in adultmales in Puskesmas Basuki Rahmat Bengkulu City in 2015. The study design wasdescriptive analytic with cross sectional approach. Study location was in PuskesmasBasuki Rahmat City of Bengkulu. Samples were selected using purposive samplingtotalling 68 people. Criterias sample were being adult males who occupied inPuskesmas Basuki Rahmat City of Bengkulu, aged ≥ 18 years, agreed to beinterviewed,and able to communicate actively. Data were obtained include BMI, WCand systolic BP adult males and processed using computer software with pearsoncorrelation analysis.The results showed that there was relationship between BMI andsystolic BP (p = 0.0005; r = 0.395); between WC and systolic BP (p = 0.004 and r =0.347) in adult males. This study concluded that there was relationship between BMIand WC with systolic BP in adult males in Puskesmas Basuki Rahmat Bengkulu Cityin 2015.

THE RELATIONSHIP OF BLOOD LEAD TO BLOOD PRESSURE IN A LONGITUDINAL STUDY OF WORKING MEN

1986 ◽  
Vol 123 (5) ◽  
pp. 800-808 ◽  
Author(s):  
S. T. WEISS ◽  
A. MUÑOZ ◽  
A. STEIN ◽  
D. SPARROW ◽  
F. E. SPEIZER
Keyword(s):  
Blood Pressure ◽  
Longitudinal Study ◽  
Blood Lead ◽  
Relationship Of ◽  
The Relationship

HUBUNGAN KEBIASAAN MENGKONSUMSI KOPI DENGAN KEJADIAN HIPERTENSI

2021 ◽  
Vol 9 (2) ◽  
pp. 73-84
Author(s):  
Budi Kristanto
Keyword(s):  
Blood Pressure ◽  
Pearson Correlation ◽  
Coffee Consumption ◽  
Sampling Technique ◽  
World Population ◽  
Cross Sectional ◽  
Pearson Correlation Test ◽  
Relationship Of ◽  
The Relationship ◽  
Consumption Habits

Latar belakang : saat ini prevalensi hipertensi secara global sebesar 22% dari total penduduk dunia. Dari sejumlah penderita tersebut, hanya kurang dari seperlima yang melakukan upaya pengendalian terhadap tekanan darah yang dimiliki. Adapun faktor yang terkait dengan tekanan darah sangat kompleks, baik yang dapat dikontrol maupun tidak dapat dikontrol. Salah satu kebiasaan yang diduga terkait dengan hipertensi adalah kebiasaan konsumsi kopi. Tujuan : mengetahui hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi. Subjek dan Metode : responden penelitian ini adalah  warga Desa Ngringo RW 22 dan 29 Kecamatan Jaten Karanganyar sejumlah 45 responden. Jenis penelitian adalah analitik observasional, desain korelasi dengan pendekatan cross sectional untuk mengetahui hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi. Teknik sampling menggunakan total sampling, Data dianalisis menggunakan uji Pearson Corelation. Hasil : mayoritas responden memiliki kebiasaan konsumsi kopi dalam kategori ringan (1-3 cangkir perhari) sebesar 97,8%, sedangkan yang kategori sedang (4-6 cangkir perhari) sebesar  2,2%. Mayoritas responden dengan tekanan darah yang normal yaitu 82,2%, dan hipertensi 17,8%. Kesimpulan : tidak ada hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi (p : 0,058).   Kata kunci : konsumsi kopi, hipertensi   THE RELATIONSHIP OF COFFEE CONSUMING HABITS WITH HYPERTENSION   Budi Kristanto, Diyono   Astract   Background : currently the global prevalence of hypertension is 22% of the total world population. Of the number of sufferers, only less than a fifth who make efforts to control their blood pressure. The factors associated with blood pressure are very complex, both controllable and uncontrollable. One of the habits thought to be associated with hypertension is the habit of consuming coffee. The aims of the study: knowing the relationship between coffee consumption habits and the incidence of hypertension. Subject and Methods : the respondents of this research were 45 respondents in Ngringo Village RW 22 and 29, Jaten, Karanganyar District. This research used observational analytic method, correlation design with cross sectional approach to determine the relationship between coffee consumption habits and the incidence of hypertension. The sampling technique used total sampling. Data were analyzed using the Pearson Correlation test. Result : the majority of respondents have a habit of consuming coffee in the light category (1-3 cups per day) of 97.8%, while the moderate category (4-6 cups per day) is 2.2%. The majority of respondents with normal blood pressure were 82.2%, and hypertension 17.8%. Conclusion : There is no relationship between coffee consumption habits and the incidence of hypertension (p: 0.058).   Keywords: coffee consumption, hypertension  

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