Transcatheter Mitral Valve Implantation: Current Status and Future Perspectives

2021 ◽  
Author(s):  
Giulio Russo ◽  
Marco Gennari ◽  
Mara Gavazzoni ◽  
Daniela Pedicino ◽  
Alberto Pozzoli ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Mitral Valve ◽  
Clinical Experience ◽  
Current Data ◽  
Current Status ◽  
Future Perspectives ◽  
Tailored Approach ◽  
Valve Implantation ◽  
Insight Into ◽  
Repair Techniques

Mitral transcatheter therapies represent the treatment of choice for all patients deemed unsuitable for cardiac surgery. So far, the largest clinical experience has been limited to percutaneous repair techniques. However, given the complexity and heterogeneity of mitral valve anatomy and pathology, transcatheter mitral valve implantation will widen the mitral valve therapies horizon, toward a patient-tailored approach. Current data about transcatheter mitral valve implantation is still limited and, although some data are promising, there are still some issues to be addressed. This review provides a comprehensive insight into the available devices and describes potential advantages and limitations of transcatheter mitral valve implantation.

scholarly journals Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 795
Author(s):  
Lukas Gorecki ◽  
Martin Andrs ◽  
Jan Korabecny
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Patient Survival ◽  
Current Status ◽  
Future Perspectives ◽  
Phase Ii Trials ◽  
Anticancer Treatment ◽  
Positive Outlook ◽  
Insight Into

Selective killing of cancer cells while sparing healthy ones is the principle of the perfect cancer treatment and the primary aim of many oncologists, molecular biologists, and medicinal chemists. To achieve this goal, it is crucial to understand the molecular mechanisms that distinguish cancer cells from healthy ones. Accordingly, several clinical candidates that use particular mutations in cell-cycle progressions have been developed to kill cancer cells. As the majority of cancer cells have defects in G1 control, targeting the subsequent intra‑S or G2/M checkpoints has also been extensively pursued. This review focuses on clinical candidates that target the kinases involved in intra‑S and G2/M checkpoints, namely, ATR, CHK1, and WEE1 inhibitors. It provides insight into their current status and future perspectives for anticancer treatment. Overall, even though CHK1 inhibitors are still far from clinical establishment, promising accomplishments with ATR and WEE1 inhibitors in phase II trials present a positive outlook for patient survival.

scholarly journals Use of artificial intelligence in imaging in rheumatology – current status and future perspectives

RMD Open ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e001063 ◽  
Author(s):  
Berend Stoel
Keyword(s):  
Artificial Intelligence ◽  
Deep Learning ◽  
Basic Research ◽  
Current Status ◽  
Future Perspectives ◽  
Clinical Imaging ◽  
The World ◽  
Human Interpretation ◽  
The Impact ◽  
Insight Into

After decades of basic research with many setbacks, artificial intelligence (AI) has recently obtained significant breakthroughs, enabling computer programs to outperform human interpretation of medical images in very specific areas. After this shock wave that probably exceeds the impact of the first AI victory of defeating the world chess champion in 1997, some reflection may be appropriate on the consequences for clinical imaging in rheumatology. In this narrative review, a short explanation is given about the various AI techniques, including ‘deep learning’, and how these have been applied to rheumatological imaging, focussing on rheumatoid arthritis and systemic sclerosis as examples. By discussing the principle limitations of AI and deep learning, this review aims to give insight into possible future perspectives of AI applications in rheumatology.

scholarly journals Mitral Valve Replacement—Current and Future Perspectives

2017 ◽  
Vol 9 ◽  
pp. 117906521771902 ◽  
Author(s):  
Johan van der Merwe ◽  
Filip Casselman
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Mitral Valve Repair ◽  
Mitral Valve Surgery ◽  
Future Perspectives ◽  
Valve Repair ◽  
Experimental Approaches ◽  
Repair Techniques

The favorable outcomes achieved with modern mitral valve repair techniques redefined the role of mitral valve replacement. Various international databases report a significant decrease in replacement procedures performed compared with repairs, and contemporary guidelines limit the application of surgical mitral valve replacement to pathology in which durable repair is unlikely to be achieved. The progressive paradigm shift toward endoscopic and robotic mitral valve surgery is also paralleled by rapid developments in transcatheter devices, which is progressively expanding from experimental approaches to becoming clinical reality. This article outlines the current role and future perspectives of contemporary surgical mitral valve replacement within the context of mitral valve repair and the dynamic evolution of exciting transcatheter alternatives.

scholarly journals Current Status and Future Perspectives of Cardioplegic Protection in Cardiac Surgery, Highlighting the Mechanisms of Targeted Cellular Components

2014 ◽  
Vol 43 (5) ◽  
pp. 239-253
Author(s):  
Yuji Maruyama ◽  
David J Chambers ◽  
Ryuzo Bessho ◽  
Masahiro Fujii ◽  
Dai Nishina ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Current Status ◽  
Future Perspectives ◽  
Cellular Components

scholarly journals Percutaneous Pulmonary Valve Implantation: Current Status and Future Perspectives

2019 ◽  
Vol 15 (4) ◽  
pp. 262-273 ◽  
Author(s):  
Bart W. Driesen ◽  
Evangeline G. Warmerdam ◽  
Gert-Jan Sieswerda ◽  
Folkert J. Meijboom ◽  
Mirella M.C. Molenschot ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Congenital Heart ◽  
Pulmonary Valve ◽  
Anatomical Variations ◽  
Current Status ◽  
Future Perspectives ◽  
Percutaneous Pulmonary Valve Implantation ◽  
Procedural Success ◽  
Valve Implantation ◽  
Percutaneous Pulmonary Valve

Patients with congenital heart disease (CHD) with right ventricle outflow tract (RVOT) dysfunction need sequential pulmonary valve replacements throughout their life in the majority of cases. Since their introduction in 2000, the number of percutaneous pulmonary valve implantations (PPVI) has grown and reached over 10,000 procedures worldwide. Overall, PPVI has been proven safe and effective, but some anatomical variations can limit procedural success. This review discusses the current status and future perspectives of the procedure.

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