scholarly journals p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

2009 ◽  
Vol 105 (7) ◽  
pp. 705-712 ◽  
Author(s):  
Joon-Young Park ◽  
Ping-yuan Wang ◽  
Takumi Matsumoto ◽  
Ho Joong Sung ◽  
Wenzhe Ma ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Dna Content ◽  
Mitochondrial Dna Content ◽  
Aerobic Exercise Capacity

scholarly journals Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity

2009 ◽  
Vol 297 (6) ◽  
pp. C1520-C1532 ◽  
Author(s):  
Michael S. Lustgarten ◽  
Youngmok C. Jang ◽  
Yuhong Liu ◽  
Florian L. Muller ◽  
Wenbo Qi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Muscle Function ◽  
Contractile Function ◽  
Muscle Fibers ◽  
Conditional Knockout ◽  
Mitochondrial Oxidative Stress ◽  
Aerobic Exercise Capacity

In vitro studies of isolated skeletal muscle have shown that oxidative stress is limiting with respect to contractile function. Mitochondria are a potential source of muscle function-limiting oxidants. To test the hypothesis that skeletal muscle-specific mitochondrial oxidative stress is sufficient to limit muscle function, we bred mice expressing Cre recombinase driven by the promoter for the inhibitory subunit of troponin ( TnIFast-iCre) with mice containing a floxed Sod2 ( Sod2 fl/fl) allele. Mn-SOD activity was reduced by 82% in glycolytic (mainly type II) muscle fiber homogenates from young TnIFastCreSod2 fl/fl mice . Furthermore, Mn-SOD content was reduced by 70% only in type IIB muscle fibers. Aconitase activity was decreased by 56%, which suggests an increase in mitochondrial matrix superoxide. Mitochondrial superoxide release was elevated more than twofold by mitochondria isolated from glycolytic skeletal muscle in TnIFastCreSod2 fl/fl mice. In contrast, the rate of mitochondrial H2O2 production was reduced by 33%, and only during respiration with complex II substrate. F2-isoprostanes were increased by 36% in tibialis anterior muscles isolated from TnIFastCreSod2 fl/fl mice. Elevated glycolytic muscle-specific mitochondrial oxidative stress and damage in TnIFastCreSod2 fl/fl mice were associated with a decreased ability of the extensor digitorum longus and gastrocnemius muscles to produce contractile force as a function of time, whereas force production by the soleus muscle was unaffected. TnIFastCreSod2 fl/fl mice ran 55% less distance on a treadmill than wild-type mice. Collectively, these data suggest that elevated mitochondrial oxidative stress and damage in glycolytic muscle fibers are sufficient to reduce contractile muscle function and aerobic exercise capacity.

scholarly journals Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD

Thorax ◽  
2010 ◽  
Vol 66 (2) ◽  
pp. 121-127 ◽  
Author(s):  
L. Puente-Maestu ◽  
A. Lazaro ◽  
A. Tejedor ◽  
S. Camano ◽  
M. Fuentes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Dna Content ◽  
Mitochondrial Dna Content

scholarly journals Skeletal muscle mitochondrial DNA content and aerobic metabolism in patients with antiretroviral therapy-associated lipoatrophy

2010 ◽  
Vol 65 (7) ◽  
pp. 1497-1504 ◽  
Author(s):  
J. Sutinen ◽  
M. S. Laaksonen ◽  
U. A. Walker ◽  
B. Setzer ◽  
J. Kemppainen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Antiretroviral Therapy ◽  
Dna Content ◽  
Aerobic Metabolism ◽  
Mitochondrial Dna Content

Effects Of Exercise In Skeletal Muscle Mitochondrial DNA Content In COPD

2010 ◽  
Author(s):  
Luis Puente-Maestu ◽  
Elena Ojeda ◽  
Teresa Gomez ◽  
Alberto Tejedor ◽  
Alberto Lazaro ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Dna Content ◽  
Mitochondrial Dna Content

The Increase in Intramyocellular Lipid in Leg Skeletal Muscle is Associated With Lowered Aerobic Exercise Capacity in Heart Failure Patients

2009 ◽  
Vol 15 (7) ◽  
pp. S164-S165
Author(s):  
Kagami Hirabayashi ◽  
Shintaro Kinugawa ◽  
Takashi Yokota ◽  
Tadashi Suga ◽  
Noriteru Morita ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Intramyocellular Lipid ◽  
Heart Failure Patients ◽  
Aerobic Exercise Capacity

scholarly journals Low-Intensity Exercise Improves Aerobic Exercise Capacity in Rats After Myocardial Infarction and the Possible Role of Skeletal Muscle Autophagy

2021 ◽  
Vol 34 (2) ◽  
pp. 226-226
Author(s):  
Li-mei Chen ◽  
Wen-wen Peng ◽  
Gui-qing Xu ◽  
Yue Guo ◽  
Ling-jie Wei ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Sham Group ◽  
Heart Weight ◽  
Low Intensity ◽  
Aerobic Exercise Capacity ◽  
Low Intensity Exercise

Abstract Background To investigate the effects of low-intensity exercise on aerobic exercise capacity and autophagy of skeletal muscle in rats after myocardial infarction (MI) and its possible mechanisms. Methods Thirty male Sprague Dawley rats, weighing 180–200 g, were randomly divided into sham, MI, and MI with exercise training (MI + Ex) groups. MI was induced by ligation of the left anterior descending artery. One week after surgery, low-intensity exercise training was carried out on a treadmill 5 days per week for 4 weeks. Results Infarct size of MI and MI + Ex groups was 30.8 ± 5.5% and 27.6 ± 5.0% of left ventricle, respectively (P > 0.05). Heart weight and heart to body weight ratio in the MI group were significantly higher than those in the sham group (P < 0.01), and were lowered by exercise training (P < 0.01). The maximal exercise distance and duration in the MI group were lower than those in the sham group (P < 0.01), but were significantly increased by exercise training (P < 0.05). Autophagosome of the gastrocnemius was not detectable in the sham group, scattered in the MI group but clustered in the MI + Ex group. Microtubule-associated protein light chain 3 (LC3-I/II) and Beclin-1 protein levels in the gastrocnemius were similar between MI and sham groups, but were significantly higher in the MI + Ex group (P < 0.05). Conclusions Low-intensity exercise improves exercise capacity in rats after MI. The effect is associated with enhanced autophagy of the skeletal muscle.

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