scholarly journals Relations of Digital Vascular Function, Cardiovascular Risk Factors, and Arterial Stiffness: The Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) Cohort Study

2014 ◽  
Vol 3 (6) ◽  
Author(s):  
Luisa C. C. Brant ◽  
Naomi M. Hamburg ◽  
Sandhi M. Barreto ◽  
Emelia J. Benjamin ◽  
Antonio L. P. Ribeiro
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Longitudinal Study ◽  
Arterial Stiffness ◽  
Cardiovascular Risk Factors ◽  
Vascular Function ◽  
Adult Health

Gender aspects of the relationship between migraine and cardiovascular risk factors: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Cephalalgia ◽  
2015 ◽  
Vol 35 (12) ◽  
pp. 1103-1114 ◽  
Author(s):  
Alessandra C Goulart ◽  
Itamar S Santos ◽  
Paulo A Lotufo ◽  
Isabela M Benseñor
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Longitudinal Study ◽  
Cardiovascular Risk Factors ◽  
Multinomial Logistic Regression ◽  
Inverse Association ◽  
Adult Health ◽  
Regression Analyses ◽  
Cross Sectional ◽  
The Relationship

Background The relationship between cardiovascular risk factors (CVRF) and migraine is controversial and might be different in both genders. These associations were evaluated in Brazilian middle-aged men and women from the Longitudinal Study of Adult Health (ELSA-Brasil). Methods The cross-sectional relationship between our main outcome, which was migraine headache (definite, probable and overall), and CVRF was evaluated in the total sample and according to gender. We calculated frequencies and odds ratios (95% CI) for this relationship using binary and multinomial logistic regression analyses in crude, age-adjusted and multivariable models adjusted by potential confounders. Results Of 14,953 individuals who completed the data about headache and CVRF, the frequency of one-year migraine was of 29.5% (22.5% in women and 7.0% in men). In the multivariable-adjusted regression analyses, an inverse association between hypertension (OR, 0.53; 95% CI, 0.36–0.79), metabolic syndrome (OR, 0.65; 95% CI, 0.43–0.99) and definite migraine were confirmed for men, but not for women. In the opposite direction, a positive association between migraine headaches (definite, probable and overall) and dyslipidemia (overall migraine OR, 1.25; 95% CI, 1.13–1.38) was observed only for women, but not for men. Conclusions A gender influence on the relationship between migraine and CVRF was verified in the ELSA-Brasil.

Abstract P298: Neck Circumference is Associated with Carotid Intimal-media Thickness but Not with Coronary Artery Calcium: Results From the Brazilian Longitudinal Study of Adult Health ELSA-Brasil

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Cristina P Baena ◽  
Paulo Lotufo ◽  
Itamar Santos ◽  
Alessandra Goulart ◽  
Marcio S Bittencourt ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Longitudinal Study ◽  
Standard Deviation ◽  
Cardiovascular Risk Factors ◽  
Subclinical Atherosclerosis ◽  
Neck Circumference ◽  
Risk Indicator ◽  
Adult Health ◽  
Standard Deviation Increase

Introduction: Neck circumference has been independently associated with cardiovascular risk factors in various populations. Whether neck circumference can be a risk indicator for subclinical atherosclerosis remains uncertain. Hypothesis: Neck circumference can be a marker of local subclinical atherosclerosis in The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: In cross-sectional and sex-specific analyses of 2,266 women (50.6 ±8.4 yrs) and 1,886 men (50.7 ±9.0 yrs) with both cc-IMT and CAC, free from previous coronary heart disease at baseline, we built logistic models using diverse cut-off points for CAC score (0vs>0, <100 vs ≥100, <400 vs ≥400 Agatston units) and cc-IMT ( < 75th percentile vs ≥75 th ; < 90th percentile vs ≥90 th ) as dependent variables, after which adjustments for age and traditional cardiovascular risk factors were made. Results: Mean (standard deviation) neck circumference was 33.6 (±2.4 cm) for women and 38.8 (±2.6 cm) for men. In fully adjusted models including sociodemographic, cardiovascular risk factors and body-mass index (BMI) and waist circumference, for each 1 standard deviation increase in neck circumference we found an odds ratio (OR, 95% CI) for having IMT above the 75th percentile of [1.52, 1.16; 1.99)]for women and [1.66, 1.28; 2.14)] for men, and above the 90th cc-IMT percentile [1.66 (1.19; 2.32)]for men but not for women [1.21 (0.80; 1.82)]. We found no association between neck circumference and CAC using several different cut-off points (p>0.05 for all). Conclusion: Neck circumference was significantly and independently associated with cc-IMT but not with CAC in women and men, indicating a possible effect of perivascular fat tissue on atherosclerosis.

scholarly journals Elevated levels of urine isocitrate, hydroxymethylglutarate, and formiminoglutamate are associated with arterial stiffness in Korean adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji-Hee Haam ◽  
Young-Sang Kim ◽  
Doo-Yeoun Cho ◽  
Hyejin Chun ◽  
Sang-Woon Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Cardiovascular Risk Factors ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Urinary Metabolites ◽  
Metabolic Disturbances ◽  
Liquid Chromatograph

AbstractRecent evidence suggests that cellular perturbations play an important role in the pathogenesis of cardiovascular diseases. Therefore, we analyzed the association between the levels of urinary metabolites and arterial stiffness. Our cross-sectional study included 330 Korean men and women. The brachial-ankle pulse wave velocity was measured as a marker of arterial stiffness. Urinary metabolites were evaluated using a high-performance liquid chromatograph-mass spectrometer. The brachial-ankle pulse wave velocity was found to be positively correlated with l-lactate, citrate, isocitrate, succinate, malate, hydroxymethylglutarate, α-ketoisovalerate, α-keto-β-methylvalerate, methylmalonate, and formiminoglutamate among men. Whereas, among women, the brachial-ankle pulse wave velocity was positively correlated with cis-aconitate, isocitrate, hydroxymethylglutarate, and formiminoglutamate. In the multivariable regression models adjusted for conventional cardiovascular risk factors, three metabolite concentrations (urine isocitrate, hydroxymethylglutarate, and formiminoglutamate) were independently and positively associated with brachial-ankle pulse wave velocity. Increased urine isocitrate, hydroxymethylglutarate, and formiminoglutamate concentrations were associated with brachial-ankle pulse wave velocity and independent of conventional cardiovascular risk factors. Our findings suggest that metabolic disturbances in cells may be related to arterial stiffness.

scholarly journals Gender Inequalities in Diagnostic Inertia around the Three Most Prevalent Cardiovascular Risk Studies: Protocol for a Population-Based Cohort Study

2021 ◽  
Vol 18 (8) ◽  
pp. 4054
Author(s):  
Concepción Carratala-Munuera ◽  
Adriana Lopez-Pineda ◽  
Domingo Orozco-Beltran ◽  
Jose A. Quesada ◽  
Jose L. Alfonso-Sanchez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Health Care ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Disease Incidence ◽  
Population Based ◽  
Gender Inequalities ◽  
Primary Health Care Centers

Evidence shows that objectives for detecting and controlling cardiovascular risk factors are not being effectively met, and moreover, outcomes differ between men and women. This study will assess the gender-related differences in diagnostic inertia around the three most prevalent cardiovascular risk factors: dyslipidemia, arterial hypertension, and diabetes mellitus, and to evaluate the consequences on cardiovascular disease incidence. This is an epidemiological and cohort study. Eligible patients will be adults who presented to public primary health care centers in a Spanish region from 2008 to 2011, with hypertension, dyslipidemia, or/and diabetes and without cardiovascular disease. Participants’ electronic health records will be used to collect the study variables in a window of six months from inclusion. Diagnostic inertia of hypertension, dyslipidemia, and/or diabetes is defined as the registry of abnormal diagnostic parameters—but no diagnosis—on the person’s health record. The cohort will be followed from the date of inclusion until the end of 2019. Outcomes will be cardiovascular events, defined as hospital admission due to ischemic cardiopathy, stroke, and death from any cause. The results of this study could inform actions to rectify the structure, organization and training of health care teams in order to correct the inequality.

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