scholarly journals Error in the Superior Temporal Gyrus? A Systematic Review and Activation Likelihood Estimation Meta-Analysis of Speech Production Studies

2020 ◽  
pp. 1-23
Author(s):  
Sophie Meekings ◽  
Sophie K. Scott
Keyword(s):  
Systematic Review ◽  
Error Correction ◽  
Speech Production ◽  
Auditory Feedback ◽  
Functional Neuroimaging ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Superior Temporal Gyrus ◽  
Activation Likelihood Estimation ◽  
Production Studies

Evidence for perceptual processing in models of speech production is often drawn from investigations in which the sound of a talker's voice is altered in real time to induce “errors.” Methods of acoustic manipulation vary but are assumed to engage the same neural network and psychological processes. This article aims to review fMRI and PET studies of altered auditory feedback and assess the strength of the evidence these studies provide for a speech error correction mechanism. Studies included were functional neuroimaging studies of speech production in neurotypical adult humans, using natural speech errors or one of three predefined speech manipulation techniques (frequency altered feedback, delayed auditory feedback, and masked auditory feedback). Seventeen studies met the inclusion criteria. In a systematic review, we evaluated whether each study (1) used an ecologically valid speech production task, (2) controlled for auditory activation caused by hearing the perturbation, (3) statistically controlled for multiple comparisons, and (4) measured behavioral compensation correlating with perturbation. None of the studies met all four criteria. We then conducted an activation likelihood estimation meta-analysis of brain coordinates from 16 studies that reported brain responses to manipulated over unmanipulated speech feedback, using the GingerALE toolbox. These foci clustered in bilateral superior temporal gyri, anterior to cortical fields typically linked to error correction. Within the limits of our analysis, we conclude that existing neuroimaging evidence is insufficient to determine whether error monitoring occurs in the posterior superior temporal gyrus regions proposed by models of speech production.

Hypnosis and pain perception: An Activation Likelihood Estimation (ALE) meta-analysis of functional neuroimaging studies

2015 ◽  
Vol 109 (4-6) ◽  
pp. 165-172 ◽  
Author(s):  
Antonio Del Casale ◽  
Stefano Ferracuti ◽  
Chiara Rapinesi ◽  
Pietro De Rossi ◽  
Gloria Angeletti ◽  
...  
Keyword(s):  
Pain Perception ◽  
Functional Neuroimaging ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Activation Likelihood Estimation

scholarly journals A Systematic Review and Activation Likelihood Estimation Meta-Analysis of fMRI Studies on Sweet Taste in Humans

2020 ◽  
Vol 150 (6) ◽  
pp. 1619-1630
Author(s):  
Carl A Roberts ◽  
Timo Giesbrecht ◽  
Nicholas Fallon ◽  
Anna Thomas ◽  
David J Mela ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Sweet Taste ◽  
Neural Representation ◽  
Sensitivity Analyses ◽  
Activation Likelihood Estimation ◽  
Data Set ◽  
Brain Responses ◽  
Human Adults

ABSTRACT Background The reward value of palatable foods is often cited as an important influence on eating behaviors, including intake of sugars. However, human neuroimaging studies have generated conflicting evidence on the basic neural representation of taste and reward responses to caloric sweeteners (sucrose and glucose), and most relevant studies have used small subject numbers. Objective We conducted a systematic review and a coordinate-based meta-analysis of studies reporting brain responses to oral sugar solutions. Methods A systematic search of MEDLINE, Scopus, and PsycINFO through October 2019 identified fMRI studies (in healthy human adults, including those with overweight or obesity) assessing differences in responses to purified sweet and nonsweet taste stimuli. Data were extracted with the primary objective of quantifying evidence for the activation of brain regions associated with caloric sweet taste sensation. We used activation likelihood estimation meta-analysis methods. We also performed multiple sensitivity analyses to assess the generality of effects. Results Of 455 unique articles, 15 met the criteria for inclusion. These contributed to 2 primary meta-analyses: 1) sucrose (13 experiments, 179 coordinates, n = 241) and 2) sucrose + glucose (16 experiments, 209 coordinates, n = 262). Consistent activation was apparent in primary taste areas: insula (69.2% of studies) and opercular cortex (76.9% of studies), precentral gyri (53.9% of studies), and globus pallidus and postcentral gyrus (30.8% of studies for each). Evidence of reward activity (caudate) was seen in the primary analyses (30.8% of studies) but not in sensitivity analysis. Conclusions We confirm the importance of primary taste areas for gustatory processing in human adults. We also provide tentative evidence for reward-related caudate activity in relation to the sweet taste of caloric sugars. A number of factors affect the observation and interpretation of brain responses, including reward-related activity. Firm conclusions require confirmation with large data set studies.

Executive functioning-related brain abnormalities associated with the genetic liability for schizophrenia: an activation likelihood estimation meta-analysis

2010 ◽  
Vol 41 (6) ◽  
pp. 1239-1252 ◽  
Author(s):  
V. M. Goghari
Keyword(s):  
Functional Neuroimaging ◽  
Meta Analysis ◽  
A Priori ◽  
Likelihood Estimation ◽  
Cortical Activation ◽  
Frontal Region ◽  
Neurocognitive Deficits ◽  
Functional Impairments ◽  
Activation Likelihood Estimation ◽  
Executive Processing

BackgroundRelatives of schizophrenia patients demonstrate abnormalities in prefrontal cortical activation during executive processing as measured by functional neuroimaging, albeit not consistently. A meta-analysis was conducted to determine whether reliable patterns of brain hypo- and hyperactivity, especially in the middle frontal region, were present in the relatives of patients.MethodSeventeen studies, containing 18 samples of relatives and controls, were included in this meta-analysis. Studies were included if relatives of schizophrenia patients were compared to controls, an executive processing task was used, and standard space coordinates were reported for the functional activations. Activation likelihood estimation (ALE) was implemented to find convergence across functional neuroimaging experiment coordinates. A separate analysis was conducted to assess the potential impact of a priori hypothesis testing used in region-of-interest (ROI) approaches on the meta-analysis results.ResultsRelatives demonstrated hypo- and hyperactivity in statistically overlapping right middle frontal regions [Brodmann area (BA) 9/10]. Use of an ROI analysis that a priori focused on prefrontal regions resulted in more findings of reduced activity in the middle frontal region.ConclusionsThe cortical regions identified by this meta-analysis could potentially serve as intermediate biological markers in the search for candidate genes for schizophrenia. As neurocognitive deficits are related to functional impairments in patients, a better understanding of neural and genetic vulnerabilities would be beneficial in our efforts to remediate these important deficits.

scholarly journals Shared and distinct functional networks for empathy and pain processing: a systematic review and meta-analysis of fMRI studies

2020 ◽  
Vol 15 (7) ◽  
pp. 709-723 ◽  
Author(s):  
Nicholas Fallon ◽  
Carl Roberts ◽  
Andrej Stancak
Keyword(s):  
Systematic Review ◽  
Functional Neuroimaging ◽  
Meta Analysis ◽  
Empirical Support ◽  
Likelihood Estimation ◽  
Anterior Cingulate ◽  
Pain Processing ◽  
Theoretical Understanding ◽  
Midcingulate Cortex ◽  
Nociceptive Processing

Abstract Background Empathy for pain is a complex phenomenon incorporating sensory, cognitive and affective processes. Functional neuroimaging studies indicate a rich network of brain activations for empathic processing. However, previous research focused on core activations in bilateral anterior insula (AI) and anterior cingulate/anterior midcingulate cortex (ACC/aMCC) which are also typically present during nociceptive (pain) processing. Theoretical understanding of empathy would benefit from empirical investigation of shared and contrasting brain activations for empathic and nociceptive processing. Method Thirty-nine empathy for observed pain studies (1112 participants; 527 foci) were selected by systematic review. Coordinate based meta-analysis (activation likelihood estimation) was performed and novel contrast analyses compared neurobiological processing of empathy with a comprehensive meta-analysis of 180 studies of nociceptive processing (Tanasescu et al., 2016). Results Conjunction analysis indicated overlapping activations for empathy and nociception in AI, aMCC, somatosensory and inferior frontal regions. Contrast analysis revealed increased likelihood of activation for empathy, relative to nociception, in bilateral supramarginal, inferior frontal and occipitotemporal regions. Nociception preferentially activated bilateral posterior insula, somatosensory cortex and aMCC. Conclusion Our findings support the likelihood of shared and distinct neural networks for empathic, relative to nociceptive, processing. This offers succinct empirical support for recent tiered or modular theoretical accounts of empathy.

scholarly journals Coordinate Based Meta-Analysis of Functional Neuroimaging Data Using Activation Likelihood Estimation; Full Width Half Max and Group Comparisons

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106735 ◽  
Author(s):  
Christopher R. Tench ◽  
Radu Tanasescu ◽  
Dorothee P. Auer ◽  
William J. Cottam ◽  
Cris S. Constantinescu
Keyword(s):  
Functional Neuroimaging ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Full Width ◽  
Activation Likelihood Estimation ◽  
Neuroimaging Data ◽  
Group Comparisons

scholarly journals Functional networks of empathy: A systematic review and meta-analysis of fMRI studies of empathy for observed pain

2018 ◽  
Author(s):  
Nicholas Fallon ◽  
Carl Roberts ◽  
Andrej Stancak
Keyword(s):  
Systematic Review ◽  
Functional Neuroimaging ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Brain Regions ◽  
Therapeutic Interventions ◽  
Clinical Aspects ◽  
Pain Processing ◽  
Empathy For Pain ◽  
Contrast Analysis

See published version here: https://doi.org/10.1093/scan/nsaa090 Background: Empathy is a phenomenon which incorporates cognitive and affective processes with importance for socio-political, interpersonal and clinical aspects of everyday life. Functional neuroimaging studies of empathy for pain demonstrate rich and heterogeneous patterns of brain activation. However, previous meta-analyses of such studies indicated a limited array of concordant activations focused on bilateral anterior insula (AI) and anterior/anterior mid-cingulate cortex (ACC/aMCC), which points to the need for further research to resolve this dichotomy. Greater understanding of the neurobiological mechanisms of empathy for pain has potential for research, therapeutic interventions and social applications.Objective: To conduct coordinate based meta-analysis (activation likelihood estimation, ALE) investigating neurobiological processes associated with empathy for observed pain. Data source: We adhered to the ‘Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRIMSA) method. Thirty-four studies comprising 897 participants and 420 reported foci were selected for ALE meta-analysis from a systematic review. In addition we contrasted ALE maps of empathy for pain with those of directly perceived pain processing in healthy people from a previous comprehensive meta-analysis (180 studies, Tanasescu 2016). Results: The ALE results revealed consistent activation across studies for empathy for observed pain in aMCC, bilateral AI, supramarginal and lateral occipitotemporal regions and inferior frontal gyri. Conjunction analysis highlighted a broad degree of overlap for empathy and direct experience of pain, but contrast analysis also indicated distinct patterns of activation for empathy for pain, particularly in bilateral supramarginal and occipitotemporal regions.Conclusion: The findings reveal an extended bilateral network underpinning empathy for observed pain which incorporates brain regions with relevance for pain processing, interoception, social cognition, and self-other distinction. The present analysis highlights an important role for supramarginal and occipitotemporal cortices in empathic responses to observed pain which were previously largely overlooked.

scholarly journals Resting State Functional Connectivity of Brain With Electroconvulsive Therapy in Depression: Meta-Analysis to Understand Its Mechanisms

2021 ◽  
Vol 14 ◽  
Author(s):  
Preeti Sinha ◽  
Himanshu Joshi ◽  
Dhruva Ithal
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Electroconvulsive Therapy ◽  
Resting State ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Cingulate Cortex ◽  
Activation Likelihood Estimation ◽  
Resting State Functional Connectivity ◽  
The Right

Introduction: Electroconvulsive therapy (ECT) is a commonly used brain stimulation treatment for treatment-resistant or severe depression. This study was planned to find the effects of ECT on brain connectivity by conducting a systematic review and coordinate-based meta-analysis of the studies performing resting state fMRI (rsfMRI) in patients with depression receiving ECT.Methods: We systematically searched the databases published up to July 31, 2020, for studies in patients having depression that compared resting-state functional connectivity (rsFC) before and after a course of pulse wave ECT. Meta-analysis was performed using the activation likelihood estimation method after extracting details about coordinates, voxel size, and method for correction of multiple comparisons corresponding to the significant clusters and the respective rsFC analysis measure with its method of extraction.Results: Among 41 articles selected for full-text review, 31 articles were included in the systematic review. Among them, 13 articles were included in the meta-analysis, and a total of 73 foci of 21 experiments were examined using activation likelihood estimation in 10 sets. Using the cluster-level interference method, one voxel-wise analysis with the measure of amplitude of low frequency fluctuations and one seed-voxel analysis with the right hippocampus showed a significant reduction (p < 0.0001) in the left cingulate gyrus (dorsal anterior cingulate cortex) and a significant increase (p < 0.0001) in the right hippocampus with the right parahippocampal gyrus, respectively. Another analysis with the studies implementing network-wise (posterior default mode network: dorsomedial prefrontal cortex) resting state functional connectivity showed a significant increase (p < 0.001) in bilateral posterior cingulate cortex. There was considerable variability as well as a few key deficits in the preprocessing and analysis of the neuroimages and the reporting of results in the included studies. Due to lesser studies, we could not do further analysis to address the neuroimaging variability and subject-related differences.Conclusion: The brain regions noted in this meta-analysis are reasonably specific and distinguished, and they had significant changes in resting state functional connectivity after a course of ECT for depression. More studies with better neuroimaging standards should be conducted in the future to confirm these results in different subgroups of depression and with varied aspects of ECT.

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