Monitoring Peripheral Venous Lactic Acid Levels Is a Meaningful, Effective and Feasible Alternative to Arterial Lactate Levels in Patients with Septic Shock.

2009 ◽  
Author(s):  
A Agheli ◽  
T Noman ◽  
C Rathnasabapathy ◽  
H Chenthilmurugan ◽  
O Nadeem ◽  
...  
Keyword(s):  
Septic Shock ◽  
Lactic Acid ◽  
Arterial Lactate ◽  
Feasible Alternative ◽  
Lactate Levels

Low Lactic Acid and Hypercholesterolemia Reduce 90-day Mortality in Patients Suffering From Septic Shock According to the Sepsis-3 Definition

2021 ◽  
Author(s):  
Dong Wang ◽  
Yali Sun ◽  
Huan Liu ◽  
Xiaojuan Zhang ◽  
Xianfei Ding ◽  
...  
Keyword(s):  
Septic Shock ◽  
Lactic Acid ◽  
Total Cholesterol ◽  
Cox Model ◽  
Health Assessment ◽  
Binary Logistic Regression ◽  
Apache Ii ◽  
Binary Logistic Regression Model ◽  
Cholesterol Levels ◽  
Lactate Levels

Abstract Background: Dyslipidemia and lactic acid levels are associated with poor prognosis of septic shock. After the revised definition of sepsis and septic shock (Sepsis-3) in 2016, data on the prognostic value of lactic acid levels and hypocholesterolemia were lacked. This study aimed to evaluate whether lactic acid and cholesterol can be used to predict mortality in ICU patients suffering from septic shock.Methods: Prospective observational study, 349 patients suffering from septic shock as defined by Sepsis-3. The COX model and the binary logistic regression model evaluate the correlation between lactic acid or total cholesterol and death from septic shock, and are adjusted according to the demographics, chronic diseases, and biomarkers of the participants.Results: Total cholesterol, total protein, and albumin levels were significantly lower, and lactic acid, acute physiology, and chronic health assessment (APACHE II) were significantly higher in the surviving group compared to those in the non-surviving group. Lactate levels < 4.4 mmol/L and total cholesterol levels < 2.42 mmol/L were associated with mortality after adjusting for confounders (odd ratio, 3.06 [95% CI, 1.78-5.27] and 1.99 [95% CI, 1.15-3.46]). In multivariate analysis, urogenital origin, albumin levels < 25 g/L, age < 60 years, and APACHE II < 20 were independent risk factors for death from septic shock.Conclusions: In those suffering from septic shock, increased blood lactate levels and decreased total cholesterol levels were associated with higher mortality. Furthermore, it was found that lactic acid and total cholesterol are sensitive markers of mortality in an ICU setting.

scholarly journals Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock

2015 ◽  
Vol 41 (5) ◽  
pp. 796-805 ◽  
Author(s):  
Gustavo A. Ospina-Tascón ◽  
Mauricio Umaña ◽  
William Bermúdez ◽  
Diego F. Bautista-Rincón ◽  
Glenn Hernandez ◽  
...  
Keyword(s):  
Septic Shock ◽  
Arterial Lactate ◽  
Content Difference ◽  
Lactate Levels

scholarly journals STUDY OF SERUM LACTATE LEVELS IN PATIENTS WITH SEPSIS ON THE BASIS OF SURVIVAL AND NON-SURVIVAL

2021 ◽  
pp. 8-10
Author(s):  
Anisha Tanwar ◽  
Bushra Fiza ◽  
Bhupesh Medatwal ◽  
Rubal Singh ◽  
Maheep Sinha
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Lactic Acid ◽  
Survival Rate ◽  
Lactate Concentration ◽  
Serum Lactate ◽  
Mortality Prediction ◽  
P Value ◽  
Lactate Levels ◽  
Sepsis And Septic Shock

INTRODUCTION:- Sepsis is a leading cause of morbidity and mortality internationally Early spotting and . interventions are essential to ensure better patient's outcome. Lactate concentration in septic patients is of particular prognostic value in predicting septic shock and mortality. AIM:- The present study was intended to evaluate the serum Lactate levels on the basis of severity rate in patients suffering of sepsis, severe sepsis and septic shock. MATERIAL & METHOD:- 100 patients diagnosed for sepsis were enrolled for the study and they were grouped as sepsis (n=30), severe sepsis (n=37)and septic shock (n=33). On the basis of survival rate serum Lactate levels in patients with sepsis were estimated in all the 3 categories of subjects according to the inclusion criteria. A p-Value of ≤0.05 were considered as statistically significant. RESULT:- In the present study when the lactate levels were evaluated among all the three categories, it was observed that the Lactate levels were found to be statistically significant (p-value <0.0001). Lactic acid evaluated on the basis of survival rate was also found to be statistically significant with the p-Value 0.015. CONCLUSION:- Lactic acid could be utilized as a reliable marker to assess prognosis at the initial phase of presentation because its initial evaluation shows good predictability in mortality prediction in sepsis patients.

The response of the kidney of the freshwater rainbow trout to true metabolic acidosis

1980 ◽  
Vol 84 (1) ◽  
pp. 227-244 ◽  
Author(s):  
K. A. Kobayashi ◽  
C. M. Wood
Keyword(s):  
Lactic Acid ◽  
Metabolic Acidosis ◽  
Blood Lactate ◽  
Renal Excretion ◽  
Total Acid ◽  
Time Courses ◽  
Lactate Levels ◽  
Urinary Acid ◽  
Proton Load ◽  
Lactate Excretion

Infusion of lactic acid into the bloodstream of trout produced a short-lived depression of blood pH and a long-lasting elevation of blood lactate. The lactate injected was distributed in a volume of 198 ml/kg. Renal excretion of lactate anion and total acid increased by approximately equal amounts during the period of high blood lactate levels, but total renal loss over 72 h accounted for only 2% of the lactate load and 6% of the proton load. Comparable differences in the time courses of blood lactate and pH changes occurred when lactacidosis was induced endogenously by normocapnic hypoxia. The immediate response of the kidney was similar to that with lactic acid infusion, but there was a long-lasting (12–72 + h) elevation of urinary acid efflux that was not associated with lactate excretion. Following hypoxia, renal excretion over 72 h accounted for 1% of the estimated lactate load and 12–25% of the proton load. A renal lactate threshold of 4–10 muequiv/ml prevents significant urinary lactate excretion. The response of the trout kidney to true metabolic acidosis is similar to that of the mammalian kidney.

scholarly journals Peculiarities of Carbohydrate Exchange in Patients with Generalized Periodontitis of Young Age Persons

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Halyna Kimak ◽  
Halyna Melnychuk ◽  
Hanna Ersteniuk
Keyword(s):  
Lactic Acid ◽  
Lactate Dehydrogenase ◽  
Carbohydrate Metabolism ◽  
Young Patients ◽  
Young Age ◽  
Lactate Dehydrogenase Activity ◽  
Significant Difference ◽  
Oral Liquid ◽  
Lactate Levels ◽  
Healthy Persons

There were studied 92 somatically healthy persons of young age (18-25 years old), with generalized periodontitis (GP) of initial-I degree of development, among them: 30 patients with chronic generalized periodontitis (CGP), who were included into group І; and 32 patients with exacerbation of the chronic generalized periodontitis (ECGP) – into group II; and 30 healthy patients. The carbohydrate metabolism indexes were studied, namely: the content of glucose, pyruvate (pyruvic acid) and lactate (lactic acid) and lactate dehydrogenase activity (LDG) in the oral liquid.We have determined that in the presence of CGP of the initial-I degree of development, and especially in its exacerbation, there is a significant increase of indicators of carbohydrate metabolism. In young patients with CGP indicators of glucose, pyruvate, lactate and LDG activity in the oral liquid increased by 2.0, 1.34, 1.58 and 1.37 (p<0.001, p<0.01) times respectively, and in case of ECGP they grew even more: by 2.71, 1.98, 1.76 and 2.07 (p<0.001) times, respectively.Among all the indicators, that characterize the carbohydrate metabolism, in addition to the level of pyruvate, in case of different course of GP a significant difference was revealed: in patients with ECGP compared with the data in CGP, glucose and lactate levels and LDG activity in the oral liquid were significantly higher - at 35.75% (p<0.05), 34.29% (p<0.01) and 36.59% (p<0.001) respectively.Detected violations of carbohydrate metabolism indeces in the oral liquid indicate the involvement of these processes in the pathogenesis of GP and the necessity of their correction. 

scholarly journals Plasma lactate levels and lactate clearance as predictors of outcome in patients with sepsis and septic shock

2020 ◽  
Vol 7 (6) ◽  
pp. 1213
Author(s):  
Rashmi Patil ◽  
Chikkanarasareddy P. S. ◽  
Mallesh K.
Keyword(s):  
Septic Shock ◽  
Clinical Decision Making ◽  
Early Recognition ◽  
Early Stage ◽  
Therapeutic Option ◽  
Lactate Clearance ◽  
Plasma Lactate ◽  
Risk Of Death ◽  
Lactate Levels ◽  
Sepsis And Septic Shock

Background: Severe sepsis and septic shock are the major causes of admission and deaths in the ICU, killing one in four (and often more) and increasing in incidence. In order to improve the clinical outcomes in these patients, it is crucial to obtain early recognition of patients who are at risk of death and to optimize the clinical decision making in a timely manner. In order to monitor the metabolic consequences of shock and hemodynamic management, plasma lactate levels can be used in critical illness. Objective of the study is to estimate plasma lactate and lactate clearance in sepsis and septic shock patients and to correlate plasma lactate and lactate clearance as predictors of mortality.Methods: This study is a prospective observational study conducted over 18months. Children with age of 1 month to 18 years admitted to the Paediatric intensive care unit with sepsis and septic shock were enrolled in the study. ABG at admission to document plasma lactate and lactate repeated at 6 and 24 hrs. Lactate clearance calculated at 6 and 24 hrs. The final outcome in terms of survival or death will be recorded.Results: Majority of the children fall in the class between 1-6 months 51(48.11%). Male comprises 69(65.09%). Among these, Sepsis 36(33.96%); followed by Pneumonia 34(32.07%). Survivors group were 35(33.02%) and non-survivor was 71(66.98%). The Non survivor group was observed to have lower mean values of lactate clearance and found to be statistically significant. Specificity of Lactate clearance was 63.52% and Sensitivity 76.02% respectively. The results were positively associated with lactate level at 24 hours found to be significant effect of survivability when compared to non-survivor.Conclusions: Lactate clearance is vital and markable sign for screening of septic shock at early stage for therapeutic option. Further, 24-hours lactate estimation (cut off values) clearance appears superior to 6 h lactate clearance in predicting mortality in such patients.

scholarly journals Developmental changes in oxygen consumption regulation in larvae of the South African clawed frog Xenopus laevis

1995 ◽  
Vol 198 (12) ◽  
pp. 2465-2475 ◽  
Author(s):  
D Hastings ◽  
W Burggren
Keyword(s):  
Oxygen Consumption ◽  
Lactic Acid ◽  
Xenopus Laevis ◽  
South African ◽  
Acute Hypoxia ◽  
Lactate Concentration ◽  
Aerobic Metabolism ◽  
Whole Body ◽  
Lactate Levels ◽  
Clawed Frog

Well-developed larval Xenopus laevis (NF stages 58&shy;66) are oxygen regulators, at least during mild hypoxia. When and how they change from oxygen conformers (the presumed condition of the fertilized egg) to oxygen regulators is unknown. Also unknown is how anaerobic metabolic capabilities change during development, especially in response to acute hypoxia, and to what extent, if any, anaerobiosis is used to supplement aerobic metabolism. Consequently, we have investigated resting rates of oxygen consumption (M.O2) and concentrations of whole-body lactate (lactic acid) during development in normoxia and in response to acute hypoxia in Xenopus laevis. M.O2 increased in an episodic, non-linear fashion during development. Resting, normoxic M.O2 increased about tenfold (to approximately 0.20 &micro;mol g-1 h-1) between NF stages 1&shy;39 and 40&shy;44, and then another tenfold between NF stages 45&shy;48 and 49&shy;51 (to approximately 2.0 &micro;mol g-1 h-1), remaining at about 2 &micro;mol g-1 h-1 for the remainder of larval development. M.O2 reached its highest level in newly metamorphosed frogs (nearly 4 &micro;mol g-1 h-1), before decreasing to about 1.0 &micro;mol g-1 h-1 in large adults. X. laevis embryos and larvae up to NF stage 54&shy;57 were oxygen conformers when exposed to variable levels of acute hypoxia. The only exception was NF stage 45&shy;48 (external gills present yet body mass still very small), which showed some capability of oxygen regulation. All larvae older than stage 54&shy;57 and adults were oxygen regulators and had the lowest values of Pcrit (the oxygen partial pressure at which M.O2 begins to decline). Whole-body lactate concentration in normoxia was about 1 &micro;mol g-1 for all larval groups, rising to about 12 &micro;mol g-1 in adults. Concentrations of lactic acid in NF stages 1&shy;51 were unaffected by even severe ambient hypoxia. However, whole-body lactate levels in NF stages 52&shy;66 increased in response to severe hypoxia, indicating that some anaerobic metabolism was being used to supplement diminishing aerobic metabolism. The largest increases in concentration of lactate occurred in late larvae and adults.

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