Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis.

1995 ◽  
Vol 152 (6) ◽  
pp. 2059-2067 ◽  
Author(s):  
R U Pawankar ◽  
M Okuda ◽  
S Hasegawa ◽  
K Suzuki ◽  
H Yssel ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Perennial Allergic Rhinitis ◽  
Interleukin 13

scholarly journals Chitinase-like protein YKL-40 from nasal mucosa as a biomarker of allergic rhinitis

2012 ◽  
Vol 9 (4) ◽  
pp. 13-17
Author(s):  
YU A Tyurin ◽  
E O Sukmanskaya ◽  
S N Kulikov ◽  
R S Fassakhov
Keyword(s):  
Allergic Rhinitis ◽  
Healthy Volunteers ◽  
Nasal Mucosa ◽  
Allergic Response ◽  
Atopic Diseases ◽  
Perennial Allergic Rhinitis

Background. Chitinase-like protein YKL-40 plays an important role in human atopic diseases. The aim of this study was to determine of the level of chitinase-like protein YKL-40 in the secretions of nasal mucosa of patients with chronic allergic rhinitis. Methods. Samples of allergic nasal mucosa were obtained from twelve patients with perennial allergic rhinitis. Measurement of nasal YKL-40 levels was performed with modification in duplicate using commercially available ELISA kits for YKL-40. The amount of nasal eosinophils and neutrophils were also determined. Results. There were significant differences between healthy volunteers and patients with allergic rhinitis for mucosal YKL-40 levels and the amount of nasal eosinophil and neutrophil cells, which have some characteristics closely associated with allergic response. The nasal YKL-40 levels in patients with allergic rhinitis were in tens times more higher than those in controls. Conclusion. Thus, we conclude that the level of chitinase-like protein YKL-40 was upregulated in allergic nasal mucosa compared with normal nasal mucosa, suggesting their roles in the pathogenesis of allergic rhinitis.

scholarly journals Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis

2001 ◽  
Vol 108 (5) ◽  
pp. 791-796 ◽  
Author(s):  
Azhar Shaida ◽  
Guy Kenyon ◽  
Jagdish Devalia ◽  
Robert J. Davies ◽  
Thomas T. MacDonald ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Matrix Metalloproteinases ◽  
Nasal Mucosa ◽  
Perennial Allergic Rhinitis

Increase in epithelial mast cell numbers in the nasal mucosa of patients with perennial allergic rhinitis

1996 ◽  
Vol 110 (10) ◽  
pp. 929-933 ◽  
Author(s):  
A. Slater ◽  
L. A. Smallman ◽  
A. B. Drake-Lee
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cells ◽  
Light Microscopy ◽  
Nasal Mucosa ◽  
Inferior Turbinate ◽  
Control Group ◽  
Perennial Allergic Rhinitis ◽  
Immunohistochemical Technique ◽  
Cell Numbers ◽  
Staining Methods

AbstractThe aim of the study was to compare the numbers and distribution of mast cells in the nasal mucosa of perennial allergic rhinitis (PAR) patients and controls, as demonstrated by different staining methods for light microscopy.Biopsies of inferior turbinate mucosa were taken from 10 patients with PAR and 10 patients undergoing septoplasty or septorhinoplasty (control group). Sections for light microscopy were stained with azure A, chloroacetate esterase and an ABC immunohistochemical technique using antibody to tryptase.Three times more mast cells were found in the epithelium of PAR patients compared to controls using the immunohistochemical technique (p = 0.0074). This method demonstrated considerably more mast cells than the other stains.The increase in epithelial mast cells is consistent with the migration of mast cells seen in seasonal allergic rhinitis, and this may be important in the phenomenon of nasal priming seen after repeated antigen exposure.

Increase in Expression of IL-4 and IL-5 Mrna in the Nasal Mucosa of Patients with Perennial Allergic Rhinitis during Natural Allergen Exposure

1997 ◽  
Vol 106 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Chul Hee Lee ◽  
Chae-Seo Rhee ◽  
Yang-Gi Min ◽  
Seung Ha Oh ◽  
Myung Sook Lee
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Allergen Exposure ◽  
Perennial Allergic Rhinitis ◽  
Control Subjects ◽  
Number Of Patients ◽  
Nasal Disease ◽  
Ifn Γ ◽  
Density Ratios

To understand the role of cytokines in allergic nasal disease in humans, we designed this study to investigate the expression of cytokine mRNA in the nasal mucosa of 10 control subjects and 10 patients with perennial allergic rhinitis using a reverse transcription—polymerase chain reaction (RT-PCR) for IL-4, IL-5 (Th2 cytokines), and IFN-γ (Th1 cytokine). Both IL-4 and IL-5 mRNAs were expressed in a significantly larger number of patients with allergic rhinitis than in control subjects. When the levels of expression of cytokines and β-actin mRNA were quantitated, the mean density ratios (cytokine/β-actin) for IL-4 and IL-5 were higher in patients with allergic rhinitis than in control subjects. In contrast, there were no differences in the number of subjects who showed expression of IFN-γ mRNA, or in mean density ratios for IFN-γ between the two groups. This study suggests that both IL-4 and IL-5 mRNAs are expressed almost universally in the nasal mucosa of patients with perennial allergic rhinitis during natural allergen exposure and also that Th2-type cytokines play a crucial role in the development of allergic nasal diseases in vivo.

scholarly journals Perennial allergic rhinitis in children: efficiency and safety of using «Ergocetal»

2021 ◽  
pp. 12-16
Author(s):  
T.R. Umanets ◽  
◽  
V.F. Lapshyn ◽  
A.A. Rudnev ◽  
O.I. Pustovalova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Nasal Congestion ◽  
School Age Children ◽  
Perennial Allergic Rhinitis ◽  
Good Tolerance ◽  
Ocular Symptoms ◽  
Positive Therapeutic Effect ◽  
High Adherence ◽  
Key Words Allergic Rhinitis

Purpose — to evaluate the efficacy and safety of levocetirizine («Ergocetal») in children with perennial allergic rhinitis (PAR). Materials and methods. 30 children aged 6–16 years with PAR were examined. All children were prescribed levocetirizine («Ergocetal») 5 mg in the form of tablets once a day for a month for the treatment of PAR. The criteria for the effectiveness of the treatment were: regression of the main nasal and ocular symptoms of PAR (rhinorrhea, nasal congestion, nasal itching, sneezing, itching and redness of the eyes) according to the visual analogue scale (VAS); dynamics of nasal eosinophilia in a smearst from the nasal mucosa. Results. The studies have shown that prescribe of levocetirizine «Ergocetal» in monotherapy for school-age children with mild and intermittent PAR had a positive therapeutic effect on nasal and ocular symptoms, as well as on the intensity of eosinophilic inflammation in the nasal mucosa. Established good tolerance and the absence of side effects of «Ergotal» in the examined children. Conclusions. Therapeutic efficacy, absence of adverse reactions, high adherence to treatment make it possible to recommend levocetirizine («Ergocetal») as monotherapy for mild and intermittent PAR in school children. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of an participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: allergic rhinitis, treatment, levocetirizine.

Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosa of patients with perennial allergic rhinitis

2001 ◽  
Vol 31 (8) ◽  
pp. 1242-1249 ◽  
Author(s):  
H. Hattori ◽  
M. Okano ◽  
T. Yoshino ◽  
T. Akagi ◽  
E. Nakayama ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Perennial Allergic Rhinitis
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