Short-Term Exposure to Air Pollution and Lung Function in the Framingham Heart Study

BackgroundDaily levels of ambient air pollution and pollen may affect lung function but have rarely been studied together. We investigated short-term exposure to pollen and air pollution in relation to lung function in school-age children from a French population-based birth cohort.MethodsThis study included 1063 children from the PARIS (Pollution and Asthma Risk: an Infant Study) cohort whose lung function and FeNO measurements were performed at age 8 years old. Exposure data were collected up to 4 days before testing. We estimated daily total pollen concentration, daily allergenic risk indices for nine pollen taxa, as well as daily concentrations of three air pollutants (particulate matter less than 10 µm (PM10), nitrogen dioxide (NO2), ozone (O3)). Children with similar pollen and air pollution exposure were grouped using multidimensional longitudinal cluster analysis. Associations between clusters of pollen and air pollution exposure and respiratory indices (FEV1, FVC, FeNO) were studied using multivariable linear and logistic regression models adjusted for potential confounders.ResultsFour clusters of exposure were identified: no pollen and low air pollution (Cluster 1), grass pollen (Cluster 2), PM10 (Cluster 3) and birch/plane-tree pollen with high total pollen count (Cluster 4). Compared with children in Cluster 1, children in Cluster 2 had significantly lower FEV1 and FVC levels, and children from Cluster 3 had higher FeNO levels. For FEV1 and FVC, the associations appeared stronger in children with current asthma. Additional analysis suggested a joint effect of grass pollen and air pollution on lung function.ConclusionDaily ambient chemical and biological air quality could adversely influence lung function in children.

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Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study

Environmental Research ◽

10.1016/j.envres.2018.10.027 ◽

2019 ◽

Vol 171 ◽

pp. 36-43 ◽

Cited By ~ 5

Author(s):

Wenyuan Li ◽

Kirsten S. Dorans ◽

Elissa H. Wilker ◽

Mary B. Rice ◽

Petter L. Ljungman ◽

...

Keyword(s):

Air Pollution ◽

Endothelial Cell ◽

Cell Activation ◽

Ambient Air ◽

Ambient Air Pollution ◽

Circulating Biomarkers ◽

Short Term ◽

Endothelial Cell Activation ◽

Heart Study ◽

Short Term Exposure

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Impact of Short-Term Exposure to Air Pollution on Lung Function of Patients with Interstitial Lung Diseases

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2892 ◽

2020 ◽

Author(s):

K. Cromar ◽

M. Ghazipura ◽

D.L. Mendoza ◽

C.S. Pirozzi

Keyword(s):

Air Pollution ◽

Lung Function ◽

Lung Diseases ◽

Interstitial Lung Diseases ◽

Short Term ◽

Short Term Exposure

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Short-term acute exposure to wildfire smoke and lung function in a Royal Canadian Mounted Police (RCMP) cohort

10.1101/2020.12.15.20248289 ◽

2020 ◽

Author(s):

Subhabrata Moitra ◽

Ali Farshchi Tabrizi ◽

Dina Fathy ◽

Samineh Kamravaei ◽

Noushin Miandashti ◽

...

Keyword(s):

Air Pollution ◽

Air Quality ◽

Lung Function ◽

Air Pollutants ◽

Linear Regression Analysis ◽

Short Term ◽

Royal Canadian Mounted Police ◽

Wildfire Smoke ◽

Peripheral Airways ◽

Short Term Exposure

ABSTRACTRationaleThe increasing incidence of extreme wildfire is becoming a concern for public health. Although long-term exposure to wildfire smoke is associated with respiratory illnesses, reports on the association between short-term occupational exposure to wildfire smoke and lung function remain scarce.MethodsIn this cross-sectional study, we analyzed data of 218 Royal Canadian Mounted Police officers (mean age: 38±9 years) deployed at the Fort McMurray wildfire in 2016. Individual exposure to air pollutants was calculated by integrating the duration of exposure with the air quality parameters obtained from the nearest air quality monitoring station during the phase of deployment. Lung function was measured using spirometry and body plethysmography. Association between exposure and lung function was examined using principal component linear regression analysis, adjusting for potential confounders.ResultsThe participants were predominantly male (71%). Mean forced expiratory volume in 1 second (FEV1), and residual volume (RV) were 76.5±5.9 and 80.1±19.5 of % predicted. A marginal association was observed between the principal air pollution component and higher RV [β: 1.55; 95%CI: -0.28 to 3.37 per interquartile range change of air pollution index], but not with other lung function indices. The association was significantly higher in participants who were screened within the first three months of deployment [2.80; 0.91 to 4.70] than those screened later [-0.28; -2.58 to 2.03], indicating a more acute effect of air pollution on peripheral airways.ConclusionAcute short-term exposure to wildfire-associated air pollutants may impose subtle but clinically important deleterious respiratory effects, particularly in the peripheral airways.

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