scholarly journals Effects of Prolonged Administration of Aqueous Extract of <i>Ocimum gratissimum</i> (Scent Leaf) on Blood Glucose and Lipid Profile in Alloxan Induced Diabetic Albino Rats

2016 ◽  
Vol 4 (3) ◽  
pp. 30 ◽  
Author(s):  
Ufele Angela Nwogor
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Aqueous Extract ◽  
Albino Rats ◽  
Prolonged Administration ◽  
Ocimum Gratissimum

scholarly journals POLYHERBAL PREPARATION AND COMPARATIVE STUDIES ON DIET-INDUCED HYPERLIPIDEMIA

2019 ◽  
pp. 190-196
Author(s):  
NUZHAT QURESHI ◽  
RAGHVENDRA DUBEY ◽  
NILESH KUMAR PATHAK
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Comparative Studies ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Albino Rats ◽  
Oral Toxicity

Objective: The objective of this research article is to develop and evaluate polyherbal preparation and comparative studies on diet-induced hyperlipidemia. Methods: After the extraction, pharmacognostical and phytochemical screening was done. The lipid-lowering activity of polyherbal formulation (T1, T2, T3, T4, and T5) may be attributed to the phytoconstituents present such as alkaloids, carbohydrates, steroids, proteins, tannins, carbohydrates, flavonoids, phenols, glycosides, and triterpenes. In acute oral toxicity study, there were no behavioral changes seen up to 4 h and no mortality was observed up to the end of 24 h even at the maximum tested dose level of 2000 mg/kg per oral. It was considered maximum safe dose. Male and female albino rats weighing 150–200 g were used for the study. Hydroalcoholic extract of all plants was prepared having a dose of 2000 mg/kg. The doses were selected according to the Organisation for Economic Cooperation and Development guideline no. 425. The procedure was divided into two phases: Phase I (observation made on day 1) and Phase II (observed the animals for the next 14 days of drug administration). Animals received a single dose of 2000 mg/kg. After the administration of Healthcare Administration, food was withheld for 3–4 h. If the animal dies, conduct the main test to determine the LD50. The study was conducted by measuring various parameters, namely, daily feed intake (g), water intake (ml), body weight (g), lipid profile high-density lipoprotein (HDL), low-density lipoprotein (LDL), CHL level (mg/dl), and blood glucose level (mg/dl). Results: Results showed a significant decrease in blood glucose level and serum lipid profile such as total cholesterol, LDL, and increasing serum HDL level, so could be useful in the treatment of hypolipidemia. Conclusion: Polyherbal formulations (T1, T2, T3, T4, and T5) have hypoglycemic activity and significantly improve lipid profile levels in diet-induced experimental rats.

scholarly journals EFFECT OF TELMISARTAN ON BLOOD GLUCOSE LEVELS AND BLOOD LIPID LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

2019 ◽  
Vol 12 (3) ◽  
pp. 1303-1308
Author(s):  
Siddamma Amoghimath ◽  
R. N. Suresha
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Blood Lipid ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Blood Lipid Levels

To evaluate the effect of telmisartan on blood glucose levels and blood lipid levels in streptozotocin induced diabetic rats. Eighteen Wistar albino rats weighing 150-200gms of either sex were randomly selected from the central animal facility, and divided into 3 groups. Diabetes was induced by injecting Streptozotocin intraperitonelly. The control group received 1% Gum acacia (oral), standard group received 0.5 mg/kg Glibenclamide (oral) and the test group received Telmisartan 7.2mg/kg body weight (oral) from 0-28 days respectively. Body weight of the individual rats were measured on the respective days before blood glucose estimation on 0, 1, 3, 7, 14, 21 & 28th day and fasting blood glucose was estimated by (ACCUCHECK) glucometer. Estimation of fasting lipid profile by lipid screening strips on 1st and 28th day. When compared to control the capillary blood glucose (CBG) levels in the Telmisartan group was less at all the intervals but comparable with that of standard drug Glibenclamide in Streptozotocin induced diabetic rats. Improved lipid profile was seen with the Telmisartan group when compared to control group in Streptozotocin induced diabetic rats. Hypoglycemic activity and improved lipid profile action was seen with Telmisartan group which is comparable to standard drug glibenclamide in streptozotocin induced diabetic albino rats.

scholarly journals Evaluation of Aqueous Extract of Alphonsea sclerocarpa for in vivo and in vitro Antidiabetic Potentials in Wistar Rats

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ravi Shankar N ◽  
Ram Kishore ◽  
Puranik SB
Keyword(s):  
Blood Glucose ◽  
Glucose Uptake ◽  
Aqueous Extract ◽  
Insulin Level ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Oral Glucose ◽  
In Vivo Evaluation

The purpose of current investigation was to investigate in vivo and in vitro anti-diabetic potentials of aqueous extract of Alphonsea sclerocarpa leaves against alloxan induced diabetes in albino rats. Two in vivo and one in vitro methods were performed for the evaluation of aqueous extract for antidiabetic activity. For in-vivo evaluation, diabetes was induced in albino rats by administering a single dose of alloxan. The study was designed to test the acute effect of aqueous extract of Alphonsea sclerocarpa (AEAS) to reduce blood glucose in OGTT. The chronic study of 21 days was performed against diabetic rats and blood glucose was determined at 1st , 7 th, 14th and 21st day. In chronic in vivo study, serum parameters insulin, urea, creatinine, total cholesterol, triglycerides, ALT and AST were also estimated at 21st day to determine the effects of aqueous and aqueous extracts on complications of diabetes mellitus. Glucose uptake by hemidiaphragm assay was performed to test the ability of extract to utilize glucose. In Oral Glucose Tolerance Test, standard glibenclamide and aqueous extract (200mg/kg and 400mg/kg) treated animals have shown significant reduction in blood glucose at 90 mins but at 120 mins. In chronic model the aqueous extract effectively reduced blood glucose levels (P<0.001) at 14th and 21st day of study in therapeutic groups and effect was comparable to that of standard. The extract could also significantly (P<0.001) reduce concentrations of SGOT, triglycerides, cholesterol and urea in serum and significantly (P<0.001) increased the insulin level in blood which proves beneficial effects of the extract in diabetes. The change in concentrations of SGPT and urea were less significant (P>0.01). The presence of extract in glucose uptake assay could significantly increase utilization of the glucose by rat hemidiaphragm. The aqueous extract of Alphonsea sclerocarpa possess significant antidiabetic properties against alloxan induced diabetic animals.

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