scholarly journals Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey

2015 ◽  
Vol 3 (5) ◽  
pp. 141
Author(s):  
Khatere Khosravian Dehkordi
Keyword(s):  
Rat Liver ◽  
Lead Acetate ◽  
Histopathological Study

scholarly journals THE EFFECT OF LEAD ACETATE ON OXYGEN UPTAKE OF RAT LIVER SLICES

1941 ◽  
Vol 140 (1) ◽  
pp. 285-291
Author(s):  
Harry D. Baernstein ◽  
J.A. Grand
Keyword(s):  
Oxygen Uptake ◽  
Rat Liver ◽  
Lead Acetate ◽  
Liver Slices

scholarly journals Inhibition of carbon dioxide fixation by lead acetate in rat liver mitochondria

1977 ◽  
Vol 166 (1) ◽  
pp. 75-79 ◽  
Author(s):  
J M Amatruda ◽  
A J Staton ◽  
L A Kiesow
Keyword(s):  
Rat Liver ◽  
Lead Acetate ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Co2 Fixation ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Lead Salts ◽  
Lactate And Pyruvate ◽  
Gluconeogenesis From Alanine ◽  
Glucose 6 Phosphate Dehydrogenase

These studies were undertaken to determine the mechanism by which intravenously administered lead salts inhibit hepatic gluconeogenesis. Within 1 h after the intravenous administration of lead acetate (10 mg), there is 97% inhibition of CO2 fixation in isolated rat liver mitochondria. This effect is concentration-dependent. The induction of phosphoenolpyruvate carboxykinase activity observed with starvation was also inhibited by intravenously administered lead acetate, but the activities of pyruvate kinase, glucose 6-phosphate dehydrogenase and pyruvate carboxylase were unaffected, as was the oxidation of palmitate and palmitoyl-CoA by mitochondria from Pb2+-treated animals. The addition of reduced glutathione to mitochondria from Pb2+-treated animals had no effect on the inhibited CO2 fixation. ATP concentrations in mitochondria from Pb2+-treated animals are decreased and the dose-response relationships for the effect of Pb2+ on CO2 fixation and ATP concentrations correspond. We conclude that the decrease in mitochondrial ATP in Pb2+-treated animals is probably responsible for the marked inhibition ov CO2 fixation, and hence the impairment of gluconeogenesis from alanine, lactate and pyruvate observed by others.

scholarly journals Effect of lead acetate and carbon particles on the expression of glutathione S-transferase YfYf in rat liver

1993 ◽  
Vol 294 (1) ◽  
pp. 301-304 ◽  
Author(s):  
S J Boyce ◽  
T J Mantle
Keyword(s):  
Single Dose ◽  
Rat Liver ◽  
Kupffer Cells ◽  
Lead Acetate ◽  
Glutathione S Transferase ◽  
Marked Elevation ◽  
Complex Response ◽  
Carbon Particles

Administration of intracardiac lead acetate produces a complex response in glutathione S-transferase (GST) YfYf expression in rat liver. The earliest response, an elevation of GST expression in Kupffer cells, can be mimicked by administering a suspension of carbon particles. The second effect of lead acetate administration is a marked elevation of GST YfYf in some but not all hepatocytes (the ‘patchy’ response). This effect is most marked 48-76 h after administration of a single dose of lead acetate and is easily detected by immunoblotting. Dexamethasone down-regulates the lead response in hepatocytes.

Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model

2016 ◽  
Vol 24 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Amit K. Jaiswal ◽  
Hemlata Chhabra ◽  
Sandipan Narwane ◽  
Nirmala Rege ◽  
Jayesh R. Bellare
Keyword(s):  
Rat Liver ◽  
Histopathological Examination ◽  
Test Group ◽  
Control Group ◽  
Histopathological Study ◽  
Fibrinogen Concentration ◽  
Quick Recovery ◽  
Electrospinning Method ◽  
Hemostatic Efficacy ◽  
And Control

This present study examined the hemostatic efficacy of nanofibrous matrix in a rat liver model. The nanofibrous matrix comprising gelatin and polycaprolactone was prepared by electrospinning method. Twelve animals underwent surgery and were followed-up for a month. Time taken to cease bleeding, activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured. Histopathological examination of liver was also done of treated and control animals. All test animals showed very rapid hemostasis after application of electrospun sheet. Histopathological study showed quick recovery of liver wound in the test group as compared to the control group. The nanofibrous matrix has proven to be not only safe and effective as hemostat but has also shown its potential for liver regeneration.

Effect of chronic treatment of haloperidol on the rat liver: a stereological and histopathological study

2008 ◽  
Vol 379 (3) ◽  
pp. 253-261 ◽  
Author(s):  
Zekai Halici ◽  
Hakan Dursun ◽  
Osman Nuri Keles ◽  
Ersan Odaci ◽  
Halis Suleyman ◽  
...  
Keyword(s):  
Rat Liver ◽  
Chronic Treatment ◽  
Histopathological Study

scholarly journals The development of glutathione S-transferase subunits in rat liver. Sensitive detection of the major subunit forms of rat glutathione S-transferase by using an e.l.i.s.a. method

1989 ◽  
Vol 262 (2) ◽  
pp. 463-467 ◽  
Author(s):  
F M G McCusker ◽  
S J Boyce ◽  
T J Mantle
Keyword(s):  
Cell Cycle ◽  
Rat Liver ◽  
Lead Acetate ◽  
Sensitive Detection ◽  
Glutathione S Transferase ◽  
Regulation Of Expression ◽  
Foetal Liver

The development of the subunits of glutathione S-transferase in rat liver shows that there is a co-ordinated development of the Ya, Yb1, Yb2 and Yc subunits but that the Yf and Yk subunits show unique patterns of development. The Yk subunit is the only form that is expressed at relatively high levels during the foetal period as well as during the adult period. In contrast with all other forms, the Yf subunit in the rat declines rapidly during the last few days before parturition and is virtually undetectable in hepatocytes of adult animals. The expression of the Yf subunit in foetal liver presents a ‘patchy’ appearance that is similar to that induced by the administration of lead acetate and may reflect cell-cycle-associated regulation of expression.

scholarly journals Histopathological Study of Chick Intestine: Effect of Probiotic and Lead Acetate

2018 ◽  
Vol 27 (1) ◽  
pp. 8-14
Author(s):  
Sinan Th. Abdullah ◽  
Enaas Sh. Mustafa ◽  
Nashaat Gh. Mustafa
Keyword(s):  
Lead Acetate ◽  
Histopathological Study

scholarly journals HEPATOPROTECTIVE ROLE OF CISSUS QUADRANGULARIS ON LEAD ACETATE-INDUCED LIVER INJURY IN FEMALE WISTAR RATS

2017 ◽  
Vol 10 (11) ◽  
pp. 182 ◽  
Author(s):  
Neethu Jayan ◽  
Susmita Das ◽  
Santhosh Kumar R ◽  
Sabina Evan Prince ◽  
Asha Devi
Keyword(s):  
Liver Injury ◽  
Lead Acetate ◽  
Lead Toxicity ◽  
Treated Group ◽  
The Body ◽  
Female Rats ◽  
Histopathological Study ◽  
Cissus Quadrangularis ◽  
Stem Extract

  Objectives: Several heavy metals like lead acetate can accumulate in the body due to exposure to the metal for a prolonged period. One of the possible mechanisms involved with lead toxicity is oxidative stress is for which liver is the target organ. The primary aim of this study was to examine the hepatoprotective role of methanolic stem extract from the herb Cissus quadrangularis on induced lead acetate liver injury in female Wistar rats.Methods: The course of the study was for 14 days. The animals were separated into 5 groups: two being control and negative and the other 3 groups based on the dosage of the methanolic extract of the plant was given. The dosage of the plant extract given was once daily for all days of course study. During the last 7 days, lead acetate was injected in the animals (25 mg/kg of body weight). The sacrifice was done 14 days later and the blood and liver samples were taken, which is then used for different antioxidant enzymatic assays.Results: Significant reduced (p < 0.05) antioxidant levels and increased lipid peroxidation levels were observed in lead acetate treated group which was ameliorated by the action of extract from Cissus quadrangularis fusiformis. Histopathological study also supported the finding.Conclusion: The results of the different antioxidant enzymatic assays supported the hepatoprotective role of methanolic stem extract of the plant Cissus quadrangularis over induced lead acetate injury in wistar female rats.

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