scholarly journals Adverse Effects of Whole Blood Donation among Voluntary Blood Donors in Jos, Nigeria

2015 ◽  
Vol 4 (1) ◽  
pp. 6 ◽  
Author(s):  
Damulak Obadiah Dapus
Keyword(s):  
Adverse Effects ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation

scholarly journals Donor Hemovigilance Programme in managing Blood Transfusion Needs: Complications of Whole Blood Donation

2013 ◽  
Vol 3 (6) ◽  
pp. 459-463 ◽  
Author(s):  
S Mangwana
Keyword(s):  
Blood Transfusion ◽  
Adverse Effects ◽  
Adverse Events ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Care Hospital ◽  
Blood Donations ◽  
Vasovagal Reactions

Background: Hemovigilance like quality systems and audits have become an integral part of Blood Transfusion Services in the developed countries and has contributed greatly to its development. Hemovigilance begins with donors and must enable the collection of information on reactions occurring during the donation of blood, selections of donors and to prevent such incidents. The aim of study was to help identify the trends of adverse events , occurring in blood donors at a tertiary-care hospital, to recommend best practices to improve donor care and safety Materials and Methods: This record-based study was conducted on all adverse events related to allogenic whole blood donations performed over 24 months. All whole blood donations were analyzed. All adverse events occurring during or at the end of the donation were noted using a standardized format and analyzed determining significance at p<0.05. Results: Overall rate was 0.3% with vasovagal reactions constituting 82%, and 18% mild syncopal reactions (p<0.001). Immediate vasovagal reaction with injury was very rare (0.007%). Vasovagal reactions showed a significant association with young age, female gender, first time donation status. Mean age of persons recording adverse effects was 30.23 ± 7.49 years as compared to those without adverse effects, 31.14 ± 8.56 years. Conclusion: Donor safety is an essential perquisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of AE, applying appropriate motivational strategies, predonation counseling, care during and after donation, developing guidelines and hemovigilance programme in countries with limited resources. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8993   Journal of Pathology of Nepal (2013) Vol. 3, 459-463

Adverse effects in blood donors after whole-blood donation: you find what you look for!

Transfusion ◽  
2004 ◽  
Vol 44 (1) ◽  
pp. 135-135 ◽  
Author(s):  
Peter Sojka ◽  
Birgitta Nilsson Sojka
Keyword(s):  
Adverse Effects ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation

Adverse effects in blood donors after whole-blood donation: a study of 1000 blood donors interviewed 3 weeks after whole-blood donation

Transfusion ◽  
2003 ◽  
Vol 43 (5) ◽  
pp. 598-603 ◽  
Author(s):  
Bruce H. Newman ◽  
Shawn Pichette ◽  
Dena Pichette ◽  
Ema Dzaka
Keyword(s):  
Adverse Effects ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation

The Informed Consent Process in Whole Blood Donation

2008 ◽  
Vol 132 (6) ◽  
pp. 947-951 ◽  
Author(s):  
Lindsay A. Alaishuski ◽  
Rodney D. Grim ◽  
Ronald E. Domen
Keyword(s):  
West Nile Virus ◽  
Informed Consent ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Informed Consent Process ◽  
Positive Test ◽  
Consent Process ◽  
West Nile ◽  
Eligibility Requirements

Abstract Context.—Informed consent in transfusion medicine has been an area lacking of significant research and it is unknown if donors fully comprehend the risks associated with whole blood donation. Objective.—To assess the adequacy of the informed consent process in whole blood donation. Design.—A brief questionnaire was constructed and distributed to whole blood donors visiting various fixed and mobile donor sites of the Central Pennsylvania Blood Bank. Questions consisted of demographic information; donor opinions of information content, length, and comprehension; and a short quiz pertaining to donor risks and eligibility. Results.—Analysis of 849 surveys demonstrated that donors comprehended a mean of 73.5% of the various donor eligibility and risks that were surveyed. Female and younger donors scored statistically higher on comprehension questions compared with male and older counterparts. Donors were most aware of (1) donor eligibility requirements related to acquired immunodeficiency syndrome comprehension, (2) the risk of dizziness postdonation, and (3) having lived in a certain country (93.7%–95.6% comprehension, respectively). Donors were least aware of (1) the risk of a possible referral to a physician for outstanding medical conditions or positive test results, (2) the risk of a positive test result, and (3) West Nile virus testing information (22.4%–49.3% comprehension, respectively). Conclusions.—Whole blood donors believed that they were giving informed consent, but a significant percentage of donors were unaware of several of the risks associated with blood donation, including participation in West Nile virus research testing. Our data suggest that donors do not fully comprehend the risks of whole blood donation and that repetition of information to the donor, and in multiple formats, strengthens the level of comprehension and thus the informed consent process.

scholarly journals Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

2020 ◽  
Author(s):  
Steven Bell ◽  
Michael Sweeting ◽  
Anna Ramond ◽  
Ryan Chung ◽  
Stephen Kaptoge ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Haemoglobin Concentration ◽  
Reference Standard ◽  
Non Invasive ◽  
Haematology Analyser ◽  
Haemoglobin Measurement ◽  
Accuracy Study ◽  
Sensitivity Specificity

SUMMARYObjectiveTo compare four haemoglobin measurement methods in whole blood donors.BackgroundTo safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant’s (NHSBT) usual method has been capillary gravimetry (copper sulphate), followed by venous HemoCue® (spectrophotometry) for donors failing gravimetry. However, gravimetry/venous HemoCue® results in 10% of donors being inappropriately bled (i.e., with haemoglobin values below the regulatory threshold).MethodsThe following were compared in 21,840 blood donors (aged ≥18 years) recruited from 10 mobile centres of NHSBT in England, with each method compared with the Sysmex XN-2000 haematology analyser, the reference standard: 1) gravimetry/venous HemoCue®; 2) “post donation” approach, i.e., estimating current haemoglobin concentration from that measured by a haematology analyser at a donor’s most recent prior donation; 3) capillary HemoCue®; and 4) non-invasive spectrometry (MBR Haemospect® or Orsense NMB200®). We assessed each method for sensitivity; specificity; proportion of donors who would have been inappropriately bled, or rejected from donation (“deferred”) incorrectly; and test preference.ResultsCompared with the reference standard, the methods ranged in test sensitivity from 17.0% (MBR Haemospect®) to 79.0% (HemoCue®) in men, and from 19.0% (MBR Haemospect®) to 82.8% (HemoCue®) in women. For specificity, the methods ranged from 87.2% (MBR Haemospect®) to 99.9% (gravimetry/venous HemoCue®) in men, and from 74.1% (Orsense NMB200®) to 99.8% (gravimetry/venous HemoCue®) in women. The proportion of donors who would have been inappropriately bled ranged from 2.2% in men for HemoCue® to 18.9% in women for MBR Haemospect®. The proportion of donors who would have been deferred incorrectly with haemoglobin concentration above the minimum threshold ranged from 0.1% in men for gravimetry/venous HemoCue® to 20.3% in women for OrSense®. Most donors preferred non-invasive spectrometry.ConclusionIn the largest study reporting head-to-head comparisons of four methods to measure haemoglobin prior to blood donation, our results support replacement of venous HemoCue® with the capillary HemoCue® when donors fail gravimetry. These results have had direct translational implications for NHS Blood and Transplant in England.

scholarly journals Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors

2019 ◽  
Vol 6 (10) ◽  
pp. e510-e520 ◽  
Author(s):  
Stephen Kaptoge ◽  
Emanuele Di Angelantonio ◽  
Carmel Moore ◽  
Matthew Walker ◽  
Jane Armitage ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Randomised Trial ◽  
Extension Study ◽  
Interval Extension

Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation

Transfusion ◽  
2011 ◽  
Vol 51 (12) ◽  
pp. 2709-2713 ◽  
Author(s):  
Sant-Rayn Pasricha ◽  
Zoe K. McQuilten ◽  
Anthony J. Keller ◽  
Erica M. Wood
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation

scholarly journals Blood Donation Fear, Perceived Rewards, Self-Efficacy, and Intention to Return Among Whole Blood Donors in China: A Social Cognitive Perspective

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhong Li ◽  
Shuge Lei ◽  
Xiaoming Li ◽  
Yilun Zhao ◽  
Yudong Dai ◽  
...  
Keyword(s):  
Whole Blood ◽  
Self Efficacy ◽  
Blood Donors ◽  
Social Cognitive ◽  
Blood Donation ◽  
Blood Collection ◽  
Extrinsic Rewards ◽  
Cognitive Perspective ◽  
Intrinsic Rewards ◽  
Intention To Return

With the increasing demand from aging population and seasonal blood shortage, recruiting and retaining blood donors has become an urgent issue for the blood collection centers in China. This study aims to understand intention to donate again from a social cognitive perspective among whole blood donors in China through investigating the association between the blood donation fear, perceived rewards, self-efficacy, and intention to return. A cross-sectional survey was conducted in six cities, which are geographically and socioeconomically distinct areas in Jiangsu, China. Respondents completed a self-administrated questionnaire interviewed by two well-trained medical students. A total of 191 blood donors were included in the current study. Descriptive analysis, correlation analysis, and a generalized linear regression model were used to explore the association between demographic characteristics, psychological factors, and intention to donate again. After controlling other covariates, donors with higher fear scores reported lower intention to return (p = 0.008). Association between self-efficacy and intention to return was statistically significant (p &lt; 0.001), whereas the association between intrinsic rewards (p = 0.387), extrinsic rewards (p = 0.939), and intention to return were statistically insignificant. This study found that either intrinsic rewards or extrinsic rewards are not significantly associated with intention to donate again among whole blood donors in China, and fear is negatively associated with intention to donate again. Therefore, purposive strategies could be enacted beyond appeals to rewards and focus on the management of donors’ fear.

The Donation Interval of 56 Days Requires Extension to 180 Days for Whole Blood Donors to Recover from Disturbances in Iron Homeostasis

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 774-774
Author(s):  
Nienke N.Schotten ◽  
Pieternel C Pasker-de Jong ◽  
Diego Moretti ◽  
Michael Bruce Zimmermann ◽  
Marian G Kraaij ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Whole Blood ◽  
Iron Homeostasis ◽  
Blood Donors ◽  
Iron Absorption ◽  
Blood Donation ◽  
Iron Parameters ◽  
Baseline Levels ◽  
Over Time ◽  
New Donors

Abstract Background: To protect whole blood donors from developing iron deficiency and anemia, many blood banks require a minimum interval of 56 days between two donations. We aimed to assess whether the donation interval of 56 days is adequate in both new and regular donors to recover from changes in iron homeostasis. Methods: Fifty male whole blood donors (25 new and 25 regular donors), were followed for 180 days after donating 500 mL of blood. Recovery of Hb and iron parameters (Hb, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), MCH concentration (MCHC), red cell distribution width (RDW), reticulocytes, reticulocyte Hb content (CHr), iron, total iron-binding capacity (TIBC), transferrin saturation (TSAT), ferritin, soluble transferrin receptor (sTfR), sTfR-F index (sTfR/log ferritin), erythropoietin (EPO) and hepcidin) was investigated and tested for differences between new and regular donors in blood drawn at baseline (before donation) and at nine time points after blood donation. Differences in iron absorption and erythrocyte iron incorporation between new and regular donors were investigated with stable iron isotopes, administered at day 8 and measured at day 29. Results: At baseline, levels of Hb and iron parameters differed between new and regular donors. In regular donors, Hb, ferritin and hepcidin were lower and EPO was higher compared to new donors. However, patterns of change in parameters over time after whole blood donation were similar for new and regular donors with an increase in EPO and decrease in Hb and hepcidin after day 2 followed by a decrease in ferritin and increase in reticulocytes, sTfR and TIBC after day 4. At day 57, only for TIBC all (100%) regular donors were back at pre-donation level (Figure 1). Percentages for other parameters ranged from 16.0% (regular donors) and 20.8% (new donors) for ferritin to above 80.0% for MCV, reticulocytes, CHr, hepcidin and ZPP (regular donors) and Hb, MCH, MCHC, reticulocytes, CHr, iron, TIBC, hepcidin and ZPP (new donors). At day 85 and 180, >90% of donors were back at their pre-donation levels for all parameters except for i) RDW, EPO, in both donor groups and ii) ferritin at day 85 in new (26.1%), and regular donors (48.0%) and at day 180 in new donors (78.3%). Importantly, for ferritin, when compared to regular donors, the increase in the percentage of new donors that reached pre-donation levels was slower over time and lower at 180 days. Iron absorption (17.0 and 21.9%, respectively) and incorporation into erythrocytes (81.6 and 83.7%, respectively) were not statistically significantly different between new and regular donors, but appeared to be higher in regular donors. Conclusion: For the majority of blood donors the current interval of 56 days is too short to fully recover from a change in Hb and iron parameters after blood donation. Regular donation results in lower ferritin levels at baseline compared to new donors. Our data suggest that ferritin is a promising candidate parameter to personalize donation intervals. Moreover, they imply that prolongation of the donation interval from 56 to 180 days would i) prevent a further decrease of ferritin levels of regular donors, and ii) reduce the risk for iron deficiency associated symptoms upon subsequent donations. Figure 1. Percentage of donors back at baseline levels (before blood donation) at day 57, 85 and 180 after blood donation. Solid lines: regular donors; dashed lines, new donors. Figure 1. Percentage of donors back at baseline levels (before blood donation) at day 57, 85 and 180 after blood donation. Solid lines: regular donors; dashed lines, new donors. Disclosures No relevant conflicts of interest to declare.

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