scholarly journals Effect of PDCA Cycle Management Mode on Drug Loss in Inpatient Pharmacy

2021 ◽  
Vol 7 (1) ◽  
pp. 23
Author(s):  
Xuliang Wu ◽  
Jufeng Li ◽  
Yanru Luo ◽  
Zhidong Zhang
Keyword(s):  
2021 ◽  
Author(s):  
Chunxia Liu ◽  
Yun Liu ◽  
Yiqing Tian ◽  
Kun Zhang ◽  
Guizhen Hao ◽  
...  

Abstract Background To explore the application effect of plan, do, check and action circulation management mode in improving the compliance of sepsis bundle treatment. Methods 132 patients with sepsis admitted from January 1 to December 31, 2018 were selected as the control group, and the bundle treatment measures of sepsis were routinely implemented, that is, the nurses received the confirmation notice of sepsis, measured the body temperature, blood pressure, central venous pressure (CVP), central venous oxygen saturation (ScvO2), indwelling catheter, etc., and the doctor ordered the infusion of antibiotics, rehydration, application of pressor drugs, blood culture and blood gas analysis, blood routine test, procalcitonin and other sample medical orders were immediately implemented by nurses, and the improvement of blood pressure, urine volume and skin endings was closely observed, Doctors and nurses reminded each other to complete the above treatment measures within 6 hours; 138 patients with sepsis admitted from January 1 to December 31, 2019 were selected as the observation group. The Department established a sepsis treatment group. All medical staff, under the leadership of the medical and nursing team leaders, took the same measures as the control group, supplemented by PDCA cycle management. Objective to compare the changes of compliance of medical staff to sepsis bundle treatment before and after the implementation of PDCA cycle management. Results Compared with the control group, the observation group achieved the completion rate of sepsis bundle treatment in 1 hour was 76.8% (65.9%), the completion rate in 3 hours was 82.6% (69.7%), and the completion rate in 6 hours was 87.7% (77.3%). The difference was statistically significant (P < 0.05). Conclusions The implementation of PDCA cycle management mode can effectively improve the compliance of medical staff to the bundle treatment of sepsis, improve the treatment efficiency of sepsis, and improve the quality of medical care.


2020 ◽  
Vol 6 (9) ◽  
pp. 72070-72084
Author(s):  
Priscilla Mendonça de Lima Melgueiro ◽  
Sil Franciley dos Santos Quaresma ◽  
Kleber Bittencourt Oliveira ◽  
Edílson Marques Magalhães
Keyword(s):  

Dysphagia ◽  
2021 ◽  
Author(s):  
Kenjiro Kunieda ◽  
Naomi Kurata ◽  
Yuki Yoshimatsu ◽  
Tomohisa Ohno ◽  
Takashi Shigematsu ◽  
...  

AbstractThe simple suspension method (SSM), developed by Kurata in 1997, is a way to suspend tablets and capsules in warm water for decay and suspension prior to their administration. This method is safe and has various advantages such as the avoidance of tube clogging and the loss of the drug. This study aimed to investigate whether a higher percentage of commonly used drugs could pass through nutrition tubes effectively using SSM, relative to that using the conventional crushing method. A tablet or capsule was inserted into a 20 mL syringe with warm water (at 55 °C). After 10 min, it was shaken in the syringe. The suspension liquid was injected into tubes of the following sizes: 8 Fr, 10 Fr, 12 Fr, 14 Fr, 16 Fr, and 18 Fr. A total of 3686 tablets and 432 capsules that are frequently used in Japan were tested. Using SSM, 3377 (91.6%) tablets and 359 (83.1%) capsules disintegrated within 10 min and passed through the tube without clogging it in the tube passage test. With the conventional crushing method, 2117 tablets (57.4%) and 272 capsules (63.0%) could be crushed. SSM reduced the risk of tube clogging and drug loss with more drugs than that with the conventional crushing method. The number of drugs indicated for administration by SSM is greater than that indicated by the conventional crushing method. Further studies are needed to consider its utility compared to conventional methods for dysphagia patients in clinical settings.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 614
Author(s):  
Hak-Il Lee ◽  
Won-Kyu Rhim ◽  
Eun-Young Kang ◽  
Bogyu Choi ◽  
Jun-Hyeok Kim ◽  
...  

Drug-eluting balloons (DEBs) have been mostly exploited as an interventional remedy for treating atherosclerosis instead of cardiovascular stents. However, the therapeutic efficacy of DEB is limited due to their low drug delivery capability to the disease site. The aim of our study was to load drugs onto a balloon catheter with preventing drug loss during transition time and maximizing drug transfer from the surface of DEBs to the cardiovascular wall. For this, a multilayer-coated balloon catheter, composed of PVP/Drug-loaded liposome/PVP, was suggested. The hydrophilic property of 1st layer, PVP, helps to separate drug layer in hydrophilic blood vessel, and the 2nd layer with Everolimus (EVL)-loaded liposome facilitates drug encapsulation and sustained release to the targeted lesions during inflation time. Additionally, a 3rd layer with PVP can protect the inner layer during transition time for preventing drug loss. The deionized water containing 20% ethanol was utilized to hydrate EVL-loaded liposome for efficient coating processes. The coating materials showed negligible toxicity in the cells and did not induce pro-inflammatory cytokine in human coronary artery smooth muscle cells (HCASMCs), even in case of inflammation induction through LPS. The results of hemocompatibility for coating materials exhibited that protein adsorption and platelet adhesion somewhat decreased with multilayer-coated materials as compared to bare Nylon tubes. The ex vivo experiments to confirm the feasibility of further applications of multilayer-coated strategy as a DEB system demonstrated efficient drug transfer of approximately 65% in the presence of the 1st layer, to the tissue in 60 s after treatment. Taken together, a functional DEB platform with such a multilayer coating approach would be widely utilized for percutaneous coronary intervention (PCI).


Author(s):  
Chao Liu ◽  
Kaida Qin

In the era of high informationization, supply chain management, as a symbol of a management era, brings us not only a new management tool, but also more importantly, updated management concepts and replanning, design, and ways to optimize business processes. The purpose of this article is to study the current information security issues that are common in China’s supply chain, such as the weak awareness of information security among corporate employees; the widespread disregard of information security management; the lack of a unified information security strategic planning and prevention mechanism; adverse selection risks and various defeats. In the specific application, starting from the overall business needs of the supply chain, referring to the framework of the supply chain information security system, through assessment and risk analysis, the security needs of the supply chain and its nodes are defined, and finally the e-commerce supply based on management information security is developed. Chain management mode. The experimental data show that the e-commerce supply chain management model based on management information security can effectively improve e-commerce operation efficiency and improve security performance. Experimental data show that the management mode of e-commerce supply chain management improves the security efficiency of e-commerce by about 20% and the operating efficiency by about 15%. The development of e-commerce is instructive.


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