scholarly journals Evaluation of CD4 Cell Progression Among HIV Infected Children Initiating ART: A Case of Adama Referral Hospital and Medical College, Ethiopia

2020 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Tayu Nigusie Abebe
Keyword(s):  
Referral Hospital ◽  
Medical College ◽  
Cell Progression ◽  
Cd4 Cell

scholarly journals Multilevel model on longitudinal data analysis in determinants of cd4 cell count among antiretroviral therapy attendant of hiv infected adults follow up in gondar teaching referral hospital, Gonder, Ethiopia.

2020 ◽  
Author(s):  
Kindu Kebede
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Multilevel Model ◽  
Immune Cell ◽  
Hemoglobin Level ◽  
Referral Hospital ◽  
Sub Saharan Africa ◽  
Cd4 Cell Count ◽  
Cd4 Cell

Abstract Background: Human immunodeficiency virus attacked an immune cell and the CD4 cell which is responsible for the body’s immune to infectious agents. Acquired immunodeficiency syndrome is one of the major public health problems in Sub-Saharan Africa including Ethiopia. The main objective of this study to identify the determinants of CD4 cell count among antiretroviral therapy attendants of infected adults follow up in Gonder teaching referral hospital, Gonder, Ethiopia implemented by SAS version 94. Methods: A retrospective cohort study was conducted on 216 regular follow up patients whose age greater than 14 years from December 1, 2012, to December 30, 2017. A multilevel model was used to identify the factors of CD4 cell count of patients and it considered variability between and within patients. Results: The mean with a standard deviation of weight, and a hemoglobin level of patients were 55.48(10.21), and 18.25(33.028) respectively. This study concluded that the variation for CD4 cell count existed between patients was 63 % and the remaining 37 % of variation existing within patients. In this study, the random coefficient time-varying covariate model was well fitted which shows weight and hemoglobin level were statistically significant predictors at a 5% level of significance for the log of CD4 cell count of patients. Conclusion: This study shows the hemoglobin level and weight of patients were statistically significant for the log of CD4 cell count of patients follow up in Gonder teaching referral hospital, Gonder, Ethiopia. Moreover, the result of the study shows that the log of CD4 count of patients increased when hemoglobin level and weight of patients increased. Hence, intervention should be given the ways to increase weight and hemoglobin levels of patients during follow up antiretroviral therapy.

scholarly journals A study of sociodemographic and clinical profiles of HIV-1 infected North Indian patients

2021 ◽  
Author(s):  
Sushanta Kumar Barik ◽  
Srikanth Prasad Tripathy ◽  
Ramesh Karunaianantham ◽  
Sathyamurthi Pattabiraman ◽  
Virendra Singh Yadav ◽  
...  
Keyword(s):  
Viral Load ◽  
Married Couples ◽  
North India ◽  
Drug Resistant ◽  
Cd4 Cell Count ◽  
Demographic Profiles ◽  
Medical College ◽  
Indian Patients ◽  
Cd4 Cell ◽  
Hiv 1

AbstractThe aim of this study was to analyze the sociodemographic, clinical, immunologic, and risk factors of drug-resistant (>1000 copies/ml) and virologically suppressed (<1000 to <40 copies /ml to target not detected levels) patients at the ART center, Sarojini Naidu Medical College, Agra, North India. A total of 193 patients on first-line antiretroviral therapy were included those were recruited from December 2009 to November 2016. The patients included in this study had a CD4 cell count of ≤ 350 cubic/mm. The details of Demographic, clinical, and social factors were collected in a patient information leaflet and statistically analyzed. After viral load, two groups of patients were observed. The drug-resistant group (N=58) had a viral load ≥1000 copies/ml and virologically suppressed group (N=135) had a viral load <1000 copies/ml to target not detected level. A comparison statement result was presented in both groups of drug-resistant and virologically suppressed patients. Males were observed in the highest frequency (42, 72.41%). The heterosexual mode of transmission was predominant (40, 68.96%, and 98,72.59%). The highest number of married couples and illiterates in the two groups. Tuberculosis was observed in the highest numbers in the two groups. The analysis of socioeconomic factors of North Indian patients will be a concern issue in the demographic profiles of HIV-1 patients. The clinical features, analysis would help clinicians in further therapy implementation, monitoring CD4 and Viral load counts of North Indian patients.

scholarly journals The effect of longitudinal body weight and CD4 cell progression for the survival of HIV/AIDS patients

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Gebru Gebremeskel Gebrerufael ◽  
Zeytu Gashaw Asfaw ◽  
Dessie Melese Chekole
Keyword(s):  
Body Weight ◽  
Aids Patients ◽  
Cell Progression ◽  
Cd4 Cell ◽  
Hiv Aids

scholarly journals A Clinical Study on Eclampsia in a Referral Hospital

2012 ◽  
Vol 4 (2) ◽  
pp. 113-115 ◽  
Author(s):  
Parneet Kaur
Keyword(s):  
Clinical Study ◽  
Antenatal Care ◽  
Magnesium Sulfate ◽  
Rural Areas ◽  
Referral Hospital ◽  
Special Focus ◽  
Specialist Care ◽  
Maternal Deaths ◽  
Medical College ◽  
District Hospitals

ABSTRACT Objective To analyze the cases of eclampsia in a referral hospital, like GGS Medical College, Faridkot, with special focus on booked/unbooked/referred, age, parity and antenatal care. Also fetomaternal outcome was seen in all the cases. Materials and methods All the cases of eclampsia referred from nearby rural areas, civil hospitals and CHCs sent here for specialist care were studied in this 2 years study from July 2003 to June 2005. Results and conclusions A total of 50 cases of eclampsia were admitted. The incidence came out to be 7.4%. Ninetyeight percent of cases were unbooked. Majority of the cases belonged to 21 to 30 years age group. Fifty-six percent of the cases were primigravida. Eighty-eight percent had no antenatal check-up at all. Thirty percent of babies were still born and 12% had early neonatal death. There were three maternal deaths. Antepartum eclampsia was most common seen in 68% of cases. We concluded that there is lack of antenatal care in rural areas and urban slums and this needs to be addressed to prevent this serious complication of pregnancy. Moreover, personnel at district hospitals and CHCs should be capable of administering magnesium sulfate, the anticonvulsant as none of the patient threw a fit after loading dose of magnesium sulfate. How to cite this article Kaur P. A Clinical Study on Eclampsia in a Referral Hospital. J South Asian Feder Obst Gynae 2012;4(2):113-115.

scholarly journals Three year survival among patients with aids-related Kaposi sarcoma treated with chemotherapy and combination antiretroviral therapy at Moi teaching and referral hospital, Kenya

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Naftali Busakhala ◽  
Gabriel Kigen ◽  
Paul Waako ◽  
R. Matthew Strother ◽  
Fredrick Chite ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Median Duration ◽  
Kaposi Sarcoma ◽  
Early Response ◽  
Referral Hospital ◽  
Combination Antiretroviral Therapy ◽  
Low Resource Settings ◽  
Low Resource ◽  
Response To Chemotherapy ◽  
Cd4 Cell

Abstract Background AIDS-related Kaposi sarcoma (AIDS-KS), a common malignancy in Kenya is associated with high morbidity and mortality. AIDS-KS is treated using bleomycin and vincristine (BV) plus or minus doxorubicin in most low resource settings, with response rates ranging from 24.8 to 87%. Survival in low resource settings has not been well documented. We report the three-year survival in a cohort of seventy patients referred to Moi Teaching and Referral Hospital (MTRH). Methods Study participants are part of a randomized phase IIA trial on the use of gemcitabine compared to bleomycin plus vincristine for the treatment of Kaposi sarcoma after combination antiretroviral therapy (cART) in Western Kenya. All patients were followed for three years in MTRH. Survival was determined by three monthly physical examination and analysed using Kaplan-Meier method, while possible determinants of survival such as baseline characteristics, type of chemotherapy, initial CD4 counts, age at enrolment, gender and early response to chemotherapy were analysed using univariate and multivariate Cox regression. Results Participants were aged between 19 and 70 years with 56% being male. The median CD4 count was 224 cells/μl, median duration of HIV diagnosis was 12.0 months and median duration of KS lesions after histology diagnosis before initiating chemotherapy was 4.8 weeks. At three years, 60 (85.7%) patients were alive. Six of those who died were under treatment with BV while four with gemcitabine. There was no difference in the probability of survival between the patients on either treatment arm (HR = 0.573 [95% C. I 0.143, 2.292; p = 0.4311]). Additionally, the hazard ratio (HR) for response after six weeks, age at enrolment and gender indicated that they were not significant determinants of survival. Patients with normal CD4 cell counts (> = 500/μl), had a HR of 0.401(0.05,3.23; p = 0.391), suggesting better survival. Conclusions Patients with AIDS-KS treated with combined antiretroviral drugs had excellent three-year survival regardless of whether they were treated with BV or gemcitabine as first line therapy. An initial CD4 cell count of > = 500/μl appeared to improve survival while gender, age and early response to chemotherapy were not predictors of survival after three years. Trial registration Number PACTR201510001.

scholarly journals A prospective study of postoperative outcome following splenectomy in immunocompromised thalassemia patient with special reference to CD4 count

2019 ◽  
Vol 7 (1) ◽  
pp. 122
Author(s):  
Monali Madhukar Patole ◽  
Mandar Madhukar Patole ◽  
Manoranjan Ghosh
Keyword(s):  
Postoperative Outcome ◽  
Cd4 Count ◽  
Paediatric Surgery ◽  
Blood Disorders ◽  
Thalassemia Patient ◽  
Cd4 Cell Count ◽  
Medical College ◽  
A Prospective Study ◽  
Surgery Department ◽  
Cd4 Cell

Background: Thalassemia are inherited blood disorders that can result in the abnormal formation of hemoglobin. Splenectomy is indicated in the transfusion-dependent patient when hypersplenism increases blood transfusion requirement and prevents adequate control of body iron with chelation therapy. Ninety percent of recipients transfused with HIV antibody-positive blood are found to be HIV infected at follow-up. Prevailing literature on effects of splenectomy on CD4 count suggests that splenectomy causes an abrupt and prolonged increase in CD4 cell count. The aims and objectives this is an Institution based prospective observational study with the aim to observe postoperative outcome in immunocompromised thalassemic patients following splenectomy, postoperative outcome following splenectomy in a patient with low CD4 count and to analyze the effect of CD 4 count if any on different patients in terms of wound infection, chest infection , urinary tract infection or infection at any other site.Methods: The study included twenty immunocompromised thalassemia Patients attending in Pediatric Surgery OPD and admitted to Paediatric Surgery department of Medical college and hospital Kolkata with splenomegaly and HIV infection for splenectomy, between January 2015 to December 2016.Simple comparative analysis of gathered data was used to evaluate postoperative outcome m and the preop and the post op CD4 count levels of splenectomised thalassaemic patients.Results: Most patients in this study were in the (3-8) years age group and all are HIV positive patients with thalassemia. In this study author found there was increased CD4 count after splenectomy and postoperative period one patient developed postoperative oral candidiasis.Conclusions: HIV-infected thalassaemic patients on ART can now safely undergo major splenectomy surgery with encouraging results and in patients with a low CD4 count, there is no relation of CD4 count and splenectomy outcome.

scholarly journals Causes for diarrhoea and infection with intestinal parasites among HIV positive patients at a referral hospital in Central Ethiopia

2019 ◽  
Author(s):  
Million Getachew Mesfun ◽  
Andre Fuchs ◽  
Martha Charlotte Holtfreter ◽  
Torsten Feldt ◽  
Dieter Häussinger
Keyword(s):  
Cell Count ◽  
Intestinal Parasites ◽  
Parasitic Infection ◽  
Referral Hospital ◽  
Parasitic Infections ◽  
Intestinal Parasitic Infection ◽  
Cd4 Cell Count ◽  
Wet Mount ◽  
Intestinal Parasitosis ◽  
Cd4 Cell

Abstract Background: Intestinal parasitic infections are a major public health challenge in many tropical countries. Opportunistic intestinal coccidia such as Cryptosporidia, Cytoisospora or Cyclospora species are common pathogens which are regularly missed using widely practiced wet mount stool microscopy techniques. Therefore, treatment choices are limited and mostly rely on empirical use of cotrimoxazole. The aim of this study was to determine the prevalence of intestinal parasitosis among HIV-infected individuals with and without diarrhoea at the Asella Teaching and Referral Hospital in Ethiopia. Methods: This institution-based cross sectional study was conducted among 163 ambulatory HIV-infected patients with and without diarrhoea. Stool samples were processed for both wet mount and Kinyoun stain. EDTA blood was collected for analysis of CD4 cell count using BD FACSCount™ Flow Cytometer. Sociodemographic and behavioural data was collected using a standardized questionnaire. Chi-squared test was used for statistical analysis. Results: The majority of study participants (62.0%, n=101) were female and the mean age was 38.2 (SD +10.7) years. 52.1% (n=85) of the participants suffered from diarrhoea. The overall prevalence of intestinal parasitic infection in the study population was 18.4% (n=30). Protozoa (Cryptosporidium spp., E. histolytica, G. lamblia and Pentatrichomonas hominis) and helminths (Taenia spp., A. lumbricoides, S. stercoralis, T. trichuria and H. nana) were detected in 12.9% (n=21) and 5.5% (n=9) of patients, respectively. The likelihood for having a parasitic infection was more than eight times higher in participants having diarrhoea. No oocysts of coccidian parasites were detected in the routinely performed wet mount stool microscopy, as expected. Conclusions: There was a high prevalence of opportunistic intestinal parasitic infection in the studied population. Considering the clinical relevance of opportunistic infections particularly in individuals with low CD4 cell count and diarrhoea, the implementation of both stool concentration and modified acid fast staining techniques should be considered to enhance the quality of health care service for HIV-infected patients in resource-limited settings as Ethiopia.

Sign in / Sign up

Export Citation Format

Share Document