Environment Sensitive Polymers in Self-Regulated Drug Delivery Systems

2020 ◽  
Vol 12 (1) ◽  
pp. 128-130
Author(s):  
Anamica ◽  
P. P. Pande
Keyword(s):  
Drug Delivery ◽  
Metal Concentration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Self ◽  
Ph Responsive ◽  
Feedback Information ◽  
Enzyme Substrates ◽  
Antibody Interactions

Environment sensitive polymers have great potential in various applications. These polymers are self-regulated. In self-regulated schemes, the controlled or limited variable is noticed, along with the output of the system that is adjusted according to the variables. Through feedback information and without external involvement, the released rate is controlled. To control the rate mechanisms, the self-regulated schemes use many methods as, enzyme substrates reactions, pH-responsive drugs solubility, antibody interactions, competitive bindings, and metal concentration dependent hydrolysis. The roles of environment sensitive polymers in self-regulated drug delivery systems are discussed in this paper.

pH responsive chitosan-coated microemulsions as drug delivery systems

2020 ◽  
pp. 1-12
Author(s):  
Daniela Díaz-Zepeda ◽  
René D. Peralta-Rodríguez ◽  
Bertha Puente-Urbina ◽  
Gladis Cortez-Mazatan ◽  
H. Iván Meléndez-Ortiz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive

scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

scholarly journals Self-aggregated nanoparticles of N -dodecyl,N ′-glycidyl(chitosan) as pH-responsive drug delivery systems for quercetin

2017 ◽  
Vol 135 (2) ◽  
pp. 45678 ◽  
Author(s):  
Rafael de Oliveira Pedro ◽  
Susana Pereira ◽  
Francisco M. Goycoolea ◽  
Carla C. Schmitt ◽  
Miguel G. Neumann
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Degradable polycaprolactone nanoparticles stabilized via supramolecular host–guest interactions with pH-responsive polymer-pillar[5]arene conjugates

2020 ◽  
Vol 11 (12) ◽  
pp. 1985-1997
Author(s):  
Peng Wei ◽  
Fabian H. Sobotta ◽  
Carolin Kellner ◽  
Damiano Bandelli ◽  
Stephanie Hoeppener ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Amphiphilic Polymers ◽  
Ph Responsive ◽  
Responsive Polymer ◽  
New Generation

Smart nano-carriers such as micelles, vesicles or nanoparticles constructed from amphiphilic polymers promise a new generation of drug delivery systems featuring localized and controlled release.

The pH-responsive calix[4]resorcinarene-mPEG conjugates bearing acylhydrazone bonds: Synthesis and study of the potential as supramolecular drug delivery systems

2020 ◽  
Vol 589 ◽  
pp. 124453 ◽  
Author(s):  
Alina M. Shumatbaeva ◽  
Julia E. Morozova ◽  
Victor V. Syakaev ◽  
Yana V. Shalaeva ◽  
Anastasia S. Sapunova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive

Dendritic chitosan as a magnetic and biocompatible nanocarrier for the simultaneous delivery of doxorubicin and methotrexate to MCF-7 cell line

2017 ◽  
Vol 41 (8) ◽  
pp. 3177-3189 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Effat Alizadeh ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Cell Line ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Line P ◽  
Simultaneous Delivery ◽  
Mcf 7

A novel smart, biocompatible, and pH-responsive magnetic highly branched chitosan was synthesized efficiently for use in dual-anticancer drug delivery systems.

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