scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

scholarly journals Comparison of Polydopamine-Coated Mesoporous Silica Nanorods and Spheres for the Delivery of Hydrophilic and Hydrophobic Anticancer Drugs

2019 ◽  
Vol 20 (14) ◽  
pp. 3408 ◽  
Author(s):  
Anna-Karin Pada ◽  
Diti Desai ◽  
Kaiyao Sun ◽  
Narayana Prakirth Govardhanam ◽  
Kid Törnquist ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Distribution ◽  
Delivery Systems ◽  
Hydrophilic Drugs

Mesoporous silica nanoparticles (MSNs) have been widely studied as drug delivery systems in nanomedicine. Surface coating of MSNs have enabled them to perform efficiently in terms of bioavailability, biocompatibility, therapeutic efficacy and targeting capability. Recent studies have suggested the use of polydopamine (PDA) as a facilitative coating for MSNs that provides sustained and pH-responsive drug release, owing to the adhesive “molecular-glue” function of PDA. This further endows these hybrid MSN@PDA particles with the ability to carry large amounts of hydrophilic drugs. In this study, we expand the feasibility of this platform in terms of exploring its ability to also deliver hydrophobic drugs, as well as investigate the effect of particle shape on intracellular delivery of both a hydrophilic and hydrophobic anticancer drug. MSN@PDA loaded with doxorubicin (hydrophilic) and fingolimod (hydrophobic) was studied via a systematic in vitro approach (cellular internalization, intracellular drug distribution and cytotoxicity). To promote the cellular uptake of the MSN@PDA particles, they were further coated with a polyethylene imine (PEI)-polyethylene glycol (PEG) copolymer. Drug-loaded, copolymer-coated MSN@PDA showed effective cellular uptake, intracellular release and an amplified cytotoxic effect with both doxorubicin and fingolimod. Additionally, rods exhibited delayed intracellular drug release and superior intracellular uptake compared to spheres. Hence, the study provides an example of how the choice and design of drug delivery systems can be tuned by the need for performance, and confirms the PDA coating of MSNs as a useful drug delivery platform beyond hydrophilic drugs.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

scholarly journals MCM-41 mesoporous silica anoparticles and their adsorption for targeting drug delivery systems

2019 ◽  
Vol 2 (4) ◽  
pp. 95-102
Author(s):  
Nguyet Tran Anh Dau ◽  
Hieu Van Le ◽  
Van Thi Thanh Tran
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Structural Characteristics ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Maximum Adsorption Capacity ◽  
Isothermal Adsorption ◽  
Water As Solvent ◽  
Mcm 41

MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of tetraorthosilicate precursor (TEOS) using cetyltrimethylammonium bromide (CTAB) as the orientation substance in alkaline (pH = 9–12), deionized water as solvent. The samples were calcinated at 550°C for 5 hours. The structural characteristics of samples were analyzed by using Small angle X-ray diffraction, transmission electron microscopy (TEM), FT-IR and isothermal adsorption of nitrogen. Optimizing the fabrication parameters, MCM-41 particles have been obtained with a spherical shape, size of 80-140 nm, pore diameter of 2–5 nm and surface area (BET) of 986,683 m2g-1. Rhodamine B adsorption of MCM-41 showed that the maximum adsorption capacity value was 299,696 mg/g, suggesting the potential of this material to design of controlled drug delivery systems.

scholarly journals Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer

2011 ◽  
Vol 19 (8) ◽  
pp. 1538-1546 ◽  
Author(s):  
Veronika Mamaeva ◽  
Jessica M Rosenholm ◽  
Laurel Tabe Bate-Eya ◽  
Lotta Bergman ◽  
Emilia Peuhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Notch Signaling ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Targeted Inhibition

scholarly journals Formulation and characterisation of self-microemulsifying drug delivery systems based on biocompatible nonionic surfactants

2014 ◽  
Vol 68 (5) ◽  
pp. 565-573 ◽  
Author(s):  
Ljiljana Djekic ◽  
Marija Primorac
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Medium Chain Triglycerides ◽  
Medium Chain

Development of self-dispersing drug delivery systems (SMEDDS) is a modern strategy for oral delivery improvement of poorly soluble drugs. Self-microemulsifying drug delivery systems (SMEDDS) are isotropic mixtures of oils and hydrophilic surfactants, which form oil-in-water (o/w) microemulsions by dilution in aqueous media (e.g., gastrointestinal fluids). Formulation of SMEDDS carriers requires consideration of a large number of formulation parameters and their influences on process of self-microemulsifying and releasing of drug. The aim of this work was formulation and characterisation of SMEDDS for oral administration of ibuprofen. In the experimental work, two series of potential SMEDDS were prepared (M1-M10), using surfactant (Labrasol?, Gattefosse), cosurfactant (PEG-40 hydrogenated castor (Cremophor? RH40), and oil (medium chain triglycerides (Crodamol? GTCC) and olive oil (Cropur? Olive)), at surfactant-to-cosurfactant mass ratios (Km) 9:1, 7:3, 5:5, 3:7, and 1:9, and 10 % or 20 % of the oil phase. Ibuprofen was dissolved in formulations in concentration of 10 %. Characterisation of the investigated formulations included evaluation of physical stability, self-microemulsification ability in 0,1M HCl (pH 1.2) and phosphate buffer pH 7.2 (USP) and in vitro drug release. Formation of o/w microemulsions with the average droplet size (Z-ave) up to 100 nm, was observed in dispersions of formulations prepared with 10% w/w of medium chain triglycerides, within the entire investigated range of the Km values (M1-M5). These formulations were selected as SMEDDS. Results of characterisation pointed out the importance of the type and concentration of the oil as well as the Km value for the self-microemulsying ability as well as drug release kinetics from the investigated SMEDDS. Ibuprofen relase was in accordance with the request of USP 30-NF 25 (at least 80 %, after 60 min) from the formulations M1 (Km 9:1) and M5 (Km 1:9). Furthermore, ibuprofen release was completed after 10 minutes from formulation M1, while the release from the carrier M5 (~30 %) as well as from the commercial tablets Brufen? (~55%) and soft capsules Rapidol? (~65 %), examined under the same conditions, was significantly slower. The present study revealed that the formulation M1 represents a potential SMEDDS which efficiently solubilises ibuprofen in acidic media, with potential to minimise the side effects, while on introduction into alkaline intestinal environment, the drug may rapidly release from the carrier and undergo apsorption.

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