Application of Multi-Slice Spiral CT in the Evaluation of Diffuse Lung Diseases

This article analyzes the manifestations, characteristics, and significance of multi-slice spiral CT for diffuse lung disease, and evaluates the diagnostic value of multi-slice CT multi-directional reconstruction for diffuse lung disease. After performing multi-slice spiral CT examination on the patient and collecting relevant data, the characteristic multi-slice CT imaging findings of diffuse lung disease were determined by statistical analysis. Diffuse lung disease is representative in multi-slice spiral CT image imaging manifestations of the disease include multiple disseminated small nodules, multiple voids, ground glass shadows, and lung consolidation. And analyze the correlation of image performance, and then use statistical methods to analyze and evaluate the value of multi-slice spiral CT characteristic images in the diagnosis of diffuse lung disease, and analyze the characteristics of these characteristic multi-slice CT image appearances. The use of high-resolution CT to screen the characteristic CT imaging findings of the same research object, and then to perform a statistical analysis of the diagnostic differences with multi-slice spiral CT, further confirmed the importance of multi-slice CT for diffuse lung disease Diagnostic value. Studies have shown that multi-slice CT imaging technology is of great significance in the evaluation of diffuse lung diseases.

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Spectrum of childhood interstitial and diffuse lung diseases at a tertiary hospital in Egypt

ERJ Open Research ◽

10.1183/23120541.00880-2020 ◽

2021 ◽

pp. 00880-2020

Author(s):

Salma G. Abdelhady ◽

Eman M. Fouda ◽

Malak A. Shaheen ◽

Faten A. Ghazal ◽

Ahmed M. Mostafa ◽

...

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Lung Diseases ◽

Demographic Data ◽

Tertiary Hospital ◽

University Hospital ◽

Systematic Evaluation ◽

Pulmonary Hemosiderosis ◽

Diffuse Lung Diseases ◽

Diffuse Lung

BackgroundChildhood interstitial and diffuse lung diseases (chILD) encompass a broad spectrum of rare pulmonary disorders. In most developing middle eastern countries, chILD is still underdiagnosed. Objective: To describe and investigate patients diagnosed with chILD in a tertiary university hospital in Egypt.MethodsWe analyzed data of consecutive subjects (<18 years) referred for further evaluation at the Children's Hospital, Ain Shams University. Diagnosis of chILD was made in accordance with the chILD-EU criteria. The following information was obtained: demographic data, clinical characteristics, chest CT findings, laboratory studies, spirometry, BAL and histopathology findings.Results22 subjects were enrolled over 24 months. Median age at diagnosis was 7 years (range 3.5–14 years). The most common manifestations were dyspnea (100%), cough (90.9%), clubbing (95.5%) and tachypnea (90.9%). Systematic evaluation led to the following diagnoses: hypersensitivity pneumonitis (n=3), idiopathic interstitial pneumonias (n=4), chILD related to chronic granulomatous disease (n=3), chILD related to small airway disease (n=3), postinfectious chILD (n=2), Langerhans cell histiocytosis (n=2), Idiopathic pulmonary hemosiderosis (n=2), granulomatous lymphocytic interstitial lung disease (n=1), systemic sclerosis (n=1), familial interstitial lung disease (n=1). Among the subjects who completed the diagnostic evaluation (n=19), treatment was changed in 13 (68.4%) subjects.ConclusionSystematic evaluation and multidisciplinary peer review of chILD patients at our tertiary hospital led to changes in management in 68% of the patients. This study also highlights the need for an Egyptian chILD network with genetic testing, as well as the value of collaborating with international groups in improving health care for children with chILD.

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Diffuse Lung Diseases With Cystic Changes

Mayo Clinic Challenging Images for Pulmonary Board Review ◽

10.1093/med/9780199756926.003.0054 ◽

2010 ◽

pp. 453-476

Author(s):

Edward C. Rosenow

Keyword(s):

Pleural Effusion ◽

High Resolution ◽

Lung Disease ◽

Tuberous Sclerosis ◽

Obstructive Lung Disease ◽

Lung Diseases ◽

Cystic Changes ◽

Diffuse Lung Diseases ◽

Diffuse Lung ◽

Restrictive Pattern

• 50% of patients have renal angiomyolipomatosis (? tuberous sclerosis) • 50% of patients have pneumothorax at diagnosis of LAM; eventually, 80% • One-third of patients have chylothorax (may be presenting feature) • High-resolution CT is diagnostic • 〉90% of patients have primarily obstructive lung disease. “Restrictive” pattern may be present as a result of pleural effusion or previous thoracotomy; however, eventually, both obstructive and restrictive patterns are present even without pleural effusion...

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Feasibility, utility, and safety of transbronchial cryobiopsy for interstitial lung diseases in Japan

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2021.731 ◽

2021 ◽

Vol 16 ◽

Author(s):

Takato Ikeda ◽

Akira Nakao ◽

Fumiyasu Igata ◽

Yoshiaki Kinoshita ◽

Hisako Kushima ◽

...

Keyword(s):

Lung Disease ◽

Lung Diseases ◽

Interstitial Lung Diseases ◽

Efficacy And Safety ◽

Diffuse Lung Disease ◽

Biopsy Site ◽

Transbronchial Lung Cryobiopsy ◽

A New Technique ◽

Diffuse Lung ◽

Average Sample

Background: Transbronchial lung cryobiopsy (TBLC) is a new technique that enables larger tissue collection than can be obtained by conventional transbronchial lung biopsy. TBLC is becoming popular worldwide and is performed for diffuse lung disease and lung cancer. However, only a few reports of TBLC have been published in Japan. This study was performed to evaluate the efficacy and safety of TBLC at our hospital and compare these findings with past reports.Methods: From April 2018 to January 2020, 38 patients who underwent TBLC for diffuse lung disease at our hospital were evaluated with respect to age, sex, biopsy site, biopsy size, diagnostic disease, and complications.Results: The patients who underwent TBLC constituted 20 men and 18 women with an average age of 63.7 years. The average sample size was 5.7 mm, and the diagnostic rate was 65.7% (25/38). Grade ≥2 complications included bleeding (15.8%), pneumothorax (2.6%), and atrial fibrillation (2.6%).Conclusions: TBLC was considered to be useful for the diagnosis of diffuse lung disease and could be safely performed.

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Diffuse Lung Disease

10.1093/med/9780199755691.003.0617 ◽

2012 ◽

Author(s):

Timothy R. Aksamit

Keyword(s):

Differential Diagnosis ◽

Respiratory Failure ◽

Lung Disease ◽

Lung Diseases ◽

Clinical Course ◽

Diffuse Lung Disease ◽

Wide Range ◽

Life Threatening ◽

Diffuse Lung ◽

Parenchymal Lung

Diffuse lung disease includes a wide range of parenchymal lung diseases that have infectious, inflammatory, malignant, drug, occupational or environmental, and other causes. Although many identifiable causes are recognized, the cause of most cases of diffuse lung disease in many published series is idiopathic. The clinical course may be acute or prolonged and may progress rapidly to life-threatening respiratory failure with death, or it may be indolent over many years. In most instances, a differential diagnosis can readily be formulated by obtaining the medical history, with emphasis on the nature of the symptoms, duration, and pertinent environmental, occupational, drug, and travel exposures.

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Transbronchial Lung Biopsy through the Fiberoptic Bronchoscope in Diffuse Lung Disease

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348947508400506 ◽

1975 ◽

Vol 84 (5) ◽

pp. 596-601 ◽

Cited By ~ 1

Author(s):

Lee R. Joyner ◽

David J. Scheinhorn

Keyword(s):

Lung Disease ◽

Lung Biopsy ◽

Patient Management ◽

Clinical Course ◽

Diagnostic Value ◽

Fiberoptic Bronchoscope ◽

Diffuse Lung Disease ◽

Forceps Biopsy ◽

Parenchymal Disease ◽

Diffuse Lung

Transbronchial forceps biopsy (TBB) of the lung through the fiberoptic bronchoscope was performed in 74 patients. A histological diagnosis compatible with the clinical course, and roentgenographic appearance was obtained in 47 (64%) patients. There were six cases with inadequate tissue and ten cases where TBB was both nondiagnostic and of no other benefit in the subsequent management of the patient. This procedure was of particular value in evaluation of acutely ill patients with diffuse parenchymal disease. TBB either gave a specific diagnosis or correctly influenced patient management in 14 (89%) of 16 acutely ill patients with diffuse parenchymal disease. There was no uncontrollable hemorrhage; in one patient (15%) pneumothorax occurred. The safety and diagnostic value of this technique in the diagnosis of diffuse lung disease is proven.

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Clinical Analysis of Transbronchial Cryobiopsy in Diagnosis of Diffuse Lung Disease

10.21203/rs.3.rs-792900/v1 ◽

2021 ◽

Author(s):

Yefei Zhu ◽

Xuling Zhao ◽

Haihong Zheng ◽

Jiaxi Feng ◽

Zhenjie Wu ◽

...

Keyword(s):

Lung Disease ◽

Interstitial Pneumonia ◽

Granulomatous Inflammation ◽

Cost Effective ◽

Diagnostic Value ◽

Clinical Analysis ◽

Allergic Alveolitis ◽

Diffuse Lung Disease ◽

Alveolar Proteinosis ◽

Diffuse Lung

Abstract Background: Rapid advances in TBCB in recent years have allowed its gradual acceptance as a diagnostic method for DLD, and an alternative to surgical lung biopsy . However, the various guidelines have yet to provide clear recommendations for TBCB. This study investigated the diagnostic value of transbronchial cryobiopsy (TBCB) for identifying diffuse lung disease (DLD) .Methods: The clinical data was reviewed of 34 patients who showed initial signs of diffuse lung lesions, interstitial pneumonia, bronchial asthma, lung cancer/infection, or pulmonary alveolar proteinosis; and underwent TBCB from December 2018 to March 2021. The safety and effectiveness of TBCB in identifying the etiology of DLD was analyzed.Results: Clear pathomorphological diagnoses were obtained for 27 (79.4%) patients, based on clinical characteristics and pathology: pulmonary fibrosis, adenocarcinoma, alveolar proteinosis, extrinsic allergic alveolitis, tuberculous granulomatous inflammation, and interstitial pneumonia. Four (11.8%) patients required multi-disciplinary discussion for diagnostic confirmation (of diffuse lesions, interstitial pneumonia, and lung infection). The etiology of 3 cases remained unknown. The rate of DLD diagnosis via TBCB was 91.2% (31/34). Associated with the TBCB procedure, 9 (26.5%) patients developed pneumothorax (6 mild, 3 moderate), and 29 (85.3%) post-biopsy bleeding (all grade 1, requiring suction and compression, but no other intervention or surgery). The average hospitalization cost and length of stay were 7988 RMB (1233 USD) and 5.48 days, respectively.Conclusion: TBCB is safe, cost-effective, requires a short hospitalization, and the diagnostic confirmation rate for DLD is high.

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