Synthesis of Nitrogen- and Chlorine-Doped Graphene Quantum Dots for Cancer Cell Imaging

2018 ◽  
Vol 18 (6) ◽  
pp. 3793-3799 ◽  
Author(s):  
Md Nafiujjaman ◽  
Hwang Joon ◽  
Kwang Soo Kwak ◽  
Yong-kyu Lee
FlatChem ◽  
2021 ◽  
pp. 100246
Author(s):  
Salar Khaledian ◽  
Farhad Nalaini ◽  
Mahmood Mehrbakhsh ◽  
Mohadese Abdoli ◽  
Saleh Salehi Zahabi

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Madison Frieler ◽  
Christine Pho ◽  
Bong Han Lee ◽  
Hana Dobrovolny ◽  
Giridhar R. Akkaraju ◽  
...  

With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both science and society. Current models of cancer cell growth and therapeutic efficacy in vitro are time-dependent and often do not consider the Emax value (the maximum reduction in the growth rate), leading to inconsistencies in the obtained IC50 (concentration of the drug at half maximum effect). In this work, we introduce a new dual experimental/modeling approach to model HeLa and MCF-7 cancer cell growth and assess the efficacy of doxorubicin chemotherapeutics, whether alone or delivered by novel nitrogen-doped graphene quantum dots (N-GQDs). These biocompatible/biodegradable nanoparticles were used for the first time in this work for the delivery and fluorescence tracking of doxorubicin, ultimately decreasing its IC50 by over 1.5 and allowing for the use of up to 10 times lower doses of the drug to achieve the same therapeutic effect. Based on the experimental in vitro studies with nanomaterial-delivered chemotherapy, we also developed a method of cancer cell growth modeling that (1) includes an Emax value, which is often not characterized, and (2), most importantly, is measurement time-independent. This will allow for the more consistent assessment of the efficiency of anti-cancer drugs and nanomaterial-delivered formulations, as well as efficacy improvements of nanomaterial delivery.


2016 ◽  
pp. 413 ◽  
Author(s):  
Faruq Mohammad ◽  
Ibrahim birma Bwatanglang ◽  
Nor Azah Yusof ◽  
Jaafar Abdullah ◽  
Mohd Zobir Hussein ◽  
...  

2021 ◽  
Vol 2011 (1) ◽  
pp. 012097
Author(s):  
Junting Tao ◽  
Hao Zou ◽  
Xinjian Lu ◽  
Xiaokun Liao ◽  
Jiaqi Pan ◽  
...  

Author(s):  
Rahul V. Khose ◽  
Prachi Bangde ◽  
Mahesh P. Bondarde ◽  
Pratik S. Dhumal ◽  
Madhuri A. Bhakare ◽  
...  

2014 ◽  
Vol 38 (9) ◽  
pp. 4519-4526 ◽  
Author(s):  
Miao Lu ◽  
Wendian Zhang ◽  
Yongkang Gai ◽  
Tan Yang ◽  
Peng Ye ◽  
...  

CdTe@SiO2–NH–CO–PEG−folate nanoparticles were successfully prepared and demonstrated tumor cell specific targeting through folate receptors via folate mediated endocytosis.


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