Interleukin Gene Polymorphisms in Age-Related Macular Degeneration

2008 ◽  
Vol 49 (2) ◽  
pp. 693 ◽  
Author(s):  
Yi-Yu Tsai ◽  
Jane-Ming Lin ◽  
Lei Wan ◽  
Hui-Ju Lin ◽  
Yushin Tsai ◽  
...  
2017 ◽  
Vol Volume 11 ◽  
pp. 1347-1358 ◽  
Author(s):  
Antonia Sarli ◽  
Iosif Skalidakis ◽  
Aliki Velissari ◽  
Chryssanthi Koutsandrea ◽  
Maria Stefaniotou ◽  
...  

2021 ◽  
pp. 112067212110026
Author(s):  
Pablo Gili ◽  
Leyre Lloreda Martín ◽  
José-Carlos Martín-Rodrigo ◽  
Naon Kim-Yeon ◽  
Laura Modamio-Gardeta ◽  
...  

Purpose: To identify the association between single-nucleotide polymorphisms (SNPs) in CFH, ARMS2, HTRA1, CFB, C2, and C3 genes and exudative age-related macular degeneration (AMD) in a Spanish population. Methods: In 187 exudative AMD patients and 196 healthy controls (61% women, mean age 75 years), 12 SNPs as risk factors for AMD in CFH (rs1410996, rs1061170, r380390), ARMS2 (rs10490924, rs10490923), HTRA1 (rs11200638), CFB (rs641153), C2 (rs547154, rs9332739), and C3 (rs147859257, rs2230199, rs1047286) genes were analyzed. Results: The G allele was the most frequent in CFH gene (rs1410996) with a 7-fold increased risk of AMD (OR 7.69, 95% CI 3.17–18.69), whereas carriers of C allele in CFH (rs1061170) showed a 3-fold increased risk for AMD (OR 3.22, 95% CI 1.93–5.40). In CFH (rs380390), the presence of G allele increased the risk for AMD by 2-fold (OR 2.52, 95% CI 1.47–4.30). In ARMS2 (rs10490924), the T-allele was associated with an almost 5-fold increased risk (OR 5.49, 95% CI 3.23–9.31). The A allele in HTRA1 (rs11200638) was more prevalent in AMD versus controls (OR 6.44, 95% CI 3.62–11.47). In C2 gene (rs9332739) the presence of C increased risk for AMD by 3-fold (OR 3.10, 95% CI 1.06–9.06). Conclusion: SNPs in CFH, ARMS2, HTRA1, and C2 genes were associated in our study with an increased risk for exudative AMD in Spanish patients.


2015 ◽  
Vol 37 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Mojgan Babanejad ◽  
Hamidreza Moein ◽  
Mohammad R. Akbari ◽  
Azadeh Badiei ◽  
Mehdi Yaseri ◽  
...  

2017 ◽  
Vol 38 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Neringa Stasiukonyte ◽  
Rasa Liutkeviciene ◽  
Alvita Vilkeviciute ◽  
Mantas Banevicius ◽  
Loresa Kriauciuniene

2016 ◽  
Vol 132 (2) ◽  
pp. 8 ◽  
Author(s):  
A. V. Shevchenko ◽  
V. F. Prokof’ev ◽  
V. I. Konenkov ◽  
V. V. Chernykh ◽  
A. V. Eremina ◽  
...  

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