scholarly journals Decreased Vascular Patterning in the Retinas of Astronaut Crew Members as New Measure of Ocular Damage in Spaceflight-Associated Neuro-ocular Syndrome

2020 ◽  
Vol 61 (14) ◽  
pp. 34
Author(s):  
Ruchi J. Vyas ◽  
Millennia Young ◽  
Matthew C. Murray ◽  
Marina Predovic ◽  
Shiyin Lim ◽  
...  
Keyword(s):  
Vascular Patterning

Exposure to high-concentration oxygen in the neonatal period induces abnormal retinal vascular patterning in mice

2016 ◽  
Vol 107 (6) ◽  
pp. 216-224 ◽  
Author(s):  
Akane Morita ◽  
Hiroko Ushikubo ◽  
Asami Mori ◽  
Kenji Sakamoto ◽  
Tsutomu Nakahara
Keyword(s):  
Neonatal Period ◽  
High Concentration ◽  
Vascular Patterning

scholarly journals Complement facilitates developmental microglial pruning of astrocyte and vascular networks

2022 ◽  
Author(s):  
Gopalan Gnanaguru ◽  
Steven J Tabor ◽  
Kentaro Yuda ◽  
Ryo Mukai ◽  
Jörg Köhl ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Cell ◽  
Vascular Density ◽  
Vascular Networks ◽  
Vascular Patterning ◽  
Vascular Growth ◽  
Vascular Bed ◽  
Retinal Microglia ◽  
The Central Nervous System

Microglia, the resident immune cell of the central nervous system, play a pivotal role in facilitating neurovascular development through mechanisms that are not fully understood. This current work resolves a previously unknown role for microglia in facilitating the developmental pruning of the astrocytic template resulting in a spatially organized retinal vascular bed. Mechanistically, our study identified that local microglial expression of complement (C)3 and C3aR is necessary for the regulation of astrocyte patterning and vascular growth during retinal development. Ablation of retinal microglia, loss of C3 or C3aR reduced developmental pruning and clearance of astrocytic bodies leading to increased astrocyte density leading to altered vascular patterning during retinal vascular development. This data demonstrates that C3/C3aR signaling is an important checkpoint required for the finetuning of vascular density during neuroretinal development.

LOP1: a gene involved in auxin transport and vascular patterning in Arabidopsis

Development ◽  
1996 ◽  
Vol 122 (6) ◽  
pp. 1811-1819 ◽  
Author(s):  
F.M. Carland ◽  
N.A. McHale
Keyword(s):  
Cell Expansion ◽  
Higher Plants ◽  
Lateral Roots ◽  
Primary Root ◽  
Vascular Patterning ◽  
Basipetal Transport ◽  
Leaf Mutant ◽  
Identification And Characterization ◽  
Axial Growth

We have taken a genetic approach to understanding the mechanisms that control vascular patterning in the leaves of higher plants. Here we present the identification and characterization of the lop1 mutant of Arabidopsis which is defective in basipetal transport of IAA. Mutant leaf midveins show disoriented axial growth, and bifurcation into twin veins that are frequently rotated out of the normal dorsal/ventral axis of the leaf. Mutant plants also display abnormal patterns of cell expansion in the midrib cortex and in the epidermis of the elongation zone of lateral roots. Lateral roots show abnormal curvature during initiation, sometimes encircling the primary root prior to growth in a normal downward direction. Mutant seedlings have normal levels of free IAA, and appear normal in auxin perception, suggesting that transport is the primary lesion. The abnormalities in vascular development, lateral root initiation and patterns of cell expansion observed in the lop] mutant are consistent with a basic disruption in basipetal transport of IAA.

scholarly journals Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis

Angiogenesis ◽  
2020 ◽  
Vol 23 (3) ◽  
pp. 411-423 ◽  
Author(s):  
Lothar C. Dieterich ◽  
Carlotta Tacconi ◽  
Franziska Menzi ◽  
Steven T. Proulx ◽  
Kübra Kapaklikaya ◽  
...  
Keyword(s):  
Vascular Patterning

scholarly journals PHABULOSA Mediates an Auxin Signaling Loop to Regulate Vascular Patterning in Arabidopsis

2015 ◽  
Vol 170 (2) ◽  
pp. 956-970 ◽  
Author(s):  
Christina Joy Müller ◽  
Ana Elisa Valdés ◽  
Guodong Wang ◽  
Prashanth Ramachandran ◽  
Lisa Beste ◽  
...  
Keyword(s):  
Auxin Signaling ◽  
Vascular Patterning

Vascular patterning: coordinated signals keep blood vessels on track

2015 ◽  
Vol 32 ◽  
pp. 86-91 ◽  
Author(s):  
Stryder M Meadows ◽  
Ondine Cleaver
Keyword(s):  
Blood Vessels ◽  
Vascular Patterning

scholarly journals Vascular Patterning

2003 ◽  
Vol 2 ◽  
pp. e0073 ◽  
Author(s):  
Simon Turner ◽  
Leslie E. Sieburth
Keyword(s):  
Vascular Patterning
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