Pathochistological and immunohistochemical study in small intestine metastasis as first clinical expression of invasive lobular breast carcinoma: Prognosis and complex treatment

The gastrointestinal metastases (GIM) of breast carcinoma (BC) are a rare clinical finding, even more rarely diagnosed as initial symptoms at unknown BC. We present a 50-year-old woman with metastases in the terminal ileum combined with multiple bone metastases from an unknown invasive carcinoma of left mammary gland. Gastrointestinal metastases are rarely observed in invasive lobular breast carcinoma. Differential diagnosis between intestinal metastases from primary BC and primary intestinal neoplasm is extremely difficult. Determination of tumor pathohistogenesis require careful pathohistological and immunohistochemical analysis. Complex treatment follows the primary neoplasm principles. The prognosis in such clinical cases is unfavorable, but after timely complex oncological treatment, including emergency operation, chemotherapy, hormone and target therapy, 36 monthly survival is achieved. Keywords: gastrointestinal metastases; invasive lobular breast carcinoma; pathohistological analysis; immunohistochemical analysis; complex treatment.

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Gastric Metastasis 14 Years after Mastectomy for Breast Lobular Carcinoma: Case Report and Literature Review

The American Surgeon ◽

10.1177/000313480607200518 ◽

2006 ◽

Vol 72 (5) ◽

pp. 456-460 ◽

Cited By ~ 4

Author(s):

Paolo Aurello ◽

Francesco D'Angelo ◽

Giulia Cosenza ◽

Sergio Petrocca ◽

Antonella Stoppacciaro ◽

...

Keyword(s):

Breast Carcinoma ◽

Lobular Carcinoma ◽

Subtotal Gastrectomy ◽

Immunohistochemical Analysis ◽

Gastric Neoplasm ◽

Surgical Specimen ◽

Symptomatic Disease ◽

Lobular Breast Carcinoma ◽

Previously Treated ◽

Rule Out

In planning treatment of a gastric neoplasm in a patient previously treated for lobular breast carcinoma, it is important to differentiate a primary gastrointestinal tract tumor from a metastatic form. We report a case of a breast lobular carcinoma metastatic to the stomach. The patient underwent a subtotal gastrectomy for symptomatic disease. Although gastric symptoms appeared 14 years after the breast carcinoma, immunohistochemical analysis of the surgical specimen helped to establish that the gastric lesion, thought to be primary, was effectively a metastatic repetition of the breast neoplasm. To better define treatment in a gastric neoplasm patient previously treated for breast carcinoma, the preoperative diagnosis should rule out a metastatic disease. The patient described received an adjuvant chemotherapy according to breast cancer protocol after gastric resection for symptomatic disease. The patient is still alive and undergoing chemotherapy for peritoneal carcinosis.

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Late gastrointestinal metastases of invasive lobular breast carcinoma mimicking Crohn’s disease

Orvosi Hetilap ◽

10.1556/oh.2010.28927 ◽

2010 ◽

Vol 151 (40) ◽

pp. 1666-1671 ◽

Cited By ~ 1

Author(s):

Judit Szabó ◽

Bernadett Falkus ◽

Éva Simon ◽

Szilveszter Brünner ◽

Ferenc Baranyay

Keyword(s):

Crohn’S Disease ◽

Breast Carcinoma ◽

Crohn's Disease ◽

Lobular Breast Carcinoma ◽

Gastrointestinal Metastases

Az invazív lobularis emlőcarcinomát – amely az emlőcarcinomák mintegy 10%-át teszi ki – szövettanilag, molekuláris genetikailag, klinikumát, metasztatizálási sajátságait tekintve különálló emlőcarcinoma-entitásnak tartják. Szemben a ductalis invazív emlőcarcinomával, késői metasztázisai főként a gyomor-bél traktust érintik. Emlőcarcinoma ritkán metasztatizál a gastrointestinumba. Általában 3–20 évvel a primer tumor felismerése után jelentkeznek a gyulladásos megbetegedést, második malignoma gyanúját keltő hasi tünetek. Az 53 éves korában meghalt emlőcarcinomás nőbeteg esetét mutatjuk be, akinél 8 évi tumormentesség után felhasi görcsös fájdalmak léptek fel, amelyek körkörös jelleggel a hátba sugároztak. A radiológiai vizsgálat Crohn-betegséget véleményezett. Az elvégzett ileumbiopszia negatív volt, a beteg ex juvantibus szteroidterápiában részesült. Mechanikus ileus lépett fel és a terminális ileum, valamint a felszálló vastagbél részleges eltávolítására került sor. Három héttel a műtét után úgynevezett késői varratelégtelenségben, peritonitis szövődményeiben meghalt. A terminalis ileum metszeteiben a beszűkült, megvastagodott bél fali rétegeit kiterjedten infiltráló kis sejtes diffúz carcinomás szövetburjánzás volt megfigyelhető. A metasztatikus carcinomás sejtek immunhisztokémiai vizsgálatokkal breast carcinoma antigénnel (BCA-1) és CA-15-3 savóval reagáltak. A beteg vörösvértest-fenotípusa alapján AB vércsoportú volt, és a carcinomás sejtek ABH vércsoport-specifikus lektinekkel és monoklonális antitestekkel intenzíven reagáltak. Orv. Hetil., 2010, 40, 1666–1671.

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Metastasis of lobular breast carcinoma in the bowel

Gastroenterología y Hepatología ◽

10.1016/j.gastrohep.2020.01.009 ◽

2020 ◽

Vol 43 (6) ◽

pp. 323-324

Author(s):

Flávio Pereira ◽

Marisa Linhares ◽

João Pinto ◽

José Tristan ◽

António Banhudo

Keyword(s):

Breast Carcinoma ◽

Lobular Breast Carcinoma

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Conservative surgery for infiltrating lobular breast carcinoma

British Journal of Surgery ◽

10.1002/bjs.1800840139 ◽

1997 ◽

Vol 84 (1) ◽

pp. 106-109 ◽

Cited By ~ 36

Author(s):

B. Salvadori ◽

E. Biganzoli ◽

P. Veronesi ◽

R. Saccozzi ◽

F. Rilkes

Keyword(s):

Breast Carcinoma ◽

Conservative Surgery ◽

Lobular Breast Carcinoma

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Case report of gastric outlet obstruction from metastatic lobular breast carcinoma

BMC Gastroenterology ◽

10.1186/s12876-015-0350-y ◽

2015 ◽

Vol 15 (1) ◽

Author(s):

Alexander H. Kim ◽

M. Joshua Shellenberger ◽

Zong Ming Chen ◽

Jinhong Li

Keyword(s):

Case Report ◽

Breast Carcinoma ◽

Gastric Outlet Obstruction ◽

Outlet Obstruction ◽

Lobular Breast Carcinoma

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A Rare Metastatic Site of Invasive Lobular Breast Carcinoma: A Case Report

Case Reports in Surgery ◽

10.1155/2021/9922296 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Sara Husain ◽

Mohamed Isa ◽

Raed Almarzooq

Keyword(s):

Breast Carcinoma ◽

Ductal Carcinoma ◽

Linitis Plastica ◽

Lobular Breast Cancer ◽

Gastric Metastasis ◽

Persistent Vomiting ◽

Metastatic Site ◽

Upper Gi ◽

Upper Gi Endoscopy ◽

Lobular Breast Carcinoma

Here, we report a case of a 42-year-old female patient with left lobular breast cancer-gastric metastasis (initially misdiagnosed five years ago as an invasive ductal carcinoma) presenting with dyspepsia, weight loss, and persistent vomiting lasting for four weeks. Upper GI endoscopy revealed evidence of linitis plastica, and histological and immunocytochemical analyses of the biopsy confirmed gastric metastasis secondary to invasive lobular breast carcinoma.

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Neuroendocrine Differentiation in Invasive Lobular Breast Carcinoma

Acta Endocrinologica (Bucharest) ◽

10.4183/aeb.2017.246 ◽

2017 ◽

Vol 13 (2) ◽

pp. 246-248 ◽

Cited By ~ 1

Author(s):

S Gradinaru

Keyword(s):

Breast Carcinoma ◽

Neuroendocrine Differentiation ◽

Lobular Breast Carcinoma

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Pathohistological and Immunohistochemical Analysis of Primary Invasive Ductal Breast Carcinoma with Signet-Ring Cell Differentiation- Differential Diagnosis, Prognosis and Complex Treatment

Medical & Clinical Research ◽

10.33140/mcr.06.03.08 ◽

2020 ◽

Vol 6 (3) ◽

Keyword(s):

Differential Diagnosis ◽

Cell Differentiation ◽

Hormone Therapy ◽

Locally Advanced ◽

Immunohistochemical Analysis ◽

Signet Ring Cell ◽

Tumor Control ◽

Complex Treatment ◽

Signet Ring ◽

Ring Cell

Primary signet ring cell carcinoma (PSRCC) of the breast is a rarely diagnosed neoplasm. We present a 76-year-old woman with a tumor formation in the left mammary gland, who has been self-medicating for a year. Pathohistological and immunohistochemical analysis proved rare primary invasive ductal carcinoma with focal (over 90%) signet ring cell differentiation, size 4 cm / 3.5 cm / 2 cm, moderately differentiated (G2). Complex oncological treatment, including radical mastectomy with axillary dissection, 6 courses of systemic adjuvant chemotherapy, radiotherapy of the chest wall and regional lymph nodes with TD 46 Gy and antiestrogenic hormone therapy, was performed. The diagnosis and the differential diagnosis of this rare tumor require precise pathohistological and immunohistochemical analysis. The prognosis and complex treatment depend on the clinical stage, hormonal and HER2 status. In locally advanced PSRCC of the breast with moderately differentiation, the combination of surgery, systemic chemotherapy, postoperative radiotherapy and antiestrogenic hormone therapy achieves long-term local tumor control without distant metastases for nearly two years.

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