Utility of Liver Function Tests after Laparoscopic Cholecystectomy

2006 ◽  
Vol 72 (12) ◽  
pp. 1238-1240 ◽  
Author(s):  
Amy Kaldor ◽  
Gabriel Akopian ◽  
James Recabaren ◽  
Magdi Alexander
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Complications ◽  
Liver Function ◽  
Bile Leak ◽  
Common Bile Duct Stones ◽  
Liver Function Tests ◽  
Entire Study ◽  
Function Tests ◽  
Significant Difference ◽  
Study Population

Many surgeons routinely obtain liver function tests (LFTs) after all laparoscopic cholecystectomies. Others argue that LFTs provide no useful information and add time and expense to the patient's hospitalization. This purpose of this study was to determine if routine postoperative LFTs predict complications. One hundred ninety-nine consecutive patients undergoing laparoscopic cholecystectomy were included in the analysis. Nine (4.5%) patients had postoperative complications: eight with retained common bile duct stones and one with a cystic duct stump leak. All were diagnosed with postoperative endoscopic retrograde cholangiopancreatography. Only four of the nine patients had hyperbilirubinemia. Overall, 39 patients had postcholecystectomy hyperbilirubinemia, with four (10%) patients having complications (three retained stones and one had a bile leak). For the entire study population, there was no difference between pre- and postoperative total bilirubin and aspartate aminotransferase levels (0.6 vs 0.6 mg/dL; P = 0.623 and 25 vs 41 U/L; P = 0.111, respectively). There was a statistically significant difference in pre- and postoperative alanine aminotransferase and alkaline phosphatase (31 vs 50 U/L; P = 0.003 and 95 vs 90 U/L; P = 0.001, respectively). Postoperative elevations in liver function tests are frequently seen after laparoscopic cholecystectomy. These elevations do not predict postoperative complications. LFTs should be obtained only when clinically indicated.

Changes in liver function tests after laparoscopic cholecystectomy with low- and high-pressure pneumoperitoneum

2019 ◽  
Vol 51 (2) ◽  
pp. 61-65
Author(s):  
Zagor Zagorac ◽  
Rastko Zivic ◽  
Miljan Milanovic ◽  
Berislav Vekic ◽  
Branislav Dakovic ◽  
...  
Keyword(s):  
High Pressure ◽  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Liver Function Tests ◽  
Function Tests

scholarly journals Aminotransferases in Chronic Active and Chronic Persistent Hepatitis

2014 ◽  
Vol 41 (2) ◽  
pp. 17-19
Author(s):  
SMF Karim ◽  
MR Rahman ◽  
S Shermin ◽  
R Sultana
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Serum Bilirubin Level ◽  
Chronic Persistent Hepatitis ◽  
Diagnosis And Prognosis ◽  
Function Tests ◽  
Significant Difference ◽  
Student’S T ◽  
Serum Aminotransferases ◽  
Age And Sex

Chronic active hepatitis (CAH) and chronic persistent hepatitis (CPH), the two histologically distinct forms of viral hepatitis present with variable clinical features. So liver function tests play the key role in diagnosis and prognosis of these disorders. Among the liver function tests, determination of serum aminotransferases: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and AST/ALT ratio are still popularly used. In fact over the transaminase tests no other enzymatic tests have any particular value. In infiltrative disorders there is damage to both mitochondrial and cytoplasmic membranes. Therefore there is a proportionally greater increase in plasma AST activity than ALT. This comparative study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka from January 2007 to December 2007 to observe the role of aminotransferases and AST/ALT ratio in CAH and CPH. With prefixed inclusion and exclusion criteria a total of 44 age and sex matched subjects were purposively enrolled in the study. Out of them 20 were CAH and 24 were CPH. Serum AST, ALT and total bilirubin were measured and AST/ALT ratio were calculated. Mentioned parameters were compared between groups. Unpaired student's t-test and chi (x2) square test were done to detect the significant difference between the groups using SPSS version 12.0. Mean age of the study subjects in CAH and CPH group were 32.20 ± 10.65 years (20-50 years) and 32.83 ± 10.68 years (20-49 years) respectively. There was no significant difference regarding age and sex distribution between the groups (p > 0.05). Mean ± SD serum AST was 295.08 ± 153.77 IU/L and 73.38 ± 45.72 IU/L and ALT was 352.44 ± 206.95 IU/L and 121.01 ± 58.77 IU/L in CAH and CPH respectively and both were statistically highly significant (p < 0.01). Mean ± SD of AST / ALT ratio in CAH and CPH were 0.87 ± 0.14 and 0.59 ± 0.14 respectively and was highly significant (p < 0.01). There was no significant difference in serum bilirubin level between the groups (20.78 ± 14.16 ?mol/L vs. 19.25 ± 15.90 ?mol /L) (p > 0.05). DOI: http://dx.doi.org/10.3329/bmj.v41i2.18795 Bangladesh Medical Journal 2012 Vol. 41 No. 2: 17-19

scholarly journals Comparison of oral rifampicin with observation alone in treatment of acute central serous Chorioretinopathy

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Anum Badar ◽  
Sadaf Khan ◽  
Sobia Usman Shah ◽  
Mohammad Tahir ◽  
Saman Babree
Keyword(s):  
Liver Function ◽  
Central Serous Chorioretinopathy ◽  
Liver Function Tests ◽  
Macular Thickness ◽  
Function Tests ◽  
Single Person ◽  
Significant Difference ◽  
Group A ◽  
Acute Central Serous Chorioretinopathy ◽  
Group B

Introduction: A randomized control trial To compare efficacy of oral rifampicin in terms of drying of macula and decrease macular thickness with observation alone in patients of acute central serous Chorioretinopathy done in Layton Rahmatulla Benevolent Trust (LRBT) Free Eye and Cancer Hospital, Lahore from January 2017 to June 2017 Methods: After getting approval from hospital Ethical committee 140 patients of CSR were included in the study. The demographic details were noted and patients were randomized by lottery methods in two groups (group A& B). Group-A was observed for spontaneous resolution, routine treatment started if no improvement noted after 6 weeks of observation alone. Group B was given oral rifampicin 600mg per day for four weeks with liver function tests being done before commencement of treatment and after 2 weeks. Oral rifampicin was stopped if patient developed deranged liver function tests. Patients were followed up at 4 weeks for macular dryness and decrease macular thickness on optical coherence tomography(OCT). All the readings were carried out and noted by single person in order to minimize bias. Results: A total of 140 patents, 70 in each group, were included In study with mean age 38.77+7.74 in Group-A and 39.14+7.97 years in Group-B. regarding gender distribution 65.71 %(n=46) in Group-A and 613.43%(n=43) in Group-B were male.   Comparison of outcome of treatment of acute central serous chorioretinopathy with oral rifampicin vs observation showed that 18.57 %(n=13) in Group-A and 41.43%(n=29) in Group-B had dry macula. Conclusion: We concluded that there is a significant difference in drying of macula in acute central serous chorioretinopathy with Rifampicin versus observation alone.

scholarly journals Assessment of Plasma Homocysteine in Acne Patients isotretinoim Therapy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Sallam ◽  
K M A Alzawahry ◽  
R M Z Haki
Keyword(s):  
Side Effects ◽  
Liver Function ◽  
Lipid Profile ◽  
Low Dose ◽  
Homocysteine Level ◽  
Liver Function Tests ◽  
High Dose ◽  
Severe Acne ◽  
Function Tests ◽  
Significant Difference

Abstract Background Acne is a chronic inflammatory disorder of the pilosebaceous unit. Oral isotretinoin is a highly effective treatment for patients with moderate and severe, but causes significant side effects. Objective To estimate homocysteine level in acne patients after treatment with isotretinoin. Patients and Methods The prospective study was conducted at Ain Shams University Faculty of Medicine, Egypt, from June 2017 to November 2017, including male or non-pregnant female patients more than 18 years of age, categorized by the Global Evaluation Acne (GEA) into 22 patients with moderate acne vulgaris and 22 patients with severe acne. Isotretinoin was started in a dosage of 0.5 mg/kg/day, and 1.0mg/kg/day in moderate and severe acne patients respectively. Baseline homocysteine level, liver function tests, serum cholesterol and lipid profile were tested before and after 3 months. Results There was significant difference (p = 0.001) in homocysteine level among all cases Moreover, homocysteine serum level in patient's group who received high dose isotretinoin (1 mg/kg/d) showed highly significant results (p = 0.001) in contrast to patient's group who received low dose isotretinoin (0.5 mg/kg/d) = 0.003). A significant increase in lipid profile and liver function test was seen in all cases. Conclusion low dose isotretinoin seems to have less side effects on basic laboratory data such as CBC, liver function tests, lipid profile and homocysteine serum levels than high dose.

Sa1303 Prediction of Persistent Common Bile Duct Stones (pCBDS): Comparison of Liver Function Tests Evolution Over 48 Hours

2013 ◽  
Vol 144 (5) ◽  
pp. S-256-S-257
Author(s):  
Madeleine Bonneviot ◽  
Ahmed Almarhabi ◽  
Marie-Pierre Garant ◽  
Jean-Daniel Baillargeon
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Common Bile Duct Stones ◽  
Liver Function Tests ◽  
Bile Duct Stones ◽  
Function Tests
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