scholarly journals Assessment of Plasma Homocysteine in Acne Patients isotretinoim Therapy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Sallam ◽  
K M A Alzawahry ◽  
R M Z Haki
Keyword(s):  
Side Effects ◽  
Liver Function ◽  
Lipid Profile ◽  
Low Dose ◽  
Homocysteine Level ◽  
Liver Function Tests ◽  
High Dose ◽  
Severe Acne ◽  
Function Tests ◽  
Significant Difference

Abstract Background Acne is a chronic inflammatory disorder of the pilosebaceous unit. Oral isotretinoin is a highly effective treatment for patients with moderate and severe, but causes significant side effects. Objective To estimate homocysteine level in acne patients after treatment with isotretinoin. Patients and Methods The prospective study was conducted at Ain Shams University Faculty of Medicine, Egypt, from June 2017 to November 2017, including male or non-pregnant female patients more than 18 years of age, categorized by the Global Evaluation Acne (GEA) into 22 patients with moderate acne vulgaris and 22 patients with severe acne. Isotretinoin was started in a dosage of 0.5 mg/kg/day, and 1.0mg/kg/day in moderate and severe acne patients respectively. Baseline homocysteine level, liver function tests, serum cholesterol and lipid profile were tested before and after 3 months. Results There was significant difference (p = 0.001) in homocysteine level among all cases Moreover, homocysteine serum level in patient's group who received high dose isotretinoin (1 mg/kg/d) showed highly significant results (p = 0.001) in contrast to patient's group who received low dose isotretinoin (0.5 mg/kg/d) = 0.003). A significant increase in lipid profile and liver function test was seen in all cases. Conclusion low dose isotretinoin seems to have less side effects on basic laboratory data such as CBC, liver function tests, lipid profile and homocysteine serum levels than high dose.

scholarly journals Assessment of Plasma Malondialdehyde in Acne Patients on Isotretinoin Therapy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M A Saleh ◽  
K M A Alzawahry ◽  
R E M Gad
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Side Effects ◽  
Serum Level ◽  
Liver Function ◽  
Lipid Profile ◽  
Acne Vulgaris ◽  
Liver Function Tests ◽  
Severe Acne ◽  
Function Tests

Abstract Background Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects predominantly adolescents and young adults. Oral isotretinoin is a highly effective treatment agent for patients with nodulocystic acne and moderate to severe acne resistant to conventional therapy, isotretinoin might have side effects of oxidative stress and lipid peroxidation. . Malondialdehyde is the end product of lipid peroxidation and is a good marker of free radical-mediated damage and oxidative stress. Objective The purpose of this study to estimate malondialdehyde level in patients on Isotretinoin treatment for moderate to severe acne and compare them with healthy control group. Patients and Methods The case-control study was conducted at Ain. Shams University Faculty of Medicine, Egypt, from October 2017 to April 2017, and comprised male or non-pregnant female patients more than 18 years of age. 88 participants were included in the study; 44 cases, categorized by the Global Evaluation Acne (GEA) into 22 patients with moderate acne vulgaris and 22 patients with severe acne in comparison to equal healthy matching group. Isotretinoin was started in a dosage of 0.5mg/kg/day, and1.0mg/kg/day in patients with moderate and severe acne vulgaris respectively. Malondialdehyde, liver function tests, lipid profile and CBC were tested at the baseline for all participants and after 3 months for the patients who started isotretnoin therapy. Results In the current study, the mean baseline level malondialdehyde among all cases was 141.39 µmo1/m1±88.90, (range: 34.5 -360) and in controls it was 40 [µmo1/m1 ±11.3, (range: 9.5-90.4) this difference was statistically highly significant (P = 0.001). There was highly significant difference in malondialdehyde serum level (p = 0.0001) among all cases after 3 months of isotretnoin therapy, also there was a significant increase in MDA serum level among moderate cases (p = 0.021) and highly significant increase of MDA in severe cases (p=.001).ALP, ALT, serum cholesterol and triglyceride significant increases were seen in all cases. Conclusion low dose isotretinoin seems to have less side effects on basic laboratory data such as CBC, liver function tests, lipid profile and Malondialdehyde serum levels than high dose.

scholarly journals SUBCHRONIC TOXICITY TEST OF COMBINATION ETHANOL EXTRACT OF DETAM 1 SOYBEAN (GLYCINE MAX L. MERR) AND JATI BELANDA (GUAZUMA ULMIFOLIA LAMK) TOWARD FUNCTION, WEIGHT, AND HISTOPATHOLOGICAL OF WISTAR RAT LIVER

2016 ◽  
Vol 9 (5) ◽  
pp. 197
Author(s):  
Meilinah Hidayat ◽  
Sijani Prahastuti ◽  
Estherolita Dewi ◽  
Dewi Safitri ◽  
Siti Farah Rahmawati ◽  
...  
Keyword(s):  
Liver Function ◽  
Toxicity Test ◽  
Low Dose ◽  
Ethanol Extract ◽  
Good Effect ◽  
Control Group ◽  
High Dose ◽  
Subchronic Toxicity ◽  
Treatment Groups ◽  
Significant Difference

ABSTRACTObjective: As an antiobesity therapy, combination extracts of Detam 1 soybean and Jati Belanda will be consumed for a long time; therefore, theirtoxicities to the liver need to be investigated. To determine the effect of subchronic toxicity test of combination of ethanol extract of Detam 1 soybean(EEDS) and ethanol extract of Jati Belanda (EEJB) on liver function with parameters: Alanine transaminase (ALT), macroscopic, and histopathologicalof liver.Methods: This study was conducted on 120 Wistar rats (60 males and 60 females), 90 days (treatment group) and 120 days (satellite group). Ratswere divided into six treatment groups (3 test materials, 1 control, and 2 satellites); each group included 10 males and 10 females.Results: ALT levels of treatment groups (low dose, medium, and high), both males and females were lower than the control group (p<0.05). Thetreatment groups demonstrated a good effects effect on liver function. Liver weight of all groups showed no significant difference compared with thecontrol group (p>0.05). Results of histopathological score interpretation of male and female liver rats of low dose groups were not disturbed; middledose groups were slightly disturbed and high dose groups were damaged. Satellite high doses of male groups were disrupted, while female groupswere not.Conclusion: The combination of EEDS and EEJB has a good effect on liver function, did not lead to change organ weight and at low doses did not causerenal histopathology damage in rats after 90 days administration.Keywords: Combination of soybean Jati Belanda, Toxicity subchronic test, Function, Weight, Histopathology, Liver.

scholarly journals Aminotransferases in Chronic Active and Chronic Persistent Hepatitis

2014 ◽  
Vol 41 (2) ◽  
pp. 17-19
Author(s):  
SMF Karim ◽  
MR Rahman ◽  
S Shermin ◽  
R Sultana
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Serum Bilirubin Level ◽  
Chronic Persistent Hepatitis ◽  
Diagnosis And Prognosis ◽  
Function Tests ◽  
Significant Difference ◽  
Student’S T ◽  
Serum Aminotransferases ◽  
Age And Sex

Chronic active hepatitis (CAH) and chronic persistent hepatitis (CPH), the two histologically distinct forms of viral hepatitis present with variable clinical features. So liver function tests play the key role in diagnosis and prognosis of these disorders. Among the liver function tests, determination of serum aminotransferases: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and AST/ALT ratio are still popularly used. In fact over the transaminase tests no other enzymatic tests have any particular value. In infiltrative disorders there is damage to both mitochondrial and cytoplasmic membranes. Therefore there is a proportionally greater increase in plasma AST activity than ALT. This comparative study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka from January 2007 to December 2007 to observe the role of aminotransferases and AST/ALT ratio in CAH and CPH. With prefixed inclusion and exclusion criteria a total of 44 age and sex matched subjects were purposively enrolled in the study. Out of them 20 were CAH and 24 were CPH. Serum AST, ALT and total bilirubin were measured and AST/ALT ratio were calculated. Mentioned parameters were compared between groups. Unpaired student's t-test and chi (x2) square test were done to detect the significant difference between the groups using SPSS version 12.0. Mean age of the study subjects in CAH and CPH group were 32.20 ± 10.65 years (20-50 years) and 32.83 ± 10.68 years (20-49 years) respectively. There was no significant difference regarding age and sex distribution between the groups (p > 0.05). Mean ± SD serum AST was 295.08 ± 153.77 IU/L and 73.38 ± 45.72 IU/L and ALT was 352.44 ± 206.95 IU/L and 121.01 ± 58.77 IU/L in CAH and CPH respectively and both were statistically highly significant (p < 0.01). Mean ± SD of AST / ALT ratio in CAH and CPH were 0.87 ± 0.14 and 0.59 ± 0.14 respectively and was highly significant (p < 0.01). There was no significant difference in serum bilirubin level between the groups (20.78 ± 14.16 ?mol/L vs. 19.25 ± 15.90 ?mol /L) (p > 0.05). DOI: http://dx.doi.org/10.3329/bmj.v41i2.18795 Bangladesh Medical Journal 2012 Vol. 41 No. 2: 17-19

Liver function tests and low-dose estrogen oral contraceptives

Contraception ◽  
1980 ◽  
Vol 22 (6) ◽  
pp. 597-603 ◽  
Author(s):  
J. Dickerson ◽  
R. Bressler ◽  
C.D. Christian
Keyword(s):  
Liver Function ◽  
Oral Contraceptives ◽  
Low Dose ◽  
Liver Function Tests ◽  
Function Tests

Effect of High Dose Acetaminophen on Liver Function Tests in Healthy Subjects

2017 ◽  
Vol 39 (8) ◽  
pp. e5-e6
Author(s):  
Y. Kumagai ◽  
I.D. Song ◽  
M. Maeda ◽  
R. Tanaka ◽  
Y. Sakamoto ◽  
...  
Keyword(s):  
Liver Function ◽  
Healthy Subjects ◽  
Liver Function Tests ◽  
High Dose ◽  
Function Tests

scholarly journals Comparison of oral rifampicin with observation alone in treatment of acute central serous Chorioretinopathy

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Anum Badar ◽  
Sadaf Khan ◽  
Sobia Usman Shah ◽  
Mohammad Tahir ◽  
Saman Babree
Keyword(s):  
Liver Function ◽  
Central Serous Chorioretinopathy ◽  
Liver Function Tests ◽  
Macular Thickness ◽  
Function Tests ◽  
Single Person ◽  
Significant Difference ◽  
Group A ◽  
Acute Central Serous Chorioretinopathy ◽  
Group B

Introduction: A randomized control trial To compare efficacy of oral rifampicin in terms of drying of macula and decrease macular thickness with observation alone in patients of acute central serous Chorioretinopathy done in Layton Rahmatulla Benevolent Trust (LRBT) Free Eye and Cancer Hospital, Lahore from January 2017 to June 2017 Methods: After getting approval from hospital Ethical committee 140 patients of CSR were included in the study. The demographic details were noted and patients were randomized by lottery methods in two groups (group A& B). Group-A was observed for spontaneous resolution, routine treatment started if no improvement noted after 6 weeks of observation alone. Group B was given oral rifampicin 600mg per day for four weeks with liver function tests being done before commencement of treatment and after 2 weeks. Oral rifampicin was stopped if patient developed deranged liver function tests. Patients were followed up at 4 weeks for macular dryness and decrease macular thickness on optical coherence tomography(OCT). All the readings were carried out and noted by single person in order to minimize bias. Results: A total of 140 patents, 70 in each group, were included In study with mean age 38.77+7.74 in Group-A and 39.14+7.97 years in Group-B. regarding gender distribution 65.71 %(n=46) in Group-A and 613.43%(n=43) in Group-B were male.   Comparison of outcome of treatment of acute central serous chorioretinopathy with oral rifampicin vs observation showed that 18.57 %(n=13) in Group-A and 41.43%(n=29) in Group-B had dry macula. Conclusion: We concluded that there is a significant difference in drying of macula in acute central serous chorioretinopathy with Rifampicin versus observation alone.

Sclerosing cholangitis in a patient treated with nivolumab

2021 ◽  
Vol 14 (5) ◽  
pp. e241700
Author(s):  
Sam Talbot ◽  
Vivienne MacLaren ◽  
Heather Lafferty
Keyword(s):  
Liver Function ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Liver Function Tests ◽  
High Dose ◽  
Mr Cholangiopancreatography ◽  
Small Cell Lung ◽  
Function Tests ◽  
Stage 4 ◽  
History Of

A 69-year-old retired miner with stage 4 non-small-cell lung cancer presented with a 2-month history of obstructive liver function tests following nivolumab immunotherapy. His case had not responded to high dose prednisolone or mycophenolate and he was admitted for investigation. MR cholangiopancreatography demonstrated areas of intrahepatic biliary tree beading and stricturing, in keeping with sclerosing cholangitis. Prednisolone and mycophenolate were stopped and ursodeoxycholic acid commenced with subsequent partial improvement of the patient’s liver function tests.

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