Helicobacter Pylori Is Not the Predominant Etiology for Peptic Ulcers Requiring Operation

2011 ◽  
Vol 77 (8) ◽  
pp. 1054-1060 ◽  
Author(s):  
Marc S. Zelickson ◽  
Cathy M. Bronder ◽  
Brent L. Johnson ◽  
Joseph A. Camunas ◽  
Dane E. Smith ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Resection ◽  
Emergency Operation ◽  
Etiologic Factor ◽  
Peptic Ulcers ◽  
Surgical Service ◽  
Perioperative Mortality ◽  
Ulcer Disease ◽  
Number Of Patients ◽  
Patch Closure

As the number of patients requiring operation for peptic ulcer disease (PUD) declines, presumed contemporary ulcer etiology has largely been derived from medically treated patients not subjected to surgery. The purpose of this study was to examine the specific causes of PUD in patients requiring surgery. Our Acute Care Surgical Service registry was reviewed for patients operated on for complications of PUD from 2004 to 2009. Emphasis was placed on individual etiologic factors for PUD. There were 128 patients (52% male, 81% white) who underwent emergency operation including: simple patch closure (n = 61, 48%); gastric resection (n = 22, 17%); gastric resection with vagotomy (n = 21,16%); vagotomy and pyloroplasty (n = 18,14%); or other procedures (n = 6, 5%). Complications necessitating operation were perforation (n = 79, 62%); bleeding (n = 29, 23%); obstruction (n = 12, 9%); and intractability (n = 8, 6%). Perioperative mortality was 12.5 per cent. Risk factors for PUD included tobacco use (50%), alcohol abuse (34%), and steroids (21%). Nonsteroidal anti-inflammatory use was confirmed in 68 (53%) patients. Of the 128 patients, 82 (64%) were tested for Helicobacter pylori, 33 (40%) of which were positive and 49 (60%) negative. Helicobacter pylori, thus, was the confirmed ulcer etiology in only 26 per cent of cases. Unlike contemporary series of medically treated PUD, Helicobacter pylori may not be the predominant etiologic factor in patients who experience complications requiring surgery. A “traditional” surgical approach with liberal use of vagotomy, not antibiotic triple therapy, may well be the preferred treatment consideration in such cases.

scholarly journals Causes and Management of Gastric and Duodenal Ulcer in Adolescents

2021 ◽  
pp. 289-297
Author(s):  
Bader Maiedh Mohsen Aladainan ◽  
Mahdi Turki Bin Ali Alfataih ◽  
Alhassan Ahmed Mohammed Aldundur ◽  
Rashed Saleh Mohammed Balhareth ◽  
Eisa Yazeed Ghazwani
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Review Literature ◽  
Peptic Ulcers ◽  
Significant Progress ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Last 300 Years ◽  
Made In

Many etiological hypotheses have been suggested to explain the development of peptic ulcers during the last 300 years (including gastric ulcer and duodenal ulcer). In the last two decades, significant progress has been made in understanding the pathophysiology of peptic ulcer disease, particularly with regard to the involvement of Helicobacter pylori and nonsteroidal anti-inflammatory medications (NSAIDs). This study will attempt to review literature on etiology and management of gastric and duodenal ulcers among adolescents.

scholarly journals RECURRENCE RATE OF HELICOBACTER PYLORI IN PATIENTS WITH PEPTIC ULCER FIVE YEARS OR MORE AFTER SUCCESSFUL ERADICATION

2016 ◽  
Vol 53 (3) ◽  
pp. 152-155 ◽  
Author(s):  
Yuri Costa Farago FERNANDES ◽  
Gabriel da Rocha BONATTO ◽  
Mauro Willeman BONATTO
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Recurrence Rate ◽  
Early Recurrence ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Gastroduodenal Mucosa ◽  
H Pylori

ABSTRACT Background Infection with Helicobacter pylori is highly prevalent worldwide, especially in developing countries. Its presence in the gastroduodenal mucosa is related with development of peptic ulcer and other illnesses. The eradication of H. pylori improves mucosal histology in patients with peptic ulcers. Objective This study was aimed to verify if H. pylori recurrence occurs five years or more after confirmed eradication in patients with peptic ulcer. Moreover, we sought to determine the recurrence rate. Methods Retrospective and longitudinal, this study was based on a sample of 201 patients from western Paraná, Brazil. The patients were diagnosed with peptic ulcer disease, in the period of 1990-2000, and followed for five years or more after successful H. pylori eradication. Patients with early recurrence - prior to five years after eradication - were excluded from the sample. Results During an average follow-up of 8 years, 180 patients (89.55%) remained negative, and 21 (10.45%) became positive for H. pylori infection. New ulcers appeared in two-thirds of the patients with H. pylori recurrence. Conclusion The recurrence of H. pylori in patients with peptic ulcer can occur in the long-term - even if the infection had been successfully eradicated and the patients had remained free of recurrence in the first years of follow-up.

scholarly journals Medical treatment and prevention of Helicobacter pylori infection

2021 ◽  
Vol 5 (9) ◽  
pp. 10-13
Author(s):  
Andrea Mirković ◽  
Nikola Savić
Keyword(s):  
Gastric Cancer ◽  
Health Care ◽  
Helicobacter Pylori ◽  
Medical Treatment ◽  
Health Problem ◽  
Helicobacter Pylori Infection ◽  
Ulcer Disease ◽  
Treatment And Prevention ◽  
Repeated Infection ◽  
Number Of Patients

Helicobacter pylori infection is one of the most commonly treated infections in gastroenterology. In the last three decades, due to recurrent or repeated infection, the incidence of this complex health problem has been constantly increasing. Studies have shown that successful treatment of this infection can prevent the occurrence of numerous complications, such as ulcer disease, dyspepsia or gastric cancer. Interventions in the prevention of Helicobacter pylori infection are numerous, they are carried out at all levels of health care and are of great importance for reducing the number of patients, but also for the occurrence of complications related to the infection. The aim of this paper is to evaluate innovations in medical treatment and prevention of Helicobacter pylori infection.

Screening and Preponderance of Peptic ulcer and its Contributing risk factors Among Basrah City Residents in Iraq

2020 ◽  
Vol 15 ◽  
Author(s):  
Ausama Jaccob ◽  
Sheima Kadhim ◽  
Amal Hassan ◽  
Ali Mohsin ◽  
Salah Muslim
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Teaching Hospital ◽  
Antiplatelet Agents ◽  
Peptic Ulcers ◽  
Medication History ◽  
Ulcer Disease ◽  
Chronic Medication ◽  
Number Of Patients ◽  
H Pylori

Background: With the recent widespread use of over- the- counter drugs, there has been a noticeable increase in the occurrence of gastrointestinal discomfort and peptic ulcer disease. However, peptic ulcer is a highly complex disorder resulting from an imbalance between gstricdestructive and protective factors. Objectives: To identifyrisk factors of peptic ulcer disease. Methods: This study was organized at Al-Basra teaching hospital and Al Sader teaching hospital in Basrah city, Iraq. Medical records and questionnaires filled by patients undergoing diagnostic and therapeutic upper gastrointestinal endoscopies following their gastric discomfort complaints. Information related to patients, disease history and medication history during six months prior to endoscopy procedures was collected. Results: A total of 476 patients were identified, including 246 (51.7%) patients with endoscopically diagnosed peptic ulcers and 230 (48.3%) patients without peptic ulcers. The population was predominately male and there were significant differences between age groups.Smoking correlated with a high relative risk;however, alcohol drinking had no significant role as a causative factor. The most extensively used drugs by patients who complained of peptic ulcers are NSAIDs, iron supplements, corticosteroids, and antiplatelet agents. A small number of patients weretreated for hypertension and diabetes, which were correlated with peptic ulcer risks. The presence of H-pylori infections was significantly associated with peptic ulcer diagnosis. Conclusion: The risk of peptic ulcer disease appeared to increase with chronic medication use and smoking, which aggravatethe contributing risk by H-pylori infections.

scholarly journals Update on Peptic Ulcers in the Pediatric Age

Ulcers ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Graziella Guariso ◽  
Marco Gasparetto
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Immunosuppressive Drugs ◽  
Stressful Events ◽  
Peptic Ulcers ◽  
Pediatric Age ◽  
Adequate Treatment ◽  
Medline Search ◽  
Ulcer Disease

Background. Peptic ulcer disease (PUD) in children is reported worldwide, although it is relatively rare as compared with adults. Helicobacter pylori (HP) infection is a common cause of PUD in the pediatric age. Other risk factors include the use of nonsteroidal anti-inflammatory agents (NSAIDs), steroids, immunosuppressive drugs, and stressful events. Aim. To critically review the evidence on epidemiology, diagnostic management, and available treatments for PUD in the pediatric age. Methods. A MEDLINE search was performed indicating keywords as “Peptic Ulcer Disease,” “Epidemiology,” “Pediatric,” “Helicobacter pylori,” “Gastric ulcer,” “Bulbar Ulcer,” and “Upper Gastrointestinal Bleeding.” A selection of clinical trials, systematic reviews, and meta-analyses within the time period 2002–2012 was performed. Results. PUD in children is reported worldwide with an estimated frequency of 8.1% in Europe and of 17.4% in the US. When the underlying cause of PUD is addressed, the prognosis is excellent. Standard triple therapy, bismuth-based quadruple therapy, and the sequential therapy represent the current recommended treatments for HP related ulcers. NSAIDs related ulcers are treated by stopping the causative medications and by administration of proton-pump inhibitors or antisecretory drugs. Conclusions. PUD still represents a major concern in the paediatric age. A careful differential diagnosis and an adequate treatment constitute an excellent prognosis.

scholarly journals Peptic Ulcers and their Complications

2020 ◽  
Vol 10 (3-s) ◽  
pp. 256-261
Author(s):  
Akhilesh Kumar ◽  
Dhanesh Kumar ◽  
Rajendra Kumar ◽  
Jhakeshwar Prasad ◽  
Mahendra Kumar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Head Injury ◽  
Peptic Ulcer Disease ◽  
Early Life ◽  
Acute Stress ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Number Of Children ◽  
H Pylori

Peptic ulcer disease (PUD) is an uncommon disorder of early life. Peptic ulceration of the stomach or duodenum is usually associated with abnormalities of the gastric mucosa such as gastritis and/or gastropathy. Gastritis and ulcers of the stomach and duodenum can be classified into either primary or secondary depending on their aetiologies. The majority of primary or unexplained peptic ulcers are the result of chronic inflammation caused by Helicobacter pylori infection. However, an increasing number of children with PUD without evidence of H. Pylori infection are now being seen. Rarely PUD is caused by hypersecretory states. Secondary ulceration occurs in response to acute stress from severe systemic illnesses such as sepsis, head injury, burns, and as sequelae to use of certain drugs. The prognosis for recovery from peptic ulcers is good as most patients will respond to treatment. Keywords:  Peptic ulcer disease, Complication, Helicobacter pylori, NSAIDs, Management.

scholarly journals A brief analysis of patients suffering from stomach or duodenal ulcers in Almaty hospital №1

2015 ◽  
Vol 28 (4) ◽  
pp. 241-243
Author(s):  
Aliya Aryzbekova ◽  
Konrad Tomasz Juszkiewicz ◽  
Donald Eduard Burgess ◽  
Andrzej Polski ◽  
Ewa Poleszak
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Urban Areas ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Drinking Alcohol ◽  
Duodenal Ulcers ◽  
Number Of Patients ◽  
Inflammatory Drugs ◽  
And Gender

AbstractPeptic ulcers are a serious problem worldwide, and affect about 4 million people each year. Their etiology is connected with the presence of Helicobacter pylori, the act of smoking, drinking alcohol, being stress, and taking excessively nonsteroidal anti-inflammatory drugs, as well as steroids. The most common symptoms are abdominal pain, nausea, chest pain and fatigue, while less frequent symptoms include vomiting and weight loss. Helicobacter pylori is responsible for about 80% of gastric and 90% of duodenal ulcer cases. In this work, an analysis is made of a correlation between stomach or duodenal ulcer and gender, residence and number of patients hospitalized in the Almaty hospital №1, from 2009-2012, in order to learn about trends in the incidence of these diseases in Kazakhstan. A total number of 950 patients with stomach and duodenal ulcers, in 2009-2012, were questioned. The patient’s residence, gender and stomach or duodenal ulcer problem were taken into account in the study. The result of this work reveals that the largest amount of hospitalized patients suffering from stomach or duodenal ulcers came from urban areas. Moreover, more women than men suffered from peptic ulcers. Furthermore, the number of patients admitted to the hospital due to duodenal ulcers did not show any variation throughout the study. However, the least number of patients suffering from gastric ulcers was noticed in December 2009, and the greatest was in October and November 2011. The obtained data show that ulcers are a serious problem in Kazakhstan.

scholarly journals Diversity of Helicobacter pylori vacA andcagA Genes and Relationship to VacA and CagA Protein Expression, Cytotoxin Production, and Associated Diseases

1998 ◽  
Vol 36 (4) ◽  
pp. 944-948 ◽  
Author(s):  
Jochen Rudi ◽  
Christof Kolb ◽  
Matthias Maiwald ◽  
Dirk Kuck ◽  
Andreas Sieg ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Signal Sequence ◽  
Peptic Ulcers ◽  
Virulence Determinants ◽  
Middle Region ◽  
Vacuolating Cytotoxin ◽  
Ulcer Disease ◽  
H Pylori

The vacuolating cytotoxin and the cytotoxin-associated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. Sixty-five H. pylori strains were isolated from dyspeptic patients (19 with peptic ulcer disease, 43 with chronic gastritis, and 3 with gastric cancer) and studied for differences in thevacA and cagA genes and their relationship to VacA and CagA expression, cytotoxin activity, and the clinical outcome of infection. By PCR, fifty-four (83.1%) of 65 strains had thevacA signal sequence genotype s1 and only 10 (15.4%) had the type s2. After primer modification, the vacAmiddle-region types m1 and m2 were detected in 24 (36.9%) and 41 (63.1%) strains, respectively. The combinations s1-m2 (31 [47.7%]) and s1-m1 (23 [35.4%]) occurred more frequently than s2-m2 (10 [15.4%]) (P = 0.01). No strain with the combination s2-m1 was found. All 19 patients with peptic ulcers harbored type s1 strains, in contrast to 32 (74.4%) of 43 patients with gastritis (P = 0.02). The vacA genotype s1 was associated with the presence of cagA (P < 0.0001), VacA expression (P < 0.0001), and cytotoxin activity (P = 0.003). The cagA gene was detectable in 48 (73.8%) of 65 isolates and present in 16 (84.2%) of 19 ulcer patients and 29 (67.4%) of 43 patients with gastritis (P = 0.17). The vacA genotypes of GermanH. pylori isolates are identical to those previously reported. H. pylori strains of vacA type s1 are associated with the occurrence of peptic ulceration and the presence ofcagA, cytotoxin activity, and VacA expression.

scholarly journals The role of Helicobacter pylori in preeclampsia and in gastric diseases in pregnant women

2020 ◽  
Vol 7 (7) ◽  
pp. 2097
Author(s):  
Jehan Sabah Hasan ◽  
Mohammed Ahmed Alshami
Keyword(s):  
Helicobacter Pylori ◽  
Pregnant Women ◽  
Epigastric Pain ◽  
Peptic Ulcers ◽  
Gastric Diseases ◽  
Number Of Patients ◽  
Mild Preeclampsia ◽  
Laboratory Investigations ◽  
H Pylori

Background: Helicobacter pylori is a gastric organism was first observed more than 100 years ago. It may cause chronic gastritis, peptic ulcers and gastric adenocarcinoma and lymphoma. It can produce some extragastric disorders including preeclampsia. This study aimed to focus on the importance of H. pylori and its relationship with preeclampsia and gastric illnesses in pregnant patients.Methods: This study includeed 100 pregnant women, half of them were healthy and the other half with preeclampsia. Patients with chronic medical illnesses were excluded. Data was collected and laboratory investigations were done including that for H. pylori. Oesophagogastroduodenoscopy then was done 6 weeks post-delivery or termination of pregnancy for symptomatic H. pylori positive women.Results: 50% of the total number were healthy, 17% had mild preeclampsia, 33% suffering from severe preeclampsia. Seropositivity for H. pylori is significantly higher in preeclampsia and significantly related to severity of preeclampsia and complications of pregnancy. Positive H. pylori test in stool was seen in (45%) of total number of patients. Epigastric pain persist in 41 (91%) of patients with positive H. pylori test in stool. Gastritis, duodenal ulcer, and gastric ulcer were found in 85.3%, 12.1% and 2.4% of symptomatic patients respectively.Conclusions: Significant correlation between Helicobacter pylori seropositivity and preeclampsia may indicate the benefit of using this parameter in the prediction and management of preeclampsia and its severity. H. pylori infection plays an important role in gastric pathologies in pregnant women that can be dealt with or may be prevented more efficiently in future. 

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