Post-Ejaculatory Pain as a Harbinger of Extraperitoneal Pelvic Metastasis Occurring Seven Years after Curative Surgery for Gastric Cancer

The role of HER-2 expression as a prognostic factor in gastric cancer (GC) is still controversial. The aim of the study was to asses HER-2 status, its correlations with clinicopathological parameters, and prognostic impact in GC patients. Tumor samples were collected from 78 patients who had undergone curative surgery. In order to evaluate the intensity of immunohistochemical (IHC) reactions two scales were applied: the immunoreactive score according to Remmele modified by the authors and standardised Hercep test score modified for GC by Hofmann et al. The HER-2 overexpression was detected by IHC in 23 (29.5%) tumors in Hercep test (score 2+/3+) and in 24 (30.7%) in IRS scale (IRS 4–12). The overexpression of HER-2 was associated with poorly differentiated tumors, but this correlation was not significant (P=0.064). No relationship was found between HER-2 expression and primary tumor size and degree of spread to regional lymph nodes. Both univariate and multivariate analyses revealed that TNM stage and patient’s age were the crucial negative prognostic factors. No correlation was observed between patient survival and expression of HER-2 estimated using both scales. This research did not confirm HER-2 expression (evaluated with immunohistochemistry) value as a prognostic tool in GC.

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Comparison of East and West Survival Nomograms in Turkish Gastric Cancer Patients Who Underwent Radical Surgery

Scandinavian Journal of Surgery ◽

10.1177/1457496918766724 ◽

2018 ◽

Vol 107 (4) ◽

pp. 308-314 ◽

Cited By ~ 1

Author(s):

Ö. Akgül ◽

S. Ocak ◽

S. B. Gündoğdu ◽

M. Yalaza ◽

C. E. Güldoğan ◽

...

Keyword(s):

Gastric Cancer ◽

Confidence Interval ◽

Survival Probability ◽

Goodness Of Fit ◽

Turkish Population ◽

Curative Surgery ◽

Goodness Of Fit Test ◽

Resectable Gastric Cancer ◽

East And West ◽

Gastric Cancer Patients

Background and Aim: The clinicopathological demonstrations of gastric cancer vary widely between Eastern and Western countries. Turkey is situated in Europe and Middle East which acts as a bridge between east and west. We aimed to validate the two popular nomograms of east and west origin by means of patients who underwent curative surgery for gastric cancer in our country. Material and Methods: Of the 202 patients diagnosed with gastric cancer between the years 2006 and 2013, 145 of these patients whose data were sufficient were included in the study. For all patients, demographic, laboratory, operative, and pathologic findings were documented. For each patient, prognostic factors were incorporated into the nomograms for estimating 5-year survival probability. Results: For a Turkish cohort, the western nomogram showed a better discriminative capacity (AUC = 0.721, 95% confidence interval 0.637–0.806) and was better calibrated (the Hosmer–Lemeshow goodness-of-fit test p = 0.323), as compared to the eastern nomogram with AUC = 0.615, 95% confidence interval 0.522–0.708, and p = 0.077, respectively. Conclusion: Western nomogram was found to be more effective than eastern nomogram in prediction of estimating 5-year survival probability in patients with resectable gastric cancer in Turkish population.

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Validation of a Nomogram to Predict Long Term Outcomes After Curative Surgery for Gastric Cancer in an Italian Cohort of Patients

Journal of Visceral Surgery ◽

10.1016/j.jviscsurg.2021.09.001 ◽

2021 ◽

Author(s):

G. Capelli ◽

A.S. Tonello ◽

V. Chiminazzo ◽

G. Lorenzoni ◽

Q.R. Bao ◽

...

Keyword(s):

Gastric Cancer ◽

Long Term Outcomes ◽

Curative Surgery ◽

Italian Cohort

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Gastric cancer

Oxford Textbook of Oncology ◽

10.1093/med/9780199656103.003.0037 ◽

2016 ◽

pp. 388-407

Author(s):

Hideaki Bando ◽

Takahiro Kinoshita ◽

Yasutoshi Kuboki ◽

Atsushi Ohtsu ◽

Kohei Shitara

Keyword(s):

Gastric Cancer ◽

Metallic Stent ◽

Curative Surgery ◽

Curative Intent ◽

Expandable Metallic Stent ◽

Pain Medications ◽

Gastric Stenosis ◽

Environmental Causes ◽

Endoscopic Placement

This chapter covers gastric cancers, beginning with epidemiology and molecular biology, including the association between Helicobacter pylori infection and gastric cancer, and other genetic and environmental causes. The role of surgical therapy in the treatment of gastric cancer including staging and resection with curative intent is presented. The medical management of gastric cancer is discussed, including adjuvant therapy after curative surgery and systemic treatment for palliation of metastatic disease, taking into account the differing biology and treatments in the East and West. The use of the first biologics in gastric cancer, trastuzumab and ramucirumab, and their mechanisms of action are described. Various modes of palliation of symptoms in patients with advanced gastric cancer include: gastrojejunostomy, endoscopic placement of a self-expandable metallic stent for gastric stenosis or obstruction, and pain control with pain medications and radiotherapy.

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