Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis

2019 ◽  
Vol 129 (3) ◽  
pp. 265-272
Author(s):  
Jonathan K. Lin ◽  
Lori C. Sakoda ◽  
Jeanne Darbinian ◽  
Melissa Socarras ◽  
Whitney Chiao ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Low Risk ◽  
Papillary Thyroid ◽  
Comparable Rate ◽  
Risk Of Death ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

Objectives: To examine the association between treatment status and mortality risk among patients with papillary thyroid cancer (PTC). Methods: We identified 3,679 adults with PTC. Thirty-one untreated patients were matched to 155 treated patients. Hazards ratios (HR) and 95% confidence intervals (CIs) were calculated to estimate all-cause and disease-specific mortality. A low-risk subgroup was analyzed for differences in all-cause mortality. Results: The adjusted HRs (95% CIs) for all-cause mortality at 5 and 10 years were 4.2 (1.7-10.3) and 4.1 (1.9-9.4) and for disease- specific mortality were 14.1 (3.4-59.3) and 10.2 (2.9-36.4), respectively, for untreated versus treated patients. The adjusted HRs (95% CIs) for all- cause mortality was 0.7 (0.1-6.4) for low-risk untreated versus matched treated patients. Conclusions: Compared to treated patients, untreated PTC patients were at higher risk of death while low-risk untreated PTC patients had comparable rate of metastasis and no increased risk of all-cause mortality. Level of evidence: 3

Risk factors associated with disease-specific mortality in papillary thyroid cancer patients with distant metastases

Endocrine ◽  
2021 ◽  
Author(s):  
Kamilla Schmitz Nunes ◽  
Leandro Luongo Matos ◽  
Beatriz Godoi Cavalheiro ◽  
Felipe Ferraz Magnabosco ◽  
Marcos Roberto Tavares ◽  
...  
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Cancer Patients ◽  
Papillary Thyroid Cancer ◽  
Distant Metastases ◽  
Papillary Thyroid ◽  
Factors Associated ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

Association of Serum Leptin with All-Cause and Disease Specific Mortality: A Meta-Analysis of Prospective Observational Studies

2018 ◽  
Vol 50 (07) ◽  
pp. 509-520 ◽  
Author(s):  
Hamed Kord-Varkaneh ◽  
Somaye Fatahi ◽  
Shahab Alizadeh ◽  
Ehsan Ghaedi ◽  
Sakineh Shab-Bidar
Keyword(s):  
Observational Studies ◽  
Meta Analysis ◽  
Healthy People ◽  
Serum Leptin ◽  
Risk Of Death ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Study Heterogeneity ◽  
Disease Specific Mortality ◽  
Disease Specific

AbstractLeptin levels may affect mortality through its link to inflammation and obesity. However, data are inconclusive. This meta-analysis was performed to investigate the association of leptin with mortality. The PubMed, Scopus, Google scholar, and reference lists of the included studies were searched for all published prospective observational studies that described the associations of serum leptin and mortality up to August 2017. Two reviewers independently assessed all potentially relevant studies for inclusion and methodological quality using standardized abstraction forms. Of 518 studies identified, 19 studies considered the association of leptin with all-cause mortality (16 208 subjects) and 12 studies evaluated the association of leptin with disease-specific mortality (13 680 subjects). In the overall analysis, no significant association was found between leptin and all-cause mortality (HR=1.028; 95% CI: 0.908–1.165; p=0.659), with a high between study heterogeneity (p˂0.001, I2=61). Subgroup analysis found that high leptin is associated with increased all-cause mortality in healthy people (HR=1.159 (95% CI, 1.032, 1.302), p=0.012), in men (HR=1.162; 95% CI: 1.036–1.302; p=0.010), and in subjects with ≥60 years old (HR=1.129; 95% CI: 1.030–1.238; p=0.010); whereas, increased leptin levels was related to the decreased cancer-specific mortality ((HR=0.550; 95% CI: 0.418–0.724), p˂0.001). Higher leptin levels in healthy people, old people, and males were associated with increased all-cause mortality, while increased leptin level was related to the reduced risk of death among patients with cancer.

scholarly journals Decision-making in Surgery or Active Surveillance for Low Risk Papillary Thyroid Cancer During the COVID-19 Pandemic

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 371
Author(s):  
Anna Sawka ◽  
Sangeet Ghai ◽  
Ogemdi Ihekire ◽  
Jennifer Jones ◽  
Amiram Gafni ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Active Surveillance ◽  
Low Risk ◽  
Observational Research ◽  
Papillary Thyroid ◽  
Missed Appointments ◽  
Physician Visits ◽  
Observational Cohort ◽  
Study Participants

We describe our experience conducting a prospective observational cohort study on the management of small, low risk papillary thyroid cancer during the COVID-19 pandemic. Our study participants are given the choice of active surveillance (AS) or surgery, and those in the AS arm are followed at the study center, whereas surgical patients undergo usual care. During the pandemic we have transitioned from in-person research patient visits to largely virtual care of patients under AS. As of 30 October 2020, we had enrolled 181 patients enrolled in our study (including 25 during the pandemic), of which 92.3% (167/181) consented to telephone communication and 79.0% (143/181) consented to secure videoconferencing communication. Prior to the pandemic, 74.5% (117/157) of our patients chose AS over surgery, whereas during the pandemic, 96.0% (24/25) chose AS. Of the 133 study patients who were under AS within the timeframe from 12 March 2020, to 30 October 2020, the percentage of patients who missed appointments was 8.3% (11/133, for neck ultrasound and physician visits, respectively) and delayed appointments was 23.3% (31/133). This preliminary data suggests that prospective observational research on AS of thyroid cancer can safely continue during the pandemic.

scholarly journals Multidisciplinary approach for risk-oriented treatment of low-risk papillary thyroid cancer in Switzerland

2019 ◽  
Author(s):  
Henryk Zulewski ◽  
Luca Giovanella ◽  
Stefan Bilz ◽  
Emanuel Christ ◽  
Andreas Haldemann ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Multidisciplinary Approach ◽  
Low Risk ◽  
Papillary Thyroid

Associations Between Handgrip Strength and Disease-Specific Mortality Including Cancer, Cardiovascular, and Respiratory Diseases in Older Adults: A Meta-Analysis

2020 ◽  
Vol 28 (2) ◽  
pp. 320-331
Author(s):  
Junga Lee
Keyword(s):  
Older Adults ◽  
Older Women ◽  
Respiratory Diseases ◽  
Handgrip Strength ◽  
Meta Analysis ◽  
Adult Participants ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

Several controversial studies linking handgrip strength and health have suggested that low handgrip strength in older adults may be related to health problems and have investigated whether there is a minimum handgrip strength level associated with reduced mortality. Thus, by meta-analysis, the authors identified an association between handgrip strength in older adults and disease-specific mortality and all-cause mortality. Thirty studies with a total of 194,767 older adult participants were included in this meta-analysis. Higher handgrip strength was associated with an 18% decrease in all-cause mortality. Lower handgrip strength was associated with increased all-cause mortality. The minimum handgrip strength in older women that did not increase all-cause mortality was 18.21 kg. Increased handgrip strength showed a decreased all-cause mortality, whereas decreased handgrip strength was associated with increased all-cause mortality. Strengthening the handgrip may help improve disease-specific mortality in older adults.

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