Mucus Gland Tumors of the Larynx and Laryngopharynx

During the 30–year period from 1939 through 1968, 20 patients were seen who had “minor salivary” tumors arising in the mucus glands of the larynx or laryngopharynx. This group comprised about 3% of more than 600 patients with mucus gland tumors of the upper aerodigestive tract treated at Memorial Sloan-Kettering Cancer Center during the same interval. In each instance the tumor was malignant, and all but three of these patients were men. Location and histology of these uncommon tumors is described. Only 2 of 18 treated cases were “cured.” Uncontrolled cervical lymph node involvement or distant metastasis was more often the reason for treatment failure, rather than local recurrence at the primary site.

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Lymph Node Involvement In Upper Aerodigestive Tract Cancers - A Clinical Study at Specialities University Hospital of Rabat

International Journal of Medicine and Surgery ◽

10.15342/ijms.v1i2.56 ◽

2014 ◽

Vol 1 (2) ◽

pp. 49-52

Author(s):

Rajae Borki ◽

Ali Elayoubi ◽

Razika Bencheikh ◽

Abdelilah Oujilal ◽

Anass Benbouzid ◽

...

Keyword(s):

Lymph Node ◽

Oral Cavity ◽

Cervical Lymph Node ◽

Maxillofacial Surgery ◽

Lymph Node Involvement ◽

Aerodigestive Tract ◽

University Hospital ◽

Upper Aerodigestive Tract ◽

Female Ratio ◽

Node Involvement

Introduction: Cervical lymph node involvement has a major impact on prognosis and treatment decisions in patients with upper aerodigestive tract (UADT) cancer. Objective: The aim of this study was to assess the incidence and pattern of cervical lymph node (LN) metastases in cancers of the upper aerodigestive tract Methods: This prospective study was conducted by the Department of ENT and Maxillofacial Surgery at Specialities University Hospital of Rabat, collecting data between October 2009 and December 2011. Lymph nodes were counted, clinically and radiologically localized, excised, then studied histologically. Results: During this period, 106 patients have been treated surgically with a recent diagnosis of UADT cancer. The average age of our patients was 55±13.3 years, while male/female ratio was 3.5 to 1. More than half of our patients were operated with cancer of the larynx (58.5%, n=62); 27.4% (n=29) of patients suffered from oral cavity cancer and 14.2% (n=15) had cancer of the hypopharinx. Cervical lymph node invasion was estimated at 31.2% clinically, and 38.7% radiologically and histologically, distributed in different sites. Although the percentage of the invasion is almost similar clinically, radiologically and histologically, the high number of false positives and true negatives according to clinical and radiological exams confirms that specificity and sensitivity of these two exams is still poor compared to histology. Conclusion: Thus, cervical metastases have to be diagnosed histologically. Moreover, the low percentage of lymph node invasions in the case of a UADT cancer suggests that the use of sentinel lymph node technique could be important, as it has been validated for small T1T2N0 tumors in the oral cavity. Further studies are needed to confirm its validity in case of other UADT tumor types

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The feasibility of contralateral lower neck sparing intensity modulation radiated therapy for nasopharyngeal carcinoma patients with unilateral cervical lymph node involvement

Oral Oncology ◽

10.1016/j.oraloncology.2017.03.010 ◽

2017 ◽

Vol 69 ◽

pp. 68-73 ◽

Cited By ~ 5

Author(s):

Ling-Long Tang ◽

Xin-ran Tang ◽

Wen-fei Li ◽

Lei Chen ◽

Li Tian ◽

...

Keyword(s):

Lymph Node ◽

Nasopharyngeal Carcinoma ◽

Cervical Lymph Node ◽

Lymph Node Involvement ◽

Intensity Modulation ◽

Node Involvement ◽

Lower Neck

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Clinical impact of cervical lymph node involvement and central neck dissection in patients with papillary thyroid carcinoma: a retrospective analysis of 368 cases

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-011-1639-2 ◽

2011 ◽

Vol 268 (8) ◽

pp. 1205-1212 ◽

Cited By ~ 35

Author(s):

Alexandre Bozec ◽

Olivier Dassonville ◽

Emmanuel Chamorey ◽

Gilles Poissonnet ◽

Anne Sudaka ◽

...

Keyword(s):

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Cervical Lymph Node ◽

Lymph Node Involvement ◽

Central Neck Dissection ◽

Clinical Impact ◽

Central Neck ◽

Papillary Thyroid ◽

Node Involvement

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Surgical management of urachal tumors: Can the umbilicus be sparred in localized disease?

Rare Tumors ◽

10.1177/2036361319847283 ◽

2019 ◽

Vol 11 ◽

pp. 203636131984728

Author(s):

Cristian Pavelescu ◽

Alexandra Pavelescu ◽

Cristian Surcel ◽

Cristian Mirvald ◽

Mario Alvarez-Maestro ◽

...

Keyword(s):

Lymph Node ◽

Surgical Treatment ◽

Local Recurrence ◽

Distant Metastasis ◽

Lymph Node Involvement ◽

Partial Cystectomy ◽

En Bloc ◽

Node Involvement ◽

Urachal Adenocarcinoma

Urachal adenocarcinoma represents the third most common histological type of non-urotelial bladder cancer. A very low incidence of this disease and the lack of prospective studies have led to a rich and heterogeneous treatment history. Currently, the standard of care for these patients is represented by partial cystectomy en bloc with resection of the urachal ligament and total omphalectomy. The aim of this article is to present our experience and results in the management of patients with urachal adenocarcinoma. Between 2005 and 2015, 16 patients have undergone surgical treatment for urachal adenocarcinoma in “Fundeni” Clinical Institute and Madrid University Hospital “Infanta Sofia.” Partial cystectomy was performed in 11 (68.76%) patients, while radical cystectomy en bloc with omphalectomy was performed in 5 (31.25%) patients, which were not amendable to a limited resection. The Sheldon classification was used, as it provides appropriate disease staging and is the most commonly utilized. Postoperative pathological results showed that 7 (43.75%) patients had localized tumors, and more than one-third (37.5%) of the patients had locally advanced Sheldon III disease, while 3 patients had distant metastasis at the time of surgery. Lymph node involvement was present in 3 patients (18.75%). Mean follow-up time was 2.5 years, ranging from 4 months to 7.6 years. Three patients (18.75%) were lost to follow-up, without any documented signs of local or systemic recurrence and were cancer free at the time of the last evaluation. In cases with lymph node involvement, local recurrence or distant metastasis, patients underwent cisplatin- or 5-fluorouracil-based salvage chemotherapy. Surgical treatment represents the gold standard, while adjuvant chemotherapy has a limited impact on overall survival. The utility of navel resection is questionable due to the rarity of direct invasion or local recurrence.

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Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature

Virchows Archiv ◽

10.1007/s00428-005-1209-3 ◽

2005 ◽

Vol 446 (5) ◽

pp. 546-554 ◽

Cited By ~ 16

Author(s):

Ömer Uluoğlu ◽

Nalan Akyürek ◽

Aytuğ Üner ◽

Uğur Coşkun ◽

Ayşegul Özdemir ◽

...

Keyword(s):

Case Report ◽

Lymph Node ◽

Dendritic Cell ◽

Cervical Lymph Node ◽

Lymph Node Involvement ◽

Cell Tumor ◽

Review Of The Literature ◽

Node Involvement

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Langerhans Cell Histiocytosis of the Thyroid with Multiple Cervical Lymph Node Involvement Accompanying Metastatic Thyroid Papillary Carcinoma

Case Reports in Pathology ◽

10.1155/2014/184237 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5

Author(s):

A. Bahar Ceyran ◽

Serkan Şenol ◽

Barış Bayraktar ◽

Şeyma Özkanlı ◽

Z. Leyla Cinel ◽

...

Keyword(s):

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Langerhans Cell Histiocytosis ◽

Cervical Lymph Node ◽

Lymph Node Involvement ◽

Langerhans Cell ◽

Papillary Thyroid ◽

Thyroid Papillary ◽

Node Involvement

A 37-year-old male case was admitted with goiter. Ultrasonography of thyroid showed a 5 cm cystic nodule in the left lobe with a 1.5 cm solid component. Fine needle aspiration biopsy revealed atypia of undetermined significance or follicular lesion. The patient was operated on. The pathological diagnosis was reported as papillary thyroid carcinoma. The immunohistochemical examination showed multiple foci of Langerhans cell histiocytosis involving both lobes. The patient died due to cardiac arrest with respiratory causes in the early postoperative period. Langerhans cell histiocytosis is a rare primary condition which involves abnormal clonal proliferation of Langerhans cells in various tissues and organs. Thyroid involvement is infrequently seen. Although the etiology is unknown, genetic components may be linked to the disease. It is also associated with a family history of thyroid disease. Papillary thyroid carcinoma is the most common malignant epithelial tumor of the thyroid gland. Langerhans cell histiocytosis presenting with papillary thyroid carcinoma is rare. The privilege of our case is langerhans cell histiocytosis of the thyroid with multiple cervical lymph node involvement accompanying cervical lymph node metastatic thyroid papillary carcinoma.

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