Myringosclerosis Caused by Increased Oxygen Concentration in Traumatized Tympanic Membranes Experimental Study

1995 ◽  
Vol 104 (8) ◽  
pp. 625-632 ◽  
Author(s):  
Cecilia Mattsson ◽  
Karin Magnuson ◽  
Sten Hellström
Keyword(s):  
Experimental Study ◽  
Oxygen Concentration ◽  
Middle Ear ◽  
Oxygen Radicals ◽  
Ambient Air ◽  
Fourth Group ◽  
Oxygen Concentrations ◽  
Tympanic Membranes

The purpose of this study was to elucidate possible relationships between the oxygen concentration of the middle ear cavity and the development of myringosclerosis. Three groups of rats with myringotomized tympanic membranes were exposed to different oxygen concentrations of 10%, 15%, and 40%, respectively, for 1 week. A fourth group was kept in ambient air. Two other groups of rats with myringotomized and intubated tympanic membranes were exposed to oxygen concentrations of 10% and 40%, respectively, for the same period of time. Otomicroscopically, all hyperoxic animals had more numerous myringosclerotic lesions compared with the ambient air group, and also displayed a pronounced hyperplasia of the keratinizing epithelium around the perforation border. By contrast, the hypoxic animals showed less pronounced myringosclerotic lesions or even completely lacked them. It is inferred that an increased oxygen concentration in the middle ear cavity will increase the likelihood of myringosclerotic deposits. The mechanism involved could be related to the formation of oxygen radicals.

Large Eddy Simulation of Multiple-Stage Ignition Process of n-Heptane Spray Flame

2019 ◽  
Vol 141 (8) ◽  
Author(s):  
Wanhui Zhao ◽  
Lei Zhou ◽  
Wenjin Qin ◽  
Haiqiao Wei
Keyword(s):  
Oxygen Concentration ◽  
Mixture Fraction ◽  
Ignition Process ◽  
Low Oxygen ◽  
Nonpremixed Combustion ◽  
Eddy Simulation ◽  
Spray Flames ◽  
Large Eddy ◽  
Initial Oxygen ◽  
Oxygen Concentrations

Large eddy simulation of n-heptane spray flames is conducted to investigate the multiple-stage ignition process under extreme (low-temperature, low oxygen, and high-temperature, high-density) conditions. At low oxygen concentrations, the first-stage ignition initiates in the fuel-rich region and then moves to stoichiometric equivalence ratio regions by decreasing the initial temperature. It is also clear that at high temperatures, high oxygen concentrations, or high densities, the reactivity of the mixture is enhanced, where high values of progress variable are observed. Analysis of key intermediate species, including acetylene (C2H2), formaldehyde (CH2O), and hydroxyl (OH) in the mixture fraction and temperature space provides valuable insights into the complex combustion process of the n-heptane spray flames under different initial conditions. The results also suggest that C2H2 appears over a wider range in the mixture fraction space at higher temperature or oxygen concentration condition, implying that it mainly forms at the fuel-rich regions. The initial oxygen concentration of the ambient gas has great influence on the formation and oxidization of C2H2, and the maximum temperature depends on the initial oxygen concentration. OH is mainly formed at the stoichiometric equivalence ratio region, which moves to high-temperature regions very quickly especially at higher oxygen concentrations. Finally, analysis of the premixed and nonpremixed combustion regimes in n-heptane spray flames is also conducted, and both premixed and nonpremixed combustion coexist in spray flames.

scholarly journals Performance evaluation of a 15 kWth biomass gasifier in downdraft and updraft operating modes: an experimental study

2018 ◽  
Vol 172 ◽  
pp. 06005
Author(s):  
K. Shanmuganandam ◽  
J. Anichai ◽  
V. Jayakumar
Keyword(s):  
Power Generation ◽  
Experimental Study ◽  
Performance Evaluation ◽  
Performance Analysis ◽  
Ambient Air ◽  
Producer Gas ◽  
Operating Modes ◽  
Feed Stock ◽  
Alternate Source ◽  
And Performance

Biomass gasifiers are equipment’s that can generate producer gas which is a renewable, alternate source of energy that can be employed for power generation and thermal applications. In this experimental study the gasifier is tested in updraft and downdraft modes and performance analysis was carried out. For both the studies, casuarina wood and ambient air were used as feed stock and gasification agent respectively. From the experimental analysis it was inferred that the performance of the biomass gasifier was higher in downdraft mode than updraft mode.

scholarly journals The FLASH effect depends on oxygen concentration

2020 ◽  
Vol 93 (1106) ◽  
pp. 20190702 ◽  
Author(s):  
Gabriel Adrian ◽  
Elise Konradsson ◽  
Michael Lempart ◽  
Sven Bäck ◽  
Crister Ceberg ◽  
...  
Keyword(s):  
Oxygen Concentration ◽  
Underlying Mechanism ◽  
Oxygen Depletion ◽  
Therapeutic Window ◽  
High Dose ◽  
Dose Rates ◽  
Conventional Dose ◽  
Oxygen Concentrations

Objective: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen depletion has been proposed as the underlying mechanism, but in vitro data to support this have been lacking. The aim of the current study was to compare FLASH to CONV irradiation under different oxygen concentrations in vitro. Methods: Prostate cancer cells were irradiated at different oxygen concentrations (relative partial pressure ranging between 1.6 and 20%) with a 10 MeV electron beam at a dose rate of either 600 Gy/s (FLASH) or 14 Gy/min (CONV), using a modified clinical linear accelerator. We evaluated the surviving fraction of cells using clonogenic assays after irradiation with doses ranging from 0 to 25 Gy. Results: Under normoxic conditions, no differences between FLASH and CONV irradiation were found. For hypoxic cells (1.6%), the radiation response was similar up to a dose of about 5–10 Gy, above which increased survival was shown for FLASH compared to CONV irradiation. The increased survival was shown to be significant at 18 Gy, and the effect was shown to depend on oxygen concentration. Conclusion: The in vitro FLASH effect depends on oxygen concentration. Further studies to characterize and optimize the use of FLASH in order to widen the therapeutic window are indicated. Advances in knowledge: This paper shows in vitro evidence for the role of oxygen concentration underlying the difference between FLASH and CONV irradiation.

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