Serum myonectin is increased after laparoscopic sleeve gastrectomy

2020 ◽  
Vol 57 (5) ◽  
pp. 360-364
Author(s):  
Lei Li ◽  
Qianqian Wang ◽  
Chengkun Qin
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Sleeve Gastrectomy ◽  
Linear Regression ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Acid Uptake ◽  
Model Assessment ◽  
Obese Patients

Objective Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. Recent studies showed that serum myonectin concentration is negatively correlated with obesity. This study was undertaken to evaluate the change of serum myonectin in obese patients after laparoscopic sleeve gastrectomy. Methods This study was performed in a population of 42 obese and 58 control subjects from April of 2018 to December of 2019. All obese subjects underwent laparoscopic sleeve gastrectomy. Anthropometric measurements, lipid profiles, HbA1c and serum myonectin were assessed at baseline and six months after laparoscopic sleeve gastrectomy. Results Serum myonectin concentrations were significantly lower in the obese patients than in the controls. Serum myonectin concentrations were increased at six months after laparoscopic sleeve gastrectomy. Simple linear regression analysis indicated that serum myonectin was negatively correlated with weight, waist circumference, hip circumference, body mass index, fasting plasma glucose, homeostasis model assessment of insulin resistance and HbA1c. Only body mass index was still inversely correlated with serum myonectin after multiple linear regression analysis. Conclusion Serum myonectin is correlated with obesity and increased after laparoscopic sleeve gastrectomy.

scholarly journals Left Atrial Deformation And Risk of Transient Ischemic Attack And Stroke In Paroxysmal Atrial Fibrillation

2021 ◽  
Author(s):  
Jian Chen ◽  
Ying Zhao ◽  
Changsheng Ma ◽  
Xin Du ◽  
Yihua He
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Mass ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Linear Regression Analysis ◽  
Volume Index ◽  
Chamber View

Abstract Left atrial (LA) remodeling is closely related to cerebral stroke, but the relationship between impaired deformability of LA in early stages and stroke/TIA is not clear. The aim of this study was to evaluate the changes of LA deformability and its relationship with stroke/TIA events by using Speckle Tracking echocardiography. In 365 patients with paroxysmal atrial fibrillation (AF) (318, Non stroke/TIA; 47, stroke/TIA), comprehensive echocardiography was performed by using speckle tracking imaging to calculate mean LA longitudinal strain and strain rate values from apical four chamber view, apical two chamber view and apical three cavity view. The patients in stroke/TIA group had greater ages, a greater proportion of men and lower LA strain rate during left ventricular (LV) early diastole (SRE), and the difference was statistically significant(p<0.05). In the univariate linear regression analysis, the following clinical and conventional echocardiographic parameters each had a significant linear correlation with SRE(p<0.001), they were E/A ratio, LA volume index, body mass index, mean E/e′, LV ejection fraction, age, proportion of hypertension. Through a multiple linear regression analysis, the results show that there is a linear dependence between SRE and E/A ratio, LA volume index and Body mass index. The regression equation is y=-1.430-0.394X1+0.012X2+0.019X3(p<0.001) (y,SRE; X1,E/A ratio; X2,LA volume index; X3,Body mass index).In the multivariate logistic regression analyses, SRE and Sex ratio were independently risk factors stroke/TIA. (SRE, OR 2.945, 95% CI 1.092-7.943, p= 0.033; Sex, OR 0.462, 95% CI 0.230-0.930, p = 0.031)In patients with paroxysmal AF, SRE could reflect the impaired deformability of LA in early stages, and it was associated with the risk of stroke/TIA.

Risk factors for development of obesity in an ethnically diverse CHD population

2019 ◽  
Vol 29 (2) ◽  
pp. 123-127
Author(s):  
Scott J. Weinreb ◽  
Abigail J. Pianelli ◽  
Sreyans R. Tanga ◽  
Ira A. Parness ◽  
Rajesh U. Shenoy
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Longitudinal Data ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Paediatric Population ◽  
Post Surgery ◽  
Significant Difference ◽  
Age Cohort

AbstractObjectivesPrevious cross-sectional studies have demonstrated obesity rates in children with CHD and the general paediatric population. We reviewed longitudinal data to identify factors predisposing to the development of obesity in children, hypothesising that age may be an important risk factor for body mass index growth.Study designRetrospective electronic health records were reviewed in all 5–20-year-old CHD patients seen between 2011 and 2015, and in age-, sex-, and race/ethnicity-matched controls. Subjects were stratified into aged cohorts of 5–10, 11–15, and 15–20. Annualised change in body mass index percentile (BMI%) over this period was compared using paired Student’s t-test. Linear regression analysis was performed with the CHD population.ResultsA total of 223 CHD and 223 matched controls met the inclusion criteria for analysis. Prevalence of combined overweight/obesity did not differ significantly between the CHD cohort (24.6–25.8%) and matched controls (23.3–29.1%). Univariate analysis demonstrated a significant difference of BMI% change in the age cohort of 5–10 (CHD +4.1%/year, control +1.7%/year, p=0.04), in male sex (CHD +1.8%/year, control −0.3%/year, p=0.01), and status-post surgery (CHD 2.03%/year versus control 0.37%, p=0.02). Linear regression analysis within the CHD subgroup demonstrated that age 5–10 years (+4.80%/year, p<0.001) and status-post surgery (+3.11%/year, p=0.013) were associated with increased BMI% growth.ConclusionsPrevalence rates of overweight/obesity did not differ between children with CHD and general paediatric population over a 5-year period. Longitudinal data suggest that CHD patients in the age cohort 5–10 and status-post surgery may be at increased risk of BMI% growth relative to peers with structurally normal hearts.

scholarly journals Laparoscopic Sleeve Gastrectomy for Mildly Obese Patients (Body Mass Index of 30 <35 kg/m2): Operative Outcome and Short-Term Results

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Roger Noun ◽  
Ghassan Chakhtoura ◽  
Marwan Nasr ◽  
Judith Skaff ◽  
Naîm Choucair ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Sleeve Gastrectomy ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Body Mass ◽  
Operative Time ◽  
Excess Weight ◽  
Obese Patients ◽  
Short Term ◽  
Preoperative Body Mass Index ◽  
Mild Obesity

Background. Data concerning laparoscopic sleeve gastrectomy (LSG) in mild obesity are under investigation.Aim/Objective. May 2010 to May 2012, 122 consecutive patients with preoperative body mass index (BMI) of33±2.5 kg/m2(range 30–34.9) undergoing LSG were studied. Mean age was33±10years (range 15–60), and 105 (86%) were women. Mean preoperative weight was91±9.7 kg (range 66–121), and preoperative excess weight was30±6.7 kg (range 19–43). Comorbidities were detected in 44 (36%) patients.Results. Mean operative time was58±15 min (range 40–95), and postoperative stay was1.8±0.19days (range 1.5–3). There were no admissions to intensive care unit and no deaths within 30 days of surgery. The rates of leaks and strictures were 0%, and of hemorrhage 1.6%. At 12 months, BMI decreased to24.7±2, and the percentage of excess weight loss (% EWL) reached 76.5%. None of the patients had a BMI below 20 kg/m2. Comorbidities resolved in 70.5% or improved in 29.5%. Patient satisfaction scoring (1–5) at least 1 year after was4.6±0.8for body image and4.4±0.6for food tolerance.Conclusion. LSG for mildly obese patients has proved to be technically relatively easy, safe, and benefic in the short term.

Correlation of serum myonectin concentrations with the presence and severity of obstructive sleep apnoea syndrome

2020 ◽  
pp. 000456322097868
Author(s):  
Huili Zou ◽  
Weiyi Yang ◽  
Yan Liu
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Total Cholesterol ◽  
Body Mass ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Acid Uptake ◽  
Model Assessment ◽  
Lower Serum ◽  
Obstructive Sleep

Objective Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating concentrations of free fatty acids in mice. This study is performed to evaluate the association between serum myonectin concentrations with the presence and severity of OSAS. Methods This study was performed in a population of 191 patients with OSAS and 105 control subjects. Serum myonectin concentrations were measured using enzyme-linked immunosorbent assay method. Results Lower serum myonectin concentrations were found in OSAS patients than in the controls. Serum myonectin concentrations were associated with a reduced risk of OSAS (OR: 0.988, 95% CI: 0.984–0.993, P <  0.001). Severe OSAS patients had significantly lower myonectin concentrations compared with mild and moderate OSAS patients ( P <  0.001 and P  =   0.001, respectively). There are lower serum myonectin concentrations in moderate patients compared with mild patients ( P  =   0.024). Pearson correlation analysis revealed that serum myonectin concentrations were negatively correlated with the severity of OSAS (r = −0.344, P <  0.001). Simple linear regression analysis showed that serum myonectin concentrations in OSAS patients were negatively correlated with body mass index, fasting plasma glucose, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C) and apnoea hypopnea index. Multiple stepwise regression analysis shows that body mass index (β = −0.289, P  =   0.03), HOMA-IR (β = −0.19, P  =   0.003), total cholesterol (β = −0.155, P  =   0.016), LDL-C (β = −0.176, P  =   0.006) and apnoea hypopnea index (β = −0.263, P <  0.001) remained to be associated with serum myonectin. Conclusion Serum myonectin concentrations are inversely correlated with the presence and severity of OSAS.

scholarly journals Predictors of Hypertension among Nonpregnant Females Attending Health Promotion Clinic with Special Emphasis on Smokeless Tobacco: A Cross-Sectional Study

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Devika Bhatt ◽  
Shashi Sharma ◽  
Ruchika Gupta ◽  
Dhirendra N. Sinha ◽  
Ravi Mehrotra
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Health Promotion ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Mass ◽  
Smokeless Tobacco ◽  
Linear Regression Analysis ◽  
High Body Mass Index ◽  
Cross Sectional

Aim. To determine the predictors of hypertension among nonpregnant females attending a health promotion clinic. Design and Setting. A cross-sectional study was conducted during March to June 2016, at the National Institute of Cancer Prevention and Research, India. Methods. The study included 319 nonpregnant females of age 20–70 years. Demographics such as age, literacy, and income were noted. History regarding use, frequency, and quantity of smokeless tobacco was taken. Height, weight, and blood pressure were measured and body mass index was calculated. Statistical Analysis. Pearson’s product-moment correlation coefficient was calculated between each of the variables of age, smokeless tobacco consumption, and body mass index versus systolic and diastolic blood pressure, respectively. The linear as well as multiple linear regression analysis was employed to identify the risk factors for hypertension. Results. A univariate linear regression analysis showed that age, smokeless tobacco consumption, and body mass index were associated with systolic blood pressure (P value < 0.001 for each). For diastolic blood pressure, high body mass index was a predictor. Multiple linear regression analysis showed that both systolic and diastolic hypertension were associated with high body mass index and low level of education. Moreover, the systolic hypertension was associated with higher age and smokeless tobacco use. Conclusion. Health promotion requires control of body mass index and smokeless tobacco cessation for preventing hypertension and its complications.

scholarly journals Shortening of Leucocyte Telomerase Length Is Independently Correlated With High Body Mass Index and Subcutaneous Obesity (Predominantly Truncal), in Asian Indian Women With Prediabetes

2021 ◽  
Author(s):  
Surya Prakash Bhatt ◽  
Anoop Misra ◽  
Ravindra Mohan Pandey ◽  
Ashish Datt Upadhyay
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Mass ◽  
Asian Indian ◽  
Quantitative Polymerase Chain Reaction ◽  
Linear Regression Analysis ◽  
Indian Women ◽  
Asian Indian Women ◽  
Multivariable Linear Regression Analysis

Abstract Introduction: Leucocyte telomerase length (LTL) are inked to accelerate aging and premature mortality. In this research, we aimed to explore the relations between biochemical and anthropometry markers and LTL in Asian Indian women with prediabetes.Methods: In this study, 797 prediabetic women (aged 20-60 years, obese, 492; non obese, 305) were recruited. Demographic and clinical profiles, medical history, skin exposure and duration of sunlight exposure were determined. Anthropometry, fasting blood glucose and serum 25-hydroxyvitamin D [25(OH) D] were evaluated. LTL was quantified by a quantitative polymerase chain reaction (qPCR). The study subjects were separated into quartiles groups according to the LTL.Results: The average telomerase length (T/S) ratio was significantly decreased with increasing age. The average telomerase length (T/S) ratio was significantly shorter in obese women with prediabetes (p<0.05). Univariate and multivariable linear regression analysis after adjustment for age, family income, education and hypertension showed that LTL was inversely correlated with body mass index (BMI), waist and hip circumference, waist-hip and waist-to-height ratio, and truncal skinfolds (subscapular, lateral thoracic, and subscapular/triceps ratio, central and total). Multivariable linear regression analysis identified BMI (93%, p<0.0001), central (92%, p<0.0001) and total skinfolds (90%, p<0.0001) as independent predictors of LTL. Conclusions: Besides age, obesity, and subcutaneous adiposity (predominantly truncal) are major contributors to telomerase shortening in Asian Indian women with prediabetes.

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