scholarly journals The Value of C-Reactive Protein in the Diagnosis of Intestinal Perforation in Typhoid Fever

1989 ◽  
Vol 26 (3) ◽  
pp. 246-248 ◽  
Author(s):  
I O Olubuyide ◽  
N M Brown ◽  
J Higginson ◽  
J T Whicher
Keyword(s):  
Early Diagnosis ◽  
Typhoid Fever ◽  
Intestinal Perforation ◽  
C Reactive Protein ◽  
Ileal Perforation ◽  
Reactive Protein

Serum C-reactive protein concentrations were measured in 28 Nigerian patients with typhoid fever on presentation at hospital and at intervals thereafter. Five of the 28 (18%) were subsequently diagnosed as suffering from ileal perforation. These patients had concentrations of C-reactive protein during the first 24 h of admission which were significantly higher (mean = 229 mg/L) than those without perforation (mean = 91 mg/L). C-reactive protein may have a role in the prediction of early diagnosis of perforation in patients with typhoid fever.

scholarly journals Fatal typhoid intestinal perforation in post tubal ligation death with an alleged medical negligence: a rare case report

2018 ◽  
Vol 7 (2) ◽  
pp. 755
Author(s):  
Pankaj Suresh Ghormade ◽  
Ajay Narmadaprasad Keoliya
Keyword(s):  
Typhoid Fever ◽  
Intestinal Perforation ◽  
Rare Case ◽  
Tubal Ligation ◽  
Medical Negligence ◽  
Free Perforation ◽  
Ileal Perforation ◽  
Rare Case Report ◽  
History Of ◽  
Difficult Challenge

Worldwide tubal sterilization is commonly used procedure for family planning method. Tubal ligation by minilaparotomy under local anaesthesia is most commonly used method of female sterilization in India. The death rate after tubal sterilizations is 72/100000 for all procedures and mainly due to general anaesthesia or vascular injuries. Iatrogenic injury to bowel can occur in minilaparotomy tubal ligations if there are dense adhesions of intestines or history of previous surgery. In the present case of interval post tubal ligation by minilaparotomy, fatal ileal perforation due to typhoid fever was detected on autopsy which was confirmed after complete histological and lab investigations. Atypical complications of typhoid fever were also noted. In developing countries, typhoid fever is the leading cause of non-traumatic free perforation of intestine and its incidence ranges from 0.9% to 39%, with a high mortality rate. This is rare case of an alleged medical negligence after surgery; in which deciding factor was cause of intestinal perforation i.e. iatrogenic or natural and it posed a difficult challenge.

scholarly journals Role of Serial C-reactive Protein (CRP) in Relation to Total Leucocyte Count, Platelet Count & Blood Culture for early Diagnosis of Neonatal Septicemia in Developing Countries

2015 ◽  
Vol 32 (2) ◽  
pp. 61-65
Author(s):  
Chiranjib Barua ◽  
Md Nurul Anwar ◽  
Md Shahidullah ◽  
Shahadat Hossain ◽  
Sharmila Barua ◽  
...  
Keyword(s):  
Developing Countries ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Neonatal Sepsis ◽  
Leucocyte Count ◽  
Control Group ◽  
Total Leucocyte Count ◽  
C Reactive Protein ◽  
Neonatal Septicemia ◽  
Reactive Protein

Neonatal septicemia is a clinical syndrome of systemic illness accompanied by bacteremia occuring in the first 28 days of life. Neonatal septicemia is one of the major causes of neonatal death in developing countries. Early diagnosis and treatment can prevent neonatal mortality and morbidity. The present study includes: 1) usefulness of CRP (C-reactive protein), Total Leucocyte Count, Platelet Count and Blood Culture in early diagnosis of Neonatal Sepsis, 2) significance of serial CRP in diagnosis of neonatal sepsis. 3) the prognostic value of CRP in neonatal sepsis. This is a prospective study done in neonatal ward, Chittagong Medical College Hospital and carried out from January 2008 to January 2011. Sample size was 300. One hundred fifty neonates with suspected sepsis as cases and 150 healthy babies as control were enrolled in this study. Seventy two percent of cases neonates were preterm and low birth weight. Common risk factors for neonatal septicemia which were identified in this study; preterm (72%), low birth weight (72%), premature rupture membrane (60%), chorioamnionitis (26%) and maternal urinary tract infection (16%) . Out of 150 cases of suspected neonatal sepsis total 80.7%% had raised CRP, in initial sample 70.39% were CRP positive and in 2nd sample additional 9.31% case were CRP positive . In control group 91% were CRP negative. CRP was positive in 100% of culture proven sepsis. Sensitivity of CRP was 80.67% and specificity of CRP was 76.44%. Leucocytosis was observed in 7% of cases and leucopenia was found in 11% of cases. In 82 % cases leucocyte count was found normal. In control group, 95% had normal leucocyte count and 5% had leucocytosis but no leucopenia. Sensitivity of leucocyte count was 18% and specificity was 20.68%. Thrombocytopenia was found in 28% of case group. Out of 150 cases only 15.33% yielded growth of organisms in blood culture. Klebsiella was the most common pathogen isolated which was followed by E.coli and Strph. aureus. Sensitivity of blood culture was 15.33% and specificity was 100% Therefore serial CRP can be taken as alternative method for diagnosis of neonatal sepsis specially in developing countries where blood culture is not readily available.J Bangladesh Coll Phys Surg 2014; 32: 61-65

Sepsis Screen Questioned

PEDIATRICS ◽  
1981 ◽  
Vol 68 (1) ◽  
pp. 153-153
Author(s):  
Patrick R. Murray
Keyword(s):  
Early Diagnosis ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Neonatal Sepsis ◽  
Screening Tests ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Leukocyte Counts ◽  
Sepsis Screen

The article by Philip and Hewitt (Pediatrics 65:1036-1041, 1980) on the early diagnosis of neonatal sepsis was interesting, but their conclusions may be misleading. They demonstrated that when at least two of five screening tests were positive (band/total neutrophils, leukocyte counts, latex C-reactive protein, erythrocyte sedimentation rate (ESR), and latex haptoglobin), neonatal sepsis could be accurately predicted in 28 of 30 (93%) infants. Two or more tests were also positive for 43 of 346 (12%) infants without proven sepsis.

scholarly journals Individual and combined bioscore model of presepsin, procalcitonin, and high sensitive C - reactive protein as biomarkers for early diagnosis of paediatric sepsis

Heliyon ◽  
2020 ◽  
Vol 6 (9) ◽  
pp. e04841
Author(s):  
Samuel Asamoah Sakyi ◽  
Anthony Enimil ◽  
David Kwabena Adu ◽  
Richard Dadzie Ephraim ◽  
Kwabena Owusu Danquah ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Biomarkers: A Definite Plus in Pneumonia

2009 ◽  
Vol 2009 ◽  
pp. 1-9 ◽  
Author(s):  
Hanssa Summah ◽  
Jie-Ming Qu
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Proinflammatory Cytokines ◽  
Leukocyte Count ◽  
Diagnostic Biomarker ◽  
C Reactive Protein ◽  
Ongoing Research ◽  
Easy Task ◽  
Reactive Protein ◽  
The Past

During the past few years, biomarkers have emerged as an indispensible tool in the diagnosis of pneumonia. To find an ideal diagnostic biomarker for pneumonia is not an easy task. Not only should it allow an early diagnosis of the condition, but it should also allow differential diagnosis from other noninfectious conditions. Ongoing research is being done in this field so as to put an array of biomarkers at the disposal of doctors to improve the diagnosis of pneumonia when patients present to them with cough or nonspecific symptoms which could easily be misinterpreted as symptoms of other conditions. Procalcitonin and soluble triggering receptor expressed on myeloid cells-1 have emerged as reliable diagnostic markers in pneumonia, and are better when compared to other markers, namely, C-reactive protein, leukocyte count, and proinflammatory cytokines. Many other biomarkers are being studied for their probable use in diagnosing pneumonia but have yet to prove their benefit.

scholarly journals Septicemia detection by blood buffy coat smear in primary health care centers

2012 ◽  
Vol 7 (1) ◽  
pp. 19-23
Author(s):  
BK Jha ◽  
YI Singh ◽  
S Mahadevmurthy ◽  
NK Chaudhary
Keyword(s):  
Health Care ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Hospital Setting ◽  
Buffy Coat ◽  
C Reactive Protein ◽  
Klebsiella Species ◽  
Reactive Protein ◽  
Primary Health Care Centers ◽  
Health Care Centers

Early diagnosis of childhood septicemia can be done by simple tests like C-reactive protein (CRP) and anticoagulant added blood centrifuged buffy coat smear (BBCS) examination, where there is no well equipped hospital setting for blood culture and identification facility in remote health care centers. This study was conducted between 1st Jan. 2007 to 27th Dec. 2007 in College of Medical Sciences, Bharatpur, Nepal. In this study we have selected 150 suspected cases of childhood septicemia for screening CRP by kit method and BBCS by two slide techniques. This kit is supplied by Span Diagnostic Pvt. Ltd. (Surat, India). Out of 150 cases of childhood septicemia of age group 0-14 years, 83 had positive C- reactive protein (CRP >6ì g/ml), 70 were positive for BBCS and blood culture was positive only in 83 cases, where predominant organism being Klebsiella species followed by Staphylococcus species. CRP test showed 100.0% sensitivity and 87.30% specificity, where BBCS showed 76.5% sensitivity and 91.2% specificity. Blood culture reports are available only after 48-72 hours and this facility is available only in well equipped centers but CRP and BBCS are easy and cheap procedure to perform even in remote areas for early diagnosis of childhood septicemia. DOI: http://dx.doi.org/10.3126/jcmsn.v7i1.5968 JCMSN 2011; 7(1): 19-23

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