Causes of sudden death related to oesophageal carcinoma

2020 ◽  
pp. 002580242096235
Author(s):  
Roger W Byard
Keyword(s):  
Squamous Cell ◽  
Upper Airway ◽  
Oesophageal Carcinoma ◽  
Squamous Cell Carcinomas ◽  
Unexpected Death ◽  
Local Extension ◽  
Airway Occlusion ◽  
First Case ◽  
Direct Growth ◽  
Fatal Haemorrhage

Two cases of recently diagnosed oesophageal squamous-cell carcinomas in men, both aged 72 years, are reported that resulted in rapid clinical deterioration and death from upper-airway occlusion and haemorrhage, respectively. In the first case, direct growth of the tumour from metastatic deposits in the paratracheal lymph nodes through the wall of the trachea resulted in lethal acute airway occlusion. In the second case, local extension of the tumour through the wall of the oesophagus into the adjacent aorta resulted in an aorto-oesophageal fistula which led to catastrophic and fatal haemorrhage. Although rare, oesophageal squamous-cell carcinomas may cause unexpected death due to quite different mechanisms, and result in the need for a detailed medico-legal assessment.

scholarly journals The Negative Impact of COVID-19 Pandemics on the Diagnosis of Lung Diseases in Brazil.

2020 ◽  
Author(s):  
Fernando Augusto Soares ◽  
Cristiano Claudino Olliveira ◽  
Mauro Canzian ◽  
Nicolle Cavalcante Gaglionone ◽  
Clóvis Klock
Keyword(s):  
Squamous Cell ◽  
Lung Diseases ◽  
Negative Impact ◽  
Substantial Reduction ◽  
Disease Diagnosis ◽  
Squamous Cell Carcinomas ◽  
Molecular Profile ◽  
Low Grade ◽  
First Case ◽  
Granulomatous Diseases

Abstract Background: COVID-19 pandemics affects the Health system all around the World. Brazil, since the first case in March, reported more than 4.0 million people infected. The pandemic's magnitude made that Hospitals prioritize the care of the secondary respiratory distress syndrome, and all elective diagnosis and treatment have been postponed. This study aimed to assess changes in patient's profiles submitted to lung or pleural biopsies comparing before and during COVID-19 pandemics.Methods: We retrospectively review the data of patients who underwent lung disease diagnostic approaches across April/May 2019 versus April/May 2020. We collect the data about the total cases, demographics, type of procedure, and disease diagnosis. Histological type, stage of the tumors, and molecular profile were also analyzed in cancer cases.Results: The number of total cases and lung biopsies dropped by more than 90% when the 2019/2020 samples were compared. Benign disease faced a more substantial reduction than cancer cases, with emphasis in granulomatous diseases. We had more advanced cases and more squamous cell carcinomas and small cell neuroendocrine carcinomas in the cancer scenario. Low-grade tumors, as carcinoids, suffered a significant reduction. Also, the molecular profile of the tumors drops in absolute numbers. Still, there was an increase of PD-L1 expression, probably because the sample comprises more squamous cell carcinomas and advanced cases.Conclusions: COVID-19 pandemics have a considerable negative impact on the management and diagnosis of lung diseases in Brazil. The consequences can be significant, and implementing a new policy to patients with lung diseases must be managed.

scholarly journals Squamous cell carcinoma arising in ovarian mature cystic teratoma: report of three cases

1970 ◽  
Vol 2 (3) ◽  
pp. 248-250 ◽  
Author(s):  
R Bashyal ◽  
MC Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Squamous Cell Carcinomas ◽  
Mature Cystic Teratoma ◽  
First Case

Malignant transformation of mature cystic teratoma of the ovary is rare. A wide variety of malignant tumors may arise within benign mature cystic teratoma. The most common form of malignant transformation of a mature cystic teratoma is squamous cell carcinoma. We report a series of three cases that developed squamous cell carcinoma in a benign ovarian cystic teratoma. Two of the carcinomas occurred in postmenopausal women: 51-year-old (case # 2) and 60 year-old (case # 3). The first case occurred in a 33-year-old woman. Histologically, all three cases were moderately differentiated squamous cell carcinomas and were confined to the ovaries. The aim of this study was to review our experience with this disease and to review the literature. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6032 JPN 2012; 2(3): 248-250

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations

Pachydermoperiostosis with cutaneous squamous cell carcinomas

1998 ◽  
Vol 37 (9) ◽  
pp. 693-696 ◽  
Author(s):  
Seung-Chul Lee ◽  
Hong-Joo Moon ◽  
Deok Cho ◽  
Dong Wook Ryang ◽  
Seong Jin Kim ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas

18F-Deoxyglucose PET for the staging of oesophageal cancer

2003 ◽  
Vol 42 (03) ◽  
pp. 90-93 ◽  
Author(s):  
N. Döbert ◽  
O. Rieker ◽  
W. Kneist ◽  
St. Mose ◽  
A. Teising ◽  
...  
Keyword(s):  
Oesophageal Cancer ◽  
Squamous Cell ◽  
Distal Part ◽  
Standard Uptake Value ◽  
Squamous Cell Carcinomas ◽  
Tumour Grading ◽  
Positron Emission ◽  
Group A ◽  
The Mean ◽  
Drop Outs

SummaryAim: Evaluation of the influence of histopathologic sub-types and grading of primaries of oesophageal cancer, relative to their size and location, on the uptake of 18F-deoxyglucose (FDG) as measured by positron emission tomography (PET). Methods: 50 consecutive patients were evaluated. There were four drop-outs due to previous surgical and/or chemotherapeutical treatments and thus in 46 patients (28 squamous cell carcinomas and 18 adenocarcinomas) a pretherapeutic PET evalution of the primary including a standard uptake value (SUV) was obtained. In 42 cases data on tumour grading were available also. Results: Squamous cell carcinomas (SCC) were in 7/13/8 cases located in the proximal, medial and distal part of the oesophagus, respectively the grading was Gx in 3, G 2 in 12, G2-3 in 7, and G3 in 6 cases. The SUVmax showed a mean of 6.5 ± 2.8 (range 1.7-13.5). Adenocarcinomas (ACA) were located in the medial oesophagus in two cases and otherwise in its distal parts. Grading was Gx in one, G2 in 4, G2-3 in 3, G3 in 3, G3-4 in 3, and G4 in one case. The mean SUVmax was 5.2 ± 3.2 (range 1-13.6) and this was not significantly different from the SCC. Concerning the tumour grading there was a slight, statistically not relevant trend towards higher SUVmax in more dedifferentiated cancer. Discussion: SCC and ACA of the oesophagus show no relevant differences in the FDG-uptake. While there was a significant variability of tumour uptake in the overall study group, a correlation of SUV and tumour grading was not found.

Epizootic of multi-centric, squamous cell carcinomas in populations of Indo-Pacific humpbacked dolphins Sousa chinensis in Thai waters

2019 ◽  
Vol 134 (2) ◽  
pp. 99-106 ◽  
Author(s):  
W Banlunara ◽  
S Techangamsuwan ◽  
N Pirarat ◽  
T Kaewamatawong ◽  
C Piewbang ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Sousa Chinensis
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