Book Review: Viral Infections of Humans, Epidemiology and Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

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Book Review: Government by the People: The Laws and Customs Regulating the Elective Sys-Tem and the Formation and Control of Political Parties in the United States

Journal of Education ◽

10.1177/002205740806800231 ◽

1908 ◽

Vol 68 (2) ◽

pp. 66-66

Keyword(s):

United States ◽

Political Parties ◽

The United States ◽

The People ◽

And Control

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Book Review: Health through Prevention and Control of Diseases.

Journal of Education ◽

10.1177/002205742610400515 ◽

1926 ◽

Vol 104 (5) ◽

pp. 119-119

Keyword(s):

Prevention And Control ◽

And Control

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Targeting unfolded protein response: a new horizon for disease control

Expert Reviews in Molecular Medicine ◽

10.1017/erm.2021.2 ◽

2021 ◽

Vol 23 ◽

Author(s):

Madhu Khanna ◽

Nishtha Agrawal ◽

Ramesh Chandra ◽

Gagan Dhawan

Keyword(s):

Unfolded Protein Response ◽

Disease Progression ◽

Viral Infections ◽

Cancer Type ◽

Unfolded Protein ◽

Diseased State ◽

Protein Response ◽

And Control ◽

Er Homeostasis ◽

Signalling Cascade

Abstract Unfolded protein response (UPR) is an evolutionarily conserved pathway triggered during perturbation of endoplasmic reticulum (ER) homeostasis in response to the accumulation of unfolded/misfolded proteins under various stress conditions like viral infection, diseased states etc. It is an adaptive signalling cascade with the main purpose of relieving the stress from the ER, which may otherwise lead to the initiation of cell death via apoptosis. ER stress if prolonged, contribute to the aetiology of various diseases like cancer, type II diabetes, neurodegenerative diseases, viral infections etc. Understanding the role of UPR in disease progression will help design pharmacological drugs targeting the sensors of signalling cascade acting as potential therapeutic agents against various diseases. The current review aims at highlighting the relevance of different pathways of UPR in disease progression and control, including the available pharmaceutical interventions responsible for ameliorating diseased state via modulating UPR pathways.

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Diagnosis and Therapeutic Management of Liver Fibrosis by microRNA

International Journal of Molecular Sciences ◽

10.3390/ijms22158139 ◽

2021 ◽

Vol 22 (15) ◽

pp. 8139

Author(s):

Tomoko Tadokoro ◽

Asahiro Morishita ◽

Tsutomu Masaki

Keyword(s):

Liver Fibrosis ◽

Viral Infections ◽

Primary Biliary Cholangitis ◽

Medical Need ◽

Key Factor ◽

Complications Of Cirrhosis ◽

And Control ◽

Functional Rnas ◽

Remarkable Progress ◽

Made In

Remarkable progress has been made in the treatment and control of hepatitis B and C viral infections. However, fundamental treatments for diseases in which liver fibrosis is a key factor, such as cirrhosis, alcoholic/nonalcoholic steatohepatitis, autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are still under development and remain an unmet medical need. To solve this problem, it is essential to elucidate the pathogenesis of liver fibrosis in detail from a molecular and cellular perspective and to develop targeted therapeutic agents based on this information. Recently, microRNAs (miRNAs), functional RNAs of 22 nucleotides, have been shown to be involved in the pathogenesis of liver fibrosis. In addition, extracellular vesicles called “exosomes” have been attracting attention, and research is being conducted to establish noninvasive and extremely sensitive biomarkers using miRNAs in exosomes. In this review, we summarize miRNAs directly involved in liver fibrosis, miRNAs associated with diseases leading to liver fibrosis, and miRNAs related to complications of cirrhosis. We will also discuss the efficacy of each miRNA as a biomarker of liver fibrosis and pathology, and its potential application as a therapeutic agent.

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