The Ability of Ultrasonic Backscatter Parametric Imaging to Characterize Bovine Trabecular Bone

2019 ◽  
Vol 41 (5) ◽  
pp. 271-289 ◽  
Author(s):  
Ying Li ◽  
Boyi Li ◽  
Yifang Li ◽  
Chengcheng Liu ◽  
Feng Xu ◽  
...  
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
Region Of Interest ◽  
Bone Microstructure ◽  
Parametric Imaging ◽  
Trabecular Bone Microstructure ◽  
Step Interval ◽  
Trabecular Bone Mass ◽  
Centroid Shift ◽  
Ultrasonic Backscatter

The ultrasonic backscatter technique holds the promise of characterizing bone density and microstructure. This paper conducts ultrasonic backscatter parametric imaging based on measurements of apparent integrated backscatter (AIB), spectral centroid shift (SCS), frequency slope of apparent backscatter (FSAB), and frequency intercept of apparent backscatter (FIAB) for representing trabecular bone mass and microstructure. We scanned 33 bovine trabecular bone samples using a 7.5 MHz focused transducer in a 20 mm × 20 mm region of interest (ROI) with a step interval of 0.05 mm. Images based on the ultrasonic backscatter parameters (i.e., AIB, SCS, FSAB, and FIAB) were constructed to compare with photographic images of the specimens as well as two-dimensional (2D) μ-CT images from approximately the same depth and location of the specimen. Similar structures and trabecular alignments can be observed among these images. Statistical analyses demonstrated that the means and standard deviations of the ultrasonic backscatter parameters exhibited significant correlations with bone density (|R| = 0.45-0.78, p < 0.01) and bone microstructure (|R| = 0.44-0.87, p < 0.001). Some bovine trabecular bone microstructure parameters were independently associated with the ultrasonic backscatter parameters (Δ R2 = 4.18%-44.45%, p < 0.05) after adjustment for bone apparent density (BAD). The results show that ultrasonic backscatter parametric imaging can provide a direct view of the trabecular microstructure and can reflect information about the density and microstructure of trabecular bone.

scholarly journals FRACTAL ANALYSIS OF TRABECULAR BONE PATTERN IN THE MANDIBLE AS AN INDICATOR OF OSTEOPOROSIS IN WOMEN - A CLINICAL STUDY

2018 ◽  
Vol 11 (2) ◽  
pp. 157 ◽  
Author(s):  
Vijayalakshmi K ◽  
Krithika C L ◽  
Raghuram P H ◽  
Kannan A
Keyword(s):  
Trabecular Bone ◽  
Pearson Correlation ◽  
Region Of Interest ◽  
Bone Microstructure ◽  
Estimation Methods ◽  
Pearson Correlation Coefficient ◽  
Pixel Size ◽  
Pearson Coefficient ◽  
Significant Difference ◽  
Trabecular Bone Microstructure

 Objectives: The objectives of this study were to estimate and compare the measurement of trabecular bone pattern in the mandible of normal and osteoporotic volunteers.Methods: A 43 female volunteers were selected as osteoporotic (n=43) group and 30 as normal (n=30) group with age ranging from 25 to 60 years were enrolled based on bone mineral densitometer (BMD) in the calcaneus bone. A detailed case history followed by digital periapical radiograph was performed. The mandibular trabecular bone pattern in these volunteers was determined using Image J software, after standardizing the pixel size and locations of the region of interest for three different regions between the two groups. Statistical analysis using independent t-test and Pearson coefficient was performed.Results: Results showed a significant difference in mean BMD values between the groups (0.52 in normal and −3.22 in osteoporotic). There are no significant differences in mean fractal dimension values between the groups (0.83 in normal and 0.82 in osteoporotic). Pearson correlation coefficient shows no significant correlation between the groups at three sites (p˃0.001).Conclusion: Although trabecular bone microstructure on an intraoral radiograph plays a key role in defining osteoporosis, the present study did not show any significant difference in its architecture between normal and osteoporotic individuals as defined by BMD. Therefore, further studies should be performed using better-standardized resolution strategies and different estimation methods to gain more insight.

The Effects of Trabecular Bone Microstructure on Compression Property of Bovine Cancellous Bone

2010 ◽  
Vol 452-453 ◽  
pp. 297-300
Author(s):  
Kazuto Tanaka ◽  
Yusuke Tanimoto ◽  
Yusuke Kita ◽  
Shinichi Enoki ◽  
Tsutao Katayama
Keyword(s):  
Mechanical Properties ◽  
Bone Density ◽  
Trabecular Bone ◽  
Young’S Modulus ◽  
Ultimate Strength ◽  
Cancellous Bone ◽  
Young's Modulus ◽  
Testing Machine ◽  
Bone Microstructure ◽  
Trabecular Bone Microstructure

To establish clinical bone assessment for osteoporosis, it is necessary to evaluate not only bone density but also trabecular bone microstructure and mechanical properties of bone. Therefore relationship between the micro-structural parameters and the mechanical properties of the cancellous bone of bovine distal femur was investigated. Compression test was carried out using universal testing machine to measure Young’s modulus and the ultimate strength. X-ray CT was used to obtain 3D image of specimens. Bone trabecular orientation was obtained from fabric ellipse by the MIL (Mean Intercept Length) analysis. Young’s modulus and ultimate strength had a high correlation with bone density respectively; furthermore ultimate strength had a high correlation with Young’s modulus.

scholarly journals Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children

2018 ◽  
Vol 33 (11) ◽  
pp. 1948-1955 ◽  
Author(s):  
Ka Yee Cheuk ◽  
Xiao-Fang Wang ◽  
Ji Wang ◽  
Zhendong Zhang ◽  
Fiona Wai Ping Yu ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Trabecular Bone ◽  
Bone Microstructure ◽  
Chinese Children ◽  
Trabecular Bone Microstructure

scholarly journals BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure

2020 ◽  
Vol 105 (4) ◽  
pp. e1344-e1357 ◽  
Author(s):  
Maria Nethander ◽  
Ulrika Pettersson-Kymmer ◽  
Liesbeth Vandenput ◽  
Mattias Lorentzon ◽  
Magnus Karlsson ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Cortical Bone ◽  
Hip Fractures ◽  
Vertebral Fractures ◽  
Genetic Risk ◽  
Bone Microstructure ◽  
Risk Scores ◽  
Site Specific ◽  
Microstructure Parameters ◽  
Trabecular Bone Microstructure

Abstract Context It is important to identify patients at highest risk of fractures. Objective To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. Design, Setting, and Participants Using 1103 single nucleotide polymorphisms (SNPs) independently associated with estimated bone mineral density of the heel (eBMD), we developed a weighted GRS for eBMD and determined its contribution to fracture prediction beyond 2 previously developed GRSs for femur neck BMD (49 SNPs) and lumbar spine BMD (48 SNPs). Associations between these GRSs and forearm (ncases = 1020; ncontrols = 2838), hip (ncases = 1123; ncontrols = 2630) and vertebral (ncases = 288; ncontrols = 1187) fractures were evaluated in 3 Swedish cohorts. Associations between the GRSs and trabecular and cortical bone microstructure parameters (n = 426) were evaluated in the MrOS Sweden cohort. Results We found that eBMDGRS was the only significant independent predictor of forearm and vertebral fractures while both FN-BMDGRS and eBMDGRS were significant independent predictors of hip fractures. The eBMDGRS was the major GRS contributing to prediction of trabecular bone microstructure parameters while both FN-BMDGRS and eBMDGRS contributed information for prediction of cortical bone microstructure parameters. Conclusions The eBMDGRS independently predicts forearm and vertebral fractures while both FN-BMDGRS and eBMDGRS contribute independent information for prediction of hip fractures. We propose that eBMDGRS captures unique information about trabecular bone microstructure useful for prediction of forearm and vertebral fractures. These findings may facilitate personalized medicine to predict site-specific fractures as well as cortical and trabecular bone microstructure separately.

Trabecular bone microstructure by means of multiples spin echo

2001 ◽  
Vol 19 (3-4) ◽  
pp. 571 ◽  
Author(s):  
S Capuani ◽  
F.M Alessandri ◽  
B Maraviglia ◽  
A Bifone
Keyword(s):  
Trabecular Bone ◽  
Spin Echo ◽  
Bone Microstructure ◽  
Trabecular Bone Microstructure
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