Remote Monitoring of Home-based Noninvasive Ventilation in Children with Obstructive Sleep Apnea-Hypopnea Syndrome and Concomitant Risk Factors

Background/Aim. It is necessary to find eligible oxidative stress markers for predicting the severity of obstructive sleep apnea hypopnea syndrome (OSAHS), a sleep disorder-related respiratory disease. We aimed to explore the correlation between oxidative stress and cognitive impairment in OSAHS patients. Methods. A total of 220 eligible patients were divided into snoring, mild to moderate OSAHS and severe OSAHS groups according to polysomnography (PSG). Apnea-hypopnea index (AHI), oxygen desaturation index (ODI) and baseline data were monitored. Oxidative stress indices were measured by colorimetry in early morning. They were divided into normal cognitive and cognitive impairment groups based on Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Independent risk factors for cognitive impairment were analyzed by multivariate logistic regression. Correlation between oxidative stress and cognitive impairment was analyzed by Pearson?s method. Receiver operating characteristic (ROC) curves were plotted to analyze the efficiency of oxidative stress combined with detection for assessing the cognitive impairment in OSAHS patients. Results. Snoring, mild to moderate OSAHS and severe OSAHS groups had significantly different snoring loudness, BMI, AHI, ODI, MoCA and MMSE scores, and levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) (P<0.05). Cognitive impairment and normal cognitive groups had different BMI, GSH-Px, MDA and SOD levels, neuroglobin, hypoxia-inducible factor, AHI and lowest nocturnal oxygen saturation (P<0.05 or P<0.01). BMI, GSH-Px, MDA, SOD, neuroglobin, hypoxia-inducible factor, AHI and lowest nocturnal oxygen saturation were independent risk factors for cognitive impairment. The MoCA and MMSE scores of cognitive impairment had positive correlations with GSH-Px and SOD, but negative correlations with MDA (P<0.05). AUCs of GSH-Px, MDA, SOD and their combination for prediction were 0.670, 0.702, 0.705 and 0.836, respectively. Conclusion. Oxidative stress may be the biochemical basis of cognitive impairment in OSAHS patients.

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Clinical Characteristics of Chinese Pediatric Obstructive Sleep Apnea Hypopnea Syndrome

10.21203/rs.3.rs-375980/v1 ◽

2021 ◽

Author(s):

Yanyu He ◽

Xueyun Xu ◽

Wenjing Gu ◽

xinxing Zhang ◽

Yuqing Wang ◽

...

Keyword(s):

Risk Factors ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Clinical Characteristics ◽

Mouth Opening ◽

Adenoid Hypertrophy ◽

Time Ratio ◽

Obstructive Sleep ◽

Lateral Film ◽

Hypopnea Syndrome

Abstract We aim to analyze the clinical characteristics of obstructive sleep apnea hypopnea syndrome (OSAHS) in children. Polysomnography (PSG) and nasopharynx lateral film were performed, and clinical data were collected in 469 children who came to the outpatient department due to "snoring during sleep with mouth opening breathing, hard breathing or suffocation". Among the enrolled children, 123 (22.6%) were diagnosed with OSAHS, with 70 were mild and 53 were moderate-severe. Percentage of adenoid hypertrophy was higher in OSAHS patients (p <0.01), instead of tonsil enlargement. The OSAHS children were agged 5 (4, 7). Compared with PS, the percentage of snoring, apnea, dyspnea, increased nocturia, and daytime sleepness were significsntly higher in moderate-severe patients (p <0.01). In OSAHS groups, AHI, ODI, Longest time of apnea were increased, while minimum SpO2 and mean SpO2 during sleep were decreased significantly (p <0.01) than PS. Time ratio of NREM1 was elevated in moderate-severe OSAHS patients (p <0.01). Time ratio of REM was elevated in mild patients(p <0.01). Compared with the preschoolers, the percentage of leg movement and sleepness were significsntly higher in school-agers (p <0.05). The youngers had higher time ratio of NREM3 and better sleep efficieny (p<0.01). However, AHI(p<0.05) and ODI(p<0.01) were higher in elder OSAHS significantly. Snoring (OR =5.745, p < 0.01), adenoid hypertrophy (OR =4.381, p < 0.01), apnea (OR =2.670, p < 0.001), dyspnea (OR =1.975, p < 0.01), and CRP (OR =1.172, p < 0.001) were independent risk factors for OSAHS. Conclusion AHI, ODI, Longest time of apnea, minimum SpO2 and mean SpO2 should be considered and analyzed simultaneously in diagnosis. The school-age OSAHS patients seems to more serious than the preschoolers. Snoring, apnea, dyspnea, adenoid hypertrophy, and CRP are risk factors for OSAHS.

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Relationship between enuresis and obstructive sleep apnea–hypopnea syndrome in children

Journal of International Medical Research ◽

10.1177/0300060520977407 ◽

2020 ◽

Vol 48 (12) ◽

pp. 030006052097740

Author(s):

Chen Sun ◽

Yingpeng Xu ◽

Chenxi Luo ◽

Qi Li

Keyword(s):

Risk Factors ◽

Obstructive Sleep Apnea ◽

Logistic Regression ◽

Sleep Apnea ◽

Pearson Correlation ◽

Apnea Hypopnea Index ◽

Chi Square ◽

Obstructive Sleep ◽

Chi Square Test ◽

Hypopnea Syndrome

Objective We explored the relationship between enuresis and obstructive sleep apnea–hypopnea syndrome (OSAHS) in children and influencing factors of enuresis with OSAHS. Methods We recruited 196 children ≥5 years old from the otolaryngology outpatient department, who experienced snoring and underwent nasopharynx lateral radiography and in-laboratory polysomnography. We analyzed correlations between the apnea–hypopnea index (AHI) and lowest oxygen saturation (L-SaO2) with age, body mass index (BMI), tonsil size, and adenoidal–nasopharyngeal (A/N) ratio using the Pearson correlation test. Differences in severe OSAHS prevalence, age, AHI, L-SaO2, tonsil size, and A/N ratio between children with and without enuresis were assessed using the chi-square test and t-test. Risk factors of enuresis were analyzed using logistic regression. Follow-up was conducted to assess remission in children with enuresis after adenotonsillectomy. Results BMI, tonsil size, and A/N ratio were correlated with AHI and L-SaO2. Severe OSAHS prevalence, AHI, tonsil size, and A/N ratio were higher and L-SaO2 were lower in children with enuresis. Logistic regression showed that BMI, AHI, tonsil size, and sleep apnea were risk factors for enuresis. Conclusions Our study findings showed that enuresis was associated with OSAHS in children. Adenotonsillectomy may improve the symptoms of enuresis.

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Metabolic Features In Patients with Obstructive Sleep Apnea Hypopnea Syndrome

Revista de Chimie ◽

10.37358/rc.18.7.6424 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1821-1825

Author(s):

Sinziana Lovin ◽

Dragos Cristian Stefanescu ◽

Razvan Hainarosie ◽

Malina Ciumasu

Keyword(s):

Risk Factors ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Intermittent Hypoxia ◽

Military Hospital ◽

Study Objective ◽

Obstructive Sleep ◽

Associated Conditions ◽

The Military ◽

Hypopnea Syndrome

Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by repeated breathing pauses during sleep, with slee disruption, intermittent hypoxia, and cardiac, metabolic and neuropsychological disturbances. Metabolic syndrome (MS) is an association of cardiovascular risk factors centered on insulin resistance.The study objective is to calculate the prevalence of MS and its components in a large group of OSAHS patients. We evaluated 350 patients addressed to The Military Hospital Iasi between 2016 and 2017 from the clinical, metabolic and polygraphic poins of view. In 235 of the 350 de patients we found OSAHS. Of the 235 patients with OSAHS, 140 (60%) meet the criteria for MS, versus 29% of the group withut OSAHS (OR = 3.608, CI = 2.1787 - 5.975). Patients with OSAHS were older, more obese, more sedentary, sleepier and presented higher cholesterol values both total cholesterol and HDL fraction, higher tryglicerides values, higher blood sugar values and blood pressure values than patients without OSAHS. The prevalence of the MS in OSAHS patients is 60%, similar to what whas reported and higher by 31% than in the non OSAHS group. Certain components and associated conditions are characteristically linked to OSAHS.

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