Erratum

2011 ◽  
Vol 145 (6) ◽  
pp. 1062-1062
Keyword(s):  
Oral Cancer ◽  
Postural Control ◽  
Head And Neck ◽  
Cancer Patients ◽  
Mirna Expression ◽  
Copy Number ◽  
The Elderly ◽  
Neck Surgery ◽  
Oral Cancer Patients ◽  
Head Neck

In the August 2011 Program issue of Otolaryngology–Head and Neck Surgery, the following presenter names were omitted from the abstracts. Serrano NA, Xu C, Houck J, Wang P, Fan W, Liu Y, Lohavanichbutr P. Association of DNA copy number and miRNA expression in OSCC. Otolaryngol Head Neck Surg. 2011;145:P60. (Original doi: 10.1177/0194599811416318a63) Melissa P. Upton, MD; Lue Ping Zhao, PhD; Michael Kao; Chu Chen, PhD; Eduardo Mendez, MD Sharma A, Doody D, Mendez E, Houck J, Lohavanichbutr P, Futran ND, Yueh B. HPV+ oral cancer patients do not have better QOL trajectory. Otolaryngol Head Neck Surg. 2011;145:P67. (Original doi: 10.1177/0194599811416318a84) Melissa P. Upton, MD; Stephen M. Schwartz, PhD, MPH; Chu Chen, MS, PhD Kasse CA, Maia D, Gazzola J, Thomaz JQ. Vestibular rehabilitation in postural control of the elderly. Otolaryngol Head Neck Surg. 2011;145:P232. (Original doi: 10.1177/0194599811415823a319) Flávia Dona, PhD

scholarly journals Identification of Targetable Pathways in Oral Cancer Patients via Random Forest and Chemical Informatics

2019 ◽  
Vol 18 ◽  
pp. 117693511988991 ◽  
Author(s):  
John Schomberg
Keyword(s):  
Head And Neck Cancer ◽  
Random Forest ◽  
Oral Cancer ◽  
Small Molecules ◽  
Head And Neck ◽  
Treatment Response ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Platinum Based Chemotherapy ◽  
Oral Cancer Patients

Treatment of head and neck cancer has been slow to change with epidermal growth factor receptor (EGFR) inhibitors, PD1 inhibitors, and taxane-/plant-alkaloid-derived chemotherapies being the only therapies approved by the U.S. Food and Drug Administration (FDA) in the last 10 years for the treatment of head and neck cancers. Head and neck cancer is a relatively rare cancer compared to breast or lung cancers. However, it is possible that existing therapies for more common solid tumors or for the treatment of other diseases could also prove effective against oral cancers. Many therapies have molecular targets that could be appropriate in oral cancer as well as the cancer in which the drug gained initial FDA approval. Also, there may be targets in oral cancer for which existing FDA-approved drugs could be applied. This study describes informatics methods that use machine learning to identify influential gene targets in patients receiving platinum-based chemotherapy, non-platinum-based chemotherapy, and genes influential in both groups of patients. This analysis yielded 6 small molecules that had a high Tanimoto similarity (>50%) to ligands binding genes shown to be highly influential in determining treatment response in oral cancer patients. In addition to influencing treatment response, these genes were also found to act as gene hubs connected to more than 100 other genes in pathways enriched with genes determined to be influential in treatment response by a random forest classifier with 20 000 trees trying 320 variables at each tree node. This analysis validates the use of multiple informatics methods to identify small molecules that have a greater likelihood of efficacy in a given cancer of interest.

Abstract 5079: A genomic copy number biomarker to identify oral cancer patients at low risk for metastasis

2012 ◽  
Author(s):  
Aditi Bhattacharya ◽  
Antoine M. Snijders ◽  
Ritu Roy ◽  
Gregory Hamilton ◽  
Jesse Paquette ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Copy Number ◽  
Low Risk ◽  
Genomic Copy Number ◽  
Genomic Copy ◽  
Oral Cancer Patients

scholarly journals Evaluation of oral mucositis in oral cancer patients undergoing radiotherapy

2018 ◽  
Vol 8 (2) ◽  
pp. 6-9
Author(s):  
Barsha Bajracharya ◽  
Subrata Bhattacharyya ◽  
Pratibha Poudel
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Radiation Exposure ◽  
Head And Neck ◽  
Cancer Patients ◽  
Oral Mucositis ◽  
Oral Cancer Patients ◽  
The Mean ◽  
Head And Neck Radiotherapy ◽  
Grade Iii

Introduction: The present study was conducted to evaluate oral mucositis in oral cancer patients receiving head and neck radiotherapy. Methods: Sixty oral cancer patients who had received at least 40 grays of radiation were included in the study. Mucositis was scored by oroscopy using WHO scale. Grades of mucositis were then compared with total dose of radiation received by the patients. Results: The cases were receiving the mean cumulative dose of standard radiation therapy of 2Gy per fraction, 5 fractions per week. All the patients developed oral mucositis. The majority had grade I mucositis, followed by grade III, II and IV. The grade of mucositis was directly proportional to the dose of radiation exposure. Conclusion: Oral mucositis occurs among all the patients undergoing head and neck radiotherapy and grade of mucositis is proportional to the dose of radiation exposure.

scholarly journals Multi-Disciplinary Team (MDT) Approach in Oral Cancer Management: An Exploratory Study

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 96s-96s
Author(s):  
F. Alobaidi ◽  
J. Doss ◽  
N. Abmurat
Keyword(s):  
Decision Making ◽  
Oral Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Treatment Plan ◽  
Well Being ◽  
Team Approach ◽  
Cancer Management ◽  
Oral Cancer Patients ◽  
Multi Disciplinary Team

Background: Treatment of oral cancer has evolved throughout the past decades which has led to the introduction of the multi-disciplinary team approach (MDT). The MDT concept has been endorsed as the main approach to ensure holistic care for oral cancer patients worldwide. In Malaysia, the MDT concept has been introduced in few hospitals throughout the country. According to the available literature, the MDT approach has improved coordination of care for oral cancer patients, communication between the different disciplines, decision making to obtain the best treatment plan, provided educational opportunities for development of the members, and improved staff and patient well-being. However, little evidence is available to support the fact that the MDT approach has improved patient survival and outcome. Aim: The aim of this study was to explore the MDT approach in the management of oral cancer patients. To our knowledge this is the first study on head and neck MDTs in Malaysia. Methods: The study was conducted at University of Malaya. A mixed-method study was commenced including both quantitative and qualitative designs. The quantitative part assessed the MDT members' attitude toward the role and use of the MDT approach in oral cancer patient management, while the qualitative part assessed the perception of the MDT members regarding the MDT approach in terms of: team structure, team process, decision making, barriers and suggestions for improvement of the MDT approach. The quantitative study was conducted through a structured self-administered questionnaire which were both content and face validated, and distributed to the members of the head and neck MDT. The qualitative study was commenced through two focus group discussions (FGDs) conducted separately. Results: The study was conducted among the head and neck MDT members at University Malaya which received a 100% response rate. The majority of the MDT members showed positive attitudes toward the MDT approach, with the seniors being more positive than the juniors. The MDT approach has improved team dynamics in terms of communication, care coordination and decision making. However, there were a few issues of miscommunication as well as long waiting lists for oncological radiotherapy machines and radiologic scanning. Conclusion: The MDT approach is certainly the preferable mode of care for oral cancer patients in University of Malaya. However, there is a need for further improvement with regards to communication between the team members, expansion of the current team composition, training of the MDT members with regards to clinical and nonclinical skills, guidelines, protocols and certain facilities. Teamwork is a fundamental perspective which is crucial for an effective MDT. As such, a better understanding of each other's roles and responsibilities within the team is essential to ensure optimum patient care and management.

scholarly journals High Expression of KLF10 Is Associated with Favorable Survival in Patients with Oral Squamous Cell Carcinoma

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 17
Author(s):  
Chung-Min Yeh ◽  
Yi-Ju Lee ◽  
Po-Yun Ko ◽  
Yueh-Min Lin ◽  
Wen-Wei Sung
Keyword(s):  
Survival Rate ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Protective Factor ◽  
Female Gender ◽  
Vital Role ◽  
Cancer Stage ◽  
Independent Prognostic Marker ◽  
Oral Cancer Patients ◽  
The Impact

Background and objectives: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Materials and Methods: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan–Meier analysis and the Cox proportional hazard model. Results: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. Conclusions: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.

scholarly journals Genetic Variants of lncRNA GAS5 Are Associated with the Clinicopathologic Development of Oral Cancer

2021 ◽  
Vol 11 (5) ◽  
pp. 348
Author(s):  
Ming-Hong Hsieh ◽  
Hsueh-Ju Lu ◽  
Chiao-Wen Lin ◽  
Chia-Yi Lee ◽  
Shang-Jung Yang ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Alcohol Drinking ◽  
Tumor Size ◽  
Genetic Variants ◽  
Tumor Stage ◽  
Advanced Tumor Stage ◽  
Advanced Tumor ◽  
Oral Cancer Patients

The long noncoding RNA, Growth arrest-specific 5 (GAS5) plays a crucial role in the development of oral cancer. However, potential genetic variants in GAS5 that affect the susceptibility and progression of oral cancer have rarely been explored. In this study, two loci of GAS5 single nucleotide polymorphisms (SNPs) (rs145204276 and rs55829688) were genotyped by using the TaqMan allelic discrimination in 1125 oral cancer patients and 1195 non-oral-cancer individuals. After statistical analyses, the distribution of both the GAS5 SNP rs145204276 and GAS5 SNP rs55829688 frequencies were similar between the study and control groups. However, the patients with GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) showed a higher tendency of moderate to poor cell differentiation of oral cancer (OR: 1.454, 95% CI: 1.041–2.031, p = 0.028). Moreover, the GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) in the non-alcohol-drinking population were associated with significantly advanced tumor stage (OR: 1.500, 95% CI: 1.081–2.081, p = 0.015) and larger tumor size (OR: 1.494, 95% CI: 1.076–2.074, p = 0.016). Furthermore, individuals with the GAS5 SNP rs145204276 variant were associated with a higher expression of GAS5 in the GTEx database (p = 0.002), and the higher GAS5 level was associated with poor cell differentiation, advanced tumor stage and larger tumor size in head and neck squamous cell carcinoma from the TCGA database (all p < 0.05). In conclusion, the GAS5 SNP rs145204276 variant is related to poor-differentiation cell status in oral cancer. Besides, the presence of the GAS5 SNP rs145204276 variant is associated with a worse tumor stage and tumor size in oral cancer patients without alcohol drinking.

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