scholarly journals Evaluation of oral mucositis in oral cancer patients undergoing radiotherapy

2018 ◽  
Vol 8 (2) ◽  
pp. 6-9
Author(s):  
Barsha Bajracharya ◽  
Subrata Bhattacharyya ◽  
Pratibha Poudel
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Radiation Exposure ◽  
Head And Neck ◽  
Cancer Patients ◽  
Oral Mucositis ◽  
Oral Cancer Patients ◽  
The Mean ◽  
Head And Neck Radiotherapy ◽  
Grade Iii

Introduction: The present study was conducted to evaluate oral mucositis in oral cancer patients receiving head and neck radiotherapy. Methods: Sixty oral cancer patients who had received at least 40 grays of radiation were included in the study. Mucositis was scored by oroscopy using WHO scale. Grades of mucositis were then compared with total dose of radiation received by the patients. Results: The cases were receiving the mean cumulative dose of standard radiation therapy of 2Gy per fraction, 5 fractions per week. All the patients developed oral mucositis. The majority had grade I mucositis, followed by grade III, II and IV. The grade of mucositis was directly proportional to the dose of radiation exposure. Conclusion: Oral mucositis occurs among all the patients undergoing head and neck radiotherapy and grade of mucositis is proportional to the dose of radiation exposure.

scholarly journals Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Eik Schiegnitz ◽  
Lena Katharina Müller ◽  
Keyvan Sagheb ◽  
Lisa Theis ◽  
Vahide Cagiran ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Dental Implants ◽  
Survival Rates ◽  
Implant Survival ◽  
Implant Placement ◽  
Patient Reported ◽  
Oral Cancer Patients

Abstract Background and purpose The aim of this clinical study was to investigate the clinical long-term and patient-reported outcome of dental implants in patients with oral cancer. In addition, analysis of the influence of radiation therapy, timing of implant insertion, and augmentation procedures on implant survival was performed. Material and methods This retrospective study investigated the clinical outcome of 711 dental implants in 164 oral cancer patients, inserted by experienced surgeons of the Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, Germany. Oral health-related quality of life (OHRQoL) was evaluated. Results Cumulative 5-year and 10-year implant survival rates for all included implants were 87.3% and 80.0%. Implants placed straight after ablative surgery (primary implant placement) and implants placed after completing the oncologic treatment (secondary implant placement) showed a comparable implant survival (92.5% vs. 89.5%; p = 0.635). Irradiation therapy had no significant influence on implant survival of secondary placed implants (p = 0.929). However, regarding implant site (native bone vs. augmented bone) and radiation therapy (non-irradiated bone vs. irradiated bone), implants inserted in irradiated bone that received augmentation procedures showed a statistically significant lower implant survival (p < 0.001). Patients reported a distinct improvement in OHRQoL. Conclusions Promising long-term survival rates of dental implants in patients after treatment of oral cancer were seen. In addition, patients benefit in form of an improved OHRQoL. However, bone augmentation procedures in irradiated bone may result in an impaired implants’ prognosis.

Effect of progressive resistive exercises on shoulder abduction range of motion in post operative oral cancer patients undergoing radiation therapy

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e216-e217 ◽  
Author(s):  
M. Chatterjee ◽  
V. Murthy ◽  
T. Gupta ◽  
S. Nair ◽  
S. Nikam ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Range Of Motion ◽  
Cancer Patients ◽  
Shoulder Abduction ◽  
Oral Cancer Patients

Erratum

2011 ◽  
Vol 145 (6) ◽  
pp. 1062-1062
Keyword(s):  
Oral Cancer ◽  
Postural Control ◽  
Head And Neck ◽  
Cancer Patients ◽  
Mirna Expression ◽  
Copy Number ◽  
The Elderly ◽  
Neck Surgery ◽  
Oral Cancer Patients ◽  
Head Neck

In the August 2011 Program issue of Otolaryngology–Head and Neck Surgery, the following presenter names were omitted from the abstracts. Serrano NA, Xu C, Houck J, Wang P, Fan W, Liu Y, Lohavanichbutr P. Association of DNA copy number and miRNA expression in OSCC. Otolaryngol Head Neck Surg. 2011;145:P60. (Original doi: 10.1177/0194599811416318a63) Melissa P. Upton, MD; Lue Ping Zhao, PhD; Michael Kao; Chu Chen, PhD; Eduardo Mendez, MD Sharma A, Doody D, Mendez E, Houck J, Lohavanichbutr P, Futran ND, Yueh B. HPV+ oral cancer patients do not have better QOL trajectory. Otolaryngol Head Neck Surg. 2011;145:P67. (Original doi: 10.1177/0194599811416318a84) Melissa P. Upton, MD; Stephen M. Schwartz, PhD, MPH; Chu Chen, MS, PhD Kasse CA, Maia D, Gazzola J, Thomaz JQ. Vestibular rehabilitation in postural control of the elderly. Otolaryngol Head Neck Surg. 2011;145:P232. (Original doi: 10.1177/0194599811415823a319) Flávia Dona, PhD

scholarly journals Efficacy of Low-cost Intraoral Prosthesis in the Era of Modern Radiation Therapy in Oral Cancer Patients

2021 ◽  
Vol 12 (6) ◽  
pp. 463-468
Author(s):  
Shivani S Desai ◽  
Dipti Patil ◽  
Adnan Calcuttawala ◽  
Nilesh Deshmane ◽  
Sharad Desai
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Low Cost ◽  
Oral Cancer Patients

Uroporphyrinogen decarboxylase gene expression in oral squamous cell carcinomas.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17002-e17002
Author(s):  
Rajkumar Kottayasamy Seenivasagam ◽  
Arun Kumar Ganesan ◽  
Rajaraman Ramamurthy ◽  
Munirajan Arasambattu Kannan ◽  
Deva Magendhra Rao
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Splice Variants ◽  
Squamous Cell Carcinomas ◽  
Uroporphyrinogen Decarboxylase ◽  
Number Of Patients ◽  
Oral Cancer Patients ◽  
The Mean

e17002 Background: Oral cancer is one of the most common cancers in India. Uroporphyrinogen decarboxylase (UROD), a key regulator of heme biosynthesis, has recently been suggested as a novel tumor-selective radiosensitizing target against head and neck cancers. Further, a recent study has suggested that tumors with UROD expression may have poorer outcomes and higher rates of recurrence. We tested the expression of UROD splice variants in oral cancer patients who were treated in our hospital to study its expression and impact on the patients. Methods: The expression of both coding and noncoding splice variants of UROD gene was tested in 42 patients (31 male, 11 female) with oral cavity squamous cell carcinomas treated in 2011-12. Pretreatment tumor biopsies were collected and mRNA was extracted using Quiagen RNeasy kit method. cDNA was synthesized using Superscript III and subjected for UROD expression using specific primers. UROD expression and clinical data of patients were analyzed using IBM SPSS 20 Software. Results: The mean age of the patients was 52 years (range 32-70). Buccal mucosa (n=17) and tongue (n=13) were the most common subsites. Seventy six percent had locally advanced disease (T3/T4 and node-positive) and high-grade (70%) cancers. Chemoradiotherapy (CRT) (n =25) and chemotherapy (CT) (n = 10) was given in 35 patients of which 5 had progressive disease. The mean follow up was 11 months. Thirty seven patients were operated, 5 developed locoregional recurrence and 2 developed spine metastases and died during follow-up. UROD was expressed in 23 (54.8%) patients (coding variant = 52.8%, noncoding = 26%). There was no correlation between UROD expression and age, sex, subsite, stage, grade or node positivity. Patients with UROD expression had a slightly poorer response to CRT/CT (30.4% vs 24.1%; p =NS). Similarly, though they had a slightly higher incidence of recurrence, the difference was not significant. Both patients with spinal recurrence had UROD expression. Conclusions: UROD is highly expressed in oral cancer patients in India. Its proposed radiosensitizing and prognostic role in treatment and outcomes though promising needs further evaluation in a larger number of patients.

scholarly journals Expertise Regarding Dental Management of Oral Cancer Patients Receiving Radiation Therapy Among Western Australian Dentists

2012 ◽  
Vol 6 (1) ◽  
pp. 197-207 ◽  
Author(s):  
AM Frydrych ◽  
LM Slack-Smith ◽  
JH Park ◽  
AC Smith
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Clinical Expertise ◽  
Willingness To Participate ◽  
Perceived Knowledge ◽  
Dental Management ◽  
Oral Cancer Patients ◽  
General Dentists ◽  
Western Australian

Objectives: Dental care forms an important part of the multidisciplinary management of oral cancer patients. The aim of this study was to examine actual and self-perceived knowledge and clinical expertise regarding dental management of oral cancer patients receiving radiation therapy among Western Australian general dentists. Materials and Methods: An invitation to participate in a web-based questionnaire was emailed to 1095 dentists registered with the Australian Dental Association (ADA), WA branch. To assess dentists’ knowledge and expertise, actual and perceived knowledge was investigated. Information regarding type of practice, practice location, year of graduation and number of oral cancer patients treated in the preceding 12 months was also obtained. Results: One hundred and ninety one dentists responded to the survey. General dentists who took part in the study appeared to possess some knowledge regarding dental management of oral cancer patients treated with radiation therapy. The majority of responders however identified deficiencies in their knowledge and willingness to participate in continuing education programs. Conclusion: In view of the rising incidence of oral cancer in Western Australia, efforts should be made to provide more clinically relevant training to dentists in this area.

Salivary Cytokine Levels and Oral Mucositis in Head and Neck Cancer Patients Treated With Chemotherapy and Radiation Therapy

2016 ◽  
Vol 96 (5) ◽  
pp. 959-966 ◽  
Author(s):  
Paolo Bossi ◽  
Cristiana Bergamini ◽  
Rosalba Miceli ◽  
Agata Cova ◽  
Ester Orlandi ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Cytokine Levels
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