Determination of significant differences in performance of the Bentley BOS-CM 40 hollow fibre membrane oxygenator and the Polystan VT5000 venotherm bubble oxygenator

Perfusion ◽  
1987 ◽  
Vol 2 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Ludwig von Segesser
Keyword(s):  
Cardiopulmonary Bypass ◽  
Hollow Fibre ◽  
Membrane Oxygenator ◽  
Mean Flow ◽  
Hollow Fibre Membrane ◽  
Fibre Membrane ◽  
Bubble Oxygenator ◽  
Venous Oxygen Saturation ◽  
The Difference

Ten mongrel dogs were connected to cardiopulmonary bypass by cavoaortic cannulation, classic roller pump and either Bentley BOS-CM 40 hollow fibre membrane oxygenator or Polystan VT5000 Venotherm bubble oxygenator for eight hours, with mean flow rate of 100 ml/kg min. Platelet counts (all values corrected by prebypass haematocrit) were significantly lower in the bubble oxygenator group after two hours of cardiopulmonary bypass (p < 0·01). Plasma haemoglobin production was significantly higher after two hours of cardiopulmonary bypass in the bubble oxygenator group (p < 0·01). Venous oxygen saturation (SvO2) was above 65% during the eight hours perfusion in the membrane oxygenator group. In the bubble oxygenator group, however, SvO2 was below 60% after six hours of cardiopulmonary bypass. After eight hours perfusion the difference in SvO2 between the two groups was significant (p < 0·05). Thus membrane oxygenators such as the Bentley BOS-CM 40 appear to be indicated in cardiopulmonary bypass of more than two hours duration.

Blood compatibility of two different types of membrane oxygenator during cardiopulmonary bypass in infants

1994 ◽  
Vol 17 (10) ◽  
pp. 543-548 ◽  
Author(s):  
Y.J. Gu ◽  
P.W. Boonstra ◽  
C. Akkerman ◽  
H. Mungroop ◽  
I. Tigchelaar ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Compatibility ◽  
Hollow Fibre ◽  
Membrane Oxygenator ◽  
Hollow Fibre Membrane ◽  
Flat Sheet ◽  
Fibre Membrane ◽  
Membrane Oxygenators ◽  
Flat Sheet Membrane ◽  
Sheet Membrane

The contact of blood with the artificial extracorporeal circuit causes a systemic inflammatory response due to blood activation. In this study, we compared two different paediatric membrane oxygenators used for extracorporeal circulation: a hollow fibre membrane oxygenator (Dideco Masterflo D-701, n=10), and a flat sheet silicone membrane oxygenator (Avecor Kolobow 800-2A, n=10). Blood compatibility was indicated by measuring complement activation as well as leukocyte and platelet activation. In patients perfused with a flat sheet membrane oxygenator, concentrations of complement split products C3a were significantly increased 30 minutes after the start of bypass (p<0.01), whereas only a mild increase of C3a was found in patients perfused with a hollow fibre membrane oxygenator. Leukocyte and platelet counts dropped uniformly in both groups after the start of bypass mainly due to hemodilution. Activation of leukocytes and platelets identified by both plasma β-glucuronidase and β-thromboglobulin was similar in both groups. Infants perfused with a flat sheet membrane oxygenator received significantly more donor blood than those perfused with a hollow fibre oxygenator (p<0.05). These results indicate that when used during paediatric cardiopulmonary bypass, a flat sheet membrane oxygenator has a higher complement activity than a hollow fibre membrane oxygenator, which is probably due to the relatively larger blood-surface contacting area of the oxygenator.

Experimental evaluation of the Dideco Masterflo paediatric hollow-fibre membrane oxygenator

Perfusion ◽  
1989 ◽  
Vol 4 (3) ◽  
pp. 223-234 ◽  
Author(s):  
L. von Segesser ◽  
B. Leskosek ◽  
F. Redha ◽  
E. Garcia ◽  
M. Turina
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Count ◽  
Arterial Oxygen Saturation ◽  
Hollow Fibre ◽  
Arterial Oxygen ◽  
Blood Gas ◽  
Mean Flow ◽  
Hollow Fibre Membrane ◽  
Plasma Haemoglobin ◽  
Fibre Membrane

Nine mongrel dogs (mean bodyweight: 29 ± 6kg) were connected to cardiopulmonary bypass byfemorojugularvenous and femoral arterial cannulation, classic roller pump and the integrated Dideco D702 Masterflo hollow-fibre membrane oxygenatorwith a mean flow rate of 70ml/kg/min for six hours. Then the animals were weaned from cardiopulmonary bypass and thereafter weaned from the ventilator. After seven days all animals were sacrificed electively for necropsy. A standard battery of blood samples was taken before the bypass, after mixing (10 minutes), after two hours, five hours and six hours of perfusion. Further samples were taken 30 minutes after bypass (spontaneous breathing), 60 minutes after bypass (after extubation), 24 hours after bypass, 48 hours after bypass and seven days after bypass. Physiologic blood gas values could be maintained throughout perfusion in all animals. Mean arterial oxygen saturation varied between 99.7% and 99.9% for the arterial side of the oxygenator compared to 77.8% and 86.6% on the venous side. Post bypass blood gas analyses showed physiologic values and no evidence of major lung trauma or pulmonary oedema in relation to the six hours' bypass. Red blood count was 5.84 ± 0.02 before and 4.63 + 0.1 million/mm3 after mixing and dropped to 3.89 ± 0.52 till the end of the bypass. After seven days the red blood count was practically normalized with over 5,000,000 erythrocytes per mm3 at the end of the observation. Blood trauma evaluated in function of plasma haemoglobin and (thrombocyte) depletion showed the following results: prebypass: 2.3 ± 0.7 μmol/l plasma haemoglobin and (220 ± 24 thousand thrombocytes per mm3); after six hours perfusion: 26.2 ± 15.5 and (137 ± 12); after seven days: 9.3 ± 4.1 and (400 ± 125). Post mortem studies did not demonstrate any deleterious lesions.

A Report on the Use of the New Capiox Hollow-Fibre Membrane Oxygenator

1984 ◽  
Vol 12 (2) ◽  
pp. 155-158
Author(s):  
H. Dodson ◽  
P. Newland,* ◽  
J. V. Pastoriza-Pinol ◽  
J. McMillan ◽  
R. McEgan
Keyword(s):  
Hollow Fibre ◽  
Membrane Oxygenator ◽  
Hollow Fibre Membrane ◽  
Fibre Membrane

Severe gas pathway obstruction of a hollow-fibre membrane oxygenator

Perfusion ◽  
1996 ◽  
Vol 11 (6) ◽  
pp. 467-470 ◽  
Author(s):  
Theodore L Zombolas ◽  
David W Fried ◽  
Benjamin N DeBenedetto ◽  
Gabriel Mattioni ◽  
Hasratt Mohamed ◽  
...  
Keyword(s):  
Hollow Fibre ◽  
Membrane Oxygenator ◽  
Hollow Fibre Membrane ◽  
Fibre Membrane

Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro

Perfusion ◽  
1998 ◽  
Vol 13 (5) ◽  
pp. 346-352 ◽  
Author(s):  
Akif Ündar ◽  
Marian C Holland ◽  
Russel V Howelton ◽  
Cherie K Benson ◽  
Jose R Ybarra ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Pulsatile Flow ◽  
Hollow Fibre ◽  
Membrane Oxygenator ◽  
Ejection Time ◽  
Hollow Fibre Membrane ◽  
University Of Texas ◽  
Membrane Oxygenators ◽  
The University

Neurologic complications are already well documented after cardiopulmonary bypass (CPB) procedures in neonates and infants. Physiologic pulsatile flow CPB systems may be the alternative to the currently used steady-flow CPB circuits. In addition to the pulsatile pump, a membrane oxygenator should be chosen carefully, because only a few membrane oxygenators are suitable for physiologic pulsatile flow. We have tested four different types of neonate-infant membrane oxygenators for physiologic pulsatility with The University of Texas neonate-infant pulsatile CPB system in vitro. Evaluation criteria were based on mean ejection time, extracorporeal circuit (ECC) pressure, and upstroke of d p/d t. The results suggested that the Capiox 308 hollow-fibre membrane oxygenator produced the best physiologic pulsatile waveform according to the ejection time, ECC pressure, and the upstroke of d p/d t. The Minimax Plus and Masterflo Infant hollow-fibre membrane oxygenators also produced adequate pulsatile flow. Only the Variable Prime Cobe Membrane Lung (VPCML) Plus flat-sheet membrane oxygenator failed to reach the criteria for physiologic pulsatility. Depending on the oxygenator used, the lowest priming volume of the infant CPB circuit was 415 ml and the highest 520 ml.

Experimental evaluation of the Dideco D903 Avant 1.7 hollow-fibre membrane oxygenator

Perfusion ◽  
1998 ◽  
Vol 13 (5) ◽  
pp. 353-359 ◽  
Author(s):  
Xavier M Mueller ◽  
Hendrick T Tevaearai ◽  
Monique Augstburger ◽  
Judith Horisberger ◽  
L K von Segesser
Keyword(s):  
Pressure Drop ◽  
Membrane Surface ◽  
Blood Gas Analysis ◽  
Hollow Fibre ◽  
Gas Analysis ◽  
Arterial Oxygen ◽  
Blood Gas ◽  
Membrane Oxygenator ◽  
Hollow Fibre Membrane ◽  
Fibre Membrane

Membrane oxygenators have now gained wide acceptance. A new hollow-fibre membrane oxygenator, the Dideco D903 Avant 1.7, with an optimized membrane surface (1.7 m2) and a wavy blood flow pattern, was tested for gas transfer and blood path resistance in a standardized setting with surviving animals. Three calves (mean body weight 63.29 ± 2.9 kg) were connected to cardiopulmonary bypass by jugular venous and carotid arterial cannulation, classic roller pump and the Dideco D903 oxygenator with a mean flow rate of 53 ± 0.1 ml/kg/min for 6 h. After this time, the animals were weaned from the CPB and thereafter from the ventilator. After 7 days, the animals were killed electively. Blood gas analysis was performed before bypass, after mixing (10 min) and then hourly for the 6 h of perfusion. Further samples were taken 30 min (spontaneous breathing) and 60 min after bypass (extubated). Physiological blood gas values could be maintained throughout perfusion in all animals. Mean arterial oxygen saturation varied between 99.3% and 99.7% for the arterial side of the oxygenator compared to 64.6% and 71% for the venous side. The highest mean pressure drop through the oxygenator was 54 mmHg. Postbypass blood gas analysis showed physiological values and no evidence of major lung trauma or pulmonary oedema in relation to the 6 h perfusion. The hollow-fibre membrane oxygenator, Dideco D903, offers excellent gas exchange capabilities and a low pressure drop under experimental conditions, despite reduced membrane surface area. The post mortem examination did not show any deleterious lesion.

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