High long-term test–retest reliability for extrastriatal 11C-raclopride binding in healthy older adults

In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test–retest reliability in a sample of younger adults. The present work demonstrates high seven-month test–retest reliability of striatal and extrastriatal 11C-raclopride BPND values in healthy, older adults (n = 27, age: 64–78 years). Mean 11C-raclopride BPND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85–0.96), absolute variability was low (mean: 4–8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BPND values correlated with previously determined 18F-fallypride BPND values (ρ = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: ρ = 0.92; p < 0.001; excluding striatum: ρ = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.

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Long-Term Test–Retest Reliability of Striatal and Extrastriatal Dopamine D2/3 Receptor Binding: Study with [11C]Raclopride and High-Resolution PET

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.2015.53 ◽

2015 ◽

Vol 35 (7) ◽

pp. 1199-1205 ◽

Cited By ~ 30

Author(s):

Kati Alakurtti ◽

Jarkko J Johansson ◽

Juho Joutsa ◽

Matti Laine ◽

Lars Bäckman ◽

...

Keyword(s):

High Resolution ◽

Intraclass Correlation ◽

Binding Potential ◽

Reference Tissue ◽

Retest Reliability ◽

Positron Emission ◽

Simplified Reference Tissue Model ◽

Test Retest Reliability

We measured the long-term test–retest reliability of [11C]raclopride binding in striatal subregions, the thalamus and the cortex using the bolus-plus-infusion method and a high-resolution positron emission scanner. Seven healthy male volunteers underwent two positron emission tomography (PET) [11C]raclopride assessments, with a 5-week retest interval. D2/3 receptor availability was quantified as binding potential using the simplified reference tissue model. Absolute variability (VAR) and intraclass correlation coefficient (ICC) values indicated very good reproducibility for the striatum and were 4.5%/0.82, 3.9%/0.83, and 3.9%/0.82, for the caudate nucleus, putamen, and ventral striatum, respectively. Thalamic reliability was also very good, with VAR of 3.7% and ICC of 0.92. Test-retest data for cortical areas showed good to moderate reproducibility (6.1% to 13.1%). Our results are in line with previous test–retest studies of [11C]raclopride binding in the striatum. A novel finding is the relatively low variability of [11C]raclopride binding, providing suggestive evidence that extrastriatal D2/3 binding can be studied in vivo with [11C]raclopride PET to be verified in future studies.

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The Automatic Assessment of Strength and Mobility in Older Adults: A Test-Retest Reliability Study

Medicina ◽

10.3390/medicina55060270 ◽

2019 ◽

Vol 55 (6) ◽

pp. 270 ◽

Cited By ~ 5

Author(s):

Daniel Collado-Mateo ◽

Pedro Madeira ◽

Francisco J. Dominguez-Muñoz ◽

Santos Villafaina ◽

Pablo Tomas-Carus ◽

...

Keyword(s):

Older Adults ◽

Intraclass Correlation ◽

Timed Up And Go ◽

Retest Reliability ◽

Healthy Older Adults ◽

Chair Stand ◽

Stand Test ◽

Chair Stand Test ◽

Sit To Stand ◽

Test Retest Reliability

Background: Simple field tests such as the Timed Up and Go test (TUG) and 30 s Chair Stand test are commonly used to evaluate physical function in the elderly, providing crude outcome measures. Using an automatic chronometer, it is possible to obtain additional kinematic parameters that may lead to obtaining extra information and drawing further conclusions. However, there is a lack of studies that evaluate the test-retest reliability of these parameters, which may help to judge and interpret changes caused by an intervention or differences between populations. Thus, the aim of this study was to evaluate the test-retest reliability of the Timed Up and Go test (TUG) and 30 s Chair Stand test in healthy older adults. Methods: A total of 99 healthy older adults participated in this cross-sectional study. The TUG and the 30 s Chair Stand test were performed five times and twice, respectively, using an automatic chronometer. The sit-to-stand-to-sit cycle from the 30 s Chair Stand test was divided into two phases. Results: Overall, reliability for the 30 s Chair Stand test was good for almost each variable (intraclass correlation coefficient (ICC) >0.70). Furthermore, the use of an automatic chronometer improved the reliability for the TUG (ICC >0.86 for a manual chronometer and ICC >0.88 for an automatic chronometer). Conclusions: The TUG and the 30 s Chair Stand test are reliable in older adults. The use of an automatic chronometer in the TUG is strongly recommended as it increased the reliability of the test. This device enables researchers to obtain relevant and reliable data from the 30 s Chair Stand test, such as the duration of the sit-to-stand-to-sit cycles and phases.

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Reliability and Validity of Turkish Myasthenia Gravis-Activities of Daily Living Scale

OTJR Occupation Participation and Health ◽

10.1177/1539449220961077 ◽

2020 ◽

pp. 153944922096107

Author(s):

Ecem Karanfil ◽

Yeliz Salcı ◽

Ayla Fil-Balkan ◽

Can Ebru Bekircan-Kurt ◽

Sevim Erdem Özdamar ◽

...

Keyword(s):

Construct Validity ◽

Myasthenia Gravis ◽

Activities Of Daily Living ◽

Daily Living ◽

Intraclass Correlation ◽

Reliability And Validity ◽

Life Questionnaire ◽

Good Test ◽

Retest Reliability ◽

Test Retest Reliability

Linguistic, reliable, and valid secondary efficacy measures are important in clinical settings and studies. The aim of the study is to report test–retest reliability and construct validity of Turkish version of Myasthenia Gravis-Activities of Daily Living Scale (MG-ADL-T) in Myasthenia Gravis (MG) patients. Fifty-two ocular and generalized individuals with MG, applying to rehabilitation center, were included in the study. MG-ADL-T, MG quality-of-life questionnaire (MG-QoL), MG composite (MGC), quantitative MG score (QMGS), and pulmonary function test were administered. Reliability was assessed with intraclass correlation coefficient (ICC) and Cronbach’s alpha. Spearman correlation test and receiver operating characteristic (ROC) analysis were performed for construct validity. MG-ADL-T had fair internal consistency (Cronbach’s α = .67), excellent test–retest reliability (ICC = 0.96) and moderate construct validity (MG-QoL, r = 0.59; QMGS, r = .58; MGC, r = .68). MG-ADL, a unique scale that evaluates activities of daily living (ADL), has good test–retest reliability and construct validity in Turkish MG patients.

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Reliability of the Polar Vantage M Sports Watch when Measuring Heart Rate at Different Treadmill Exercise Intensities

Sports ◽

10.3390/sports8090117 ◽

2020 ◽

Vol 8 (9) ◽

pp. 117

Author(s):

Mike Climstein ◽

Jessica L. Alder ◽

Alyce M. Brooker ◽

Elissa J. Cartwright ◽

Kevin Kemp-Smith ◽

...

Keyword(s):

Heart Rate ◽

Treadmill Exercise ◽

Intraclass Correlation ◽

Good Test ◽

Good Reliability ◽

Measurement Variability ◽

Retest Reliability ◽

Activity Monitors ◽

Test Retest Reliability ◽

Standard Error Of Measurement

Background: Usage of wrist-worn activity monitors has rapidly increased in recent years, and these devices are being used by both fitness enthusiasts and in clinical populations. We, therefore, assessed the test–retest reliability of the Polar Vantage M (PVM) watch when measuring heart rate (HR) during various treadmill exercise intensities. Methods: HR was measured every 30 s (simultaneous electrocardiography (ECG) and PVM). Test–retest reliability was determined using an intraclass correlation coefficient (ICC) with 95% confidence intervals (CIs). Standard error of measurement (SEM) and smallest real difference (SRD) were used to determine measurement variability. Results: A total of 29 participants completed the trials. ICC values for PVM during stages 1, 2 and 5 demonstrated good to excellent test–retest reliability (0.78, 0.78 and 0.92; 95% CI (0.54–0.90, 0.54–0.9, 0.79–0.97)). For PVM during stages 0 (rest), 3 and 4, the ICC values indicated poor to good reliability (0.42, 0.68 and 0.58; 95% CI (−0.27–0.73, 0.32–0.85, 0.14–0.80)). Conclusion: This study identified that the test–retest reliability of the PVM was comparable at low and high exercise intensities; however, it revealed a poor to good test–retest reliability at moderate intensities. The PVM should not be used in a clinical setting where monitoring of an accurate HR is crucial to the patients’ safety.

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Imaging the Cannabinoid CB1 Receptor in Humans with [11C] OMAR: Assessment of Kinetic Analysis Methods, Test–Retest Reproducibility, and Gender Differences

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.2015.46 ◽

2015 ◽

Vol 35 (8) ◽

pp. 1313-1322 ◽

Cited By ~ 34

Author(s):

Marc D Normandin ◽

Ming-Qiang Zheng ◽

Kuo-Shyan Lin ◽

N Scott Mason ◽

Shu-Fei Lin ◽

...

Keyword(s):

Gender Differences ◽

Kinetic Analysis ◽

Human Subjects ◽

Intraclass Correlation ◽

Volume Of Distribution ◽

Absolute Deviation ◽

Retest Reliability ◽

Analysis Methods ◽

Test Retest Reliability

The Radiotracer [11C]OMAR was developed for positron emission tomography (PET) imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to evaluate kinetic analysis methods, determine test–retest reliability, and assess gender differences in receptor availability. Dynamic PET data were acquired in 10 human subjects, and analyzed with one-tissue (1T) and two-tissue (2T) compartment models and by the Logan and multilinear analysis (MA1) methods to estimate regional volume of distribution ( VT). The 2T model inclusive of a vascular component (2TV) and MA1 were the preferred techniques. Test–retest reliability of VT was good (mean absolute deviation ~ 9%; intraclass correlation coefficient ~ 0.7). Tracer parent fraction in plasma was lower in women ( P < 0.0001). Cerebral uptake normalized by body weight and injected dose was higher in men by 17% ( P < 0.0001), but VT was significantly greater in women by 23% ( P < 0.0001). These findings show that [11C]OMAR binding can be reliably quantified by the 2T model or MA1 method and demonstrate the utility of this tracer for in vivo imaging of CB1R. In addition, results from the present study indicate that gender difference in receptor binding should be taken into consideration when [11C]OMAR is used to quantify CB1R availability in neuropsychiatric disorders.

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Dopamine D2 Receptor Blockade and Antimigraine Action of Flunarizine

Cephalalgia ◽

10.1046/j.1468-2982.1994.014003235.x ◽

1994 ◽

Vol 14 (3) ◽

pp. 235-240 ◽

Cited By ~ 14

Author(s):

C Wöber ◽

T Brücke ◽

C Wöber-Bingöl ◽

S Asenbaum ◽

P Wessely ◽

...

Keyword(s):

Single Photon ◽

Dopamine D2 Receptor ◽

Photon Emission ◽

D2 Receptor ◽

High Specificity ◽

D2 Receptors ◽

Binding Potential ◽

Receptor Blockade ◽

Dopamine D2

We studied in vivo the influence of flunarizine on dopamine D2 receptors and investigated whether dopamine D2 receptor blockade is involved in its antimigraine action. Eleven migraine patients, treated with flunarizine, 10 mg per day, underwent single photon emission computer tomography (SPECT) using [123I] labeled iodobenzamide, a ligand with high affinity and high specificity for D2 receptors. There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls. The efficacy of flunarizine in migraine prophylaxis failed to correlate with the degree of the dopamine D2 receptor blockade. The antimigraine action of flunarizine may not involve antidopaminergic mechanisms.

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Test-Retest Reliability of the StepWatch Activity Monitor Outputs in Healthy Adults

Journal of Physical Activity and Health ◽

10.1123/jpah.7.5.671 ◽

2010 ◽

Vol 7 (5) ◽

pp. 671-676 ◽

Cited By ~ 27

Author(s):

Suzie Mudge ◽

Denise Taylor ◽

Oliver Chang ◽

Rosita Wong

Keyword(s):

Activity Index ◽

Intraclass Correlation ◽

Objective Measure ◽

Activity Monitor ◽

Healthy Adults ◽

Peak Activity ◽

Good Test ◽

Retest Reliability ◽

Step Rate ◽

Test Retest Reliability

Background:Activity Monitors give an objective measure of usual walking performance. This study aimed to examine the test-retest reliability of the StepWatch Activity Monitor outputs (mean steps/day; peak activity index; sustained activity indices of 1, 5, 20, 30, 60 minutes; steps at high, medium, and low stepping rates).Methods:Thirty healthy adults age 18 to 49 years wore the StepWatch for 2 3-day periods at least 1 week apart.Results:The intraclass correlation coefficients of the StepWatch outputs ranged from 0.44 to 0.91 over 3 days. The coefficient of variation ranged from 3.0% to 51.3% over the monitoring periods, with higher variation shown for shorter monitoring periods. The most reliable 5 outputs had 95% limits of agreement between 3-day periods that were less than 40%. These were mean steps/day (±39.1%), highest step rate in 1 (±17.3%) and 5 (±37.4%) minutes, peak activity index (±25.6%), and percentage of inactive time (±9.52%).Conclusions:Mean steps/day, highest step rate in 1 and 5 minutes, peak activity index, and percentage of inactive time have good test-retest reliability over a 3-day monitoring period, with lower reliability shown by the other StepWatch outputs. Monitoring over 1 or 2 days is less reliable.

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The Modified Gait Efficacy Scale: Establishing the Psychometric Properties in Older Adults

Physical Therapy ◽

10.2522/ptj.20110053 ◽

2012 ◽

Vol 92 (2) ◽

pp. 318-328 ◽

Cited By ~ 41

Author(s):

Alaina M. Newell ◽

Jessie M. VanSwearingen ◽

Elizabeth Hile ◽

Jennifer S. Brach

Keyword(s):

Older Adults ◽

Correlation Coefficient ◽

Internal Consistency ◽

Intraclass Correlation ◽

Community Dwelling ◽

Self Report ◽

Retest Reliability ◽

And Performance ◽

Test Retest Reliability ◽

Community Dwelling Older Adults

BackgroundPerceived ability or confidence plays an important role in determining function and behavior. The modified Gait Efficacy Scale (mGES) is a 10-item self-report measure used to assess walking confidence under challenging everyday circumstances.ObjectiveThe purpose of this study was to determine the reliability, internal consistency, and validity of the mGES as a measure of gait in older adults.DesignThis was a cross-sectional study.MethodsParticipants were 102 community-dwelling older adults (mean [±SD] age=78.6±6.1 years) who were independent in ambulation with or without an assistive device. Participants were assessed using the mGES and measures of confidence and fear, measures of function and disability, and performance-based measures of mobility. In a subsample (n=26), the mGES was administered twice within a 1-month period to establish test-retest reliability through the intraclass correlation coefficient (ICC [2,1]). The standard error of measure (SEM) was determined from the ICC and standard deviation. The Cronbach α value was calculated to determine internal consistency. To establish the validity of the mGES, the Spearman rank order correlation coefficient was used to examine the association with measures of confidence, fear, gait, and physical function and disability.ResultsThe mGES demonstrated test-retest reliability within the 1-month period (ICC=.93, 95% confidence interval=.85, .97). The SEM of the mGES was 5.23. The mGES was internally consistent across the 10 items (Cronbach α=.94). The mGES was related to measures of confidence and fear (r=.54–.88), function and disability (Late-Life Function and Disability Instrument, r=.32–.88), and performance-based mobility (r=.38–.64).LimitationsThis study examined only community-dwelling older adults. The results, therefore, should not be generalized to other patient populations.ConclusionThe mGES is a reliable and valid measure of confidence in walking among community-dwelling older adults.

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Reliability of Subjective Pain Ratings and Nociceptive Flexion Reflex Responses as Measures of Conditioned Pain Modulation

Pain Research and Management ◽

10.1155/2014/698246 ◽

2014 ◽

Vol 19 (2) ◽

pp. 93-96 ◽

Cited By ~ 22

Author(s):

Carlo Jurth ◽

Benno Rehberg ◽

Falk von Dincklage

Keyword(s):

Intraclass Correlation ◽

Pain Modulation ◽

Hot Water ◽

Conditioned Pain Modulation ◽

Good Test ◽

Retest Reliability ◽

Reflex Responses ◽

Pain Ratings ◽

Subjective Pain ◽

Test Retest Reliability

BACKGROUND: The endogenous modulation of pain can be assessed through conditioned pain modulation (CPM), which can be quantified using subjective pain ratings or nociceptive flexion reflexes. However, to date, the test-retest reliability has only been investigated for subjective pain ratings.OBJECTIVE: To compare the test-retest reliability of CPM-induced changes, measured using subjective pain ratings and nociceptive flexion reflexes, to provide a reliable scoring parameter for future studies.METHOD: A total of 40 healthy volunteers each received painful electrical stimuli to the sural nerve to elicit nociceptive flexion reflexes. Reflex sizes and subjective pain ratings were recorded before and during the immersion of the contralateral hand in hot water to induce CPM as well as innocuous water as control. Measurements were repeated in a retest 28 days later.RESULTS: Intraclass correlation coefficients showed good test-retest reliabilities of CPM during the hot water stimulus for both scoring parameters. Subjective pain ratings also correlated between test and retest during the control stimulus.CONCLUSIONS: Subjective pain ratings and nociceptive flexion reflexes show comparable test-retest reliabilities, but they reflect different components of CPM. While subjective pain ratings appear to incorporate cognitive influences to a larger degree, reflex responses appear to reflect spinal nociception more purely.

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Test-Retest and Interrater Reliability of the Functional Movement Screen

Journal of Athletic Training ◽

10.4085/1062-6050-48.2.11 ◽

2013 ◽

Vol 48 (3) ◽

pp. 331-336 ◽

Cited By ~ 51

Author(s):

Rebecca Shultz ◽

Scott C. Anderson ◽

Gordon O. Matheson ◽

Brandon Marcello ◽

Thor Besier

Keyword(s):

Interrater Reliability ◽

Intraclass Correlation ◽

Video Recording ◽

Functional Movement Screen ◽

Good Test ◽

Good Reliability ◽

Functional Movement ◽

Retest Reliability ◽

Test Retest Reliability ◽

First Session

Context: The Functional Movement Screen (FMS) is a popular test to evaluate the degree of painful, dysfunctional, and asymmetric movement patterns. Despite great interest in the FMS, test-retest reliability data have not been published. Objective: To assess the test-retest and interrater reliability of the FMS and to compare the scoring by 1 rater during a live session and the same session on video. Design: Cross-sectional study. Setting: Human performance laboratory in the sports medicine center. Patients or Other Participants: A total of 21 female (age = 19.6 ± 1.5 years, height = 1.7 ± 0.1 m, mass = 64.4 ± 5.1 kg) and 18 male (age = 19.7 ± 1.0 years, height = 1.9 ± 0.1 m, mass = 80.1 ± 9.9 kg) National Collegiate Athletic Association Division IA varsity athletes volunteered. Intervention(s): Each athlete was tested and retested 1 week later by the same rater who also scored the athlete's first session from a video recording. Five other raters scored the video from the first session. Main Outcome Measure(s): The Krippendorff α (K α) was used to assess the interrater reliability, whereas intraclass correlation coefficients (ICCs) were used to assess the test-retest reliability and reliability of live-versus-video scoring. Results: Good reliability was found for the test-retest (ICC = 0.6), and excellent reliability was found for the live-versus-video sessions (ICC = 0.92). Poor reliability was found for the interrater reliability (K α = .38). Conclusions: The good test-retest and high live-versus-video session reliability show that the FMS is a usable tool within 1 rater. However, the low interrater K α values suggest that the FMS within the limits of generalization should not be used indiscriminately to detect deficiencies that place the athlete at greater risk for injury. The FMS interrater reliability may be improved with better training for the rater.

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