Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer’s disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40—89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13—8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=−1.43), hippocampus (−1.25), superior frontal gyrus (−1.70), middle frontal gyrus (−1.99), posterior cingulate (−2.46), and precuneus (−2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.

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Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)

10.1101/2020.04.27.063164 ◽

2020 ◽

Cited By ~ 3

Author(s):

Cathal McCrory ◽

Giovanni Fiorito ◽

Belinda Hernandez ◽

Silvia Polidoro ◽

Aisling M. O’Halloran ◽

...

Keyword(s):

Longitudinal Study ◽

Functional Health ◽

Interindividual Variation ◽

Predictive Utility ◽

Clinical Phenotypes ◽

Age Related ◽

Wide Range ◽

All Cause Mortality ◽

Health Cognition

ABSTRACTThe aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. The present study examines the associations of four epigenetic clocks - Horvath, Hannum, PhenoAge, GrimAge - with a wide range of clinical phenotypes, and with all-cause mortality at up to 10-year follow-up in a sample of 490 participants in the Irish Longitudinal Study on Ageing. Results indicate that the GrimAge clock represents a step-improvement in the predictive utility of the epigenetic clocks for identifying age-related decline in an array of clinical phenotypes.

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Overweight and isolated

International Journal of Behavioral Development ◽

10.1177/0165025416647799 ◽

2016 ◽

Vol 41 (3) ◽

pp. 390-404 ◽

Cited By ~ 14

Author(s):

Megan Ames ◽

Bonnie Leadbeater

Keyword(s):

Social Support ◽

Longitudinal Study ◽

Interpersonal Relationships ◽

Young Adulthood ◽

Romantic Relationship ◽

Weight Status ◽

Interpersonal Problems ◽

Time Varying ◽

Age Related ◽

Age Related Changes

This longitudinal study investigates whether there are particularly salient ages when being overweight is related to problems in interpersonal relationships (i.e., physical, relational, and verbal victimization, lack of friend social support, dating status, and romantic relationship worries). Participants were from a large, six-wave longitudinal study ( N = 662, 48% males, M age at T1 = 15.5 years, SD = 1.9 years). We use time-varying effect models to estimate how the associations between weight status and interpersonal problems differ from ages 12 to 28. Gender differences are also investigated. Findings show that youth who are overweight are more likely to experience verbal victimization, feel less supported by their peers, and are less likely to date than youth who are not overweight from mid-adolescence into early young adulthood. Further, females who are overweight are more likely to be physically victimized at ages 15 to 22 than females who are not overweight. The results provide a better understanding of age-related changes in interpersonal problems among youth who are overweight from adolescence into young adulthood.

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Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)

NeuroImage ◽

10.1016/j.neuroimage.2021.117741 ◽

2021 ◽

Vol 229 ◽

pp. 117741

Author(s):

Caoilfhionn Ní Leidhin ◽

Jason McMorrow ◽

Daniel Carey ◽

Louise Newman ◽

Wilby Williamson ◽

...

Keyword(s):

Longitudinal Study ◽

Cerebral Perfusion ◽

Age Related

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Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing

PLoS ONE ◽

10.1371/journal.pone.0204833 ◽

2018 ◽

Vol 13 (10) ◽

pp. e0204833 ◽

Cited By ~ 14

Author(s):

Asri Maharani ◽

Piers Dawes ◽

James Nazroo ◽

Gindo Tampubolon ◽

Neil Pendleton ◽

...

Keyword(s):

Longitudinal Study ◽

Cognitive Decline ◽

Cataract Surgery ◽

Age Related ◽

Age Related Cognitive Decline ◽

English Longitudinal Study

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Correction: Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing

PLoS ONE ◽

10.1371/journal.pone.0208045 ◽

2018 ◽

Vol 13 (11) ◽

pp. e0208045 ◽

Cited By ~ 1

Author(s):

Asri Maharani ◽

Piers Dawes ◽

James Nazroo ◽

Gindo Tampubolon ◽

Neil Pendleton ◽

...

Keyword(s):

Longitudinal Study ◽

Cognitive Decline ◽

Cataract Surgery ◽

Age Related ◽

Age Related Cognitive Decline ◽

English Longitudinal Study

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Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging

BMC Medicine ◽

10.1186/s12916-021-01973-y ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Xikun Han ◽

Samantha Sze-Yee Lee ◽

Nathan Ingold ◽

Nigel McArdle ◽

Anthony P. Khawaja ◽

...

Keyword(s):

United Kingdom ◽

Longitudinal Study ◽

Macular Degeneration ◽

Sleep Apnoea ◽

Incidence Rates ◽

Age Related Macular Degeneration ◽

Uk Biobank ◽

Age Related ◽

The Uk

Abstract Background Sleep apnoea, a common sleep-disordered breathing condition, is characterised by upper airway collapse during sleep resulting in transient hypoxia, hypoperfusion of the optic nerve, and spike in intracranial pressure. Previous studies have reported conflicting findings on the association of sleep apnoea with glaucoma, and there are limited reports on the link between sleep apnoea and age-related macular degeneration (AMD). Methods Middle-aged and older participants from the longitudinal United Kingdom (UK) Biobank (n = 502,505) and the Canadian Longitudinal Study on Aging (CLSA; n = 24,073) were included in this analysis. Participants in the UK Biobank and the CLSA were followed for 8 and 3 years, respectively. Participants with diagnosed glaucoma or AMD at baseline were excluded from the analysis. In the UK Biobank, sleep apnoea and incident cases of glaucoma and AMD were identified through hospital inpatient admission, primary care records, and self-reported data. Multivariable Cox proportional hazards models were used to explore associations of sleep apnoea with incidence of glaucoma or AMD. Results During the 8-year follow-up in the UK Biobank, glaucoma incidence rates per 1000 person-years were 2.46 and 1.59 for participants with and without sleep apnoea, and the AMD incidence rates per 1000 person-years were 2.27 and 1.42 for participants with and without sleep apnoea, respectively. Multivariable adjusted hazard ratios of glaucoma and AMD risk for sleep apnoea were 1.33 (95% confidence interval [CI] 1.10–1.60, P = 0.003) and 1.39 (95% CI 1.15–1.68, P < 0.001) relative to participants without sleep apnoea. In the CLSA cohort, disease information was collected through in-person interview questionnaires. During the 3-year follow-up, glaucoma incidence rates per 1000 person-years for those with and without sleep apnoea were 9.31 and 6.97, and the AMD incidence rates per 1000 person-years were 8.44 and 6.67, respectively. In the CLSA, similar associations were identified, with glaucoma and AMD odds ratios of 1.43 (95% CI 1.13–1.79) and 1.39 (95% CI 1.08–1.77), respectively, in participants with sleep apnoea compared to those without sleep apnoea (both P < 0.001). Conclusions In two large-scale prospective cohort studies, sleep apnoea is associated with a higher risk of both glaucoma and AMD. These findings indicate that patients with sleep apnoea might benefit from regular ophthalmologic examinations.

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