Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer’s disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40—89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13—8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=−1.43), hippocampus (−1.25), superior frontal gyrus (−1.70), middle frontal gyrus (−1.99), posterior cingulate (−2.46), and precuneus (−2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.

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Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months

Ophthalmology Retina ◽

10.1016/j.oret.2019.03.010 ◽

2019 ◽

Vol 3 (8) ◽

pp. 637-648 ◽

Cited By ~ 6

Author(s):

S. Tammy Hsu ◽

Atalie C. Thompson ◽

Sandra S. Stinnett ◽

Ulrich F.O. Luhmann ◽

Lejla Vajzovic ◽

...

Keyword(s):

Longitudinal Study ◽

Macular Degeneration ◽

Visual Function ◽

Age Related Macular Degeneration ◽

Age Related

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IC-P-100: Cross-Sectional and Longitudinal Study of Age-Related Shrinkage in the Superior,Middle and Inferior Frontal Gyrus in Old and Very Old Age

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.114 ◽

2010 ◽

Vol 6 ◽

pp. S40-S40

Author(s):

Olof E. Lindberg ◽

Carl-Henrik Ehrenkrona ◽

Linnea Engström ◽

Leif A. Svensson ◽

Eva Öhrndahl ◽

...

Keyword(s):

Longitudinal Study ◽

Old Age ◽

Inferior Frontal Gyrus ◽

Cross Sectional ◽

Very Old ◽

Age Related ◽

Very Old Age

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Bidirectional Association Between Depression and Hearing Loss: Evidence From the China Health and Retirement Longitudinal Study

Journal of Applied Gerontology ◽

10.1177/07334648211042370 ◽

2021 ◽

pp. 073346482110423

Author(s):

Chao Wu

Keyword(s):

Hearing Loss ◽

Longitudinal Study ◽

Cognitive Decline ◽

Age Related ◽

Bidirectional Association ◽

Health Related ◽

Clinically Significant ◽

Using Data ◽

Bidirectional Associations ◽

Age Related Hearing Loss

The relationship between depression and age-related hearing loss (ARHL) is not fully understood. This study tested the bidirectional associations between clinically significant depressive symptoms (CSDSs) and ARHL in middle-aged and older adults using data from the China Health and Retirement Longitudinal Study. Among 3,418 participants free of baseline ARHL, baseline CSDS was associated with an increased odds of incident ARHL (odds ratio [OR]: 1.51). Cognitive decline, BMI, and arthritis partially mediated the longitudinal CSDS–ARHL association and explained 24% of the variance in the total effect. Among 4,921 participants without baseline CSDS, baseline ARHL was associated with an increased odds of incident CSDS (OR: 1.37). The bidirectional associations remained significant after adjustments for baseline demographic factors, comorbidities, and other health-related covariates. Depression may contribute to the development of ARHL, and vice versa. Interventions in depression, cognitive decline, and arthritis may delay the onset of ARHL and break the vicious circle between them.

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Sex-differences in age-related grip strength decline: A 10-year longitudinal study of community-living middle-aged and older Japanese

The Journal of Physical Fitness and Sports Medicine ◽

10.7600/jpfsm.5.87 ◽

2016 ◽

Vol 5 (1) ◽

pp. 87-94 ◽

Cited By ~ 6

Author(s):

Rumi Kozakai ◽

Fujiko Ando ◽

Heung Youl Kim ◽

Atsumu Yuki ◽

Rei Otsuka ◽

...

Keyword(s):

Sex Differences ◽

Longitudinal Study ◽

Grip Strength ◽

Community Living ◽

Middle Aged ◽

Age Related

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Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.790926 ◽

2021 ◽

Vol 13 ◽

Author(s):

Pei-Lun Kuo ◽

Ann Zenobia Moore ◽

Frank R. Lin ◽

Luigi Ferrucci

Keyword(s):

Dna Methylation ◽

Longitudinal Study ◽

Smoking History ◽

Future Research ◽

Age Related ◽

Epigenetic Age ◽

Epigenetic Age Acceleration ◽

Baltimore Longitudinal Study ◽

Age Related Hearing Loss ◽

The Relationship

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated diseases and mortality. However, the association between epigenetic age acceleration and hearing remains unknown. Our study aims to investigate the relationship between epigenetic age acceleration and audiometric hearing in the Baltimore Longitudinal Study of Aging (BLSA).Methods: Participants with both DNA methylation and audiometric hearing measurements were included. The main independent variables are epigenetic age acceleration measures, including intrinsic epigenetic age acceleration—“IEAA,” Hannum age acceleration—“AgeAccelerationResidualHannum,” PhenoAge acceleration—“AgeAccelPheno,” GrimAge acceleration—“AgeAccelGrim,” and methylation-based pace of aging estimation—“DunedinPoAm.” The main dependent variable is speech-frequency pure tone average. Linear regression was used to assess the association between epigenetic age acceleration and hearing.Results: Among the 236 participants (52.5% female), after adjusting for age, sex, race, time difference between measurements, cardiovascular factors, and smoking history, the effect sizes were 0.11 995% CI: (–0.00, 0.23), p = 0.054] for Hannum’s clock, 0.08 [95% CI: (–0.03, 0.19), p = 0.143] for Horvath’s clock, 0.10 [95% CI: (–0.01, 0.21), p = 0.089] for PhenoAge, 0.20 [95% CI: (0.06, 0.33), p = 0.004] for GrimAge, and 0.21 [95% CI: (0.09, 0.33), p = 0.001] for DunedinPoAm.Discussion: The present study suggests that some epigenetic age acceleration measurements are associated with hearing. Future research is needed to study the potential subclinical cardiovascular causes of hearing and to investigate the longitudinal relationship between DNA methylation and hearing.

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Do social factors mediate or moderate the sensory-cognitive associations in older adults in the Canadian Longitudinal Study on Aging?

10.31234/osf.io/y8mh9 ◽

2019 ◽

Author(s):

Anni Hämäläinen ◽

Natalie Phillips ◽

Walter Wittich ◽

Paul Mick ◽

M Kathleen Pichora-Fuller

Keyword(s):

Longitudinal Study ◽

Cognitive Decline ◽

Social Factors ◽

Pure Tone Audiometry ◽

Sensory Function ◽

Sensory Loss ◽

Protective Effects ◽

Social Variables ◽

Cross Sectional ◽

Age Related

Sensory and cognitive function both tend to decline with increasing age. Sensory impairments are risk factors for age-related cognitive decline and dementia. One hypothesis about sensory-cognitive associations is that sensory loss results in social isolation which, in turn, is a risk factor for cognitive decline. We tested whether social factors are associated with cognitive and sensory function, and whether sensory-cognitive associations are mediated or moderated by social factors. We used cross-sectional data from 30,029 participants in the Canadian Longitudinal Study of Aging, aged 45-85 years, who had no reported cognitive impairment or diagnosis of dementia. We found strong independent associations of self-reported social variables with hearing (pure-tone audiometry), vision (pinhole-corrected visual acuity), and executive function and weaker associations with memory. The moderating and mediating effects of social variables on sensory-cognitive associations were weak and mostly non-significant, but social factors could be slightly more important for females and older people. Partial retirement (relative to full retirement or not being retired) may have protective effects on cognition in the presence of hearing loss. These findings confirm the association between social factors and sensory and cognitive measures. However, support is weak for the hypothesis that social factors shape sensory-cognitive associations.

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Age-related accident risks: Longitudinal study of Swedish iron ore miners

American Journal of Industrial Medicine ◽

10.1002/(sici)1097-0274(199610)30:4<479::aid-ajim14>3.0.co;2-1 ◽

1996 ◽

Vol 30 (4) ◽

pp. 479-487 ◽

Cited By ~ 13

Author(s):

Lucie Laflamme ◽

Vera L. G. Blank

Keyword(s):

Longitudinal Study ◽

Iron Ore ◽

Age Related

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Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study

Experimental Gerontology ◽

10.1016/0531-5565(94)90036-1 ◽

1994 ◽

Vol 29 (5) ◽

pp. 531-541 ◽

Cited By ~ 102

Author(s):

Anders Wikby ◽

Boo Johansson ◽

Frederick Ferguson ◽

Jadwiga Olsson

Keyword(s):

Longitudinal Study ◽

Very Old ◽

Immune Parameters ◽

Age Related ◽

Age Related Changes

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Age-related effects of compression rate and duration in cardiopulmonary resuscitation

Journal of Applied Physiology ◽

10.1152/jappl.1990.68.2.554 ◽

1990 ◽

Vol 68 (2) ◽

pp. 554-560 ◽

Cited By ~ 40

Author(s):

J. M. Dean ◽

R. C. Koehler ◽

C. L. Schleien ◽

I. Berkowitz ◽

J. R. Michael ◽

...

Keyword(s):

Relaxation Time ◽

Cardiopulmonary Resuscitation ◽

Cerebral Perfusion Pressure ◽

Chest Wall ◽

Duty Cycle ◽

Cerebral Perfusion ◽

Perfusion Pressure ◽

Age Groups ◽

Compression Rate ◽

Age Related

The effects of various compression rate and duration combinations on chest geometry and cerebral perfusion pressure during cardiopulmonary resuscitation (CPR) were studied in immature swine. Pentobarbital-anesthetized 2- and 8-wk-old piglets received CPR after ventricular fibrillation. At compression rates of 40, 60, 80, 100, 120, and 150/min, duty cycle (compression duration/total cycle time) was increased from 10 to 80% by 10% increments. Mean aortic and sagittal sinus pressures, pulsatile displacement, and deformity of the anterior chest wall were measured. Increasing duty cycle increased cerebral perfusion pressure until chest relaxation time was compromised. Inadequate chest recoil, development of static chest deformation, and limitation of pulsatile chest wall movement occurred in both age groups when relaxation time was very short (150-200 ms in 2-wk-old piglets, 250-300 ms in 8-wk-old piglets). These changes in chest geometry correlated with deterioration of cerebral perfusion pressure only in 8-wk-old piglets. In the younger group, perfusion pressures plateaued but did not deteriorate. These data emphasize the importance of duty cycle in generating cerebral perfusion pressure and indicate that younger animals can tolerate high compression rates except at extremely long duty cycles.

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