scholarly journals Delayed increase in serum acetaminophen concentration after ingestion of a combination medications: a case report

2018 ◽  
Vol 46 (8) ◽  
pp. 3435-3439 ◽  
Author(s):  
Junko Yamaguchi ◽  
Kosaku Kinoshita ◽  
Akihiro Noda ◽  
Makoto Furukawa ◽  
Atsushi Sakurai
Keyword(s):  
Case Report ◽  
Serum Concentration ◽  
Potential Risk ◽  
Liver Dysfunction ◽  
Treatment Strategy ◽  
Single Agent ◽  
Oral Intake ◽  
Over The Counter ◽  
Acetaminophen Overdose ◽  
Over Time

Acetaminophen is absorbed rapidly after oral intake, and serum concentration peaks within 4 hours. The Rumack–Matthew (RM) nomogram is widely used to identify the potential risk of liver dysfunction. However, the RM nomogram was intended for use only when a single agent was ingested. We report the case of a patient with overdose ingestion of an over-the-counter combination cold medication that contained acetaminophen, where the patient’s serum concentration increased over time. Over-the-counter combination cold medications are designed to relieve cold symptoms. However, the possibility that other agents that were present in the drug may change gastrointestinal kinetics should also be considered. The risk of liver dysfunction cannot be accurately determined from a single serum acetaminophen concentration measurement. Because of the risk of a delayed increase in the serum acetaminophen concentration, monitoring for liver dysfunction and developing a treatment strategy that includes N-acetylcysteine are required. This case report is targeted to clinical physicians who treat patients with acetaminophen overdose resulting from ingestion of multiple agents, and it reviews points of consideration when using the RM nomogram in acute intoxication.

scholarly journals Propranolol Abuse: A Case Report on the Harmful Consequence of Over-the-Counter Medications

2020 ◽  
Vol 42 (4) ◽  
pp. 394-396
Author(s):  
Vigneshvar Chandrasekaran ◽  
Karthick Subramanian ◽  
Avin Muthuramalingam
Keyword(s):  
Case Report ◽  
Over The Counter ◽  
Harmful Consequence

scholarly journals What the Cardiologist Needs to Consider in the Management of Oncologic Patients with STEMI-Like Syndrome; A Case Report and Literature Review

2021 ◽  
Vol 14 (6) ◽  
pp. 563
Author(s):  
Aneta Aleksova ◽  
Giulia Gagno ◽  
Alessandro Pierri ◽  
Carla Todaro ◽  
Alessandra Lucia Fluca ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Case Report ◽  
Side Effects ◽  
Single Agent ◽  
St Segment Elevation ◽  
Cardiac Catheterization Laboratory ◽  
Cardiac Side Effects ◽  
Coronary Syndrome ◽  
St Segment ◽  
Oncologic Patients

In pre-hospital care, an accurate and quick diagnosis of ST-segment elevation myocardial infarction (STEMI) is imperative to promptly kick-off the STEMI network with a direct transfer to the cardiac catheterization laboratory (cath lab) in order to reduce myocardial infarction size and mortality. Aa atherosclerotic plaque rupture is the main mechanism responsible for STEMI. However, in a small percentage of patients, emergency coronarography does not reveal any significant coronary stenosis. The fluoropyrimidine agents such as 5-Fluorouracil (5-FU) and capecitabine, widely used to treat gastrointestinal, breast, head and neck cancers, either as a single agent or in combination with other chemotherapies, can cause potentially lethal cardiac side effects. Here, we present the case of a patient with 5-FU cardiotoxicity resulting in an acute coronary syndrome (ACS) with recurrent episodes of chest pain and ST-segment elevation.. Our case report highlights the importance of widening the knowledge among cardiologists of the side effects of chemotherapeutic drugs, especially considering the rising number of cancer patients around the world and that fluoropyrimidines are the main treatment for many types of cancer, both in adjuvant and advanced settings.

Case Report: Recognition of Nonhepatic Coma in the Setting of Acetaminophen Overdose

2004 ◽  
Vol 49 (11-12) ◽  
pp. 1977-1980 ◽  
Author(s):  
Aftab Ala ◽  
Thomas Schiano ◽  
Andrew Burroughs ◽  
Satish Keshav
Keyword(s):  
Case Report ◽  
Acetaminophen Overdose

SURGICAL DEBRIDEMENT AS A TREATMENT STRATEGY FOR CERVICOFACIAL ACTINOMYCOSIS: REVIEW OF LITERATURE AND A CASE REPORT

2020 ◽  
Vol 130 (3) ◽  
pp. e168-e169
Author(s):  
KAROLYNY MARTINS BALBINOT ◽  
ANTONIA TAIANE LOPES DE MORAIS ◽  
YASMIM RODRIGUES SENA ◽  
BEATRIZ MARTINS VOSS ◽  
GIORDANNA PEREIRA CHEMELO ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Strategy ◽  
Surgical Debridement ◽  
Review Of Literature

A Case Report of Delirium Induced by Herbal Laxative Senna

2021 ◽  
Vol 11 (6) ◽  
pp. 231-233
Author(s):  
Nimitha K J ◽  
Porimita Chutia ◽  
Pooja Misal
Keyword(s):  
Case Report ◽  
Serum Sodium ◽  
Elderly Population ◽  
Oral Intake ◽  
Mental Illnesses ◽  
Electrolyte Imbalance ◽  
Normal Limits ◽  
Icd 10 ◽  
Current Scenario ◽  
History Of

Constipation is one major complaint in elderly population. It may be due to physiological and anatomical reasons of aging, but it can be also due chronic medical and mental illnesses and due to use of multiple medications. Constipation itself is a precipitating factor for delirium. Drugs used for constipation can also be the culprit. A 64-year-old female who had a history of hypertension and chronic constipation presented with symptoms of confused and altered behavior, decreased oral intake, decreased sleep. On history taking it was known that she was using Herbal medication containing senna glycoside and other compounds since 8-9months. On examination she had signs of dehydration, disoriented and attention was impaired. On investigation her serum sodium was 122.6 mmol/ and other investigations were within normal limits. She was diagnosed as a case of Delirium according to ICD-10 criteria. Her dehydration was corrected by giving intravenous fluids and serum sodium level was corrected using salt capsules 2 tablets thrice daily. For disturbed sleep she was prescribed Tab Melatonin 10mg at bedtime and constipation was treated with per rectal enema and syrup lactulose 30ml at bedtime. Patient improved in 1 week time. Senna a herbal laxative used to treat constipation. It can alter intestinal electrolyte transportation and irritates intestinal mucosa. It is due to increased peristalsis and increased defecation and even diarrhea Prolonged use can cause dehydration, electrolyte imbalance and delirium. Senna, an over-the-counter laxative with FDA approval is a matter of concern in the current scenario. This case report warns into the judicious use of laxatives containing senna in elderly population. Key words: Delirium, Herbal Laxative, Senna, Constipation.

scholarly journals Nitrogenous metabolism in Thoroughbred and Arabian foals from birth to five months of age

2006 ◽  
Vol 58 (4) ◽  
pp. 525-529 ◽  
Author(s):  
G. Piccione ◽  
A. Costa ◽  
F. Fazio ◽  
F. Grasso ◽  
G. Caola
Keyword(s):  
Uric Acid ◽  
Serum Concentration ◽  
Nitrogen Metabolism ◽  
Rectal Temperature ◽  
Total Protein ◽  
Critical Period ◽  
Critical Period Of Development ◽  
Over Time ◽  
Time Point ◽  
Nitrogenous Metabolism

The maturation of nitrogen metabolism was studied in six Thoroughbred and six Arabian foals. Rectal temperature, heart and respiratory rates and serum concentration of several hematochemical parameters (total protein, urea, uric acid, creatinine, and albumine) were monitored from birth to 5 months of age. In both breeds, all the parameters except albumine showed significant differences over time (P<0.05). The two breeds did not differ from each other at any time point. Statistically significant decreases in urea and creatinine concentrations were related to the growth needs of foals during this critical period of development.

scholarly journals Cerebral Proliferative Angiopathy: Case Report

2018 ◽  
Vol 37 (02) ◽  
pp. 131-133 ◽  
Author(s):  
Luana Gatto ◽  
Rodrigo Brisson ◽  
Zeferino Demartini ◽  
Gelson Koppe ◽  
Carlos Rocha
Keyword(s):  
Case Report ◽  
Endovascular Procedures ◽  
Brain Parenchyma ◽  
Neurological Deficits ◽  
Motor Deficit ◽  
Brain Arteriovenous Malformation ◽  
Cerebral Vascular Disease ◽  
Functional Brain ◽  
History Of ◽  
Over Time

AbstractProliferative angiopathy (PA) is a rare cerebral vascular disease in which anomalous vessels continually recruit additional feeder arteries, amid a functional brain parenchyma. We report the case of a young woman with progressive history of headache, motor deficit, seizures and drowsiness. She received a misdiagnosis of brain arteriovenous malformation (AVM) and evolved with dysarthria and cognitive decline after an unsuccessful embolization performed at another institution. We opted for conservative treatment with periodic control by imaging tests. Proliferative angiopathy differs in natural history, prognosis, histopathology and treatment of the usual AVMs. Endovascular procedures aggravate the neurological deficits, which are usually progressive and tend to worsen over time.

scholarly journals Intestinal perforation after radical cystectomy due to drain: Case report

2014 ◽  
Vol 86 (4) ◽  
pp. 295
Author(s):  
Salih Budak ◽  
Hüseyin Aydemir ◽  
Hasan Salih Saglam ◽  
Oztug Adsan
Keyword(s):  
Bladder Cancer ◽  
Case Report ◽  
Radical Cystectomy ◽  
Urinary Diversion ◽  
Potential Risk ◽  
Intestinal Perforation ◽  
Standard Treatment ◽  
Foley Catheter ◽  
Current Standard ◽  
Current Standard Treatment

The current standard treatment for nonmetastatic invasive bladder cancer is radical cystectomy with urinary diversion. Radical cystectomy surgery carries a serious potential risk of complications. In this case report, an intestinal perforation which was thought to be occurred due to a Foley catheter placed as a drain after the cystectomy is presented.

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