scholarly journals Branch atheromatous disease has a stronger association with late-onset epileptic seizures than lacunar infarction in Japanese patients

2019 ◽  
Vol 48 (1) ◽  
pp. 030006051983157
Author(s):  
Kaoru Obata ◽  
Masako Kinoshita ◽  
Kazuaki Sato ◽  
Masaki Chin ◽  
Sen Yamagata ◽  
...  
Keyword(s):  
Late Onset ◽  
Epileptic Seizures ◽  
Japanese Patients ◽  
Lacunar Infarction ◽  
Branch Atheromatous Disease

scholarly journals Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity

2021 ◽  
Vol 10 (13) ◽  
pp. 2776
Author(s):  
Miren Altuna ◽  
Sandra Giménez ◽  
Juan Fortea
Keyword(s):  
Down Syndrome ◽  
Functional Outcomes ◽  
Clinical Presentation ◽  
Late Onset ◽  
Current Knowledge ◽  
Epileptic Seizures ◽  
Myoclonic Epilepsy ◽  
Increased Risk ◽  
Number Of Individuals

Individuals with Down syndrome (DS) have an increased risk for epilepsy during the whole lifespan, but especially after age 40 years. The increase in the number of individuals with DS living into late middle age due to improved health care is resulting in an increase in epilepsy prevalence in this population. However, these epileptic seizures are probably underdiagnosed and inadequately treated. This late onset epilepsy is linked to the development of symptomatic Alzheimer’s disease (AD), which is the main comorbidity in adults with DS with a cumulative incidence of more than 90% of adults by the seventh decade. More than 50% of patients with DS and AD dementia will most likely develop epilepsy, which in this context has a specific clinical presentation in the form of generalized myoclonic epilepsy. This epilepsy, named late onset myoclonic epilepsy (LOMEDS) affects the quality of life, might be associated with worse cognitive and functional outcomes in patients with AD dementia and has an impact on mortality. This review aims to summarize the current knowledge about the clinical and electrophysiological characteristics, diagnosis and treatment of epileptic seizures in the DS population, with a special emphasis on LOMEDS. Raised awareness and a better understanding of epilepsy in DS from families, caregivers and clinicians could enable earlier diagnoses and better treatments for individuals with DS.

A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease

1993 ◽  
Vol 163 (2) ◽  
pp. 166-168 ◽  
Author(s):  
Akira Ueki ◽  
Mikihiko Kawano ◽  
Yoshio Namba ◽  
Masanobu Kawakami ◽  
Kazuhiko Ikeda
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Frequency ◽  
Late Onset ◽  
Japanese Patients ◽  
Apolipoprotein E4

Late onset epileptic seizures A retrospective study of 250 patients

2009 ◽  
Vol 72 (4) ◽  
pp. 380-384 ◽  
Author(s):  
José Luis Pérez López ◽  
Jesús Longo ◽  
Fernando Quintana ◽  
Consuelo Diez ◽  
José Berciano
Keyword(s):  
Retrospective Study ◽  
Late Onset ◽  
Epileptic Seizures

Generalized epileptic seizures as the presenting symptom of lacunar infarction in the brain

1988 ◽  
Vol 235 (8) ◽  
pp. 472-474 ◽  
Author(s):  
E. Avrahami ◽  
V. E. Drory ◽  
M. J. Rabey ◽  
D. F. Cohn
Keyword(s):  
Epileptic Seizures ◽  
Lacunar Infarction ◽  
The Brain

scholarly journals Late Onset of Acute Urticaria after Bee Stings

2016 ◽  
Vol 8 (3) ◽  
pp. 341-343 ◽  
Author(s):  
Yuko Asai ◽  
Hisashi Uhara ◽  
Atsushi Miyazaki ◽  
Minoru Saiki ◽  
Ryuhei Okuyama
Keyword(s):  
Allergic Reaction ◽  
Late Onset ◽  
Japanese Patients ◽  
Specific Ige ◽  
Medical Interview ◽  
Ige Antibodies ◽  
Acute Urticaria ◽  
Bee Sting ◽  
History Of ◽  
Specific Ige Antibodies

Here we report the cases of five patients with a late onset of acute urticaria after a bee sting. The ages of the five Japanese patients ranged from 33 to 86 years (median: 61). All patients had no history of an allergic reaction to bee stings. The onset of urticaria was 6–14 days (median: 10) after a bee sting. Although four of the patients did not describe experiencing a bee sting at their presentation, the subsequent examination detected anti-bee-specific IgE antibodies. So, we think a history of a bee sting should thus be part of the medical interview sheet for patients with acute urticaria, and an examination of IgE for bees may help prevent a severe bee-related anaphylactic reaction in the future.

scholarly journals Predominant Corticospinal Tract Involvement in a Late Infant with Krabbe Disease

2016 ◽  
Vol 7 ◽  
pp. JCM.S40470 ◽  
Author(s):  
Ayumi Yoshimura ◽  
Tetsuya Kibe ◽  
Kaori Irahara ◽  
Norio Sakai ◽  
Kenji Yokochi
Keyword(s):  
Corticospinal Tract ◽  
Late Onset ◽  
Brain Magnetic Resonance Imaging ◽  
Japanese Patients ◽  
Krabbe Disease ◽  
Compound Heterozygous ◽  
Homozygous Mutation ◽  
Pathophysiological Mechanism ◽  
Spastic Quadriplegia ◽  
Tract Involvement

A case of late-infantile Krabbe disease in a patient who presented with developmental regression and spastic quadriplegia in late infancy is reported. Brain magnetic resonance imaging (MRI) at 11 months of age showed predominant corticospinal tract involvement, which usually appears in adult Krabbe disease. Galactocerebrosidase activity in lymphocytes and skin fibroblasts was very low. Genetic testing revealed compound heterozygous mutations of the galactocerebrosidase ( GALC) gene, c.635_646 delinsCTC and c.1901T>C [p.L618S], both of which are known pathogenic mutations. It has been reported that the c.1901T>C [p.L618S] mutation is associated with the late-onset phenotype and, in a past case, a homozygous mutation at this location showed predominant corticospinal tract involvement on MRI. Although further analysis is needed to identify the pathophysiological mechanism, this combination of mutations is likely to be associated with this unusual MRI finding in late-infantile Krabbe disease. Because these types of mutations are common for Japanese patients, it is possible that there are more undiagnosed and late-diagnosed patients of late-infantile Krabbe disease who display limited lesions on MRI. Pediatricians should be aware that patients with late-infantile Krabbe disease can present with predominant corticospinal tract involvement on MRI.

scholarly journals Childhood epileptic seizures imitating migraine and encephalitis

2012 ◽  
Vol 140 (9-10) ◽  
pp. 558-562
Author(s):  
Ruzica Kravljanac ◽  
Milena Djuric
Keyword(s):  
Antiepileptic Drugs ◽  
Clinical Presentation ◽  
Late Onset ◽  
Clinical Manifestations ◽  
Epileptic Seizures ◽  
Childhood Epilepsy ◽  
Visual Hallucinations ◽  
Seizure Recurrence ◽  
Acute Therapy ◽  
Epileptic Discharges

Introduction. Paroxismal events can resemble epileptic seizures, however, some epileptic seizures, especially benign occipital childhood epilepsies can imitate migraine, cycling vomiting or encephalitis. Objective. The aim of this study was evaluation of clinical and electroencephalographic (EEG) features and outcome in children with benign occipital childhood epilepsies. Methods. Investigation included 18 patients with benign occipital childhood epilepsies hospitalized in the period from 2007 to 2010. The diagnosis was based on clinical and EEG characteristics of seizures, while treatment included acute therapy for seizures and chronic antiepileptic drugs. Prognosis was analyzed in terms of neurological outcome and seizure recurrence rate. Results. Benign occipital childhood epilepsy with early onset was diagnosed in 15 children. Vegetative symptoms, mostly ictal vomiting (13), eye deviation and loss of consciousness (13) dominated in the clinical presentation. The most frequent EEG findings showed occipital epileptic discharges. Benign occipital childhood epilepsy with late onset was diagnosed in three cases. Seizures were manifested by visual hallucinations, headache and secondary generalized convulsions. All three patients were administered chronic antiepileptic drugs and had good outcome. Conclusion. In our patients, clinical manifestations of benign occipital epilepsies had some similarities with clinical features of migraine and encephalitis. It could explain misdiagnosis in some of them. Knowledge about main features and differences between each of these disorders is crucial for making appropriate diagnosis.

Clinical Evaluation of Lacunar Infarction and Branch Atheromatous Disease

2013 ◽  
Vol 22 (4) ◽  
pp. 406-412 ◽  
Author(s):  
Taizen Nakase ◽  
Shotaroh Yoshioka ◽  
Masahiro Sasaki ◽  
Akifumi Suzuki
Keyword(s):  
Clinical Evaluation ◽  
Lacunar Infarction ◽  
Branch Atheromatous Disease
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