scholarly journals Malignant glomus tumor of the thyroid gland: a case report

2019 ◽  
Vol 47 (6) ◽  
pp. 2723-2727
Author(s):  
Yinhua Liu ◽  
Rongrong Wu ◽  
Tao Yu ◽  
Yingya Cao ◽  
Linming Lu
Keyword(s):  
Thyroid Gland ◽  
Smooth Muscle Actin ◽  
Final Diagnosis ◽  
Multiple Organ ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Chemotherapy Drugs ◽  
Multiple Round ◽  
Initial Discovery ◽  
The Right

Objective Primary malignant glomus tumors of the thyroid gland are a rare occurrence. Methods A 68-year-old man found a mass on the right side of his neck in October 2017. An X-ray examination on 9 January 2018 showed multiple round reinforced masses in both sides of the lung. Computed tomography imaging of the neck showed a low-density mass on the right side of the thyroid gland. Results The immunohistochemistry results were positive for smooth muscle actin, calponin, collagen IV, and Ki-67 60%. The patient received chemotherapy starting on 17 January 2018, 8 February 2018, and 11 March 2018. The chemotherapy drugs included ifosfamide, epirubicin, and cisplatin. However, the patient subsequently developed multiple organ failure and died in April 2018, approximately 6 months after the initial discovery of the mass in his neck. Conclusions Primary malignant glomus tumors of the thyroid gland are rare, and examination of their pathology and immunohistochemistry is vital for making an accurate final diagnosis. This case also indicates that primary malignant glomus tumors of the thyroid gland may have a poor prognosis, despite chemotherapy.

scholarly journals A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review

2018 ◽  
Vol 12 ◽  
pp. 117955491881353
Author(s):  
Yanling Zhang ◽  
Heng Tang ◽  
Huaiyuan Hu ◽  
Xiang Yong
Keyword(s):  
Thyroid Gland ◽  
Tumor Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Frozen Sections ◽  
Ki 67 ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Painless Mass ◽  
The Right

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Frozen sections showed a spindle cell tumor of the thyroid gland. The nuclei of some of the tumor cells were obviously enlarged and deeply stained. Pseudocapsule invasion was observed in small foci. Samples showed neither mitosis nor necrosis and the nature of the tumor was difficult to determine. Paraffin sections showed a well-circumscribed nodular composed of intersecting fascicles of spindled to slightly epithelioid cells with eosinophilic cytoplasm and blunt-ended, cigar-shaped nuclei. We observed no significant nuclear atypia, mitotsis, or necrosis. Immunohistochemical staining showed the tumor cells to be positive for α-smooth muscle actin and h-caldesmon but negative for TG, TTF1, PAX8, S-100, CT, CK, and CD34. The ki-67 index was very low (<1%). Primary thyroid leiomyoma is rare and difficult to diagnose using frozen sections. Diagnosis requires immunohistochemical staining. Leiomyoma may be mistaken for other thyroid tumors also characterized by spindle cells.

scholarly journals Ultrasonographic and Scintigraphic Findings of Thyroid Hemiagenesis in a Child: Report of a Rare Male Case

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Ümit Yaşar Ayaz ◽  
Sevin Ayaz ◽  
Mehmet Ercüment Döğen ◽  
Arman Api
Keyword(s):  
Thyroid Gland ◽  
Thyroid Tissue ◽  
Invasive Procedure ◽  
Final Diagnosis ◽  
Left Lobe ◽  
Current Status ◽  
Complementary Method ◽  
Thyroid Hemiagenesis ◽  
Right Lobe ◽  
The Right

Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of thyroid gland fails to develop. It is much rarer in males. There is a higher incidence of associated thyroid disorders in patients with thyroid hemiagenesis; therefore early and prompt diagnosis is important for children. We present the ultrasonographic and scintigraphic findings of thyroid hemiagenesis in an eight-year-old-boy. On ultrasonography (US), left lobe of the thyroid gland could not be demonstrated and the right lobe showed minimal hyperplasia. Its echogenicity was normal and no nodule was seen. On thyroid scintigraphy, left lobe of thyroid gland or any ectopic thyroid tissue could not be demonstrated, while the right lobe showed minimal hyperplasia. Without performing any invasive procedure, we enrolled the child in a follow-up program with the guidance of US and scintigraphy, which were effective both in making the final diagnosis of thyroid hemiagenesis and in evaluating the current status of the present thyroid tissue. In conclusion, if only one thyroid lobe is detected in a pediatric case initially with US or scintigraphy, the diagnosis of thyroid hemiagenesis should be suggested and, before any unnecessary or invasive attempt, the other complementary method (scintigraphy/US) should be performed.

scholarly journals Pyothorax-associated Lymphoma: a Case Report and Review

2020 ◽  
Author(s):  
Fangyuan Dong ◽  
Yongzhi Wu ◽  
Sufen Wang ◽  
Guomin Sun ◽  
Qinqin Zhang ◽  
...  
Keyword(s):  
Chest Pain ◽  
Rare Disease ◽  
Single Case ◽  
Lower Lobe ◽  
Final Diagnosis ◽  
Patient Treatment ◽  
Ki 67 ◽  
Chronic Empyema ◽  
The Right ◽  
Fdg Pet Ct

Abstract Background: Pyothorax-associated lymphoma is a rare disease with variations in endemic prevalence. PAL arising from a posttraumatic empyema are a rare occurrence.Case presentation: a male patient, 83 years old. Twenty years earlier, the patient fell from a height, sustaining a fracture to the right rib, which improved after conservative treatment. In September 2018, the patient had right chest pain (ribs 9–10). In February 2019, the chest pain became worse during sleep. CT examination showed inflammation of the right lower lobe, chronic empyema on the right with subdiaphragmatic infection, fibrosis of the right lung, atherosclerosis, thickening of the left pleura with rib destruction, and membranous calcification around the lesion. After 5 days of treatment with cefoperazone, sulbactam sodium, and ornidazole, the patient’s chest pain did not improve. The results of 18F-FDG PET/CT showed the following: a solid mass in the lower right thoracic cavity. Immunohistochemistry showed that the tumor cells were negative for CD20 and CD3, positive for background mature T lymphocytes, positive for Pax-5, positive for MUM-1, Ki-67 (70%, +); AE1/AE3, CD138, Bcl-6, CD10, CD5, CD56, MPO (-); CD79α (part +), EMA (part +), CD38 (+), bcl-2 (+). In situ hybridization (CISH): EBER+. Mini-CHOP chemotherapy was implemented on April 11, 2019. The patient stopped taking analgesics on the day of chemotherapy. The pain disappeared one week later, and the EBV-DNA fell to the normal range. In the later stage, the family members of the patient declined further patient treatment and reexamination. The patient’s condition worsened in July 2019 and he died on September 25, 2019.Conclusion: Pathological morphology is vital important to make a final diagnosis and avoid misdiagnosis or miss diagnosis. This case is described by a combination of imaging and pathological examinations that reports the clinical pathological diagnosis and treatment process of a single case of pyothorax-associated lymphoma, and it provides some diagnostic information regarding the rare disease of PAL.

scholarly journals Glomus tumor of small intestine: case report and review of literature

2021 ◽  
Author(s):  
Yan Tan ◽  
Xinyi Wang ◽  
Guifang Yang ◽  
Lan Liu ◽  
Jun Fang ◽  
...  
Keyword(s):  
Small Intestine ◽  
Glomus Tumor ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Proliferation Index ◽  
Review Of Literature ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Single Balloon ◽  
Single Balloon Enteroscopy

Abstract BackgroundGlomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases of glomus tumors located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features.Case presentationA 30-year-old female referred to our hospital with the chief complain of melena and fatigue for 3 weeks. Oral single-balloon enteroscopy discovered a 2.0*2.0cm tumor without epithelial lining in the jejunum. The patient then underwent partial enterectomy. HE stain illustrated that the tumor was interspersed with congestive capillaries of various size, and admixed with smooth muscle bundles. Immunohistochemical study showed that the tumor cells were strongly positive for SMA and collagen type Ⅳ. The Ki-67 proliferation index was less than 1% and mitotic activity is very low (about 1/50 HPF). The case was finally diagnosed as benign glomus tumor.ConclusionsGlomus tumors arising from the small intestine are extremely rare. The final diagnosis is made by histological and immunohistochemical examination. Although there is no standardized management pathway for these patients, early diagnosis and treatment are important for a good prognosis.

scholarly journals Glomus Tumor of Small Intestine: Case Report and Review of Literature

2021 ◽  
Author(s):  
Yan Tan ◽  
Xinyi Wang ◽  
Guifang Yang ◽  
Lan Liu ◽  
Jun Fang ◽  
...  
Keyword(s):  
Small Intestine ◽  
Glomus Tumor ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Proliferation Index ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Pathologic Features ◽  
Single Balloon ◽  
Single Balloon Enteroscopy

Abstract Background: Glomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases of glomus tumors located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features.Case presentation: A 30-year-old female referred to our hospital with the chief complain of melena and fatigue for 3 weeks. Oral single-balloon enteroscopy discovered a 2.0*2.0cm tumor without epithelial lining in the jejunum. The patient then underwent partial enterectomy. HE stain illustrated that the tumor was interspersed with congestive capillaries of various size, and admixed with smooth muscle bundles. Immunohistochemical study showed that the tumor cells were strongly positive for SMA and collagen type Ⅳ. The Ki-67 proliferation index was less than 1% and mitotic activity is very low (about 1/50 HPF). The case was finally diagnosed as benign glomus tumor. Conclusion: Glomus tumors arising from the small intestine are extremely rare. The final diagnosis is made by histological and immunohistochemical examination. Although there is no standardized management pathway for these patients, early diagnosis and treatment are important for a good prognosis.

scholarly journals Glomus Tumor of the Stomach: A Rare Cause of Upper Gastrointestinal Bleeding

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Enzo Fabrício Ribeiro Nascimento ◽  
Fábio Piovezan Fonte ◽  
Roberta Laís Mendonça ◽  
Ronaldo Nonose ◽  
Carlos Alberto Fonte de Souza ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Bleeding ◽  
Glomus Tumor ◽  
Upper Gastrointestinal Bleeding ◽  
Smooth Muscle Actin ◽  
Muscularis Propria ◽  
Gastric Body ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Upper Gastrointestinal

Introduction. Glomus tumors (GTs) are benign neoplasm originating from the glomus body, commonly described in subungual region. The involvement abdominal is rare. Our aim is to describe a case of glomus tumor of the stomach that presented upper gastrointestinal bleeding. A 34-year-old woman was admitted with upper gastrointestinal bleeding and underwent an upper endoscopy that showed bleeding arising from an ulcerated lesion, treated by sclerosis therapy. A new endoscopy confirmed a submucosal lesion in upper portion of the stomach. During the laparotomy, a tumor at the upper anterior wall of gastric body was found and resected by a vertical gastrectomy. The pathological exam revealed hyperplastic smooth muscle fibers of the muscularis propria of the stomach wall, surrounded by hyaline stroma. The immunohistochemistry panel was positive for smooth muscle actin and type IV collagen, with low rate of mitosis studied by Ki-67 which allowed the final diagnosis of a gastric glomus tumor.Discussion. The majority of intraperitoneal glomus tumors occur in the stomach, and it is phenotypically similar to those localized in peripheral sites. Gastric GT generally is a benign tumor although it can be malignant and have the potential to metastasize.Conclusion. Even though gastric glomus tumor is rarely described, it should be considered as a possible cause of a major upper gastrointestinal bleeding.

Case report: a case of primary pulmonary glomus tumor

2020 ◽  
Author(s):  
shuangshuang Deng ◽  
Jianhao Huang ◽  
Qi Yin ◽  
Jinli Gao ◽  
Feilong Wang ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Glomus Tumor ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Final Diagnosis ◽  
Case Presentation ◽  
Glomus Tumors ◽  
Disease Case ◽  
The Right

Abstract Background Glomus tumors, as extremely rare tumors of the lung, since their rarity and the variety of the clinical symptoms, tend to be misdiagnosed. The location of these tumors as well as their early diagnosis is a pivot for the prognosis of the disease. Case presentation We report a case of old patient whose final diagnosis was primary pulmonary glomus tumor. She initially was found a nodule in the right lung, which was enlarged during follow-up and finally confirmed after surgery. Postoperative pathology was considered as a primary pulmonary glomus tumor. There has been no evidence of tumor recurrence or metastasis so far. Conclusion Primary pulmonary glomus tumor is rare. The clinical manifestations are related symptoms occupying lesions in the lung. The diagnosis of the tumor depends on histopathology and immunohistochemistry. Surgical resection is considered as the most effective treatment for this condition.

scholarly journals Intraosseous schwannoma of the proximal humerus with pathologic fracture

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Jiang Huajun ◽  
Qu Wei ◽  
Wu Yuxuan ◽  
Yang Jingjing
Keyword(s):  
Proximal Humerus ◽  
Pathologic Fracture ◽  
Bone Allograft ◽  
Excisional Biopsy ◽  
Final Diagnosis ◽  
Pathological Examination ◽  
Ki 67 ◽  
Intraosseous Schwannoma ◽  
S 100 ◽  
The Right

Abstract Background Intraosseous schwannomas are extremely rare in the humerus, and less than five cases have been reported previously in the literature. This is the first report of its origin in the proximal humerus with pathologic fracture. We herein present this case to discuss the reason for its rarity and share our experience of management. Case presentation A 55-year-old female patient presented with pain in the right shoulder, which was caused by tripping and falling over a board. Radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) showed considerable tumor in proximal humerus, which connected with a fracture. For this suspected tumor, we performed two operations. Pathological examination demonstrated typical picture of a schwannoma, showing whorls and interlacing fascicles of schwannoma spindle cells. Immunohistochemistry, the tumor cells were diffusely positive for S-100 protein, SOX-10 and CD68, while they were completely negative for desmin, DOG-1, AE1/AE3 and P63. The Ki-67 index was about 10%. No mitoses or features of malignancy were identified. The final diagnosis of intraosseous schwannoma was made. The treatment for intraosseous schwannoma with pathologic fracture includes excisional biopsy, curettage, bone allograft, and fracture fixation. The patient recovered well. After the surgery, the patient gradually regained mobility and the pain subsided. There was no recurrence after 6 months of follow-up by X-ray. Conclusions Although very rare, intraosseous schwannoma should be taken under consideration in the differential diagnosis of benign-appearing osseous tumor in the proximal humerus with pathologic fracture.

scholarly journals Salivary Gland Myoepithelioma with Focal Capsular Invasion

2009 ◽  
Vol 88 (7) ◽  
pp. 1005-1009 ◽  
Author(s):  
Banu Dogan Gun ◽  
Sukru Oguz Ozdamar ◽  
Burak Bahadir ◽  
Lokman Uzun
Keyword(s):  
Salivary Gland ◽  
Tumor Cells ◽  
Smooth Muscle Actin ◽  
Minor Component ◽  
Final Diagnosis ◽  
Capsular Invasion ◽  
Spindle Cells ◽  
Painless Mass ◽  
The Right ◽  
A Minor

Salivary gland tumors that display myoepithelial differentiation exclusively or predominantly are relatively uncommon, and the assessment of malignancy in a myoepithelial tumor can be difficult. We report a case of parotid gland myoepithelioma composed predominantly of spindle cells with focal capsular invasion. The patient was a 65-year-old woman who presented with a painless mass in the right preauricular region. Histologically, the tumor had a solid and multinodular growth pattern and was predominantly made up of spindle cells with a minor component of epithelioid cells with moderate cellular atypia. Focal regions of tumor cells infiltrated the capsule with tongue-like processes, hut tumor infiltration into the adjacent parotid tissue was absent. The tumor cells showed strong cytoplasmic immunoexpression of vimentin, pankeratin, S-100 protein, and smooth-muscle actin. Immunostains with glial fibrillary acidic protein, melanoma marker, epithelial membrane antigen, and carcinoembryonic antigen were negative. Expression of p53 was observed focally in the nuclei of the tumor cells. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors.

Pleomorphic Leiomyosarcoma of the Adrenal Gland

2003 ◽  
Vol 127 (1) ◽  
pp. e32-e35
Author(s):  
Mario G. Lujan ◽  
Mai P. Hoang
Keyword(s):  
Adrenal Gland ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Neoplastic Cells ◽  
Ki 67 ◽  
Posterior Aspect ◽  
History Of ◽  
Mitotic Figures ◽  
The Right ◽  
Superior Pole

Abstract Primary leiomyosarcomas arising in the adrenal gland are exceedingly rare, with only 3 cases reported in the literature. We present the clinical, morphologic, and immunohistochemical features of a pleomorphic leiomyosarcoma, a variant of leiomyosarcoma that has not been described in the adrenal gland. A 63-year-old man presented with a 1-year history of enlarging right upper quadrant mass and pulmonary nodule. A diagnosis of metastatic pulmonary carcinoma to the adrenal gland was rendered on a needle biopsy specimen. Preoperative chemotherapy reduced only the pulmonary mass but not the adrenal mass, which continued to enlarge. Documented by computed tomography and confirmed at surgery, the tumor had completely replaced the right adrenal gland, invading into both the posterior aspect of the right liver and the superior pole of the right kidney. Histologic sections showed a diffuse proliferation of pleomorphic, large, and polygonal neoplastic cells with prominent nucleoli. Many bizarre mitotic figures were present. The neoplastic cells were strongly positive for desmin, calponin, and vimentin. Approximately 80% of the neoplastic cells were positive for the proliferation marker Ki-67. They were negative for smooth muscle actin, muscle-specific actin, myoglobin, myogenin, CD117, cytokeratins, carcinoembryonic antigen, epithelial membrane antigen, chromogranin, CD34, CD31, S100 protein, and HMB-45.

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